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Delorme's operation plus sphincteroplasty for complete rectal prolapse associated with traumatic fecal incontinence

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The Journal of Biomedical Research 2015年第4期29卷 326-331页

作者： Mohamed M.Osman Walid M.Abd El Maksoud yosry s.gawe.sh Department of General surgery Faculty of MedicineUniversity of Alexandria

Rectal prolapse associated with traumatic fecal incontinence is a rare clinical combination. This study was designed to assess Delorme＇s operation with sphincteroplasty as a surgical management of this combination in terms of recurrence and improvement of fecal incontinence. In this prospective study, we enrolled patients suffering from short, full-thickness rectal prolapse associated with traumatic fecal incontinence who had been admitted to Alexandria Main University Hospital during the period of May 2010-January 2013. Preoperative data including cause of trauma, duration of symptoms, results of anal manometry, and degree of fecal incontinence using Wexner score were collected from all patients. Delorme＇s procedure with overlap sphincteroplasty was done in all patients. Recurrence of prolapse and improvement of fecal incontinence were assessed after 1, 3, 6 and 12 months. The study included 13 patients aged （32±8.7） years, 9 females and 4 males. Cause of sphincteric injury included previous anal surgery in 7 patients and normal labor in 6 patients. Duration between sphinctefic injury and operation was （8.08±2.47） months. Preoperative Wexner＇s mean score was 16.07±3.4. Early postoperative complications included superficial wound infection （69.2%）, minor wound dehiscence （61.5%）, and postoperative bleeding （7.6%）. Recurrence was detected in 1 patient at 6 month follow-up. Wexner＇s score showed significant improvement for all patients after 6 months （4.00±2.04）. In conclusion, combination of Delorme＇s procedure and sphincteroplasty for treatment of patients with short complete rectal prolapse associated with traumatic fecal incontinence is a safe, effective surgical management with satisfactory results regarding anatomical and functional outcomes.

关键词： rectal prolapse fecal incontinence Delorme's operation sphincteroplasty.

Advanced fabrication for electrospun three-dimensional nanofiber aerogels and scaffolds

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Bioactive Materials 2020年第4期5卷 963-979页

作者： Yujie Chen Muhammad shafiq Mingyue Liu yosry Morsi Xiumei Mo state Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620PR China Department of Chemistry Pakistan Institute of Engineering&Applied Sciences(PIEAS)Nilore45650IslamabadPakistan Faculty of Engineering and Industrial sciences Swinburne University of TechnologyBoroondaraVIC3122Australia

Electrospinning is a versatile strategy for creating nanofiber materials with various structures,which has broad application for a myriad of areas ranging from tissue engineering,energy harvesting,filtration and has become one of the most important academic and technical activities in the field of material science in recent *** addition to playing a significant role in the construction of two-dimensional(2D)nanomaterials,electrospinning holds great promise as a robust method for producing three-dimensional(3D)aerogels and *** article reviews and summarizes the recent advanced methods for fabricating electrospun three-dimensional nanofiber aerogels and scaffolds,including gas foaming,direct electrospinning of 3D nanofibrous scaffold,short nanofibers assembling into 3D aerogels/scaffolds,3D printing,electrospray,origami and cell sheet engineering,centrifugal electrospinning,and other ***,intriguing formation process,crosslinking pathway,properties,and applications of 3D aerogels and scaffolds are also *** together,these aerogels and scaffolds with various excellent features present tremendous potential in various fields.

关键词： Electrospun nanofibers Three-dimensional scaffolds Aerogels Tissue engineering

Electrospinning:An emerging technology to construct polymer-based nanofibrous scaffolds for diabetic wound healing

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Frontiers of Materials science 2021年第1期15卷 10-35页

作者： Atta ur Rehman KHAN yosry MORsI Tonghe ZHU Aftab AHMAD Xianrui XIE Fan YU Xiumei MO state Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China Faculty of Engineering and Industrial sciences Swinburne University of TechnologyBoroondaraVIC 3122Australia Multidisciplinary Center for Advanced Materials of shanghai University of Engineering science College of Chemistry and Chemical EngineeringShanghai University of Engineering ScienceShanghai 201620China Department of Bioscience cOMSATS Institute of Information TechnologyPakistan

A chronic wound in diabetic patients is a major public health concern withsocioeconomic and clinical *** underlying medical condition of diabeticpatients deteriorates the wound through physiological,metabolic,molecular,and ***,a wound enters a vicious pathological inflammatory *** therapeutic approaches are in practice to manage diabetic wounds hence ensuringthe regeneration ***-based biomaterials have come up with hightherapeutic *** efforts have been devoted,over the years,to build aneffective wound healing material using *** electrospinning technique,although not new,has turned out to be one of the most effective strategies in buildingwound healing biomaterials due to the special structural advantages of electrospunnanofibers over the other *** this review,careful integration of allelectrospinning approaches has been presented which will not only give an insight intothe current updates but also be helpful in the development of new therapeutic materialconsidering pathophysiological conditions of a diabetic wound.

