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STUDY ON FRICTION BEHAVIOR OF PRELOADED LINEAR ROLLING GUIDES

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STUDY ON FRICTION BEHAVIOR OF PRELOADED LINEAR ROLLING GUIDE...

Treatment strategies for advanced hepatocellular carcinoma:Sorafenib vs hepatic arterial infusion chemotherapy

第一届中日机械零件国际学术研讨会

作者： yoshio ishikawa Hideyuki Ohtaki Keiichi Watanuki Saitama University UrawaJapan

＜正＞In order to get the high rigidity linear rolling guides are usually added the *** under the conditions changing the quantity of the preload and the radial load on linear rolling guides,the experimental values of... 详细信息

关键词： Linear Rolling Guide Rolling Friction Differential Slipping Friction Preload Steel Ball

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World Journal of Hepatology 2018年第9期10卷 571-584页

作者： Issei Saeki Takahiro Yamasaki Masaki Maeda Takuro Hisanaga Takuya Iwamoto Koichi Fujisawa Toshihiko Matsumoto Isao Hidaka yoshio Marumoto Tsuyoshi ishikawa Naoki Yamamoto Yutaka Suehiro Taro Takami Isao Sakaida Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of MedicineYamaguchi 755-8505Japan Department of Oncology and Laboratory Medicine Yamaguchi University Graduate School of MedicineYamaguchi 755-8505Japan Department of Medical Education Yamaguchi University Graduate School of MedicineYamaguchi 755-8505Japan Center of Research and Education for Regenerative Medicine Yamaguchi University Graduate School of MedicineYamaguchi755-8505Japan Center for Clinical Research Yamaguchi University HospitalYamaguchi 755-8505Japan Yamaguchi University Health Administration Center Yamaguchi 753-8511Japan

Sorafenib is used worldwide as a first-line standardsystemic agent for advanced hepatocellular carcinoma(HCC) on the basis of the results of two large-scale Phase Ⅲ trials. Conversely,hepatic arterial infusion chemotherapy(HAIC) is one of the most recommended treatments in Japan. Although there have been no randomized controlled trials comparing sorafenib with HAIC,several retrospective analyses have shown no significant differences in survival between the two therapies. Outcomes are favorable for HCC patients exhibiting macroscopic vascular invasion when treated with HAIC rather than sorafenib,whereas in HCC patients exhibiting extrahepatic spread or resistance to transcatheter arterial chemoembolization,good outcomes are achieved by treatment with sorafenib rather than HAIC. Additionally,sorafenib is generally used to treat patients with Child-Pugh A,while HAIC is indicated for those with either Child-Pugh A or B. Based on these findings,we reviewed treatment strategies for advanced HCC. We propose that sorafenib might be used as a first-line treatment for advanced HCC patients without macroscopic vascular invasion or Child-Pugh A,while HAIC is recommended for those with macroscopic vascular invasion or Child-Pugh A or B. Additional research is required to determine the best second-line treatment for HAIC non-responders with Child-Pugh B through future clinical trials.

关键词： Treatment strategy Hepatic arterial infusion chemotherapy Sorafenib Hepatocellular carcinoma

An Observational Study on the Clinical and Nutritional Factors Determining the Kidney Function at One Year after Transplantation

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Food and Nutrition Sciences 2018年第11期9卷 1299-1315页

作者： Nao Kawabata Toshiko Sato Koji Nanmoku Daisuke Nagata Shizukiyo ishikawa Shun Ishibashi Takashi Yagisawa yoshio Uehara Department of Clinical Nutrition Jichi Medical University Hospital Shimotsuke Tochigi Japan Graduate School of Home Economics Kyoritsu Women’s University Tokyo Japan Division of Renal Surgery and Transplantation Department of Urology Jichi Medical University Shimotsuke Tochigi Japan Division of Nephrology Department of Internal Medicine Jichi Medical University Shimotsuke Tochigi Japan Medical Education Center Jichi Medical University Shimotsuke Tochigi Japan Division of Endocrinology and Metabolism Department of Internal Medicine Jichi Medical University Shimotsuke Tochigi Japan

