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Materials Sciences and Applications 2021年第1期12卷 42-51页

作者： Masanori kobayashi Department of Physical Therapy College of Life and Health Sciences Chubu University Kasugai Japan

Excellent firm bonding between the biomaterials and bone tissue (osseointegration and osteo-conductivity) has been desired for the stability in vivo of dental implants and artificial joints. Much has been learned about this concept, which has led to significant improvements in the design and surface modification of implants in the field of implant dentistry, orthopedic surgery. We have already reported that low-intensity pulsed ultrasound (LIPUS) irradiation can accelerate the bone bonding ability of the bio-conductive materials such as bioactive titanium and hydroxyapatite implant. However, it is still unclear whether the LIPUS could have same effect to different types of the bioactive-materials. Therefore, in this study, the differences of bone-like hydroxyapatite formation on some kind of hydroxyapatite surface in simulated body fluid (SBF) under the LIPUS irradiation were investigated. Two kinds of hydroxyapatite samples immersed in SBF was exposed to ultrasound waves, the bone-like apatite on the surface was analyzed by Scanning electron microscopy and X-ray diffraction. As a result, the enhancement of hydroxyapatite formation on the surface by LIPUS was confirmed, the initial epitaxial nucleation and crystal growth of apatite depended on crystal structure of the surface of matrix materials.

关键词： Low-Intensity Pulsed Ultrasound (LIPUS) Simulated Body Fluid (SBF) Hydroxyapatite (HA) Osseointegration Osteo-Conductivity

Pregnancy and medications for inflammatory bowel disease:An updated narrative review

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World Journal of Clinical Cases 2023年第8期11卷 1730-1740页

作者： Shintaro Akiyama Joshua M Steinberg Mariko kobayashi Hideo Suzuki Kiichiro Tsuchiya Department of Gastroenterology Faculty of MedicineUniversity of TsukubaTsukuba 305-8575IbarakiJapan Department of Inflammatory Bowel Disease Gastroenterology of the RockiesDenverCO 80027United States

Inflammatory bowel disease(IBD)is often diagnosed during the peak reprodu-ctive years of young *** with active IBD around conception are at a significantly increased risk of disease relapse during pregnancy,which is associated with poor pregnancy and neonatal *** these substantial risks,it is prudent that disease remission should ideally be achieved before ***,some patients may experience a disease flare-up even if they are in a state of remission before *** must continue their IBD medications to reduce the risk of disease flare and subsequent poor outcomes during the gestational and postpartum *** treating IBD flare-ups during pregnancy,the management is quite similar to the therapeutic approach for non-pregnant patients with IBD,including 5-aminosalicylate,steroids,calcineurin inhibitors(CNIs),and biologic *** the data regarding the safety of CNIs in pregnant women with IBD is limited,the findings in our recent meta-analysis suggest that CNIs may be safer to use in those with IBD than in solid organ transplant *** are several types of biologics and small-molecule therapies currently approved for IBD,and physicians should thoroughly understand their clinical benefits and safety profiles when utilizing these treatments in the context of *** review highlights recent studies,including our systematic review and meta-analysis,and discusses the clinical advantages and safety considerations of biologics and small molecules for pregnant women with IBD.

关键词： Inflammatory bowel disease Pregnancy Safety Biologics Small molecules

Gastrointestinal stromal tumor of the ampulla of Vater:A case report

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World Journal of Gastroenterology 2014年第16期20卷 4817-4821页

作者： Masayoshi kobayashi Nobuto Hirata So Nakaji Toshiyasu Shiratori Hiroyuki Fujii Eiji Ishii Department of Gastroenterology Kameda Medical CenterChiba 296-0041Japan

Gastrointestinal stromal tumors (GISTs) usually develop in the stomach and small intestine and only rarely occur at the ampulla of Vater, with only 11 cases reported in the literature. We report a case of a GIST of the ampulla of Vater. A 36-year-old, previously healthy man presented with a loss of consciousness lasting a few minutes. A gastroduodenal endoscopy revealed a submucosal tumor with central ulceration at the ampulla of Vater. The enhanced computed tomography scan revealed a smooth-outlined hypervascular solid mass (24 mm × 30 mm) in the second part of the duodenum. Neither lymphadenopathy nor metastasis was observed. Magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography showed normal bile and pancreatic ducts. Biopsies were collected from the ulcerative lesion, and the tumor was diagnosed as a GIST. A submucosal tumor with central ulceration may be a characteristic form of GISTs of the ampulla of Vater, and biopsy studies are useful for the diagnosing such tumors. The patient underwent pancreatoduodenectomy, and the operative specimen revealed a 2.2-cm GIST with 1 mitosis per 50 high-power fields. The gold standard for treatment of GISTs is surgical resection without rupture of a capsule. If technically possible, local resection may be considered. However, when the location of the lesion presents challenges, a pancreatoduodenectomy should be performed for GIST of the ampulla of Vater.

