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Lysophosphatidic acid induced nuclear translocation of nuclear factor-κB in Panc-1 cells by mobilizing cytosolic free calcium

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World Journal of Gastroenterology 2008年第28期14卷 4473-4479页

作者： yoshiyuki arita Tetsuhide Ito Takamasa Oono Ken Kawabe Terumasa Hisano Ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan

AIM: To clarify whether Lysophosphatidic acid (LPA) activates the nuclear translocation of nuclear factor-κB (NF-κB) in pancreatic cancer. METHODS: Panc-1, a human pancreatic cancer cell line, was used throughout the study. The expression of LPA receptors was confirmed by reverse-transcript polymerase chain reaction (RT-PCR). Cytosolic free calcium was measured by fluorescent calcium indicator fura-2, and the localization of NF-κB was visualized by immunofluorescent method with or without various agents, which effect cell signaling. RESULTS: Panc-1 expressed LPA receptors, LPA1, LPA2 and LPA3. LPA caused the elevation of cytosolic free calcium dose-dependently. LPA also caused the nuclear translocation of NF-κB. Cytosolic free calcium was attenuated by pertussis toxin (PTX) and U73122, an inhibitor of phospholipase C. The translocation of NF-κB was similarly attenuated by PTX and U73122, but phorbol ester, an activator of protein kinase C, alone did not translocate NF-κB. Furthermore, the translocation of NF-κB was completely blocked by Ca2+ chelator BAPTA-AM. Thapsigargin, an endoplasmic- reticulum Ca2+-ATPase pump inhibitor, also promoted the translocation of NF-κB. Staurosporine, a proteinkinase C inhibitor, attenuated translocation of NF-κB induced by LPA. CONCLUSION: These findings suggest that protein kinase C is activated endogenously in Panc-1, and protein kinase C is essential for activating NF-κB with cytosolic calcium and that LPA induces the nuclear translocation of NF-κB in Panc-1 by mobilizing cytosolic free calcium.

关键词： Lysophosphatidic acid Nuclear translocation Nuclear factor-κB Cytosolic free calcium Panc-1

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Chemoradiotherapy with twice-weekly administration of low-dose gemcitabine for locally advanced pancreatic cancer

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World Journal of Gastroenterology 2008年第34期14卷 5311-5315页

作者： Hisato Igarashi Tetsuhide Ito Ken Kawabe Terumasa Hisano yoshiyuki arita Toyoma Kaku Ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical ScienceKyushu University

AIM:To evaluate the chemoradiotherapy for locally advanced pancreatic cancer utilizing low dose gemcitabine as a radiation sensitizer administered twice weekly. METHODS: We performed a retrospective analysis of chemoradiotherapy utilizing gemcitabine administered twice weekly at a dose of 40 mg/m2. After that, maintenance systemic chemotherapy with gemcitabine, at a dose of 1000 mg/m2, was administered weekly for 3 wk with 1-wk rest until disease progression or unacceptable toxicity developed. RESULTS: Eighteen patients with locally advanced unresectable pancreatic cancer were enrolled. Three of those patients could not continue with the therapy; one patient had interstitial pneumonia during radiation therapy and two other patients showed liver metastasis or peritoneal metastasis during an early stage of the therapy. The median survival was 15.0 mo and the overall 1-year survival rate was 60%, while the median progression-free survival was 8.0 mo. The subgroup which showed the reduction of tumor development, more than 50% showed a tendency for a better prognosis; however, other parameters including age, gender and performance status did not correlate with survival. The median survival of the groups that died of liver metastasis and peritoneal metastasis were 13.0 mo and 27.7 mo, ***: Chemoradiotherapy with low-dose gemcitabine administered twice weekly could be effective to patients with locally advanced pancreatic cancer; however, patients developing liver metastases had a worse prognosis. Another chemoradiotherapy strategy might be needed for those patients, such as administrating one or two cycles of chemotherapy initially, followed by chemoradiotherapy for the cases with no distant metastases.