关键词： diabetic wound healing inflammation polymers bioactive substances hydrogel electrospinning nanofibers

Antifouling evaluation of extracts from Red sea soft corals against primary biofilm and biofouling

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Asian Pacific Journal of Tropical Biomedicine 2017年第11期7卷 991-997页

作者： yosry Abdel Aziz soliman Ahmed Mohammed Brahim Ahmed Hussein Moustafa Mohamed Abdel Fattah Hamed Marine Chemistry Lab. Marine Environment DivisionNational Institute of Oceanography and FisheriesSuezEgypt Department of Chemistry Faculty of ScienceZagazig UniversityZagazigEgypt

Objectives: To evaluate antifouling property of extracts from Red sea soft corals against primary biofilm and ***: seven species of soft corals sarcophyton glaucum(a), sinularia compressa,sinularia cruciata(a), Heteroxenia fuscescens(a), sarcophyton glaucum(b), Heteroxenia fuscescens(b) and sinularia cruciata(b) were chosen to test their extracts as antibacterial and antifouling agents in Eastern Harbour of Alexandria, Mediterranean *** compounds of soft corals were extracted by using methanol and concentrated under vacuum. The residues of extracts were mixed in formulation of inert paint which consisted of rosin, chlorinated rubber and ferrous oxide against micro and macro fouling organisms. The formulated paints were then applied on PVC panels twice by brush,hanged in a steel frame and immersed in Eastern Harbour of Alexandria Mediterranean sea followed by visual inspection and photographic ***: After 185 days of immersion in seawater, the antifouling results agreed with the antibacterial results where extracts of sinularia compressa and Heteroxenia fuscescens(b) gave the best activity against marine fouling tubeworms and barnacles. The inhibition activity was correlated with the major functional groups(hydroxyl, amino, carbonyl,aliphatic(fatty acids), C]C of alkene or aromatic rings and CeC l of aryl halides) of the ***: The strong antifouling activity makes them promising candidates for new antifouling additives. After the screening and application of natural organic compounds from soft corals, marine organisms show activity against micro and macro fouling organisms.

关键词： Antibacterial Antifouling Paints seawater Marine Organisms

Regulation of nerve cells using conductive nanofibrous scaffolds for controlled release of Lycium barbarum polysaccharides and nerve growth factor

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Regenerative Biomaterials 2023年第1期10卷 919-932页

作者： Jing Wang Yuan Liu Minmin Lv Xiaoli Zhao Kwok Fai so Hui Li Mohamed EL-Newehy Hany EL-Hamshary yosry Morsi Xiumei Mo Research Center for Human Tissues and Organs Degeneration Institute of Biomedicine and BiotechnologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055P.R.China Department of Orthopedics Shanghai Sixth People’s HospitalShanghai201306P.R.China University of Hong Kong-shenzhen Hospital Shenzhen518053P.R.China state Key Laboratory of Brain and Cognitive sciences The University of Hong KongPokfulamHong KongP.R.China Department of Ophthalmology The University of Hong KongPokfulamHong KongP.R.China Guangdong-Hong Kong-Macao Institute of CNs Regeneration Jinan UniversityGuangzhouP.R.China Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451P.O.Box 2455Saudi Arabia Faculty of Engineering and Industrial sciences Swinburne University of TechnologyBoroondaraVIC 3122Australia state Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversitySongjiangShanghai201600P.R.China

Currently,more and more patients suffer from peripheral nerve injury due to trauma,tumor and other causes ***-based nerve conduits are increasingly recognized as a potential alternative to nerve autografts for the treatment of peripheral nerve ***,an ideal nerve conduit must offer topological guidance and biochemical and electrical signal transduction *** this work,aligned conductive nanofibrous scaffolds comprising polylactic-co-glycolic acid and multiwalled carbon nanotubes(MWCNTs)were fabricated via coaxial electrospinning,and nerve growth factor(NGF)and Lycium barbarum polysaccharides(LBP)purified from the wolfberry were loaded on the core and shell layers of the nanofibers,*** were confirmed to accelerate long-distance axon regeneration after severe peripheral nerve *** addition,the synergistic promotion of LBP and NGF on nerve cell proliferation and neurite outgrowth was *** were introduced into the aligned fibers to further increase the electrical conductivity,which promoted the directional growth and neurite extension of neurons in ***,the combination of conductive fibrous scaffolds with electrical stimulation that mimics endogenous electric fields significantly promoted the differentiation of PC12 cells and the axon outgrowth of *** on robust cell-induced behaviors,conductive composite fibers with optimized fiber alignment may be used for the promotion of nerve recovery.

