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Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease

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World Journal of Stem Cells 2018年第11期10卷 146-159页

作者： Saifun Nahar yoshiki Nakashima Chika Miyagi-Shiohira Takao Kinjo Zensei Toyoda Naoya Kobayashi Issei Saitoh Masami Watanabe Hirofumi Noguchi Jiro Fujita Department of Infectious Respiratory and Digestive Medicine Graduate School of Medicine University of the Ryukyus Okinawa 903-0215 Japan Department of Regenerative Medicine Graduate School of Medicine University of the Ryukyus Okinawa 903-0215 Japan Department of Basic Laboratory Sciences School of Health Sciences in the Faculty of Medicine University of the Ryukyus Okinawa 903-0215 Japan Okayama Saidaiji Hospital Okayama 704-8192 Japan Division of Pediatric Dentistry Graduate School of Medical and Dental Science Niigata University Niigata 951-8514 Japan Department of Urology Okayama Univer sity Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan

Adipose-derived mesenchymal stem cells （ADSCs） are a treatment cell source for patients with chronic liver injury. ADSCs are characterized by being harvested from the patient’s own subcutaneous adipose tissue, a high cell yield （ i.e. , reduced immune rejection res-ponse）, accumulation at a disease nidus, suppression of excessive immune response, production of various growth factors and cytokines, angiogenic effects, anti-apoptotic effects, and control of immune cells via cell-cell interaction. We previously showed that conditioned medium of ADSCs promoted hepatocyte proliferation and improved the liver function in a mouse model of acute liver failure. Furthermore, as found by many other groups, the administration of ADSCs improved liver tissue fbrosis in a mouse model of liver cirrhosis. A comprehensive protein expression analysis by liquid chromatography with tandem mass spectrometry show-ed that the various cytokines and chemokines produced by ADSCs promote the healing of liver disease. In this review, we examine the ability of expressed protein com-ponents of ADSCs to promote healing in cell therapy for liver disease. Previous studies demonstrated that ADSCs are a treatment cell source for patients with chronic liver injury. This review describes the various cytokines and chemokines produced by ADSCs that promote the healing of liver disease.

关键词： Cell transplantation therapy Cytokine Hepatocytes Liquid chromatography with tandem mass spectrometry Liver cirrhosis Adipose-derived mesenchymal stem cells

南黄海中部泥质区7200年以来东亚冬季风变化的沉积记录

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中国科学：地球科学 2012年第10期42卷 1568-1581页

作者：胡邦琦杨作升赵美训 yoshiki SAITO 范德江王利波国土资源部海洋油气资源与环境地质重点实验室青岛海洋地质研究所青岛266071 中国科学院地球环境研究所黄土与第四纪地质国家重点实验室西安710075 中国海洋大学海洋地球科学学院青岛266100 中国海洋大学海洋化学理论与工程技术教育部重点实验室青岛266100 Geological Survey of Japan National Institute of Advanced Industrial Science and Technology(AIST)TsukubaIbaraki305-8567Japan

对南黄海中部泥质区的三个柱样(ZY-1,ZY-2和ZY-3孔)进行了AMS14C测年、沉积层序以及沉积物敏感粒级的分析.结果表明此三孔的岩性上下均一且沉积连续,均为黏土质粉沙,是全新世高海平面以来的沉积产物.ZY-1,ZY-2和ZY-3孔的粒度垂向变化特... 详细信息

对南黄海中部泥质区的三个柱样(ZY-1,ZY-2和ZY-3孔)进行了AMS14C测年、沉积层序以及沉积物敏感粒级的分析.结果表明此三孔的岩性上下均一且沉积连续,均为黏土质粉沙,是全新世高海平面以来的沉积产物.ZY-1,ZY-2和ZY-3孔的粒度垂向变化特征基本一致,主要受控于现代黄海环流体系中冬季风驱动的黄海近岸海流的强弱,间接反映了东亚冬季风强弱变化.利用ZY-1,ZY-2和ZY-3孔的沉积物敏感粒级获得了近7200年来高分辨率的东亚冬季风替代指标,发现在7.2～4.2ka期间东亚冬季风强盛且波动大,4.2～1.8ka期间东亚冬季风表现为中等强度且比较稳定,东亚冬季风强度在1.8～0ka期间虽较弱,但在此阶段后期略有上升.中全新世以来,南黄海中部泥质区所记录的东亚冬季风变化趋势在千年尺度上与已报道的东亚夏季风强度变化趋势基本一致,主要受控于轨道驱动的太阳辐射量冬、夏季季节性变化差异;但在百年尺度上东亚冬季风增强事件则与夏季风减弱事件相对应,呈现反向变化,可能是对太阳活动减弱的敏感响应.

