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Treatment strategies for advanced hepatocellular carcinoma:Sorafenib vs hepatic arterial infusion chemotherapy

World Journal of Hepatology 2018年第9期10卷 571-584页

作者： Issei Saeki Takahiro Yamasaki Masaki Maeda Takuro Hisanaga Takuya Iwamoto Koichi Fujisawa Toshihiko Matsumoto Isao Hidaka yoshio marumoto Tsuyoshi Ishikawa Naoki Yamamoto Yutaka Suehiro Taro Takami Isao Sakaida Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of MedicineYamaguchi 755-8505Japan Department of Oncology and Laboratory Medicine Yamaguchi University Graduate School of MedicineYamaguchi 755-8505Japan Department of Medical Education Yamaguchi University Graduate School of MedicineYamaguchi 755-8505Japan Center of Research and Education for Regenerative Medicine Yamaguchi University Graduate School of MedicineYamaguchi755-8505Japan Center for Clinical Research Yamaguchi University HospitalYamaguchi 755-8505Japan Yamaguchi University Health Administration Center Yamaguchi 753-8511Japan

Sorafenib is used worldwide as a first-line standardsystemic agent for advanced hepatocellular carcinoma(HCC) on the basis of the results of two large-scale Phase Ⅲ trials. Conversely,hepatic arterial infusion chemotherapy(HAIC) is one of the most recommended treatments in Japan. Although there have been no randomized controlled trials comparing sorafenib with HAIC,several retrospective analyses have shown no significant differences in survival between the two therapies. Outcomes are favorable for HCC patients exhibiting macroscopic vascular invasion when treated with HAIC rather than sorafenib,whereas in HCC patients exhibiting extrahepatic spread or resistance to transcatheter arterial chemoembolization,good outcomes are achieved by treatment with sorafenib rather than HAIC. Additionally,sorafenib is generally used to treat patients with Child-Pugh A,while HAIC is indicated for those with either Child-Pugh A or B. Based on these findings,we reviewed treatment strategies for advanced HCC. We propose that sorafenib might be used as a first-line treatment for advanced HCC patients without macroscopic vascular invasion or Child-Pugh A,while HAIC is recommended for those with macroscopic vascular invasion or Child-Pugh A or B. Additional research is required to determine the best second-line treatment for HAIC non-responders with Child-Pugh B through future clinical trials.

关键词： Treatment strategy Hepatic arterial infusion chemotherapy Sorafenib Hepatocellular carcinoma

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Optical grade (Gd_(0.95-x)Lu_(x)Eu_(0.05))_(3)Al_(5)O_(12) ceramics with near-zero optical loss: Effects of Lu^(3+) doping on structural feature, microstructure evolution, and far-red luminescence

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Journal of Advanced Ceramics 2024年第1期13卷 113-123页

作者： Zhigang Sun Ji-Guang Li Huiyu Qian yoshio Sakka Tohru SSuzuki Bin Lu School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China Research Center for Electronic and Optical Materials National Institute for Materials ScienceIbaraki 305-0044Japan Key Laboratory of Photoelectric Detection Materials and Devices of Zhejiang Province Ningbo 315211China