关键词： Gastrointestinal stromal tumor Ampulla of Vater Submucosal tumor Bleeding Biopsy Pancreatoduodenectomy

SAPO-34上甲醇及二甲醚吸附等温线及吸附热测量与分析(英文)

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催化学报 2013年第12期34卷 2192-2199页

作者： Yasukazu kobayashi 李玉新王垚王德峥清华大学化学工程系

在25,60和100°C下分别测定了甲醇及二甲醚在SAPO-34分子筛上的吸附等温线,同时用微量热法测定了微分吸附热与覆盖率的关系曲线(量热线),提出了吸附数据需要利用双吸附位Langmuir方程拟合,并获取了相应的吸附参数.对比测得的吸附等温线... 详细信息

在25,60和100°C下分别测定了甲醇及二甲醚在SAPO-34分子筛上的吸附等温线,同时用微量热法测定了微分吸附热与覆盖率的关系曲线(量热线),提出了吸附数据需要利用双吸附位Langmuir方程拟合,并获取了相应的吸附参数.对比测得的吸附等温线与量热线发现,在一定压力下,当甲醇及二甲醚在SAPO-34上达到一定吸附量后,随着吸附质分压增加,量热线快速下降,而吸附等温线显示出吸附量仍然继续增加.由此推断,在SAPO-34分子筛上存在两种吸附位——常规吸附位及弱吸附位,其中弱吸附位在高分压下继续吸附.如缺乏量热数据提供的常规吸附位饱和吸附量数据,对吸附等温线进行单吸附位拟合获取吸附参数极易导致错误结果,尤其是当吸附质分压较高时.建议采用双吸附位Langmuir方程,参照量热线提供的常规吸附位的饱和吸附量,通过拟合可以获得两种吸附位的吸附参数.

关键词：双吸附位Langmuir方程甲醇吸附二甲醚吸附吸附热 SAPO-34

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Enhancing tissue regeneration studies with luciferase-transgenic rats and bioluminescence imaging: A comprehensive review

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第4期6卷 214-218页

作者： Poh-Ching Tan Eiji kobayashi Qingfeng Li Shuangbai Zhou Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Department of Kidney Regenerative Medicine Jikei University School of Medicine

Bioluminescence imaging(BLI) in rodent models has revolutionized preclinical research in recent decades,enabling precise and noninvasive observation of cellular and molecular processes in vivo. Among various bioluminescent systems, the firefly luciferase-luciferin system is one of the most widely employed for in vivo cell tracking. This comprehensive review focuses on using luciferase-transgenic(Luc-Tg) rat models, known as firefly rats, in conjunction with BLI to investigate tissue regeneration and stem cell dynamics. Compared with other imaging modalities, BLI offers enhanced tissue penetration, reduced background noise, and the capacity to perform longitudinal studies with fewer animals, aligning with ethical research principles. Applications of Luc-Tg rats in fat grafting, soft tissue expansion, hair growth cycle analysis, and other skin studies are discussed,demonstrating the versatility and precision of BLI in tracking complex biological processes. Integrating advanced analytical and genome-editing techniques with BLI promises to enhance data interpretation's accuracy and efficiency. These advancements have deepened our understanding of the cellular fate and mechanisms underlying tissue regeneration, presenting promising avenues for optimizing therapeutic strategies in reconstructive surgery and regenerative medicine. Combining luciferase reporter genes and BLI is crucial to unraveling complex biological phenomena, advancing soft tissue regeneration research, and developing innovative therapeutic strategies for various medical conditions.