关键词：东亚冬季风南黄海中部泥质区敏感粒级太阳活动中全新世

Annual Component Analysis of Pacific Oysters （Crassostrea gigas） and Mussels （Mytilus gallopro vincialis）

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Journal of Shipping and Ocean Engineering 2014年第7期4卷 203-213页

作者： Yumiko yoshiki Chiho Mizukoshi Uno Masatoshi Department of Food Science Ishikawa Prefectural University Ishikawa 922-0134 Japan

To study the change in components of Pacific oysters （Crassostrea gigas） and mussels （Mytilus galloprovincialis） over a year, their annual obesity ratio, umami components （glutamic acid and glycogen）, functional components （Zn, Mn, Cu, and vitamin B12）, and Cd and noroviruses （NoVs） contents were quantified. In oysters, the obesity ratio and chemical components showed seasonal changes depending on the spawning season. Glutamic acid content increased from November to March. In contrast, glycogen content peaked in May and November. Mineral content markedly increased during spawning. From the comparison of NoVs GI and GII strains, oyster predominately infected by the GI. A remarkable difference in NoVs contents was observed depending on the oyster farms. In mussels, glutamic acid, Zn and Cu contents were stable throughout the year. Mussels＇ Cd content was about one-fifths times lower than that found in oysters. Although the NoVs strain was affected by the collection area, mussels from both areas showed decreased NoVs contents in summer, corresponding with the consumption season of mussels in Japan. Our comparative study on the seasonal variability in the chemical components and NoVs contents in pacific oysters （C. gigas） and mussels （M. galloprovincialis） clearly showed an association with physiological and environmental factors.

关键词： Oyster mussel seasonal variation mineral norovirus.

Organic-inorganic Polymer Nano-hybrids Based on Sol-gel Reaction

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复旦学报（自然科学版） 2007年第5期46卷 556-页

作者： yoshiki Chujo Department of Polymer Chemistry Kyoto University

1 Results Nano-ordered composite materials consisting of organic polymers and inorganic materials have been attracting attention for the purpose of the creation of high-performance or high-functional polymeric materials. Especially,the word of "polymer hybrid" claims the blends of organic and inorganic components at nano-level dispersion. By using this idea,an enhancement of mechanical strength of organic polymers with silica particles is *** transparency of this material is another important ...

关键词： polymer hybrids nano-materials sol-gel reaction

Transarterial chemoembolization for hepatocellular carcinoma: A review of techniques

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World Journal of Hepatology 2014年第12期6卷 844-850页

作者： Norihiro Imai Masatoshi Ishigami Yoji Ishizu Teiji Kuzuya Takashi Honda Kazuhiko Hayashi yoshiki Hirooka Hidemi Goto Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine Aichi 466-8560 Japan

Hepatocellular carcinoma(HCC)is one of the most common malignant diseases *** curative therapies,including resection,liver transplantation,and percutaneous ablation(percutaneous ethanol injection and radiofrequency ablation),are applicable for only a portion of the HCC population,transcatheter arterial chemoembolization(TACE)has been recognized as an effective palliative treatment option for patients with advanced *** is also used even for single HCCs in which it is difficult to perform surgical resection or locoregional treatment due to systemic co-morbidities or anatomical *** has become widely adopted in the treatment of *** using computed tomography-angiography,TACE is capable of performing diagnosis and treatment at the same ***,TACE plays an important role in the multidisciplinary treatment for HCC when combined with other *** this review,we first discuss the history of TACE,and then review the previous findings about techniques of achieving a locoregional treatment effect(liver infarction treatment,e.g.,ultra-selective TACE,balloon-occluded TACE),and the use of TACE as a drugdelivery system for anti-cancer agents(palliative,e.g.,platinum complex agents,drug-eluting beads)for multiple lesions.