关键词： Advanced pancreatic cancer Chemoradio-therapy Gemcitabine Radiosensitizer Tumor marker

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Acute pancreatitis associated with peroral double-balloon enteroscopy: A case report

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World Journal of Gastroenterology 2006年第11期12卷 1802-1804页

作者： Kuniomi Honda Takahiro Mizutani Kazuhiko Nakamura Naomi Higuchi Kenji Kanayama Yorinobu Sumida Shigetaka Yoshinaga Soichi Itaba Hirotada Akiho Ken Kawabe yoshiyuki arita Tetsuhide Ito Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu UniversityFukuokaJapan

A 58-year-old Japanese man had tarry stool and severe anemia. Neither upper nor lower gastrointestinal （GI） endoscopy showed any localized lesions. Thus, the source of his GI bleeding was suspected to be in the small intestine, and he underwent peroral double-balloon enteroscopy （DBE） using EN-450T5 （Fujinon-Toshiba ES System Co., Tokyo, Japan）. There were no lesions considered to be the source of GI bleeding. After the procedure, the patient began to experience abdominal pain. Laboratory tests revealed hyperamylasemia and abdominal computed tomography revealed an inflammation of the pancreas and the peripancreas. He was thus diagnosed to have acute pancreatitis. Conservative treatments resulted in both clinical and laboratory amelioration. He had no history of alcohol ingestion, gallstone disease or pancreatitis. Magnetic resonance cholangiopancreatography demonstrated no structural alterations and no stones in the pancreatobiliary ductal system. As his abdominal pain started after the procedure, his acute pancreatitis was thus thought to have been related to the peroral DBE. This is the first reported case of acute pancreatitis probably associated with peroral DBE.

关键词： Enteroscopy Small intestine Pancreatitis complication

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Continuous regional arterial infusion therapy with gabexate mesilate for severe acute pancreatitis

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World Journal of Gastroenterology 2008年第41期14卷 6382-6387页

作者： Yoshifumi Ino yoshiyuki arita Tetsuro Akashi Toshinari Kimura Hisato Igarashi Takamasa Oono Masayuki Furukawa Ken Kawabe Keiichiro Ogoshi Jiro Ouchi Toshihiko Miyahara Ryoichi Takayanagi Tetsuhide Ito Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Department of Social Insurance Nakabaru Hospital Department of Gastroenterology Saiseikai Fukuoka General Hospital Department of Gastroenterology Fukuoka Higashi Medical Center Division of Gastroenterology National Kyushu Cancer Center National Hospital Organization Kyushu Medical Center

AIM： To evaluate the efficacy of continuous regional arterial infusion therapy （CRAI） with gabexate mesilate and antibiotics for severe acute pancreatitis （SAP）. METHODS： We conducted a prospective study on patients who developed SAP with or without CRAI. Out of 18 patients fulfilled clinical diagnostic criteria for SAP in Japan, 9 patients underwent CRAI, while 9 patients underwent conventional systemic protease inhibitor and antibiotics therapy （non-CRAI）. CRAI was initiated within 72 h of the onset of pancreatitis. Gabexate mesilate （2400 mg/d） was continuously administered for 3 to 5 d. The clinical outcome including serum inflammation-related parameters were examined. RESULTS- The duration of abdominal pain in the CRAI group was 1.9 =1：0.26 d, whereas that in the non-CRAI group was 4.3 ±0.50. The duration of SIRS in the CRAI group was 2.2 ± 0.22 d, whereas that in the non- CRAI group was 3.2 ± 0.28. Abdominal pain and SIRS disappeared significantly in a short period of time after the initiation of CRAI using gabexate mesilate. The average length of hospitalization significantly differed between the CRAI and non-CRAI groups, 53.3 ± 7.9 d and 87.4± 13.9 d, respectively. During the first two weeks, levels of serum CRP and the IL6/IL10 ratio in the CRAI group tended to have a rapid decrease compared to those in the non-CRAI group. CONCLUSION： The present results suggest that CRAI using gabexate mesilate was effective against SAP.

