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Development and application of traffic accident density estimation models using kernel density estimation

Journal of Traffic and Transportation Engineering(English Edition) 2016年第3期3卷 262-270页

作者： Seiji Hashimoto Syuji yoshiki Ryoko Saeki Yasuhiro Mimura Ryosuke Ando Shutaro Nanba Graduate School of Environmental and Life Science Okayama UniversityOkayama 700-0807Japan Department of Civil Engineering Fukuoka UniversityFukuoka 814-0180Japan Fukuyama Consultants Co.Ltd. Futeuotea 812-0013Japan International Development Consultants Co.Ltd. Aichi 460-0008Japan Toyota Transportation Research Institute Aichi 471-0024Japan

Traffic accident frequency has been decreasing in Japan in recent years. Nevertheless, many accidents still occur on residential roads. Area-wide traffic calming measures including Zone 30, which discourages traffic by setting a speed limit of 30 km/h in residential areas, have been implemented. However, no objective implementation method has been established. Development of a model for traffic accident density estimation explained by GIS data can enable the determination of dangerous areas objectively and easily, indicating where area-wide traffic calming can be implemented preferentially. This study examined the relations between traffic accidents and city characteristics, such as population, road factors, and spatial factors. A model was developed to estimate traffic accident density. Kernel density estimation （KDE） techniques were used to assess the relations efficiently. Besides, 16 models were developed by combining accident locations, accident types, and data types. By using them, the applicability of traffic accident density estimation models was examined. Results obtained using Spearman rank correlation show high coefficients between the predicted number and the actual number. The model can indicate the relative accident risk in cities. Results of this study can be used for objective determination of areas where area-wide traffic calming can be implemented preferentially, even if sufficient traffic accident data are not available.

关键词： Traffic safety Kernel density estimation (KDE) Hotspots Zone 30

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Autopsy study of anatomical features of the posterior gastric artery for surgical contribution

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World Journal of Gastroenterology 2006年第33期12卷 5357-5359页

作者： Takehiro Okabayashi Michiya Kobayashi Isao Nishimori Kazuya Yuri Takanori Miki yoshiki Takeuchi Saburo Onishi Kazuhiro Hanazaki Keijiro Araki Department of Surgery Kochi Medical School Kohasu-Okocho Nankoku-City Japan Department of Gastroenterology and Hepatology Kochi Medical School Kohasu-Okocho Nankoku-City Japan Department of Anatomy Kochi Medical School Kohasu-Okocho Nankoku-City Japan Department of Anatomy and Neurobiology Kagawa University Ikenobe-Kidagun Japan

AIM： To investigate features of the posterior gastric arten/（PGA） with respect to incidence, location and size by using autopsy subjects. METHODS： Autopsies were performed on 72 cadavers of adults with no history of abdominal operations. The localization of the PGA, the distance between the root of the splenic artery and the origin of the PGA, and the external diameter of the PGA were examined. RESULTS： The PGA was recognized in all patients. In 70 （97.2%） cadavers, the PGA branched from the splenic artery, and one female in this group had two PGAs. In 1 （1.4%） patient, the PGA originated from the root of the celiac trunk and in another （1.4%） patient, the PGA branched from the superior polar artery. Overall, the PGA extended for a length of 5.8-12.2 （mean, 8.4） cm from the root of the splenic artery, and the external diameter of the PGA was 1.2-3.2 （mean, 2） mm. CONCLUSION： The anatomical features of the PGA can be readily observed and characterized by autopsy. This study has provided valuable information on the features of the PGA useful in the planning of surgical treatment.

关键词： Posterior gastric artery Gastric carcinoma Autopsy

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From bench to bedside, work in cell-based myocardial regeneration therapy

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Journal of Biomedical Science and Engineering 2014年第2期7卷 86-103页

作者： Shigeru Miyagawa yoshiki Sawa Department of Cardiovascular Surgery Osaka University Graduate School of Medicine El Osaka Japan

In clinical cellular cardiomyoplasty, bone marrow cells and myoblasts are introduced mainly to ischemic cardiomyopathy tissue via several cell delivery systems, such as needle injection or catheter. These clinical studies have demonstrated the safety and feasibility of this technique, but its effectiveness for treating heart failure, especially in the long term, is still under discussion. Neither of these cell types can differentiate into cardiomyocytes;rather, they improve the failing heart mainly by the paracrine effects of some cytokines, such as Hepatocyte growth factor (HGF) and Vascular endothelial growth factor (VEGF). Thus, many researchers have a great interest in stem cells, which exist in bone marrow, circulating blood, atrium, and adipose tissue, and can differentiate into cardiomyocytes. Although several stem cells with the potential to differentiate into various cell types have been reported, few can differentiate into cardiomyocytes. Moreover, beating cells that can demonstrate synchronized contraction with native cardiomyocytes are critical for the complete repair of severe heart failure. Therefore, stem cells with a high differentiation capacity should be explored for the goal of completely repairing severely damaged myocardium. In this review, we summarize the clinical protocols and basic experiments for cellular cardiomyoplasty using bone marrow cells, myoblasts, and other stem cells.