关键词： Hepatocellular carcinoma Transcatheter arterial chemoembolization Balloon-occluded transcatheter arterial chemoembolization Drug-eluting bead

Efficacy of long-term rifaximin treatment for hepatic encephalopathy in the Japanese

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World Journal of Hepatology 2019年第6期11卷 531-541页

作者： Shinya Nishida Koichi Hamada Noriyuki Nishino Daizo Fukushima Ryota Koyanagi Yoshinori Horikawa yoshiki Shiwa Satoshi Saitoh Department of Gastroenterology Shin-Yurigaoka General HospitalKawasaki 215-0026Japan Department of Gastroenterology Southern-Tohoku General HospitalKoriyama 963-8563Japan Department of Minimally Invasive Surgical and Medical Oncology Fukushima Medical UniversityFukushima 960-1295Japan Department of Hepatology Toranomon HospitalTokyo 105-8470Japan

BACKGROUND Hepatic encephalopathy(HE)is a complication of liver cirrhosis and can result in neuropsychological and neuromuscular dysfunctions in ***,an antibiotic,has been reported to decrease the occurrence of overt HE and also improve cognitive function in studies from Europe and the United States of *** is not enough evidence of the relationship between the long-term use of rifaximin and its clinical effects in the *** To determine the clinical effects of long-term rifaximin therapy in decompensated liver cirrhosis patients,with overt HE or *** In this single-center retrospective observational cohort study,we reviewed the data of 38 patients who had taken rifaximin at the dose of 1200 mg/d for more than 24 *** primary outcome measured was the efficacy of long-term rifaximin use,and secondary outcome measured was the safety of its long-term use as determined by its influence on portosystemic shunts as well as Escherichia coli-related ***,we compared the prognosis between the rifaximin group and control cases,matched for hepatic elasticity assessed by magnetic resonance ela-stography,age,and Child-Pugh *** Of the 38 patients included in the study,12(31.6%)had overt HE,27(71.1%)had complications of esophageal varices,and 9(23.7%)had hepatocellular carcinoma(HCC).The control group was matched for age,Child-Pugh classification,liver stiffness,and presence of *** median of serum ammonia level before treatment was 104μg/dL(59-297),and 2 wk after treatment,it significantly decreased to 85μg/dL(34-153)(P=0.002).A significantly low value of 80.5μg/dL(44-150)was maintained 24 wk after *** long-term use of rifaximin did not cause a decline in liver *** occurred in 2 patients,who improved with the administration of probiotics,and there were no cases of aborted rifaximin therapy owing to adverse *** patients with Child C,the survival was short,but there

关键词： Hepatic encephalopathy Rifaximin Hepatic cirrhosis Spontaneous portosystemic shunt Magnetic resonance elastography Child-Pugh classification

Mapping hydrocarbon-induced mineralogical alteration in the northern Tian Shan using ASTER multispectral data

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Mapping hydrocarbon-induced mineralogical alteration in the ...

Endoscopic ultrasound-guided fine needle aspiration in the differentiation of type 1 and type 2 autoimmune pancreatitis

中国科学院地质与地球物理研究所2007学术年会

作者：付碧宏 yoshiki Ninomiya State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics.Chinese Academy of Sciences Geological Survey of Japan AIST.Higashi 1-1-1.Tsukuba 305-8567Japan

Seepage from hydrocarbon reservoirs can cause a number of chemical and/or mineralogical changes in overlying rocks and *** surface changes can be detected by remote sensing imaging *** Advanced Spaceborne Thermal Emission and Reflection Radiometer(ASTER) is an advanced multispectral imaging system in the visible and near infrared(VNIR) to shortwave infrared(SWIR) *** ratios of ASTER VNIR and SWIR data to detect red bed bleaching and secondary carbonate formation induced by hydrocarbon seepage are proposed through analysis of the spectral properties of rock *** show that ASTER band ratios of 2/1 and 4/8 can discriminate bleached red beds and secondary carbonate minerals due to hydrocarbon seepage in the northern Tian Shan. They are in good agreement with mineral identification using X-ray *** ratio technique derived from ASTER data may provide a potential approach for hydrocarbon exploration in areas with sparse vegetation cover.

