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Continuity of the optimal value function and optimal solutions of parametric mixed-integer quadratic programs

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Applied Mathematics(A Journal of Chinese Universities) 2010年第4期25卷 391-399页

作者： CHEN Zhi-ping han you-pan Department of Scientific Computing and Applied Software, Faculty of Science, Xi’an Jiaotong University, Xi’an 710049, China Department of Scientific Computing and Applied Software Faculty of Science Xi’an Jiaotong University Xi’an China

To properly describe and solve complex decision problems, research on theoretical properties and solution of mixed-integer quadratic programs is becoming very important. We establish in this paper different Lipschitz-type continuity results about the optimal value function and optimal solutions of mixed-integer parametric quadratic programs with parameters in the linear part of the objective function and in the right-hand sides of the linear constraints. The obtained results extend some existing results for continuous quadratic programs, and, more importantly, lay the foundation for further theoretical study and corresponding algorithm analysis on mixed-integer quadratic programs.

关键词： Mixed-integer quadratic program optimal value function optimal solution.

Altered regional brain activity and functional connectivity in primary intravaginal anejaculation patients revealed by resting-state fMRI

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Asian Journal of Andrology 2024年第5期26卷 510-516页

作者： Qing-Qiang Gao Jian-Huai Chen Jia-Ming Lu Bin Wang you-Feng han Song-Zhan Gao Jie Yang Yu-Tian Dai Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing 210008China Department of Andrology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Andrology Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China Department of Radiology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Andrology The Third Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Urology Jiangsu Provincial People’s HospitalFirst Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Urology People’s Hospital of Xinjiang Kizilsu Kirgiz Autonomous PrefectureKizilsu Kirgiz Autonomous Prefecture 845350China

Ejaculation is regulated by the central nervous ***,the central pathophysiology of primary intravaginal anejaculation(PIAJ)is *** present study aimed to examine the changes in regional brain activity and functional connectivity underlying PIAJ.A total of 20 PIAJ patients and 16 healthy controls(HCs)were enrolled from September 2020 to September 2022 in the Department of Andrology,Nanjing Drum Tower Hospital(Nanjing,China).Magnetic resonance imaging data were acquired from all participants and then were *** measures of fractional amplitude of low-frequency fluctuation(fALFF),regional homogeneity(ReHo),and functional connectivity(FC)were calculated and compared between the *** patients showed increased fALFF values in the left precuneus compared with ***,PIAJ patients showed increased ReHo values in the left precuneus,left postcentral gyrus,left superior occipital gyrus,left calcarine fissure,right precuneus,and right middle temporal gyrus,and decreased ReHo values in the left inferior parietal gyrus,compared with ***,brain regions with altered fALFF and ReHo values in PIAJ patients showed increased FC with widespread cortical regions,which included the frontal,parietal,temporal,and occipital regions,compared with *** conclusion,increased regional brain activity in the parietal,temporal,and occipital regions,and increased FC between these brain regions,may be associated with PIAJ occurrence.

关键词： fractional amplitude of low-frequency fluctuation functional connectivity primary intravaginal anejaculation regional homogeneity resting-state functional magnetic resonance imaging

Development, applications and challenges of ReaxFF reactive force field in molecular simulations

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Frontiers of Chemical Science and Engineering 2016年第1期10卷 16-38页

作者： you han Dandan Jiang Jinli Zhang Wei Li Zhongxue Gan Junjie Gu School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China ENN Group State Key Laboratory of Low Carbon Energy of Coal Langfang 065001 China Mechanical and Aerospace Engineering Carleton University 1125 Colonel By Drive Ottawa Ontario K1S5B6 Canada

As an advanced and new technology in molecular simulation fields, ReaxFF reactive force field has been developed and widely applied during the last two decades. ReaxFF bridges the gap between quantum chemistry （QC） and non-reactive empirical force field based molecular simulation methods, and aims to provide a transferable potential which can describe many chemical reactions with bond formation and breaking. This review presents an overview of the development and applications of ReaxFF reactive force field in the fields of reaction processes, biology and materials, including （1） the mechanism studies of organic reactions under extreme conditions （like high temperatures and pressures） related with high-energy materials, hydrocarbons and coals, （2） the structural properties ofnanomaterials such as graphene oxides, carbon nanotubes, silicon nanowires and metal nanoparticles, （3） interfacial interactions of solid-solid, solid-liquid and biological/inorganic surfaces, （4） the catalytic mechanisms of many types of metals and metal oxides, and （5） electrochemical mechanisms of fuel cells and lithium batteries. The limitations and challenges of ReaxFF reactive force field are also mentioned in this review, which will shed light on its future applications to a wider range of chemical environments.