关键词： Severe acute pancreatitis Arterial infusion Gabexate mesilate Antibiotics

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19^th Himalaya-Karakoram-Tibet Workshop

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Episodes 2005年第1期28卷 53-54页

作者： Gautam Pitambar arita Kazunori COE for Neo-Science of Natural History Graduate School of Science Hokkaido University

The 19^th Himalaya-Karakoram-Tibet Workshop (HKT19), as an annual international workshop devoted to presentations of new research findings in the Earth sciences and related disciplines from the Himalaya-Karakoram-Tibet (HKT) region and discussion on the burning issues, was held in Niseko, a famous ski resort in Hokkaido,Japan. The HKT19 Organizing Committee hosted the workshop together with two 21^st Century Center of Excellence Programs,namely, COE for the “Neo-Science of Natural History” (Hokkaido University, Project Leader: H. Okada), COE for “Dynamics of the Sun-Earth-Life Interactive System”,(Nagoya University, Project Leader: ***), and the Division of Earth and Planetary Sciences, Hokkaido University,

关键词：喜马拉雅山喀喇昆仑山西藏自治区青藏高原地质构造

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Examination of inverse Hall-Petch relation in nanostructured aluminum alloys by ultra-severe plastic deformation

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Journal of Materials Science & Technology 2021年第32期91卷 78-89页

作者： Abbas Mohammadi Nariman A.Enikeev Maxim YuMurashkin Makoto arita Kaveh Edalati WPI International Institute for Carbon-Neutral Energy Research(WPI-I2CNER)Kyushu UniversityFukuoka 819-0395Japan Institute of Physics of Advanced Materials Ufa State Aviation Technical UniversityUfa 450008Russia Department of Materials Science and Engineering Faculty of EngineeringKyushu UniversityFukuoka 819-0395Japan International Joint Laboratory for Light Alloys(MOE) College of Materials Science and EngineeringChongqing UniversityChongqing400045China

To have an insight into the occurrence of inverse Hall-Petch relationship in ultrafine-grained(UFG) aluminum alloys produced by severe plastic deformation(SPD),ultra-SPD(*** several ten thousand shear strains via high-pressure torsion,HPT) followed by aging is applied to an Al-La-Ce *** nanograin sizes of 40 and 80 nm are successfully achieved together with strain-induced Lomer-Cottrell dislocation lock formation and aging-induced semi-coherent Al_(11)(La,Ce)_3 *** of hardening mechanisms in this alloy compared to SPD-processed pure aluminum with micrometer grain sizes,SPD-processed Al-based alloys with submicrometer grain sizes and ultra-SPD-processed Al-Ca alloy with nanograin sizes reveals the presence of two breaks in the Hall-Petch ***,a positive upbreak appears when the grain sizes decrease from micrometer to submicrometer which is due to extra hardening by solute-dislocation ***,a negative down-break and softening occur by decreasing the grain sizes from submicrometer to nanometer which is caused by weakening the dislocation hardening mechanism with minor contribution of the inverse Hall-Petch *** analyses confirm that nanograin formation is not necessarily a solution for extra hardening of Al-based alloys and other accompanying strategies such as grain-boundary segregation and precipitation are required to overcome such a down-break and softening.

关键词： Aluminum-lanthanum-cerium alloys Nanostructured alloys Reverse Hall-Petch relationship Precipitation hardening Dislocation hardening

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Management of neuroendocrine liver metastasis:Searching for new prognostic factor and appraising repeat hepatectomy

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 410-412页

作者： Junichi arita Sho Kiritani Kiyoshi Hasegawa Hepato-Biliary and Pancreatic Surgery Division Department of SurgeryGraduate School of MedicineUniversity of TokyoTokyoJapan

Gastro-enteric and pancreatic neuroendocrine neoplasm(NEN)is categorized as a borderline malignant tumor and was historically called carcinoid,meaning *** tumors usually grow slower than most carcinoma tumors originat... 详细信息

关键词： organs metastasis liver neoplasm

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Hydriding properties of uranium alloys for purposes of searching for new hydrogen storage materials

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Nuclear Science and Techniques 2015年第1期26卷 121-126页

作者： Michio Yamawaki Takuya Yamamoto Yuji arita Fumihiro Nakamori Kazuhito Ohsawa Kenji Konashi Research Institute of Nuclear Engineering University of Fukui1-2-4 Kanawa-cho Tsuruga Fukui 914-0055 Japan Research Institute for Applied Mechanics Kyushu University6-1 Kasuga-koen Kasuga Fukuoka 816-8580 Japan Institute for Materials Research Tohoku University 2145-2 Narita-choOarai Higashi-Ibaragi-gun Ibaragi 311-1313 Japan