A chemical co-precipitation strategy was employed to synthesize a series of(Gd_(0.95−x)Lu_(x)Eu_(0.05))_(3)Al_(5)O_(12)(x=0.1−0.95)powder phosphors,followed by vacuum sintering to achieve transparent garnet ceramic *** density functional theory indicated Lu_(3)Al_(5)O_(12) was formed in priority compared with Gd_(3)Al_(5)O_(12) during solid-phase *** high-temperature sintering,the Lu^(3+)substitution for Gd^(3+)suppressed point mass diffusion leading to a smaller grain *** in-line transmittances of bulk specimens with x=0.1,0.3,0.5,0.7,and 0.95 nm were~83.5%,80.1%,68.8%,73.7%,and 82.2%at 710 nm(Eu^(3+)emission center),respectively,among which the sample of x=0.1 exhibited the optical grade with near-zero optical loss in agreement with the defect-free single crystal(~100%of the theoretical transmittance).The resulting particle and ceramic materials both presented characteristic Eu^(3+)emission arising from 5D0→7FJ(J=1−4)transition,where the dominant far-red emission at~710 nm arising from ^(5)D_(0)→^(7)F_(4) transition overlapped with the absorption of phytochrome(PFR).The photoluminescence excitation and photoluminescence intensities of(Gd_(0.95−x)Lu_(x)Eu_(0.05))_(3)Al_(5)O_(12) powders and ceramics generally increased at a higher Gd^(3+)/Lu^(3+)***^(3+)dopants delayed the fluorescence lifetime while the bulk samples had shorter lifetime compared to the particle *** transparent(Gd_(0.85)Lu_(0.1)Eu_(0.05))3Al_(5)O_(12) ceramic phosphor exhibited good thermal stability with a high thermal quenching temperature above 533 *** designed ceramic phosphor-converted light-emitting diode had a saturation injection current of 435 mA and a current-dependent color rendering *** importantly,our report marked the developmental stage of transparent ceramic materials towards zero optical loss.

关键词： transparent ceramics garnet phosphors light-emitting diode(LED) optical properties Gibbs free energy

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Contemplative neuroaesthetics and architecture:A sensorimotor exploration

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Frontiers of Architectural Research 2024年第1期13卷 97-111页

作者： Zakaria Djebbara Juliet King Amir Ebadi yoshio Nakamura Julio Bermudez Department of Architecture DesignMediaand TechnologyAalborg UniversityAalborgDenmark Biopsychology und Neuroergonomy Technical University BerlinBerlinGermany Art Therapy Department The George Washington UniversityWashington DCUnited States Department of Neurology Indiana University School of MedicineIndianapolisUnited States Dellustration Washington DCUnited States Pain Research Center Division of Pain MedicineDepartment of AnesthesiologyUniversity of Utah School of MedicineUtahUnited States School of Architecture and Planning The Catholic University of AmericaWashington DCUnited States

This paper takes initial steps towards developing a theoretical framework of contemplative neuroaesthetics through sensorimotor *** first argue that this new area has been largely omitted from the contemporary research agenda in neuroaesthetics and thus remains a domain of untapped *** seek to define this domain to foster a clear and focused investigation of the capacity of the arts and architecture to induce phenomenological states of a contemplative *** proposing a sensorimotor account of the experience of architecture,we operationalize how being attuned to architecture can lead to contemplative *** contrasting the externally-induced methods with internally-induced methods for eliciting a contemplative state of mind,we argue that architecture may spontaneously and effortlessly lead to such states as certain built features naturally resonate with our sensorimotor *** suggest that becoming sensible of the resonance and attunement process between internal and external states is what creates an occasion for an externallyinduced contemplative ***,we review neuroscientific studies of architecture,elaborate on the brain regions involved in such aesthetic contemplative responses,provide architectural examples,and point at the contributions that this new area of inquiry may have in fields such as the evidence-based design movement in architecture.

关键词： Neuropheno menology Neuroaesthetics Contemplative states Architectural experience Well-being

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Expression levels of K_(ATP)channel subunits and morphological changes in the mouse liver after exposure to radiation

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World Journal of Experimental Medicine 2024年第2期14卷 103-113页

作者： Ming Zhou Tao-Sheng Li Hiroshi Abe Hideo Akashi Ryoji Suzuki yoshio Bando Department of Anatomy Akita University Graduate School of MedicineAkita 010-8543Japan Department of Stem Cell Biology Atomic Bomb Disease InstituteNagasaki UniversityNagasaki 852-8523Japan Sendai Old Age Refresh Station A Long-term Care Health FacilitySendai 981-1105Japan