关键词： Stem Cells Heart Failure Cell Therapy

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Net biome production of managed forests in Japan

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Science China(Life Sciences) 2002年第Z1期45卷 109-115页

作者： Alexandrov Georgii Yamagata yoshiki National Institute for Environmental Studies Tsukuba Ibaraki 305-8506 Japan

Net biome production (NBP) is considered as the most appropriate concept for analyzing long-term and large-scale changes of the carbon cycle induced by land use. We have estimated NBP potential of Japanese managed forests, based on their age structure, to be 16 Mt C/a. Fifty-nine percent of this sink is located in the warm-temperate broadleaf forest zone and the remaining 39% is located in the cool-temperate broadleaf forest zone. This potential of NBP could be achieved under a long rotation period (70 a) and may serve as a target for sink enhancement efforts with the potential to uptake up to 4% of current fossil fuel emissions.

关键词： aboveground biomass, carbon sinks, land use.

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超声熔体处理Al-7%Si合金坯料的半固态铸造

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铸造 2012年第4期61卷 425-430页

作者： yoshiki Tsunekawa Masahiro Okumiya Takahiro Motomura 丰田工业大学

由于从循环利用的废料中不断累积增加Fe元素等杂质元素,所以铸造铝合金零部件高性能的要求往往很难实现。要求合金中粗大板条状的含铁化合物β-Al5FeSi在不使用变质剂和昂贵的纯铝锭条件下转变成无害的形貌结构。在凝固过程中通过利用... 详细信息

由于从循环利用的废料中不断累积增加Fe元素等杂质元素,所以铸造铝合金零部件高性能的要求往往很难实现。要求合金中粗大板条状的含铁化合物β-Al5FeSi在不使用变质剂和昂贵的纯铝锭条件下转变成无害的形貌结构。在凝固过程中通过利用超声振动来检测分析其对具有不同铁含量的Al-7%Si合金坯料的显微组织的变质效果。在感应加热至半固态温度583℃后,立即对超声熔体处理的坯料进行触变铸造,然后对触变铸造的铸件进行微观组织和拉伸性能检测分析。在触变铸造时,要求球形的初生α-Al相充填合金组织中的微小孔洞中,以便首先确定在坯料中通过超声熔体处理使合金显微组织产生变质效果。在605~630℃温度范围内进行超声熔体处理时,初生α-Al相从树枝状晶转变为细小的圆球形形貌。与未进行超声熔体处理的坯料相比,坯料超声熔体处理后合金中的粗大板条状β-Al5FeSi化合物相变得明显细小。升至583℃后进行半固态铸造不会明显改变β-Al5FeSi化合物的尺寸大小,可是却会使初生α-Al相的形貌变得更圆整,这有利于触变铸造。经预先加热的坯料进行触变铸造后,由于低的铸造温度,产生了快速凝固效果,使得合金中的共晶硅层片变得特别细小。在对超声熔体处理的坯料进行触变铸造时,具有不同铁含量的触变试样的抗拉强度变化并不大,即使合金含铁量达到2%。然而,用未处理的Al-7%Si-2%Fe合金坯料进行触变铸造时,其强度较差,仅为80 MPa,而用超声熔体处理的同种合金坯料,其抗拉强度达180 MPa。用超声熔体处理的不同含铁量的Al-7%Si合金坯料进行触变铸造时,其伸长率也提高了约一倍,例如触变铸造超声熔体处理的Al-7%Si-0.5%Fe合金坯料时,试样的伸长率为11%,而未进行超声熔体处理的同种合金触变铸造试件,其伸长率只有5%。

关键词：铸造Al-Si合金超声辐射触变铸造 α-Al 含铁化合物

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Non-Kramers doublet ground state in a quaternary cubic compound PrRu_(2)In_(2)Zn_(18) investigated by ultrasonic measurements

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Chinese Physics B 2024年第6期33卷 405-411页

作者：张化远 Kazuhei Wakiya Mitsuteru Nakamura Masahito Yoshizawa yoshiki Nakanish Graduate School of Science and Engineering Iwate UniversityMorioka 020-8551Japan