Hydriding properties of uranium alloys have been studied to search for new hydrogen storage materials to be applied to hydrogen energy systems. Application of uranium-base hydrogen storage materials can be expected to alleviate the risk, as well as to reduce the cost incurred by globally-stored large amounts of depleted uranium left after uranium enrichment. Various uranium alloys have been examined in terms of hydrogen absorptiondesorption properties, among which UNi Al intermetallic compound showed promising characteristics, such as lower absorption-desorption temperatures and better anti-powdering strength. First principle calculation has been carried out on UNi Al hydride to predict the change of crystal structure and the lattice constant with increasing hydrogen content, which showed this calculation to be promising in predicting candidates for good hydrogen absorbers.

关键词：氢化性能储氢材料铀合金第一原理计算金属间化合物能源系统解吸温度晶格常数

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Production of CH4in a Low-Pressure CO2/H2Discharge with Magnetic Field

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Journal of Materials Science and Chemical Engineering 2015年第12期3卷 69-77页

作者： Keisuke arita Satoru Iizuka Department of Electrical Engineering Graduate School of Engineering Tohoku University Sendai Japan

Production of CH4 has been established using a low-pressure square-pulse cross-field CO2/H2 discharge with magnetic field. The conversion rate from CO2 to CH4 was investigated by changing the discharge parameters such as applied power and discharge distance, together with magnetic field strength. Carbon dioxide was reduced by hydrogen. The discharge took place across the magnetic field inside a glass tube. Decomposition of CO2 and CH4 selectivity are found to be dependent on power density. Energy efficiency for methane production is increased in a narrow discharge. Preferable improvements of CO2 decomposition, CH4 selectivity, and energy efficiency were established.

关键词： Carbon Dioxide Methane Pulse Discharge Magnetic Field

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Identifying bereaved grievers with greatest medical or social service needs in Japan

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Family Medicine and Community Health 2022年第1期10卷 1-9页

作者： Carl Becker Yozo Taniyama Megumi Kondo-arita Noriko Sasaki Shinya Yamada Kayoko Yamamoto Policy Science Unit School of MedicineKyoto UniversityKyotoJapan Department of Religious Studies Tohoku UniversitySendaiJapan Nakayama International Center Osaka Medical CollegeTakatsukiJapan Department of Healthcare Economics and Quality Management Graduate School of MedicineKyoto UniversityKyotoJapan Department of Ethnology National Museum of Japanese HistorySakuraJapan Department of Nursing Tenri Health Care UniversityTenriJapan

Objective Severe grief adversely affects the health of bereaved families,potentially burdening medical and community health *** for effective community health maintenance must identify the people likely to face severe effects of *** present study identified characteristics of mourners who experience severe grief within a year of bereavement to confirm whether this grief increased their reliance on Japanese medical and social *** We conducted a nationwide postal survey of Japanese bereaved within the previous year,to compare those reporting daily or overwhelming‘heavy’grief to those with less heavy grief,in terms of demographic and socioeconomic details,daily work and non-work activity,frequency of medical and social service ***/participants In 2019,with the support of the Ministry of Education and the All Japan Funeral Co-Operation,we distributed approximately 5500 questionnaires to Japanese who had presided at funerals within the past year for anonymous *** January of 2020,we received 1078 complete voluntary responses from bereaved *** Half of the‘heavy grief’group(n=143)reported adverse effects on health and daily life,including needs for pharmacological,medical or welfare *** of husbands or children were particularly connected to severe grief;‘unexpected’death from cancer caused the greatest ***(even part-time)buffered against severe grief;grief was greater for the unemployed and substantially worse for those who lost significant income at the same time as they lost loved *** These findings suggest that prior counselling should reduce the shock of bereavement and economic loss,which increases subsequent medical *** professionals and community health workers can use the above factors to target in advance the family members in greatest danger of heavy grief,to intervene lest grief adversely affect their physical and psychological health after ber

关键词： service sided return

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