BACKGROUND ATP sensitive K+(K_(ATP))channels are ubiquitously distributed in various of cells and tissues,including the *** play a role in the pathogenesis of myocardial and liver *** To evaluate the radiation-induced changes in the expression of K_(ATP)channel subunits in the mouse liver to understand the potential role of K_(ATP)channels in radiation *** Adult C57BL/6 mice were randomly exposed toγ-rays at 0 Gy(control,n=2),0.2 Gy(n=6),1 Gy(n=6),or 5 Gy(n=6).The livers were removed 3 and 24 h after radiation *** and eosin staining was used for morphological observation;immunohistochemical staining was applied to determine the expression of K_(ATP)channel subunits in the liver *** Compared with the control group,the livers exposed to 0.2 Gyγ-ray showed an initial increase in the expression of Kir6.1 at 3 h,followed by recovery at 24 h after *** to a high dose of 5.0 Gy resulted in decreased expression of Kir6.1 and increased expression of SUR2B at 24 ***,the expression of Kir6.2,SUR1,or SUR2A had no remarkable changes at 3 and 24 h after exposure to any of these *** The expression levels of Kir6.1 and SUR2B in mouse liver changed differently in response to different radiation doses,suggesting a potential role for them in radiation-induced liver injury.

关键词： Radiation exposure ATP-sensitive K^(+)channel Mouse Liver

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Composite electronic orders induced by orbital Kondo effect

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Science Bulletin 2016年第20期61卷 1563-1582页

作者： yoshio Kuramoto Institute of Materials Structure Science High Energy Accelerator Research Organization

In a large number of rare-earth and actinide systems,Kondo effect tends to suppress magnetic orders by making the spin singlet between localized and conduction electron *** the presence of orbital degrees of freedom,however,there emerge exotic electronic orders induced by Kondo *** orbital Kondo effect can collectively make diagonal and off-diagonal(superconducting) *** the particle-hole symmetry in conduction bands,these orders are all degenerate,forming a macroscopic SO(5) *** paper discusses recent theoretical development on these electronic orders which are relevant to Pr^(3+) and U^(4+) systems with even number of f electrons per *** the superconducting order,each conduction–electron pair is coupled with local degrees of freedom,forming a composite entity with a staggered spatial *** quasi-particle spectrum is best interpreted as virtual hybridization with resonant states at the Fermi *** order parameter for URu_2Si_2 in the hidden order state is discussed in the context of composite *** discussed are related issues such as homogeneous odd-frequency pairing and SO(5) theory for hightemperature superconductors.

关键词： Orbital Kondo effect Composite orderOdd-frequency order S0(5) symmetry -Non-Kramers states

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A new path in lighting and display:white light emitting diode with a single active layer

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Science Bulletin 2021年第9期66卷 860-861,M0003页

作者： yoshio Bando Australian Institute for Innovative Materials(AIIM) University of Wollongong(UOW)North WollongongNSW 2500Australia Institute of Molecular Plus Tianjin UniversityTianjin 300072China

Light sources,especially white light sources,are indispensable and their development is strongly correlated with the progress of our technology-based *** light sources have evolved from the primitive flame-based devices of 600,000 years ago to the current LED and electroluminescence devices,and continue to illuminate human activities and technological *** 2014 Nobel Prize in Physics was awarded to Professor Shuji Nakamura et *** their outstanding contributions in the invention of blue light emitting diodes and white light emitting diodes(WLED),which have become some of the most important sources for lighting,televisual displays,and for other applications[1].

关键词：发光层 diodes lighting

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Recent Progress in One-dimensional ZnS Nanostructures:Syntheses and Novel Properties

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Journal of Materials Science & Technology 2008年第4期24卷 512-519页

作者： yoshio BANDO Dmitri GOLBERG Nanoscale World Premier International Center for Materials Nanoarchitectonics and Nanoscale Materials Center National Institute for Materials ScienceNamiki 1-1TsukbaIbaraki 305-0044Japan

In this review, the progress made during the last two years with respect to the syntheses and novel properties of one-dimensional （1D） ZnS nanostructures is presented. Primarily the research on 1D ZnS nanostructures has been of growing interest owing to their promising applications in nanoscale optoelectronic devices. Diverse 1D ZnS nanostructures with delicately-tuned morphologies, sizes, and microstructures have been synthesized through relatively simple and well-controlled techniques. Some novel properties of the nanomaterials have been explored and the relationships between their structural features and functions have been understood gradually.