关键词： ReaxFF reaction interfacial interaction catalyst mechanism nanomaterials fuel cell

Ultrasound Assisted Synthesis of Nanoscale NH2-MIL-53(Fe) for the Adsorption of Dye

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Chinese Journal of Structural Chemistry 2021年第1期40卷 42-46,2页

作者： WU Xue-Min LIU Long-Xue LIU Ling you Zi-han GUO Hong-Xu CHEN Zhang-Xu College of Chemistry Chemical Engineering and EnvironmentMinnan Normal UniversityZhangzhou 363000China Fujian Provincial Key Laboratory of Ecology-toxicological Effects&Control for Emerging Contaminants Putian University 351100China

Nanometer blocks of amide-functionalized Fe(Ⅲ)-based metal-organic frameworks,NH2-MIL-53(Fe),were prepared via ultrasonic method without any surfactants at room temperature and atmospheric *** characterization for the as-prepared nano-structured MOFs was established by XRD,SEM,TEM,XPS and N2 *** as-prepared sample with high specific surface area(179.9 m^(2)·g^(-1))showed excellent adsorption for methylene blue in the liquid *** as-prepared NH_(2)-MIL-53(Fe)adsorbent seems to be a promising material in practice for organic dye removal from aqueous solution.

关键词： NH2-MIL-53(Fe) ultrasonic method removal methylene blue

Effect of supercritical water on the stability and activity of alkaline carbonate catalysts in coal gasification

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Journal of Energy Chemistry 2013年第3期22卷 459-467页

作者： Jinli Zhang Xiaoxia Weng you han Wei Li Zhongxue Gan Junjie Gu School of Chemical Engineering and Technology Tianjin University State Key Laboratory of Low Carbon Energy of Coal ENN Group

The stability and activity of alkaline carbonate catalysts in supercritical water coal gasification has been investigated using density functional theory method. Our calculations present that the adsorption of Na2CO3 on coal are more stable than that of K2CO3, but the stability of Na2CO3 is strongly reduced as the cluster gets larger. In supercritical water system, the dispersion and stability of Na2CO3 catalyst on coal support is strongly improved. During coal gasification process, Na2CO3 transforms with supercritical water into NaOH and NaHCO3, which is beneficial for hydrogen production. The transformation process has been studied via thermodynamics and kinetics ways. The selectively catalytic mechanism of NaOH and the intermediate form of sodium-based catalyst in water-gas shift reaction for higher hydrogen production has also been investigated. Furthermore, NaOH can transform back to Na2CO3 after catalyzing the water-gas shift reaction. Thus, the cooperative effects between supercritical water and Na2CO3 catalyst form a benignant circle which greatly enhances the reaction rate of coal gasification and promotes the production of hydrogen.

关键词： supercritical water alkaline carbonates coal gasification hydrogen production density functional theory

Zinc oxide nanoparticles reduce the chemoresistance of gastric cancer by inhibiting autophagy

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World Journal of Gastroenterology 2021年第25期27卷 3851-3862页

作者： you-han Miao Li-Ping Mao Xiao-Juan Cai Xiao-Ying Mo Qi-Qi Zhu Fei-Tong Yang Mei-Hua Wang Department of Infectious Disease Nantong Third People’s HospitalNantong 226006Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is a common malignancy that results in a high rate of cancerrelated ***(DDP)-based chemotherapy is the first-line clinical treatment for GC therapy,but chemotherapy resistance remains a severe clinical *** oxide nanoparticle(ZnO-NP)has been identified as a promising anti-cancer agent,but the function of ZnO-NP in GC development is still *** To explore the effect of ZnO-NP on chemotherapy resistance during GC *** ZnO-NP was synthesized,and the effect and underlying mechanisms of ZnO-NP on the malignant progression and chemotherapy resistance of GC cells were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assays,colony formation assays,transwell assays,wound healing assays,flow cytometry,and Western blot analysis in GC cells and DDP-resistant GC cells,and by tumorigenicity analyses in nude *** Our data revealed that ZnO-NP was able to inhibit proliferation,migration,and invasion and induce apoptosis of GC ***,ZnO-NP significantly reduced the half maximal inhibitory concentration(IC50)of DDP for the inhibition of cell proliferation of DDP-resistant SGC7901/DDP cell *** was increased in DDP-resistant GC cells,as demonstrated by elevated light chain 3-like protein 2(LC3II)/LC3I and Beclin-1 expression and repressed p62 expression in SGC7901/DDP cells compared to SGC7901 ***,ZnO-NP inhibited autophagy in GC cells and treatment with DDP induced autophagy,which was reversed by ***,ZnO-NP attenuated the tumor growth of DDP-resistant GC cells in *** We conclude that ZnO-NP alleviates the chemoresistance of GC cells by inhibiting *** findings present novel insights into the mechanism by which ZnO-NP regulates the chemotherapy resistance of ***-NP may serve as a potential therapeutic candidate for GC *** potential role of ZnO-NP in the clinical treatment of GC needs clarif

