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Anti-EGFR antibody monotherapy for colorectal cancer with severe hyperbilirubinemia: A case report

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 557-562页

作者： Toshiaki Tsurui Yuya Hirasawa Yutaro Kubota Kiyoshi yoshimura Takuya Tsunoda Department of Medical Oncology Showa UniversityTokyo 1428555Japan Department of Clinical Immuno Oncology Clinical Research Institute of Clinical Pharmacology and TherapeuticsShowa UniversityTokyo 1578577Japan

BACKGROUND Hyperbilirubinemia with hepatic metastases is a common complication and a poor prognostic factor for colorectal cancer(CRC).Effective drainage is often im-possible before initiating systemic chemotherapy,owing to the liver’s diffuse metastatic ***,an appropriate chemotherapeutic approach for the treatment of hyperbilirubinemia is currently *** SUMMARY The patient,a man in his 50s,presented with progressive fatigue and severe *** tomography revealed multiple hepatic masses with thick-ened walls in the sigmoid colon,which was pathologically confirmed as a well-differentiated *** RAS or BRAF mutations were *** Eastern Cooperative Oncology Group(ECOG)performance status(PS)score was *** drainage was impossible due to the absence of a dilated bile duct,and panitumumab monotherapy was promptly ***,the bilirubin level decreased and then normalized,and the patient’s PS improved to zero ECOG score after four cycles of therapy without significant adverse *** Anti-EGFR antibody monotherapy is a safe and effective treatment for RAS wild-type CRC and hepatic metastases with severe hyperbilirubinemia.

关键词： Colorectal neoplasms Panitumumab Chemotherapy Hyperbilirubinemia Jaundice Case report

A Hydrogen-Bonded,Hexagonally Networked,Layered Framework with Large Aperture Designed by Structural Synchronization of a Macrocycle and Supramolecular Synthon

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Precision Chemistry 2024年第5期2卷 221-228页

作者： Hiroki yoshimura Ryusei Oketani Miki Naruoka Norimitsu Tohnai Ichiro Hisaki Division of Chemistry Graduate School of Engineering ScienceOsaka UniversityToyonakaOsaka 560-8531Japan Department of Applied Chemistry Graduate School of EngineeringOsaka UniversitySuitaOsaka 565-0871Japan

To develop porous organic frameworks,precise control of the stacking manner of two-dimensional porous motifs and structural characterization of the resultant framework are *** these points of view,porous molecular crystals formed through reversible intermolecular hydrogen bonds,such as;hydrogen-bonded organic frameworks(HOFs),can provide deep insight because of their high crystallinity,affording single-crystalline X-ray diffraction *** this study,we demonstrate that the stacking manner of hydrogen-bonded hexagonal network(HexNet)sheets can be controlled by synchronizing a homological triangular macrocyclic tecton and a hydrogen-bonded cyclic supramolecular synthon called the phenylene triangle.A structure of the resultant HOF was crystallographically characterized and revealed to have a large channel aperture of 2.4 *** HOF also shows thermal stability up to 290°C,which is higher than that of the conventional HexNet frameworks.

关键词： hydrogen-bonded organicframeworks hexagonalnetwork macrocycle carboxylicacid porosity

Comparison of isotope-based linear and Bayesian mixing models in determining moisture recycling ratio

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Journal of Arid Land 2024年第6期16卷 739-751页

作者： XIAO Yanqiong WANG Liwei WANG Shengjie Kei yoshimura SHI Yudong LI Xiaofei Athanassios A ARGIRIOU ZHANG Mingjun Key Laboratory of Resource Environment and Sustainable Development of Oasis of Gansu Province College of Geography and Environmental ScienceNorthwest Normal UniversityLanzhou 730070China Northwest Institute of Eco-Environment and Resources Chinese Academy of SciencesLanzhou 730000China Atmosphere and Ocean Research Institute University of TokyoKashiwa 277-8568Japan School of Environmental Science and Engineering Shaanxi University of Science and TechnologyXi'an 710021China Laboratory of Atmospheric Physics Department of PhysicsUniversity of PatrasPatras GR-26500Greece