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World Journal of Gastroenterology 2012年第29期18卷 3883-3888页

作者： Takuya Ishikawa Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Hirosh Matsubara Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Masanao Nakamura Ryoji Miyahara Naoki Ohmiya Hidemi Goto yoshiki Hirooka Department of Gastroenterology Nagoya University Graduate School of Medicine65 Tsuruma-choShowa-kuNagoya 466-8550Japan Department of Endoscopy Nagoya University Hospital65 Tsuruma-choShowa-kuNagoya 466-8550Japan

AIM:To investigate the usefulness of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) in the differentiation of autoimmune pancreatitis(AIP).METHODS:We retrospectively reviewed 47 of 56 AIP patients who underwent EUS-FNA and met the Asian diagnostic *** 47 EUS-FNA specimens,we evaluated the presence of adequate material and characteristic features of lymphoplasmacytic sclerosing pancreatitis(LPSP) and idiopathic duct-centric pancreatitis(IDCP) mentioned in the International Consensus Diagnostic Criteria and examined if these findings make a contribution to the differential diagnosis of type 1 and type 2 AIP.A disposable 22-gauge needle was used for ***:Adequate specimens including pancreatic tissue for differentiating AIP from cancer were obtained from 43 of 47 patients who underwent ***-FNA was performed from the pancreatic head in 21 cases,which is known to be technically difficult when performed by core biopsy;there was no significant difference in the results compared with pancreatic *** of 47 patients met level 1 findings of LPSP and 5 patients met level 2 findings of *** one met level 1 findings of IDCP,but 3 patients met level 2 findings of *** 10 seronegative cases,2 cases were diagnosed with "definitive type 1 AIP",and 3 cases were diagnosed with "probable type 2 AIP" when considering both the level 2 histological findings and response to ***:EUS-FNA is useful in the differentiation of type 1 and type 2 AIP,particularly in seronegative cases.

关键词： Autoimmune pancreatitis Endoscopic ultrasound-guided fine needle aspiration Idiopathic duct centric pancreatitis Lymphoplasmacytic sclerosing pancreatitis Pancreatic cancer

Obstructive jaundice caused by secondary pancreatic tumor from malignant solitary fibrous tumor of pleura:A case report

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World Journal of Gastroenterology 2006年第30期12卷 4922-4926页

作者： Norie Yamada Chiaki Okuse Masahito Nomoto Mayu Orita yoshiki Katakura Toshiya Ishii Takuo Shinmyo Hiroaki Osada Ichiro Maeda Hiroshi Yotsuyanagi Michihiro Suzuki Fumio Itoh Division of Gastroenterology and Hepatology Department of Internal Medicine St. Marianna University School of Medicine 2-16-1 Sugao Miyamae-ku Kawasaki 216-8511 Japan Department of Chest Surgery St. Marianna University School of Medicine 2-16-1 Sugao Miyamae-ku Kawasaki 216-8511 Japan Department of Diagnostic Pathology St. Marianna University School of Medicine 2-16-1 Sugao Miyamae-ku Kawasaki 216-8511 Japan Division of Infectious Diseases Department of Internal Medicine University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan

A 77-year-old man on systemic chemotherapy against postoperative bilateral multiple lung metastases of malignant solitary fibrous tumor of the pleura suffered from pruritus and jaundice. Blood examination showed elevated levels of hepatobiliary enzymes. Abdominal computed tomography showed a tumor with peripheral enhancement in the pancreatic head, accompanied with the dilatation of intra- and extra-hepatic bile ducts. He was diagnosed as having obstructive jaundice caused by a pancreatic head tumor. The pancreatic head tumor was presumably diagnosed as the metastasis of malignant solitary fibrous tumor of the pleura, because the findings on the pancreatic head tumor on abdominal CT were similar to those on the primary lung lesion of malignant solitary fibrous tumor of the pleura. The pancreatic tumor grew rapidly after the implantation of metallic stent in the inferior part of the common bile duct. The patient died of lymphangitis carcinomatosa of the lungs. Autopsy revealed a tumor that spread from the pancreatic head to the hepatic hilum. Microscopically, spindle-shaped cells exhibiting nuclear atypicality or division together with collagen deposition were observed. Immunohistochemically the pancreatic head tumor cells were negative for staining of α-smooth muscle actin （α-SMA） or CD117, but positive for vimentin, CD34 and CD99. These findings are consistent with those on malignant solitary fibrous tumor of the pleura. We report the first case of obstructive jaundice caused by a secondary pancreatic tumor from malignant solitary fibrous tumor of the pleura.

关键词： Malignant solitary fibrous tumor of the pleura Secondary pancreatic tumor Obstructive jaundice