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Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis

World Journal of Gastroenterology 2006年第40期12卷 6473-6499页

作者： yoshiyuki takahara Mitsuo Takahashi Hiroki Wagatsuma Fumihiko Yokoya Qing-Wei Zhang Mutsuyo Yamaguchi Hiroyuki Aburatani Norifumi Kawada Exploratory and Applied Pharmaceutical Research Department Pharmaceutical Company Ajinomoto Co. Inc Kawasaki 210-8681 Japan Biochemical Information project BiolT Business Development Group Fujitsu Limited Tokyo Japan Center for Collaborative Research Research Center for Advanced Science and Technology the University of Tokyo Tokyo Japan Department of Hepatology Graduate School of Medicine Osaka City University Osaka Japan

AIM: To determine the gene expression profile data for the whole liver during development of dimethylni-trosamine (DMN)-induced hepatic fibrosis.METHODS: Marker genes were identified for different types of hepatic cells, including hepatic stellate cells (HSCs), Kupffer cells (including other inflammatory cells), and hepatocytes, using independent temporal DNA microarray data obtained from isolated hepatic cells. RESULTS: The cell-type analysis of gene expression gave several key results and led to formation of three hypotheses: (1) changes in the expression of HSC-specific marker genes during fibrosis were similar to gene expression data in in vitro cultured HSCs, suggesting a major role of the self-activating characteristics of HSCs in formation of fibrosis; (2) expression of mast cell-specific marker genes reached a peak during liver fibrosis, suggesting a possible role of mast cells in formation of fibrosis; and (3) abnormal expression of hepatocyte-specific marker genes was found across several metabolic pathways during fibrosis, including sulfur-containing amino acid metabolism, fatty acid metabolism, and drug metabolism, suggesting a mechanistic relationship between these abnormalities and symptoms of liver fibrosis. CONCLUSION: Analysis of marker genes for specific hepatic cell types can identify the key aspects of fibro-genesis. Sequential activation of inflammatory cells and the self-supporting properties of HSCs play an important role in development of fibrosis.

关键词：基因表达肝疾病病理治疗临床

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Serial changes in expression of functionally clustered genes in progression of liver fibrosis in hepatitis C patients

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World Journal of Gastroenterology 2008年第13期14卷 2010-2022页

作者： yoshiyuki takahara Mitsuo Takahashi Qing-Wei Zhang Hirotaka Wagatsuma Maiko Mori Akihiro Tamori Susumu Shiomi Shuhei Nishiguchi Exploratory & Applied Pharmaceutical Research Department Pharmaceutical Company Ajinomoto Co. Inc. 1-1 Suzuki-cho Kawasaki-ku Kawasaki 210-8681 Japan Department of Nuclear Medicine Graduate School of Medicine Osaka City University Osaka Japan Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine Hyogo College of Medicine Nishinomiya Japan

AIM: To investigate the relationship of changes in expression of marker genes in functional categories or molecular networks comprising one functional category or multiple categories in progression of hepatic fibrosis in hepatitis C (HCV) patients. METHODS: Marker genes were initially identified using DNA microarray data from a rat liver fibrosis model. The expression level of each fibrosis associated marker gene was analyzed using reverse transcription-polymerase chain reaction (RT-PCR) in clinical biopsy specimens from HCV-positive patients (n = 61). Analysis of changes in expression patterns and interactions of marker genes in functional categories was used to assess the biological mechanism of fibrosis. RESULTS: The profile data showed several biological changes associated with progression of hepatic fibrosis. Clustered genes in functional categories showed sequential changes in expression. Several sets of clustered genes, including those related to the extracellular matrix (ECM), inflammation, lipid metabolism, steroid metabolism, and some transcription factors important for hepatic biology showed expression changes in the immediate early phase (F1/F2) of fibrosis. Genes associated with aromatic amino acid (AA) metabolism, sulfur-containing AA metabolism and insulin/ Wnt signaling showed expression changes in the middle phase (F2/F3), and some genes related to glucose metabolism showed altered expression in the late phase of fibrosis (F3/F4). Therefore, molecular networks showing serial changes in gene expression are present in liver fibrosis progression in hepatitis C patients. CONCLUSION: Analysis of gene expression profiles from a perspective of functional categories or molecular networks provides an understanding of disease and suggests new diagnostic methods. Selected marker genes have potential utility for biological identification of advanced fibrosis.

