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A critical role of gastric mucosal ascorbic acid in the progression of acute gastric mucosal lesions induced by compound 48/80 in rats

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World Journal of Gastroenterology 2005年第9期11卷 1324-1332页

作者： yoshio kamiya Yoshiji Ohta Yoichiro Imai Tomiyasu Arisawa Hiroshi Nakano Department of Internal Medicine Department of Chemistry Department of Clinical Biochemistry

AIM: To study the role of gastric mucosal ascorbic acid(AA) in the progression of acute gastric mucosal lesions induced by compound 48/80 (C48/80), a mast cell degranulator, in ***: C48/80 (0.75 mg/kg) was intraperitoneally injected to fasted Wistar rats. Oral administration of AA (10, 50 or 100 mg/kg) was performed 0.5 h after C48/80treatment. Determinations for gastric mucosal lesion severity and blood flow, and assays for gastric mucosal total AA, reduced AA, oxidized AA, vitamin E, thiobarbituric acid reactive substances (TBARS), adherent mucus, nitrite/nitrate (NOx), non-protein SH (NPSH), and myeloperoxidase(MPO), and serum total AA, reduced AA, oxidized AA,and NOx were conducted 0.5 and 3 h after C48/***: Gastric mucosal lesions occurred 0.5 h after C48/80 treatment and progressed at 3 h. Gastric mucosal blood flow decreased 0.5 h after C48/80 treatment but the decrease was recovered at 3 h. Gastric mucosal total AA, reduced AA, vitamin E, and adherent mucus concentrations decreased 3 h after C48/80 *** mucosal oxidized AA concentration remained unchanged after C48/80 treatment. Gastric mucosal NPSH concentration decreased 0.5 h after C48/80 treatment,but the decrease was recovered at 3 h. Gastric mucosal TBARS concentration and MPO activity increased 0.5 h after C48/80 treatment and further increased at 3 *** total AA and reduced AA concentrations increased 0.5 h after C48/80 treatment and further increased at 3 h, while serum oxidized AA concentration increased at 0.5 h. Serum and gastric mucosal NOx concentrations increased 3 h after C48/80 treatment. AA administration to C48/80-treated rats at 0.5 h after the treatment prevented the gastric mucosal lesion progression and the changes in gastric mucosal total AA, reduced AA, vitamin E, adherent mucus, NOx, and TBARS concentrations and MPO activity and serum NOx concentration found at 3 h after the treatment dose-dependently. The AA administration to C48/80-treated

关键词： Compound 48/80 Ascorbic acid Non-protein SH Vitamin E Nitric oxide Lipid peroxidation Inflammation

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First Principles Guiding Principles for the Switching Process in Oxide ReRAM

First Principles Guiding Principles for the Switching Proces...

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2012 IEEE 11th International Conference on Solid-State and Integrated Circuit Technology(ICSICT-2012)

作者： K.Shiraishi M.Y.Yang K.kamiya B.Magyari-Kpe Masaaki Niwa yoshio Nishi Graduate School of Pure and Applied Sciences University of Tsukuba Department of Electrical Engineering Stanford University

First principles calculations became crucial techniques for designing future electronics engineering. In this paper,we describe the typical examples which aim the designing of future electron devices such as modern resistive random access memories（ReRAM）by using the knowledge obtained by the first principles calculations.

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Development of an adaptive array based on subband signal processing

Development of an adaptive array based on subband signal pro...

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2000年第五届国际天线、电波传播与电磁理论学术会议

作者： Yukihiro kamiya acr.atr.co.jp Satoshi Denno acr.atr.co.jp Yoshihiko Mizuguchi acr.atr.co.jp Masaaki Katayama Akira Ogawa yoshio Karasawa ATR Adaptive Commun. Res. Labs. 2-2 Hikaridai Seikacho Sorakugun Kyoto 619-0288 Japan y-kamiya ATR Adaptive Commun. Res. Labs. 2-2 Hikaridai Seikacho Sorakugun Kyoto 619-0288 Japan y-kamiya ATR Adaptive Commun. Res. Labs. 2-2 Hikaridai Seikacho Sorakugun Kyoto 619-0288 Japan y-kamiya Department of Information Electronics Nagoya University Department of Information Electronics Nagoya University Department of Electrical Engineering The University of Electro-Communications

＜正＞ Adaptive arrays are recognized as a solution to multipath fading environments that can be a serious problem in high-speed mobile communication systems. However, huge computational loads are required due to its spatio-temporal signal processing. Subband signal processing has been known as a parallel signal processing scheme on the frequency domain. It allows us to allocate heavy computational loads to several processors when it is implemented in DSPs （Digital Signal Processor） or

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