关键词： Gastric cancer Progression Chemoresistance Zinc oxide nanoparticle Autophagy MTT assays

A Kind of Essential Surfaces in the Complements of Knots

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Communications in Mathematical Research 2013年第2期29卷 143-147页

作者： han you-fa Pan Sheng-jun Wang Shu-xin Lei Feng-chun School of Mathematics Liaoning Normal University

In this paper, by the twist-crossing number of knots, we give an upper bound on the Euler characteristic of a kind of essential surfaces in the complements of alternating knots and almost alternating knots, which improves the estimation of the Euler characteristic of the essential surfaces with boundaries under certain conditions. Furthermore, we give the genus of the essential surfaces.

关键词： essential surface twist-crossing number almost alternating knot reduced graph

Graphene-anchored sodium single atoms:A highly active and stable catalyst for transesterification reaction

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Nano Research 2024年第6期17卷 4979-4985页

作者： Song-Song Peng Yao Nian Xing-Ru Song Xiang-Bin Shao Chen Gu Zhi-Wei Xing Shi-Chao Qi Peng Tan you han Xiao-Qin Liu Lin-Bing Sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)College of Chemical EngineeringNanjing Tech University30 South Puzhu RoadNanjing 211816China School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

Solid strong base catalysts have received considerable attention in various organic reactions due to their facile separation,neglectable corrosion,and environmental *** great progress has been made in the preparation of solid strong base catalysts,it is still challenging to avoid basic sites aggregation on support and active sites loss in reaction ***,we report a tandem redox strategy to prepare Na single atoms on graphene,producing a new kind of solid strong base catalyst(Na1/G).The base precursor NaNO_(3)was first reduced to Na2O by graphene(400℃)and successively to single atoms Na anchored on the graphene vacancies(800℃).Owing to the atomically dispersed of basicity,the resultant catalyst presents high activity toward the transesterification of methanol and ethylene carbonate to synthesize dimethyl carbonate(turnover frequency(TOF)value:125.7 h^(−1)),which is much better than the conventional counterpart Na2O/G and various reported solid strong bases(TOF:1.0-90.1 h^(−1)).Furthermore,thanks to the basicity anchored on graphene,the Na1/G catalyst shows excellent durability during *** work may provide a new direction for the development of solid strong base catalysts.

关键词： solid strong base catalyst basic sites redox graphene single Na atoms

Optimizing ABA-based chemically induced proximity for enhanced intracellular transcriptional activation and modification response to ABA

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Science China Life Sciences 2024年第12期67卷 2650-2663页

作者： Zeng Zhou Yue-Qi Wang Xu-Nan Zheng Xiao-Hong Zhang Lu-Yao Ji Jun-you han Ze-Cheng Zuo Wei-Liang Mo Li Zhang College of Life Sciences Fujian Agriculture and Forestry University Basic Forestry and Proteomics Research Center Fujian Agriculture and Forestry University Jilin Province Engineering Laboratory of Plant Genetic Improvement College of Plant Science Jilin University

Abscisic acid(ABA)-based chemically induced proximity(CIP) is primarily mediated by the interaction of the ABA receptor pyrabactin resistance 1-like 1(PYL1) and the 2C-type protein phosphatase ABI1, which confers ABA-induced proximity to their fusion proteins, and offers precise temporal control of a wide array of biological processes. However, broad application of ABA-based CIP has been limited by ABA response intensity. In this study, we demonstrated that ABA-induced interaction between another ABA receptor pyrabactin resistance 1(PYR1) and ABI1 exhibited higher ABA response intensity than that between PYL1 and ABI1 in HEK293T cells. We engineered PYR1-ABI1and PYL1-ABI1 into ABA-induced transcriptional activation tools in mammalian cells by integration with CRISPR/d Cas9 and found that the tool based on PYR1-ABI1 demonstrated better ABA response intensity than that based on PYL1-ABI1 for both exogenous and endogenous genes in mammalian cells. We further achieved ABA-induced RNA m6A modification installation and erasure by combining ABA-induced PYR1-ABI1 interaction with CRISPR/d Cas13, successfully inhibiting tumor cell proliferation. We subsequently improved the interaction of PYR1-ABI1 through phage-assisted continuous evolution(PACE), successfully generating a PYR1 mutant(PYR1m) whose interaction with ABI1 exhibited a higher ABA response intensity than that of the wild-type. In addition, we tested the transcriptional activation tool based on PYRm-ABI1 and found that it also showed a higher ABA response intensity than that of the wild type. These results demonstrate that we have developed a novel ABA-based CIP and further improved upon it using PACE, providing a new approach for the modification of other CIP systems.

关键词： ABA chemically induced proximity transcriptional activation m6A modification protein evolution