We performed ultrasonic measurements on a quaternary cubic compound PrRu_(2)In_(2)Zn_(18) to explore the ground state properties derived from non-Kramers Γ_(3) doublet of Pr^(3+).PrRu_(2)In_(2)Zn_(18) is a quaternary derivative of the ternary compound PrRu_(2)Zn_(20) that exhibits a structural phase transition at T_S=138 *** PrRu_(2)In_(2)Zn_(18),the Zn atoms at the 16c site in PrRu_(2)Zn_(20) are selectively replaced by In atoms.A monotonic increase was observed in the temperature dependence of elastic constants C_L=(C_(11)+2C_(12)+4C_(44))/3 and C_(T)=(C_(11)-C_(12)+C_(44))/3 in the temperature range around T_(S) to which an elastic softening was observed in(C_(11)-C_(12))/2 for PrRu_(2)Zn_(20).The disappearance of the softening indicates that the structural transition in PrRu_(2)Zn_(20) is suppressed by the substitution of Zn ions by In ones with a larger ionic ***,the C_(T) of PrRu_(2)In_(2)Zn_(18) exhibits a precursor Curie-type elastic softening toward low temperatures being responsible for the non-Kramers Γ_(3) ground *** discuss the ground state and the evolution of the elastic properties of the different single-crystal samples of PrRu_(2)In_(2)Zn_(18) grown under different conditions.

关键词： ultrasonic measurements non-Kramers doublet structural phase transition crystalline electric field effect

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Clinical utility of a new endoscopic scoring system for Crohn's disease

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World Journal of Gastroenterology 2015年第34期21卷 9974-9981页

作者： Kazuhiro Morise Takafumi Ando Osamu Watanabe Masanao Nakamura Ryoji Miyahara Osamu Maeda Kazuhiro Ishiguro yoshiki Hirooka Hidemi Goto Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine Department of Endoscopy Nagoya University Hospital

AIM:To evaluate the clinical value of the newly modified Simple Endoscopic Score for Crohn's disease(m SES-CD).METHODS:Seventy-six Crohn's disease(CD) patients who underwent transanal double balloon endoscopy(DBE) in our hospital between 2003 and 2012 were retrospectively reviewed. DBE is defined as small intestinal endoscopy using two attached balloons. We included patients with stenosis which hampered passage of the scope and those who underwent DBE with observation for at least 80 cm from the ileocecal valve. Our new m SES-CD assesses the endoscopic activity of two consecutive small intestinal segments located 0-40 cm and 40-80 cm from the ileocecal valve by DBE,in addition to the activity of four colorectal segments. To compare the usefulness of m SES-CD with SES-CD,we similarly divided the patients into two groups according to total m SES-CD score(low disease activity group, 0.05). Multivariate analysis by a Cox proportional hazards model identified m SES-CD as an independent factor for surgery-free survi

关键词： Crohn’s disease Modified Simple Endoscopic Score M

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Solid pseudopapillary neoplasm of the pancreas in a young male with main pancreatic duct dilatation: A case report

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World Journal of Clinical Cases 2021年第36期9卷 11382-11391页

作者： Saki Nakashima yoshiki Sato Tsunao Imamura Daisuke Hattori Tetsuo Tamura Rikako Koyama Junichiro Sato Yuta Kobayashi Masaji Hashimoto Department of Neurology The University of Tokyo HospitalBunkyo-ku 113-8655TokyoJapan Department of Gastroenterology Toranomon HospitalTokyo 105-0001Japan Department of Pathology Toranomon HospitalTokyo 105-0001Japan Department of Gastrointestinal Surgery Toranomon HospitalTokyo 105-0001Japan

BACKGROUND Solid pseudopapillary neoplasms(SPNs)are rare tumors of the ***,they occur in young females,often have characteristic imaging features,such as cystic components and calcification,and have few effects on the pancreatic *** SUMMARY A 31-year-old man was admitted to our hospital with the chief complaint of epigastric *** was only mild tenderness in his upper abdomen,and blood tests showed only a slight increase in alkaline ***-enhanced computed tomography showed a 40-mm-diameter,hypovascular mass in the head of the pancreas,and the main pancreatic duct upstream of the mass was severely *** resonance imaging showed low intensity on T1-weighted images,with high intensity on T2-weighted image in some *** ductal adenocarcinoma was the primary differential *** vein infiltration could not be ruled out,so this case was a candidate for neoadjuvant ***,endoscopic ultrasound-guided fine needle aspiration was performed,and pathological evaluation and immunostaining suggested a diagnosis of ***,pancreatoduodenectomy was *** year after the operation,the patient is alive with no *** Main pancreatic duct dilatation is usually a finding of suspected pancreatic ***,pancreatic duct dilatation can occur in SPN depending on the location and growth ***,SPN should be considered in the differential diagnosis of tumors with pancreatic duct dilatation,and pathological evaluation by endoscopic ultrasound-guided fine needle aspiration should be actively performed.