Stable water isotopes are natural tracers quantifying the contribution of moisture recycling to local precipitation,i.e.,the moisture recycling ratio,but various isotope-based models usually lead to different results,which affects the accuracy of local moisture *** this study,a total of 18 stations from four typical areas in China were selected to compare the performance of isotope-based linear and Bayesian mixing models and to determine local moisture recycling *** the three vapor sources including advection,transpiration,and surface evaporation,the advection vapor usually played a dominant role,and the contribution of surface evaporation was less than that of *** the abnormal values were ignored,the arithmetic averages of differences between isotope-based linear and the Bayesian mixing models were 0.9%for transpiration,0.2%for surface evaporation,and–1.1%for advection,respectively,and the medians were 0.5%,0.2%,and–0.8%,*** importance of transpiration was slightly less for most cases when the Bayesian mixing model was applied,and the contribution of advection was relatively *** Bayesian mixing model was found to perform better in determining an efficient solution since linear model sometimes resulted in negative contribution *** test with two isotope scenarios indicated that the Bayesian model had a relatively low sensitivity to the changes in isotope input,and it was important to accurately estimate the isotopes in precipitation ***,the Bayesian mixing model should be recommended instead of a linear *** findings are useful for understanding the performance of isotope-based linear and Bayesian mixing models under various climate backgrounds.

关键词： moisture recycling stable water isotope linear mixing model Bayesian mixing model China

The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally?

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Cellular & Molecular Immunology 2018年第4期15卷 335-345页

作者： Teizo yoshimura Department of Pathology and Experimental Medicine Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama UniversityKita-kuOkayama 700-8558Japan

Macrophages are one of the most abundant leukocyte populations infiltrating tumor tissues and can exhibit both tumoricidal and tumor-promoting *** 1989,we reported the purification of monocyte chemoattractant protein-1(MCP-1)from culture supernatants of mitogen-activated peripheral blood mononuclear cells and tumor ***-1 is a potent monocyte-attracting chemokine,identical to the previously described lymphocyte-derived chemotactic factor or tumor-derived chemotactic factor,and greatly contributes to the recruitment of blood monocytes into sites of inflammatory responses and *** in vitro-cultured tumor cells often produce significant amounts of MCP-1,tumor cells are considered to be the main source of ***,various nontumor cells in the tumor stroma also produce MCP-1 in response to *** performed in vitro and in vivo have provided evidence that MCP-1 production in tumors is a consequence of complex interactions between tumor cells and non-tumor cells and that both tumor cells and non-tumor cells contribute to the production of *** MCP-1 production was once considered to be a part of host defense against tumors,it is now believed to regulate the vicious cycle between tumor cells and macrophages that promotes the progression of tumors.

关键词： chemokines cytokines inflammation macrophages tumor microenvironment

Efficient Origin-Destination Estimation Using Microscopic Traffic Simulation with Restricted Rerouting

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Computer Modeling in Engineering & Sciences 2023年第5期135卷 1091-1109页

作者： Kazuki Abe Hideki Fujii Shinobu yoshimura Vector Research Institute Inc.Shibuya-kuTokyo150-0002Japan School of Engineering The University of TokyoBunkyo-kuTokyo113-8656Japan

Traffic simulators are utilized to solve a variety of traffic-related *** such simulators,origin-destination(OD)traffic volumes as mobility demands are required to input,and we need to estimate *** authors regard an OD estimation as a bi-level programming problem,and apply a microscopic traffic simulation model to ***,the simulation trials can be computationally expensive if full dynamic rerouting is allowed,when employing multi-agent-based models in the estimation *** paper proposes an efficient OD estimation method using a multi-agent-based simulator with restricted dynamic rerouting to reduce the computational *** though,in the case of large traffic demand,the restriction on dynamic rerouting can result in heavier *** authors resolve this problem by introducing constraints of the bi-level programming problem depending on link *** results show that the accuracy of the link traffic volume reproduced with the proposed method is virtually identical to that of existing methods but that the proposed method is more computationally efficient in a wide-range or high-demand context.

关键词： ODestimation microscopic traffic simulation dynamic rerouting bi-level programming multi-agent basedmodel

Performance of fluoride and boron compounds against drywood and subterranean termites and decay and mold fungi

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Journal of Forestry Research 2020年第4期31卷 1425-1434页

作者： S.Nami Kartal Evren Terzi Tsuyoshi yoshimura Faculty of Forestry Istanbul University-Cerrahpas¸a34473 BahcekoyIstanbulTurkey RISH Kyoto UniversityUjiKyoto 611-1100Japan

Sodium fluoride(NaF)and disodium octaborate tetrahydrate(DOT)are well-known fungicides for preventing and remediating decay in wood and wood structures,due to their excellent diffusion properties in *** efficacy of both compounds against drywood termites is,however,inadequately studied;there is a lack of information on the development of proper protection and control methods against drywood termites using these diffusible *** this study,the threshold values of fluoride and boron against drywood and subterranean termites and decay and mold fungi were assessed in laboratory *** Cryptomeria japonica ***(sugi)sapwood specimens with four different concentrations of NaF and DOT applied by either dipping or vacuum processes were subjected to attack by drywood termites,Incisitermes minor(Hagen)for 6 *** specimens were also tested against subterranean termites,Coptotermes formosanus Shiraki for 3 *** decay and mold resistance tests were then performed to determine the efficacy of the compounds against fungal *** showed 80%or greater drywood termite mortality in wood specimens treated with NaF at a retention level of1.7 kg m-3 or *** DOT treated groups,higher retention levels(greater than 6.8 kg m-3)were needed to reach up to 80%or more termite *** general,weight losses in NaF-treated specimens were slightly lower than those in DOT-treated *** levels of around1.2 kg m-3 for NaF and 1.6 kg m-3 for DOT were high enough to reach the JIS K 1571 threshold requirement of weight loss less than 3%in subterranean termite resistance *** higher termite mortality values were seen in the DOT than NaF treatments at respective retention *** decay resistance tests,no weight losses were seen at a NaF retention level of 2.3 kg m-3;however,a retention level of nearly 4 kg m-3 for DOT was needed for complete protection against both test *** most cases,lower weight losses were obtained i

关键词： NaF DOT Remedial treatments Termites Fungi

The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis

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Cellular & Molecular Immunology 2023年第7期20卷 714-738页

作者： Teizo yoshimura Chunning Li Yuze Wang Akihiro Matsukawa Department of Pathology and Experimental Medicine Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama University2-5-1 ShikataKita-kuOkayama 700-8558Japan.

Breast cancer is the most prevalent cancer worldwide,and metastasis is the leading cause of death in cancer *** monocyte chemoattractant protein-1(MCP-1/CCL2)was isolated from the culture supernatants of not only mitogen-activated peripheral blood mononuclear leukocytes but also malignant glioma cells based on its in vitro chemotactic activity toward human ***-1 was subsequently found to be identical to a previously described tumor cell-derived chemotactic factor thought to be responsible for the accumulation of tumor-associated macrophages(TAMs),and it became a candidate target of clinical intervention;however,the role of TAMs in cancer development was still controversial at the time of the discovery of *** in vivo role of MCP-1 in cancer progression was first evaluated by examining human cancer tissues,including breast *** correlations between the level of MCP-1 production in tumors and the degree of TAM infiltration and cancer progression were *** contribution of MCP-1 to the growth of primary tumors and metastasis to the lung,bone,and brain was examined in mouse breast cancer *** results of these studies strongly suggested that MCP-1 is a promoter of breast cancer metastasis to the lung and brain but not *** mechanisms of MCP-1 production in the breast cancer microenvironment have also been *** the present manuscript,we review studies in which the role of MCP-1 in breast cancer development and progression and the mechanisms of its production were examined and attempt to draw a consensus and discuss the potential use of MCP-1 as a biomarker for diagnosis.

关键词： Breast cancer chemokines chemokine receptors metastasis macrophages

Experimental Analysis of Flow Structure in Contra-Rotating Axial Flow Pump Designed with Different Rotational Speed Concept

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Journal of Thermal Science 2013年第4期22卷 345-351页

作者： Linlin Cao Satoshi Watanabe Toshiki Imanishi Hiroaki yoshimura Akinori Furukawa Graduate School of Engineering Kyushu University Department of Mechanical Engineering Kyushu University Oita National College of Technology

As a high specific speed pump, the contra-rotating axial flow pump distinguishes itself in a rear rotor rotating in the opposite direction of the front rotor, which remarkably contributes to the energy conversion, the reduction of the pump size, better hydraulic and cavitation performances. However, with two rotors rotating reversely, the significant interaction between blade rows was observed in our prototype contra-rotating rotors, which highly affected the pump performance compared with the conventional axial flow pumps. Consequently, a new type of rear rotor was designed by the rotational speed optimization methodology with some additional considerations, aiming at better cavitation performance, the reduction of blade rows interaction and the secondary flow suppression. The new rear rotor showed a satisfactory performance at the design flow rate but an unfavorable positive slope of the head - flow rate curve in the partial flow rate range less than 40% of the design flow rate, which should be avoided for the reliability of pump-pipe systems. In the present research, to understand the internal flow field of new rear rotor and its relation to the performances at the partial flow rates, the velocity distributions at the inlets and outlets of the rotors are firstly investigated. Then, the boundary layer flows on rotor surfaces, which clearly reflect the secondary flow inside the rotors, are analyzed through the limiting streamline observations using the multi-color oil-film method. Finally, the unsteady numerical simulations are carded out to understand the complicated internal flow structures in the rotors.

关键词： Contra-rotating rotors Internal flow Limiting streamlines Tip leakage vortex Corner separation

Effect of multifunction cavitation using phosphoric acid on fatigue and surface properties of AZ31 magnesium alloy

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镁合金学报(英文) 2023年第6期11卷 1996-2005页

作者： Shunta Matsuoka Fumihiro Kato Toshihiko yoshimura Masataka Ijiri Shoichi Kikuchi Graduate School of Integrated Science and Technology Shizuoka University3-5-1 JohokuNaka-kuHamamatsuShizuoka432-8561Japan Department of Mechanical Engineering Sanyo-Onoda City University1-1-1 Daigaku-DoriSanyo-OnodaYamaguchi 756-0884Japan Tokyo Metropolitan University 1-1 Minami-OsawaHachiojiTokyo 192-0397Japan Department of Mechanical Engineering Faculty of EngineeringShizuoka University3-5-1 JohokuNaka-kuHamamatsu-shiShizuoka 432-8561Japan

Magnesium alloy is attractive for lightweight construction but often suffers from poor corrosion resistance and low *** processing with chemicals,i.e.,multifunction cavitation(MFC),was introduced to form a high-corrosion film and improve the fatigue properties of an AZ31 magnesium *** analysis and plane bending fatigue tests were conducted for the MFC-treated magnesium alloy at a stress ratio,R,*** mechanical action of cavitation bubbles improved the fatigue life of magnesium alloys due to increasing the surface hardness and generating compressive residual ***,the combined mechanical and electrochemical action during MFC formed pits on the *** pits were large enough to easily nucleate an initial fatigue *** addition,the magnesium alloys without pit formation,for which a coating process using phosphoric acid was conducted after MFC using water,showed superior fatigue properties.

关键词： Magnesium alloy Multifunction cavitation Surface modification Fatigue Residual stress