关键词： conductive nanofibrous scaffold LBP NGF nerve cells electrical stimulation

A soft tissue adhesive based on aldehyde-sodium alginate and amino-carboxymethyl chitosan preparation through the schiff reaction

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Frontiers of Materials science 2017年第3期11卷 215-222页

作者： Yu WU Liu YUAN Nai-an shENG Zi-qi GU Wen-hao FENG Hai-yue YIN yosry MORsI Xiu-mei MO Key Laboratory of Textile science & Technology (Ministry of Education) College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China Faculty of Engineering and Industrial sciences Swinburne University of Technology Hawthorn Vic 3122 Australia shandong International Biotechnology Park Development Co. Ltd. Yantai 264003 China

sodium alginate and carboxymethyl chitosan have been extensively applied in tissue engineering and other relative fields due to their low price and excellent biocompatibility. In this paper, we oxidized sodium alginate with sodium periodate to convert 1,2-hydroxyl groups into aldehyde groups to get aldehyde-sodium alginate （A- sA）. Carboxymethyl chitosan was modified with ethylenediamine （ED） in the presence of water-soluble N-（3-Dimethylaminopropyl）-N＇-ethylcarbodiimide hydrochloride （EDC） to introduce additional amino groups to get amino-carboxymethyl chitosan （A-Cs）. Upon mixing the A-sA and A-Cs aqueous solutions together, a gel rapidly formed based on the schiff＇s base reaction between aldehyde groups in A-sA and amino groups in A-Cs. FTIR analysis confirmed the characteristic peak of schiff＇s base group in the hydrogel. It was confirmed that the gelation time be dependent on the aldehyde group content in A-sA and amino group content in A-Cs. The fasted hydrogel formation takes place within 10 min. The data of bonding strength and cytotoxicity measurement also showed that the hydrogel had good adhesion and biocompatibility. All these results support that this gel has the potential as soft tissue adhesive.

关键词： oxidized sodium alginate amino-carboxymethyl chitosan tissue adhesive schiff's base

Preparation and Characterization of Chitosan Nanofibers Containing silver Nanoparticles

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Journal of Donghua University(English Edition) 2017年第1期34卷 105-110页

作者：于奎周香香 El-Aassar M R 朱同贺吴俣王娟冯文浩 MORsI yosry 莫秀梅 Key Laboratory of Textile science & Technology College of Materials Science and Engineering Donghua University Shanghai 201620 China College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China Polymer Materials Research Department Advanced Technology and New Material Institute City of Scientific Research and Technological Applications ( SRTA-City ) New Borg El-Arab City Alexandria 21934 Egypt Faculty of Engineering and Industrial sciences Swinburne University of Technology Hawthorn Vic 3122 Australia shandong International Biotechnology Park Development Co. Ltd. Yantai 264670 China

Chitosan(Cs)nanofibers containing silver nanoparticles(AgNPs)were prepared by in-situ reducing method.A water soluble carboxymethyl chitosan(CMCT)was applied for the preparation of *** impact factor such as the concentration of CMCT,silver nitrate(AgNO_3)content,temperature and the heating time during the preparation of AgNPs were *** result showed that the proper value of the concentration of CMCT,AgNO_3content,temperature and the heating time were set as0.1%,20μL AgNO_3(1.7 mol/L),90°and 3 h,separately and the maximum concentration of AgNPs could be *** solve the spinnability of chitosan nanofiber,a super high molecular weight polyethylene oxide(PEO)was introduced to the system,and a new mixed solvent system was prepared by adding acetic acid,dimethyl sulfoxide(DMsO)and several drops of Triton X-100TMto distilled ***/PEO(80/20)with the concentration of 3%was dissolved in the mixed solvent to prepare electrospinning solution for Cs/PEO(80/20)nanofiber *** Cs containing AgNPs electrospun solution could be prepared by replacing the distilled water to silver nanoparticle solution during the preparation of mixed *** visible(UV-Vis)spectra and transmission electron microscope(TEM)results showed that silver nanoparticles were prepared *** membranes with and without AgNPs were acquired via a traditional electrospinning *** two nanofiber membranes were characterized by scanning electron microscope(sEM)images and mechanical *** could be noticed from the sEM images that there was a good morphology and random distribution for the nanofibers with an average fiber diameter of 180 *** mechanical property results showed that the addition of AgNPs decreased the mechanical strength significantly but the mechanical strength could still support wound dressing application.

关键词： chitosan(Cs) silver nanoparticles(AgNPs) electrospinning wound dressing

Fabrication and characterization of Antheraea pernyi silk fibroin-blended P（LLA-CL） nanofibrous scaffolds for peripheral nerve tissue engineering

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Frontiers of Materials science 2017年第1期11卷 22-32页

作者： Juan WANG Binbin sUN Muhammad Aqeel BHUTTO Tonghe ZHU Kui YU Jiayu BAO yosry MORsI Hany EL-HAMshARY Mohamed EL-NEWEHY Xiumei MO state Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China shandong International Biotechnology Park Development Co. Ltd. Yantai 264670 China College of Materials science and Engineering Donghua University Shanghai 201620 China Faculty of Engineering and Industrial sciences Swinburne University of Technology Hawthorn Vic 3122 Australia Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia Department of Chemistry Faculty of Science Tanta University Tanta 31527 Egypt

Electrospun nanofibers have gained widespreading interest for tissue engineering application. In the present study, ApF/P（LLA-CL） nanofibrous scaffolds were fabricated via electrospinning. The feasibility of the material as tissue engineering nerve scaffold was investigated in vitro. The average diameter increased with decreasing the blend ratio of ApF to P（LLA-CL）. Characterization of 13C NMR and FTIR clarified that there is no obvious chemical bond reaction between ApF and P（LLA-CL）. The tensile strength and elongation at break increased with the content increase of P（LLA-CL）. The surface hydrophilic property of nanofibrous scaffolds enhanced with the increased content of ApF. Cell viability studies with schwann cells demonstrated that ApFIP（LLA-CL） blended nanofibrous scaffolds significantly promoted cell growth as compare to P（LLA-CL）, especially when the weight ratio of ApF to P（LLA-CL） was 25：75. The present work provides a basis for further studies of this novel nanofibrous material （ApF/P（LLA-CL）） in peripheral nerve tissue repair or regeneration.

关键词： KEYWORDs: ApFIP(LLA-CL) electrospinning nanofibers scaffolds schwann cells peripheral nerve tissue engineering

Multifunctional bioactive core-shell electrospun membrane capable to terminate inflammatory cycle and promote angiogenesis in diabetic wound

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Bioactive Materials 2021年第9期6卷 2783-2800页

作者： Atta ur Rehman Khan Kai Huang Mina shahriari Khalaji Fan Yu Xianrui Xie Tonghe Zhu yosry Morsi Zhao Jinzhong Xiumei Mo state Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620PR China Department of sports Medicine Department of OrthopedicsShanghai Jiao Tong University Affiliated Sixth People’s HospitalNo.600 Yishan RoadShanghai200233PR China Microbiological Engineering and Industrial Biotechnology Group College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620PR China Multidisciplinary Centre for Advanced Materials of shanghai University of Engineering science College of Chemistry and Chemical EngineeringShanghai University of Engineering ScienceNo.333 Longteng RoadShanghai201620PR China Faculty of Engineering and Industrial sciences Swinburne University of TechnologyBoroondaraVIC3122Australia

Diabetic wound(DW)healing is a major clinical challenge due to multifactorial complications leading to prolonged *** nanofibrous(NF)membranes,due to special structural features,are promising biomaterials capable to promote DW healing through the delivery of active agents in a controlled ***,we report a multifunctional composite NF membrane loaded with ZnO nanoparticles(NP)and oregano essential oil(OEO),employing a new loading strategy,capable to sustainedly co-deliver bioactive *** characterization revealed the successful fabrication of loaded nanofibers with strong in vitro anti-bacterial and anti-oxidant ***,in vivo wound healing confirmed the potential of bioactive NF membranes in epithelialization and granulation tissue *** angiogenesis was greatly prompted by the bioactive NF membranes through expression of vascular endothelial growth factor(VEGF).Moreover,the proposed NF membrane successfully terminated the inflammatory cycle by downregulating the pro-inflammatory cytokines interleukin􀀀6(IL-6)and matrix metalloproteinases-9(MMP-9).In vitro and in vivo studies revealed the proposed NF membrane is a promising dressing material for the healing of DW.

关键词： Bioactive NF membrane Diabetic wound healing Antibacterial Antioxidant Anti-inflammatory Angiogenesis