关键词：肝纤维化丙肝标记基因基因表达新陈代谢转录因子

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AN IMPLEMENTATION OF A MODEL MANAGEMENT SYSTEM

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中国有色金属学会会刊：英文版 1995年第4期5卷 151-157页

作者： Chen, XH takahara, Y CENT S UNIV TECHNOL DEPT BUSINESS ADMCHANGSHA 410083PEOPLES R CHINA TOKYO INST TECHNOL TOKYO 152JAPAN

ＡＮＩＭＰＬＥＭＥＮＴＡＴＩＯＮＯＦＡＭＯＤＥＬＭＡＮＡＧＥＭＥＮＴＳＹＳＴＥＭＣｈｅｎＸｉａｏｈｏｎｇ（ＤｅｐａｒｔｍｅｎｔｏｆＢｕｓｉｎｅｓｓＡｄｍｉｎｉｓｔｒａｔｉｏｎＣｅｎｔｒａｌＳｏｕｔｈＵｎｉｖｅｒｓｉｔ... 详细信息

ＡＮＩＭＰＬＥＭＥＮＴＡＴＩＯＮＯＦＡＭＯＤＥＬＭＡＮＡＧＥＭＥＮＴＳＹＳＴＥＭＣｈｅｎＸｉａｏｈｏｎｇ（ＤｅｐａｒｔｍｅｎｔｏｆＢｕｓｉｎｅｓｓＡｄｍｉｎｉｓｔｒａｔｉｏｎＣｅｎｔｒａｌＳｏｕｔｈＵｎｉｖｅｒｓｉｔｙｏｆＴｅｃｈｎｏｌｏｇｙ，Ｃｈａ...

关键词： general systems theory(GST) model management model description language(MDL) model integration environment(MIE) decision support system(DSS) menu system annual production planning

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Direct-acting antivirals for hepatitis C virus-infected patients with hepatocellular carcinoma

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World Journal of Hepatology 2022年第6期14卷 1190-1199页

作者： Kazuto Tajiri Hiroyuki Ito Kengo Kawai Yoshiro Kashii Yuka Hayashi Aiko Murayama Masami Minemura Terumi takahara Yukihiro Shimizu Ichiro Yasuda Department of Gastroenterology Toyama University HospitalToyama 930-0194Japan Department of Gastroenterology Takaoka Municipal HospitalTakaoka 933-8550Japan Gastroenterology Center Nanto Municipal HospitalNanto 932-0211Japan Department of Gastroenterology Saiseikai Toyama HospitalToyama 931-8533Japan

BACKGROUND Hepatocellular carcinoma(HCC)in hepatitis C virus(HCV)-infected patients has a high risk of recurrence.Although eradication of HCV is expected to reduce this risk,the risk in patients with a history of HCC may be high after treatment with direct-acting antivirals(DAAs).AIM To determine the risk factors for HCC recurrence in patients with HCV and a history of HCC.METHODS The risk of HCC recurrence in patients with a history of HCC and/or of HCC occurrence in patients without a history of HCC after DAA therapy was retrospectively analyzed in 311 HCV patients treated at our institution and several neighboring hospitals.The frequency and predictors of HCC recurrence/occurrence after DAA treatment were included in these analyses.The clinical course of HCC before and after DAA treatment was also evaluated.RESULTS HCV patients with a history of HCC were older and had greater progression of liver fibrosis and diabetes than patients without a history of HCC.Median recurrence-free survival(RFS)was 1092 d in patients with a history of HCC,and post-DAA HCC recurrence/occurrence was observed in 29 patients(53.7%)with and 5(1.9%)without a history of HCC over 6 years(P<0.001).RFS in patients with a history of HCC did not differ significantly before and after DAA treatment.The frequency of HCC recurrence/occurrence in patients with a history of HCC was lower after than before DAA treatment.Multivariate analysis showed that the incidence rate of HCC recurrence/occurrence before DAA treatment was the only independent predictor of HCC recurrence/occurrence after DAA treatment.Liver function was well preserved and clinical course was good in patients with HCC recurrence/occurrence after DAA therapy.CONCLUSION DAA therapy in patients infected with HCV is also effective in patients with a history of HCC.Curative treatment for HCC is desirable before DAA therapy.The frequency of HCC recurrence/occurrence before DAA therapy was associated with a significantly increased risk of HCC recurrence after DAA therapy.Careful observat

关键词： Direct-acting antivirals Hepatitis C virus Hepatocellular carcinoma Recurrence Liver fibrosis Curative treatment

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FUZZY DECISION MAKING FOR SELECTION OF INFORMATION SYSTEM DEVELOPMENT APPROACH

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中国有色金属学会会刊：英文版 1998年第1期8卷 173-177页

作者： Chen, Xiaohong Liu, Mai takahara, Yasuhiko Central South Univ of Technology Changsha China

ＦＵＺＺＹＤＥＣＩＳＩＯＮＭＡＫＩＮＧＦＯＲＳＥＬＥＣＴＩＯＮＯＦＩＮＦＯＲＭＡＴＩＯＮＳＹＳＴＥＭＤＥＶＥＬＯＰＭＥＮＴＡＰＰＲＯＡＣＨ①ＣｈｅｎＸｉａｏｈｏｎｇａｎｄＬｉｕＭａｉＣｏｌｅｇｅｏｆＢｕｓｉｎｅｓａｎ... 详细信息

ＦＵＺＺＹＤＥＣＩＳＩＯＮＭＡＫＩＮＧＦＯＲＳＥＬＥＣＴＩＯＮＯＦＩＮＦＯＲＭＡＴＩＯＮＳＹＳＴＥＭＤＥＶＥＬＯＰＭＥＮＴＡＰＰＲＯＡＣＨ①ＣｈｅｎＸｉａｏｈｏｎｇａｎｄＬｉｕＭａｉＣｏｌｅｇｅｏｆＢｕｓｉｎｅｓａｎｄＭａｎａｇｅｍｅｎｔ，Ｃｅｎｔｒ...

关键词： ISDA fuzzy decision making fuzzy synthetic descrimination model

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Polystyrene-based blend nanorods with gradient composition distribution

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Science China Chemistry 2012年第5期55卷 726-734页

作者： WU Hui SU ZhaoHui TERAYAMA Yuki takahara Atsushi Institute for Materials Chemistry and Engineering Kyushu University Fukuoka 819-0395 Japan State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Graduate School of Engineering Kyushu University Fukuoka 819-0395 Japan

The polystyrene-based polymer blends, partially miscible poly(bisphenol A carbonate)/polystyrene (PC/PS) and completely miscible poly(2,6-dimethylphenylene oxide)/polystyrene (PPO/PS), in nanorods with gradient composition distribution were discussed. The polymer blend nanorods were prepared by infiltrating the polymer blends into nanopores of anodic aluminum oxide (AAO) templates via capillary action. Their morphology was investigated by micro-Fourier transform infrared spectroscopy (micro-FTIR) and nano-thermal analysis (nano-TA) with spatial resolution. The composition gradient of polymer blends in the nanopores is governed by the difference of viscosity and miscibility between the two polymers in the blends and the pore diameter. The capillary wetting of porous AAO templates by polymer blends offers a unique method to fabricate functional nanostructured materials with gradient composition distribution for the potential application to nanodevices.

关键词：聚合物共混物聚苯乙烯组成分布梯度多孔氧化铝模板傅里叶变换红外光谱纳米器件功能纳米材料

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Time to take another Iook at perceived disadvantages of robotic hepatectomy

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 208-210页

作者： Yasushi Hasegawa Hiroyuki Nitta Takeshi takahara Akira Sasaki Department of Surgery Iwate Medical University School of MedicineMorioka CityIwateJapan

Robotic hepatectomy remains controversial to date,despite continuous advances in the technology and more surgeons gaining experience with the method.Melstrom et al.(1)recently published an interesting article in Hepatobiliary Surgery and Nutrition,titled"Selecting incision-dominant cases for robotic liver resection:towards outpatient hepatectomy with rapid recovery."The authors evaluated 97 cases of robotically-assisted liver resection(RLR)arguing that it is difficult to reach the superior-posterior liver segments with the straight instruments used in conventional laparoscopic liver resection(LLR).The articulated instruments of the surgical robot are better suited for hepatectomies in these difficult-to-reach areas of the liver.They concluded that cases where the incision of an open approach would be large and affect recovery results in the highest likelihood of patients benefitting from a robotic approach.We think that the authors present an interesting perspective by focusing on the strong points of RLR compared to LLR.

关键词： hepatectomy Surgery straight

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Countermeasure Against Regenerative and Forced Chatter of Flexible Workpieces in Milling Processs Using Bi-directional Excitation

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第1期35卷 10-19页

作者： Nakano Yutaka De Silva Amal Dilanka takahara Hiroki Akiyama Yu Department of Mechanical Engineering School of EngineeringTokyo Institute of Technology Department of Mechanical Sciences and Engineering Graduate School of Science and EngineeringTokyo Institute of Technology

A novel extended methodology for chatter suppression in milling process by applying external forced vibrations to the workpiece in two orthogonal directions which are the feed and cross-feed directions.Both the regenerative and forced chatter suppression during the milling process of flexible workpieces are investigated.Here,the workpiece is subject to a sinusoidal periodic force in the feed direction to disrupt the regenerative effect.Additionally,to minimize the forced chatter,the workpiece is subject to the periodic excitation force in cross-feed direction.This force is proportional to the magnitude of the estimated cutting force in cross-feed direction and has a phase opposite to the cutting force to minimize the vibration amplitudes.The effectiveness of the proposed method is evaluated numerically and experimentally,for the spindle speed located in both the local minima and local maxima of the stability lobe diagram.The numerical simulations indicate significant suppression effect in terms of vibration amplitudes,resulting in suppression of both the regenerative chatter and the forced chatter.Experiments were conducted by using a workpiece-mounted active stage composed of flexure hinges and driven by piezoelectric actuators.The experimental results agree qualitatively with the numerical simulations.The proposed method indicates a remarkable vibration reduction effect for both regenerative and forced chatters.

关键词： self-excited vibration vibration control regenerative chatter forced chatter milling

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Application of Polymerizable Surfactant in the Preparation of Polystyrene/Nano-Fe_3O_4 Composite

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Journal of Wuhan University of Technology(Materials Science) 2010年第2期25卷 184-187页

作者：李瑞雪赵建青 Hideyuki Otsuka Atsushi takahara College of Materials Science and Engineering South China University of Technology Institute for Materials Chemistry and Engineering Kyushu University 744 Motooka Nishi-ku Fukuoka 819-0395 Japan

Monooctadecyl maleate, as a polymerizable surfactant, was synthesized by the mono-esterification of maleic anhydride and octadecanol, and was utilized to surface-modify nano-Fe3O4 particles. A polymerizable magnetic fluid was obtained by directly dispersing modified nano-Fe3O4 particles into styrene monomer, and the polystyrene/nano-Fe3O4 composite was prepared through free radical polymerization of polymerizable magnetic fluid. The structure and dispersion status in different dispersion phases of modified nano-Fe3O4 particles were studied by Fourier transform infrared （FTIR） spectrometry, X-ray diffraction （XRD） and transmission electron microscopy （TEM）, respectively. The experimental results show that the nano-Fe3O4 particles modified by monooctadecyl maleate with the size of about 7-10 nm can be uniformly dispersed into styrene and fixed in the composite during the procedure of polymerization. Thermogravimetric analysis （TGA） and vibrating sample magnetometry （VSM） indicate that the thermal stability of polystyrene/nano-Fe3O4 composite is improved compared to that of pure polystyrene, and the composite is a sort of superparamagnetic materials.

关键词： polymerizable surfactant nano-Fe3O4 particles polystyrene composite

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Preparation and characterization of cross-linked β-cyclodextrin polymer/Fe_3O_4 composite nanoparticles with core-shell structures

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Chinese Chemical Letters 2011年第2期22卷 217-220页

作者： Rui Xue Li Shu Mei Liu Jian Qing Zhao Hideyuki Otsuka Atsushi takahara College of Materials Science and Engineering South China University of TechnologyGuangzhou510640China Institute for Materials Chemistry and Engineering Kyushu UniversityFukuoka 819-0395Japan

Cross-linkedβ-cyclodextrin polymer/Fe3O4 composite nanoparticles with core-shell structures were prepared via cross linking reaction on the surface of carboxymethylβ-cyclodextrin（CM-β-CD） modified Fe3O4 nanoparticles inβ-cyclodextrin alkaline solution by using epichlorohydrin as crosslinking agent.The morphology,structure and magnetic properties of the prepared composite nanoparticles were investigated by transmission electron microscopy（TEM）,Fourier transform infrared（FTIR） spectrometry,X-ray diffraction（XRD） measurement,thermogravimetric analysis（TGA） and Vibrating sample magnetometry （VSM）,respectively.

关键词： Cross-linkedβ-cyclodextrin polymer Fe3O4 nanoparticles Composite nanoparticles Core-shell structures

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