关键词： Firefly rat Fat grafting Luciferase Stem cells Skin expansion

Intraarterial and intravenous contrast enhanced CT and MR imaging of multi-step hepatocarcinogenesis defining the early stage of hepatocellular carcinoma development

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Hepatoma Research 2020年第6期6卷 107-120页

作者： Satoshi kobayashi Kazuto Kozaka Toshifumi Gabata Osamu Matsui Tetsuya Minami Department of Quantum Medical Technology Kanazawa University Graduate School of Medical SciencesKanazawa 920-0942Japan Department of Radiology Kanazawa University Graduate School of Medical SciencesKanazawa 920-8641Japan Department of Radiology Kanazawa Medical UniversityUchinada 920-0293Japan

Liver cancer is the second leading cause of cancer deaths in men worldwide,and the 6th and 7th cause of cancer deaths in men and women in developed countries.70%-90%of primary liver cancer is hepatocellular *** B or C viruses and chronic inflammation due to alcohol intake are the main risk factors for hepatocellular *** of the key approaches for the early detection of hepatocellular carcinoma is to understand the specific imaging findings of liver nodules in the multi-step hepatocrcinogenesis *** this article,we review the imaging findings of multistep hepatocarcinogenesis,with a focus on the early detection of malignant,cirrhotic nodules with CT and MRI.

关键词： Hepatocellular carcinoma multistep hepatocarcinogenesis early hepatocellular carcinoma dysplastic nodule CT MRI

混合气体中SAPO-34上单个物种的表面浓度(英文)

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催化学报 2014年第3期35卷 430-436页

作者： Yasukazu kobayashi 李玉新王垚王德峥清华大学化学工程系北京100084

运用Langmuir等温线方程和理想吸附溶液理论(IAST)两种方法计算了SAPO-34在混合气体中的单个物种表面浓度,并对比了计算值与实验值的吻合程度.考察了两个二元混合体系,分别为80 oC的甲醇和二甲醚以及25 oC的二甲醚和乙烯混合气,发现IAS... 详细信息

运用Langmuir等温线方程和理想吸附溶液理论(IAST)两种方法计算了SAPO-34在混合气体中的单个物种表面浓度,并对比了计算值与实验值的吻合程度.考察了两个二元混合体系,分别为80 oC的甲醇和二甲醚以及25 oC的二甲醚和乙烯混合气,发现IAST计算值在实验压力范围内均与实验结果吻合;但是Langmuir理论计算值仅在酸性位覆盖率低于1/3时与实验值吻合较好,随着压力增加严重偏离实验值,而且Langmuir理论不能描述随压力增加低饱和吸附量物种覆盖率降低的现象.因此,针对包含不同饱和吸附量组分的混合气,Langmuir理论仅适用于描述表面浓度低时的反应动力学,当表面浓度高时应该采用IAST方法.

关键词：理想吸附溶液理论吸附等温线混合气体吸附 SAPO-34

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Statistical Approach for Classification of Dinosaur Eggs from the Heyuan Basin at the Northeast of Guangdong Province

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Acta Geologica Sinica(English Edition) 2012年第2期86卷 294-303页

作者： Kohei TANAKA LU Junchang LIU Yi HUANG Zhiqing Yoshitsugu kobayashi HUANG Dong Darla K. ZELENITSKY Department of Geoscience University of Calgary Calgary T2N1N4 Canada Institute of Geology Chinese Academy of Geological Sciences Beijing 10037 China Heyuan Museum Heyuan 517000 China Hokkaido University Museum Hokkaido University Sapporo 060-0810 Japan

The Zhutian and Dafeng formations （Upper Cretaceous） of the Heyuan Basin in northeastern Guangdong Province, China, have produced thousands of dinosaur eggs. Macromorphological features （egg diameter, egg shape, outer surface texture, and shell thickness） of 461 eggs were analyzed using non-destructive techniques and subjected to statistical analyses in order to assess their diversity and taxonomic affinities. Three types （1, 2 and 3） of eggs were discerned based on shape and outer surface morphology. Type 1 eggs are spherical to ellipsoidal in shape and have a rough surface. Three subtypes （Type 1-A-l, l-A-2, and l-B） are apparent from scatter plots and cluster analyses of egg diameters and shell thickness. Type 2 eggs are elongate with linear ornamentation on the surface, and are comparable to eggs that belong to the oofamily Elongatoolithidae. Type 3 eggs are elongate with a smooth surface, and are assigned to the oofamily Prismatoolithidae. Macromorphological features of the various egg types suggest that Type 1 could have been laid by ornithischian, sauropod or therizinosaur dinosaurs, Type 2 by oviraptorids, and Type 3 by troodontids. This study represents the first comprehensive statistical analysis of macrofeatures of dinosaur eggs, and reveals taxonomic diversity in the dinosaurs that were laying eggs in the Upper Cretaceous Heyuan area heretofore unrecognized in skeletal remains.