Objective: The aim of the present study was to investigate the clinical and nutritional factors influencing the renal function of the transplanted kidney during a one-year follow-up period after transplantation. Patients: The present prospective observational study included 52 patients who underwent kidney transplantation at Jichi Medical University Hospital from 2014 to 2016. Results: The serum creatinine (sCr) concentration at one month after transplantation was closely related to the concentration at 12 months. The recipients were divided into two groups based on the sCr concentration at one month after transplantation. Recipients with a sCr concentration greater than or equal to the median were classified into Group H, while those with concentrations that were less than the median were classified into Group L. A stepwise multiple regression analysis demonstrated that the salt intake in male recipients was an independent predictor of the renal function at 12 months (β = 0.663, p β = 0.618, p < 0.01). Moreover, in female recipients, the BMI and serum uric acid values in Group H were significantly higher than those in Group L. The BMI values of the female recipients in Group H were significantly higher than those in Group L at all times during the follow-up period (p < 0.01). Conclusion: The daily salt intake was independently associated with the renal function at one year after kidney transplantation in male recipients. In female recipients, the BMI was independently associated with the sCr concentration during the one-year follow-up period.

关键词： Salt Obesity Uric Acid Serum Creatinine Kidney Function

Characteristics of nanoparticles emitted from burning of biomass fuels

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Journal of Environmental Sciences 2014年第9期26卷 1913-1920页

作者： Mitsuhiko Hata Jiraporn Chomanee Thunyapat Thongyen Linfa Bao Surajit Tekasakul Perapong Tekasakul yoshio Otani Masami Furuuchi College of Science and Engineering Kanazawa UniversityKakuma-machiKanazawaIshikawa 920-1192Japan Department of Chemistry Faculty of SciencePrince of Songkla UniversityHat YaiSongkhla 90112Thailand Graduate School of Natural Science and Technology Kanazawa UniversityKakuma-machiKanazawaIshikawa 920-1192Japan Energy Technology Research Center and Department of Mechanical EngineeringFaculty of EngineeringPrince of Songkla UniversityHat YaiSongkhla 90112Thailand National Center of Excellence for Environmental and Hazardous Waste Management (EHWM) Southern Consortium Universities at Prince ofSongkla UniversityHat YaiSongkhla 90112Thailand

The characteristics of the particles of the smoke that is emitted from the burning ofbiomass fuels were experimentally investigated using a laboratory-scale tube furnace and different types of biomass fuels： rubber wood, whole wood pellets and rice husks. Emitted amounts of particles, particle-bound polycyclic aromatic hydrocarbons （PAHs） and water-soluble organic carbon （WSOC） are discussed relative to the size of the emitted particles, ranging to as small as nano-size （〈70 nm）, and to the rate of heating rate during combustion, differential thermal analysis （DTA） and thermogravimetric analysis （TG） techniques were used to examine the effect of heating rate and biomass type on combustion behaviors relative to the characteristics of particle emissions. In the present study, more than 30% of the smoke particles from the burning ofbiomass fuel had a mass that fell within a range of 〈 100 nm. Particles smaller than 0.43 μm contributed greatly to the total levels of toxic PAHs and WSOC. The properties of these particles were influenced by the fuel component, the combustion conditions, and the particle size. Although TC--DTA results indicated that the heating rate in a range of 10-20℃did not show a significant effect on the combustion properties, there was a slight increase in the decomposition temperature as heating rate was increased. The nano-size particles had the smallest fraction of particle mass and particle-bound PAHs, but nonetheless these particles registered the largest fraction of particle-bound WSOC.

关键词： Wood biomassNano-particlesPolycyclic aromatic hydrocarbonsWater-soluble organic carbon

A Rapid Bioassay for Classical and L-Type Bovine Spongiform Encephalopathies

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Open Journal of Veterinary Medicine 2013年第1期3卷 79-85页

作者： Yuichi Matsuura Yukiko ishikawa Robert A. Somerville Takashi Yokoyama Ken’ichi Hagiwara yoshio Yamakawa Tetsutaro Sata Tetsuyuki Kitamoto Shirou Mohri Prion Disease Research Center National Institute of Animal Health Tsukuba Japan

The rapid detection of infectivity of several agents that cause Creutzfeldt-Jakob disease has previously been achieved by assaying for deposits of abnormal prion protein (PrPSc) in follicular dendritic cells in the spleens of transgenic mice carrying the human prion protein gene. In this study, transgenic mice expressing the bovine prion protein were inoculated intraperitoneally with classical (C-type) or atypical L-type bovine spongiform encephalopathies (BSE). Proteinase-resistant PrPSc were detected in the spleens of all transgenic mice at 75 days after inoculation with both types of BSE. Infectivity in PrPSc-positive spleens of the transgenic mice revealed that prions of C- and L-type BSE replicated. These results suggest that bioassay system by the transgenic mice could be useful for the rapid detection of BSE infectivity with discriminating between C- and L-type BSEs.

关键词： Bovine Spongiform Encephalopathy Follicular Dendritic Cell Transgenic Mice

Podocyte loss and albuminuria of KK-Ay mouse: A spontaneous animal model for human type 2 diabetic nephropathy

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Journal of Diabetes Mellitus 2012年第3期2卷 346-352页

作者： Yuji ishikawa Takamichi Ito Mitsuo Tanimoto Shinji Hagiwara Masako Furukawa Saori Yamaguchi Keisuke Omote Katsuhiko Asanuma Tomohito Gohda yoshio Shimizu Kazuhiko Funabiki Satoshi Horikoshi Yasuhiko Tomino Division of Nephrology Department of Internal Medicine Faculty of Medicine Juntendo University Tokyo Japan

Podocyte loss was well known in type 2 diabetic nephropathy patients. The objective of the present study was to determine the number of podocytes and the degree of albuminuria in diabetic KK-Ay/Ta (KK-Ay) mice which had been reported as diabetic nephropathy model. Diabetic KK-Ay mice, diabetic KK/Ta mice and non-diabetic BALB/cA Jcl (BALB/cA) mice were studied. We analyzed glomerular lesions in all mice by morphometric analysis and immunofluorescence to determine the number of podocytes. Level of urinary albumin was also measured. Glomerular enlargement and mesangial expansion were observed in KK-Ay mice. Mean number of podocytes per glomerulus (NG pod) in diabetic KK-Ay mice was significantly lower than that in non-diabetic BALB/cA mice. Mean NG pod/glomerular area (GA) per glomerulus was also significantly decreased in diabetic KK-Ay mice. The level of urinary albumin/creatinine ratio (ACR) in diabetic KK-Ay mice was significantly higher than that in non-diabetic BALB/cA mice. These data suggest that podocyte loss might induce albuminuria in KK-Ay mice. This finding confirmed our previous report that KK-Ay mice, especially in terms of histological findings, are a suitable animal model for glomerular injury in type 2 diabetic nephropathy.

关键词： Podocyte Loss Albuminuria Diabetic Rodent Model Diabetes Type 2 DiabeticNephropathy

The Perineal Membrane: Its Composite Fibers and Nerve Content, and Relationship to the Levator Ani and Deep Transverse Perineal Muscles

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Open Journal of Obstetrics and Gynecology 2014年第7期4卷 405-415页

作者： Tetsuji Kurokawa Nobuyuki Hinata Hiromasa Sasaki Gen Murakami Masato Fujisawa Shin-Ichi Abe yoshio Yosida Department of Anatomy Tokyo Dental College Tokyo Japan Department of Obstetrics and Gynecology Fukui University School of Medicine Fukui Japan Department of Urology Kobe University Graduate School of Medicine Kobe Japan Division of Gynecology and Obstetrics Ishikawa Prefectural Central Hospital Kanazawa Japan Division of Internal Medicine Iwamizawa Kojin-kai Hospital Iwamizawa Japan

The perineal membrane (PM) is a thick, elastic fiber-rich, smooth muscle-poor membrane extending along the vestibule and lower vaginal wall and embedding the urethrovaginal sphincter and compressor urethrae muscles. To provide a better understanding of the topographical relationship between the PM and the levator ani muscle, we examined histological sections from 15 female cadavers. The composite fibers of the PM were usually continuous with that of a fascia covering the inferior or lateral surface of the levator ani (fascia diaphragmatis pelvis inferior) rather than the endopelvic fascia covering the superior or medial surface of the latter muscle. However, this fascial connection was sometimes interrupted by a venous plexus. The deep transverse perineal muscle was consistently adjacent to the posterolateral aspect of the PM, but whether it extended superficially or deeply to the PM depended on size of the muscle. In contrast to the endopelvic fascia embedding abundant middle-sized nerves (cavernous and sphincter nerves;0.05 - 0.1 mm in thickness), the PM contained very thin nerves: many in 10 cadavers but few in 5 cadavers. Most of the nerves seemed to be sensory on the basis of immunohistochemistry. The levator ani muscle was considered likely to provide traction force to the PM, but active elevation appeared to be difficult because of the highly elastic nature of the PM and the interrupting venous plexus. Loss of nerves in the PM might be one of a number of factors that can accelerate pelvic organ prolapse.

关键词： Vagina Levator Ani Muscle Perineal Membrane Smooth Muscles Elastic Fibers Nerves

比较血管紧张素受体拮抗剂与利尿剂或与钙拮抗剂联合治疗对尿蛋白排泄的疗效

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中华高血压杂志(中英文) 2011年第8期19卷 797-797页

作者： yoshio Matsui Kazuo Eguchi Joji ishikawa Kazuyuki Shima-da Kazuomi Kario 罗冬梅

研究者试图验证与血管紧张素受体拮抗剂(angiotensin receptor blocker,ARB)/钙拮抗剂联合治疗比较,ARB/利尿剂联合治疗是否通过较大程度降低夜间血压,从而较大程度降低尿白蛋白与肌酐比值(urinary albumin-creatinine ratio,UACR)。

关键词：钙拮抗剂血管紧张素血管紧张肽寡肽奥美沙坦利尿剂联合治疗

Comparison of peg-interferon, ribavirin plus telaprevir vs simeprevir by propensity score matching

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World Journal of Hepatology 2015年第28期7卷 2841-2848页

作者： Hideki Fujii Takeshi Nishimura Atsushi Umemura Taichiro Nishikawa Kanji Yamaguchi Michihisa Moriguchi yoshio Sumida Hironori Mitsuyoshi Chihiro Yokomizo Saiyu Tanaka Hiroki ishikawa Kenichi Nishioji Hiroyuki Kimura Shiro Takami Yasuyuki Nagao Takayuki Takeuchi Toshihide Shima Yoshihiko Sawa Masahito Minami Kohichiroh Yasui Yoshito Itoh Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Department of Gastroenterology Japanese Red Cross Kyoto Daiichi Hospital Department of Gastroenterology and Hepatology North Medical Center Kyoto Prefectural University of Medicine Department of Gastroenterology Osaka General Hospital of West Japan Railway Company Center for Digestive and Liver Diseases Nara City Hospital Department of Gastroenterology and Hepatology Omihachiman Community Medical Center Health Care Division Kyoto Second Red Cross Hospital Department of Gastroenterology Otsu Municipal Hospital Department of Gastroenterology Matsushita Memorial Hospital Higashiomicity Notogawa Hospital Center of Gastroenterology and Hepatology Saiseikai Suita Hospital Department of Internal Medicine Aiseikai Yamashina Hospital

AIM: To compare efficacy of telaprevir(TVR) and simeprevir(SMV) combined with pegylated interferon(PEG-IFN) and ribavirin(RBV) while treating chronic hepatitis C(CHC). METHODS: In all, 306 CHC patients were included in this study. There were 159 patients in the TVR combination therapy group and 147 patients in the SMV combination therapy group. To evaluate pretreatment factors contributing to sustained virological response at 12 wk(SVR12), univariate and multivariate analyses were performed in TVR and SMV groups. To adjust for patient background between TVR and SMV groups, propensity score matching was performed. Virological response during treatment and SVR12 were ***: Overall rates of SVR12 [undetectable serum hepatitis C virus(HCV) RNA levels] were 79.2% and 69.4% in TVR and SMV groups, respectively. Patients in the SMV group were older, had higher serum HCV RNA levels, lower hemoglobin, higher prevalence of unfavorable interleukin-28B(IL28B) genotype(rs8099917), and poorer response to previous PEG-IFN and RBV treatment. Propensity score matching was performed to adjust for backgrounds(n = 104) and demonstrated SVR12 rates of 74.0% and 73.1% in the TVR and SMV groups, respectively. In the TVR group, discontinuation rates were higher because of adverse events; however, breakthrough and nonresponse was more frequent in the in SMV group. Multivariate analysis revealed IL28 B genotype(rs8099917) as the only independent predictive factor of SVR12 in both ***: SVR12 rates were almost identical following propensity score matching.

关键词： Chronic hepatitis C Combination therapy Pegylated interferon Simeprevir Telaprevir Propensityscore matching Protease inhibitor