关键词： Solid pseudopapillary neoplasm Endoscopic ultrasound-guided fine-needle aspiration Main pancreatic duct dilatation Male Case report

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Localized type 1 autoimmune pancreatitis superimposed upon preexisting intraductal papillary mucinous neoplasms

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World Journal of Gastroenterology 2013年第47期19卷 9127-9132页

作者： Takahiro Urata yoshiki Naito Yoshihiro Izumi Yoshi Takekuma Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Kenji Notohara Michio Hifumi Department of Gastroenterology Japanese Red Cross Kumamoto HospitalKumamoto 861-8520Japan Department of Pathology Kurume University School of MedicineKurume CityFukuoka 830-0011Japan Department of Surgery Japanese Red Cross Kumamoto HospitalKumamoto 861-8520Japan Department of Pathology Japanese Red Cross Kumamoto HospitalKumamoto 861-8520Japan Department of Anatomic Pathology Kurashiki Central HospitalKurashiki CityOkayama 701-01Japan

A 70-year-old woman was found to have 2 cystic lesions in the head of the pancreas on abdominal ultrasonography during a routine medical *** ultrasonography(EUS)and magnetic resonance cholangiopancreatography showed multilocular cysts in the head of the pancreas without dilation of the main pancreatic *** patient was followed-up semiannually with imaging studies for suspected branch duct-type intraductal papillary mucinous neoplasm(IPMN).At 3 years after initial presentation,hypoechoic lesions were observed around each pancreatic cyst by ***-weighted imaging showed high-intensity regions corresponding to these ***,a diagnosis of invasive carcinoma derived from IPMN could not be excluded,and subtotal stomach-preserving pancreaticoduodenectomy was *** macroscopic examination of the surgical specimen showed whitish solid masses in the head of the pancreas,with multilocular cysts within each ***,each solid mass consisted of inflammatory cells such as lymphocytes and plasma ***,immunochemical staining revealed immunoglobulin G4-positive cells,and many obliterating phlebitides were *** cysts consisted of mucus-producing epithelial cells and showed a papillary growth *** on these findings,we diagnosed multiple localized type 1 autoimmune pancreatitis occurring only in the vicinity of the branch ducttype IPMN.

关键词： Autoimmune pancreatitis Intraductal papillary mucinous neoplasm Immunoglobulin G4 Endoscopic ultrasonography Diffusion-weighted imaging

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Overexpression of ETS-1 is associated with malignan＇ biological features of prostate cancer

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Asian Journal of Andrology 2012年第6期14卷 860-863页

作者： Bo Li Yosuke Shimizu Takashi Kobayashi Naoki Terada Koji Yoshimura Tomomi Kamba yoshiki Mikami Takahiro Inoue Hiroyuki Nishiyama Osamu Ogawa Department of Urology Kyoto University Graduate School of Medicine Kyoto 606-8507 Japan Minimally Invasive Urology Center Shandong Provincial Hospital Affiliated to Shandong University Jinan 250000 China Department of Urology Columbia University Herbert Irving Cancer Center New York NY 10032 USA Department of Diagnostic Pathology Kyoto University Hospital Kyoto 606-8507 Japan Department of Urology Faculty of Medicine University of Tsukuba Ibaraki 305-8575 Japan

E26 transformation-specific-1 （ETS-1）, an ETS family transcription factor, has been reported to play an important role in a variety of physiological and pathological processes, but clinical implications of ETS-1 expression in prostate cancer （PCa）, particularly high-risk cases, including response to androgen-deprivation therapy （ADT） have yet to be elucidated. We examined the expression of ETS- 1 using immunohistochemical staining of paraffin-embedded prostate carcinoma tissue obtained by needle biopsy from 69 mostly advanced PCa patients. ETS-1 expression was compared with the clinicopathological characteristics of the 69 patients, including 25 who underwent ADT as a primary treatment. As a result, PCa patients with higher expression of ETS-1 were significantly more likely to be of high stage and high Gleason score （P〈O.05）. There was no significant association between ETS-1 expression and the initial prostate-specific antigen （PSA） level. In the 25 patients treated by ADT, the staining score for ETS-1 was significantly associated with rapid development of castration-resistant disease within 24 months （P〈O.05）, whereas the Gleason score and PSA level were not. In conclusion, increased ETS-1 expression was associated with a higher stage, higher Gleason score and shorter time to castration-resistant progression. These data suggest that immunostaining for ETS-1 could be a molecular marker for predicting a poor clinical outcome for PCa patients, oarticularlv those with hi^h-risk disease.

关键词： castration resistant E26 transformation-specific-1 (ETS-1) immunohistochemistry prostate cancer

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