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A short climatology of black and brown carbon and their sources at a suburban site impacted by smoke in Brazil

Journal of Environmental Sciences 2024年第2期136卷 498-511页

作者： Admir Creso Targino Patricia Krecl Gabriel yoshikazu Oukawa Eva Maria Mollinedo Graduate Program in Environmental Engineering Federal University of TechnologyAv.Pioneiros 3131LondrinaPR 86036-370Brazil Department of Environmental Engineering Federal University of TechnologyAv.Pioneiros 3131LondrinaPR 86036-370Brazil

Emissions from biomass burning challenge efforts to curb air pollution in cities downwind of fire-prone regions,as they contribute large amounts of brown carbon(Br C)and black carbon(BC)*** investigated the patterns of Br C and BC concentrations using Aethalometer data(atλ=370 and 880 nm,respectively)spanning four years at a site impacted by the outflow of *** data required to be post processed for the shadowing effect since,without correction,concentrations would be between 29%and 35%*** Br C concentrations were consistently higher than the BC concentrations,indicating the prevalence of aerosols from biomass *** results were supported by the Angstrom coefficient(A_(370/880)),with values predominantly larger than 1(mean±standard deviation:1.25±0.31).A_(370/880)values below 1 were more prevalent during the wet season,which suggests a contribution from fossil fuel *** observed sharp Br C and BC seasonal signals,with mean minimum concentrations of 0.40μg/m^(3)and 0.36μg/m^(3),respectively,in the wet season,and mean maximum concentrations of 2.05μg/m^(3)and 1.53μg/m^(3)in the dry *** largest concentrations were observed when northerly air masses moved over regions with a high density of fire *** burning of residential solid waste and industrial combustion caused extreme Br C and BC concentrations under favourable wind *** neither pollutant is included in any ambient air quality standards,our results suggest that transboundary smoke may hamper efforts to meet the World Health Organization guidelines for fine particles.

关键词： Light-absorbing carbonaceous matter Black carbon Wildfires Biomass burning Aethalometer

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Co-infection with Neisseria mucosa in a patient with tuberculous otitis media

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Journal of Otology 2024年第1期19卷 1-4页

作者： Tatsuya Hioki Kazuaki Soejima Yuki Goto Makoto Sugiura Takumi Umemura Yoshimi Ishihara yoshikazu Mutoh Daisuke Sakanashi Hiroshige Mikamo Department of Clinical Laboratory Tosei General Hospital160 Nishioiwake-choSetoAichi489-8642Japan Department of Respiratory Medicine and Allergy Tosei General Hospital160 Nishioiwake-choSetoAichi489-8642Japan Department of Otolaryngology Tosei General Hospital160 Nishioiwake-choSetoAichi489-8642Japan Department of Infection Control Team Tosei General Hospital160 Nishioiwake-choSetoAichi489-8642Japan Department of Infectious Diseases Tosei General Hospital160 Nishioiwake-choSetoAichi489-8642Japan Department of Infection Prevention and Control Aichi Medical University Hospital1-1 YazakokarimataNagakuteAichi480-1195Japan Department of Clinical Infectious Diseases Aichi Medical University1-1 YazakokarimataNagakuteAichi480-1195Japan

Tuberculous otitis media(TOM) is a rare manifestation caused by Mycobacterium tuberculosis with low incidence rates among extrapulmonary tuberculosis cases. Diagnosis is often delayed because of the presence of several clinical manifestations and the high prevalence of secondary bacterial infections. Few reports have attributed secondary bacterial infections in patients with TOM to commensal Neisseria. Thus, understanding the pathogenic mechanisms and clinical features of commensal Neisseria is important, considering its recent presentation as an infection-causing pathogen. Neisseria mucosa is a commensal inhabitant in humans and is generally considered non-pathogenic but can cause infection in rare cases. Here, we report an atypical secondary infection caused by Neisseria mucosa in an 81-year-old woman with TOM being treated for pulmonary tuberculosis. