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Recurrence of hepatocellular carcinoma with rapid growth after spontaneous regression

World Journal of Gastroenterology 2004年第22期10卷 3385-3387页

作者： TomokiNakajima MichihisaMoriguchi TadashiWatanabe MasaoNoda NobuakiFuji MasahitoMinami yoshitoitoh TakeshiOkanoue MolecularGastroenterologyandHepatology KyotoPrefecturalUniversityofMedicineGraduateSchoolofMedicalScienceKyotoJapan DepartmentofSurgery KyotoPrefecturalYosanoumiHospitalKyotoJapan

We report an 80-year-old man who presented with sponta- neous regression of hepatocellular carcinoma(HCC).He complained of sudden right flank pain and low-grade fever. The level of protein induced by vitamin K antagonist(PIVKA)- II was 1 137 mAU/mL.A computed tomography scan in November 2000 demonstrated a low-density mass located in liver S4 with marginal enhancement and a cystic mass of 68 mm×55 mm in liver S6,with slightly high density content and without marginal *** revealed that the tumor in S4 with a size of 25 mm×20 mm was a typical hypervascular HCC,and transarterial chemoembolization was ***,the tumor in S6 was hypovascular and atypical of HCC,and thus no therapy was *** December 2000,the cystic mass regressed spontaneously to 57 min×44 mm,and aspiration cytology revealed bloody fluid,and the mass was diagnosed cytologically as class I. The tumor in S4 was treated successfully with a 5 mm margin of safety around *** PIVKA-II level normalized in February *** July 2001,the tumor regressed further but presented with an enhanced area at the posterior *** November 2001,the enhanced area extended,and a biopsy revealed well-differentiated HCC,although the previous tumor in S4 *** demonstrated two tumor stains,one was in S6,which was previously hypovascular, and the other was in ***,the PIVKA-II level started to rise with the doubling time of 2-3 wk,and the tumor grew rapidly despite repeated transarterial embolization with gel *** February 2003,the patient died of bleeding into the peritoneal cavity from the tumor that occupied almost the entire right *** the acute onset of the symptoms,we speculate that local ischemia possibly due to rapid tumor growth,resulted in intratumoral bleeding and/or hemorrhagic necrosis,and finally spontaneous regression of the initial tumor in S6.

关键词： Aged Aged, 80 and over Carcinoma, Hepatocellular Cell Division Humans Ischemia Liver Neoplasms Male Neoplasm Recurrence, Local Remission, Spontaneous Tomography, X-Ray Computed

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Lack of evidence for leukocyte maternal microchimerism in primary biliary cirrhosis

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World Journal of Gastroenterology 2004年第16期10卷 2415-2416页

作者： Kenichi Nomura Yoshio Sumida Takaharu Yoh Atsuhiro Morita Yosuke Matsumoto SawakoTaji NaohisaYoshida MasahitoMinami yoshitoitoh ShigeoHoriike Keisho Kataoka Masafumi Taniwaki Takeshi Okanoue Molecular Hematology and Oncology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyoto 602-0841Japan Department of Internal Medicine National Nara HospitalNara 630-8305Japan Department of Internal Medicine Aiseikai Yamashina HospitalKyoto 607-8086Japan Ayabe city Hospital Kyoto 623-0011Japan Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyoto 602-0841Japan Clinical Molecular Genetics and Laboratory Medicine Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyoto 602-0841Japan

AIM:It is reasonable to assume that microchimerism could also be involved in the induction of primary biliary cirrhosis (PBC).However,previous reports investigated only fetus-microchimerism in women *** microchimerism has not been investigated until now. The current study aimed to clear either maternal microchimerism was involved in the pathogenesis of PBC or not. METHODS:We used fluorescence in situ hybridization on paraffin-embedded tissue (We called“Tissue-FiSH”.) to determine whether maternal cells infiltrated in male patients who were diagnosed as having ***-FiSH was performed by using both X and Y specific probes on the biopsy liver sample of 3 male PBC patients. RESULTS:Infiltrating lymphocytes demonstrated both X and Y signals in all 3 male patients. CONCLUSION:Maternal microchimerism dose not play a significant role in *** may not relate to fetus and maternal microchimerism.

关键词： Chimera Chromosomes, Human, X Chromosomes, Human, Y Female Humans In Situ Hybridization, Fluorescence Leukocytes Liver Liver Cirrhosis, Biliary Lymphocytes Male Research Support, Non-U.S. Gov't

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