关键词： Semiconductors ZnS Nanomaterlals Nanostructures Filed-emitters

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On a conjecture of Chowla and Walum

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Science China Mathematics 2010年第10期53卷 2755-2771页

作者： TANIGAWA yoshio Graduate School of of Mathematics Nagoya University

We show the asymptotic behaviour of the mean square of the sum n c√x naPk(x/n),where Pk(x) = Bk({x}) and Bk(x) denotes the Bernoulli polynomial of degree k and c > 0 is a real number such that c2 is *** result implie... 详细信息

关键词： the Dirichlet divisor problem error term mean square the Bernoulli polynomial the Vorono formula Chowla and Walum’s conjecture.

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Roles of Helicobacter pylori BabA in gastroduodenal pathogenesis

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World Journal of Gastroenterology 2008年第27期14卷 4265-4272页

作者： yoshio Yamaoka Department of Medicine-Gastroenterology Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine

Interactions between BabA and Lewis b (Leb) related antigens are the best characterized adhesin-receptor interactions in Helicobacter pylori (H pylori). Several mechanisms for the regulation of BabA expression are predicted, including at both transcriptional and translational levels. The formation of chimeric proteins (babA /B or babB /A chimeras) seems to play an especially important role in translational regulation. Chimeric BabB/A protein had the potential to bind Leb; however, protein production was subject to phase variation through slipped strand mispairing. The babA gene was cloned initially from strain CCUG17875, which contains a silent babA1 gene and an expressed babA2 gene. The sequence of these two genes differs only by the presence of a 10 bp deletion in the signal peptide sequence of babA1 that eliminates its translational initiation codon. However, the babA1 type deletion was found only in strain CCUG17875. A few studies evaluated BabA status by immunoblot and confirmed that BabA-positive status in Western strains was closely associated with severe clinical outcomes. BabA-positive status also was associated with the presence of other virulence factors (e.g. cagA-positive status and vacA s1 genotype). A small class of strains produced low levels of the BabA protein and lacked Leb binding activity. These were more likely to be associated with increased mucosal inflammation and severe clinical outcomes than BabA-positive strains that exhibited Leb binding activity. The underlying mechanism is unclear, and further studies will be necessary to investigate how the complex BabA-receptor network is functionally coordinated during the interaction of H pylori with the gastric mucosa.

关键词： Helicobacter pylori BabA Pathogenesis Lewis antigens

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Markov decision processes associated with two threshold probability criteria

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控制理论与应用（英文版） 2013年第4期11卷 548-557页

作者： Masahiko SAKAGUCHI yoshio OHTSUBO Department of Mathematics Faculty of ScienceKochi University

This paper deals with Markov decision processes with a target set for nonpositive rewards. Two types of threshold probability criteria are discussed. The first criterion is a probability that a total reward is not greater than a given initial threshold value, and the second is a probability that the total reward is less than it. Our first （resp. second） optimizing problem is to minimize the first （resp. second） threshold probability. These problems suggest that the threshold value is a permissible level of the total reward to reach a goal （the target set）, that is, we would reach this set over the level, if possible. For the both problems, we show that 1） the optimal threshold probability is a unique solution to an optimality equation, 2） there exists an optimal deterministic stationary policy, and 3） a value iteration and a policy space iteration are given. In addition, we prove that the first （resp. second） optimal threshold probability is a monotone increasing and right （resp. left） continuous function of the initial threshold value and propose a method to obtain an optimal policy and the optimal threshold probability in the first problem by using them in the second problem.

关键词： Markov decision process Minimizing risk model Threshold probability Policy space iteration

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