关键词： dinosaur egg Nanxiong Group Late Cretaceous Heyuan Basin Guangdong China

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Circulating tumor cells and cell-free tumor DNA analyses in urothelial cancer using the LiquidBiopsy platform

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Current Urology 2022年第2期16卷 99-106页

作者： Minoru kobayashi Hideyuki Abe Kyoko Arai Satoshi Murakami Takao Kamai Department of Urology Utsunomiya Memorial HospitalTochigi320-0811Japan Department of Urology Yuai Memorila HospitalIbarakiJapan Department of Urology Dokkyo Medical UniversityTochigiJapan Diagnostic Division Abbott Japan LLCTokyoJapan

Background:Emerging data suggested that liquid biopsy such as detection of circulating tumor cells(CTCs)and cell-free tumor DNA analysis augments the management of patients with urothelial cancer(UC).We presented our pilot experience of liquid biopsy using the Ion Torrent platform to detect CTCs and genomic alterations in *** and methods:Blood or urine samples from 16 patients were subjected to CTC and plasma/urine cell-free tumor DNA isolation for next generation sequencing(NGS)using the Ion S5 system to detect mutations among 50 oncogenes on the Ion AmpliSeq Cancer Hotspot ***:The Ion Torrent platform detected a higher number of CTCs than those in previous studies using the CellSearch^(TM)***,mutations were detected in 13/16(81.3%)patients with a median number of 18(range 12-25).NGS isolated 17 hotspot mutations from 11 genes and 41 novel genomic alterations from 24 genes,some of which are supposed to be clinically ***:The Ion Torrent platform efficiently detected CTCs compared with previous *** with the present system also allowed for detection of gene alterations which are likely to be therapeutic targets and provided an attractive tool to guide personalized therapy for patients with advanced UC.

关键词： Cell-free DNA Cell-free tumor DNA Circulating tumor cell Next generation sequencing Urothelial cancer

Visible Light-Induced Photocatalysis on Carbon Nitride Deposited Titanium Dioxide： Hydrogen Production from Sacrificial Aqueous Solutions

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Chinese Journal of Chemistry 2017年第2期35卷 165-172页

作者： Shinya Higashimoto Kohji Hikita Masashi Azuma Mari Yamamoto Masanari Takahashi Yoshihisa sakata Masaya Matsuoka Hisayoshi kobayashi Department of Applied Chemistry College of Engineering Osaka Institute of Technology 5-16-10miya Asahi-ku Osaka 535-8585 Japan Osaka Municipal Technical Research Institute 1-6-50 Morinomiya Joto-ku Osaka 536-8553 Japan Graduate School of Science andEngineering Yamaguchi University 2-16-1 Tokiwadai Ube 755-8611 Japan Department of Applied Chemistry Graduate School of Engineering Osaka Prefecture University 1-1 Gakuen-cho Naka-ku Sakai Osaka 599-8531 Japan Department of Chemistry and Materials Technology Kyoto Institute of Technology Matsugasaki Sakyo-ku Kyoto 606-8585 Japan

Carbon and nitrogen species-involved TiO2 （CN-TiO2） were systematically synthesized by thermal condensa- tion of cyanuric acid on the TiO2 surface. And the photocatalytic reactions for H2 production from sacrificial aque- ous solutions were performed on several CN-TiO2 photocatalyst under visible-light irradiation. The photocatalytic activity of the CN-TiO2 was influenced by total amounts of carbon and nitrogen species, and the preferable activity was ten times higher than that of pristine carbon nitride. Here, the states of the CN-TiO2 photocatalyst were charac- terized by XPS, FT-IR and UV-Vis spectroscopy as well as DFT calculations. The photo-electrochemical measure- ments confirmed that the enhancement of H2 production is associated with effective charge separation under photo- excitation of highly dispersed carbon nitride on the TiO2 surface.

关键词： carbon nitride TiO2 visible light photo-electrochemistry DFT calculation sacrificial H2 production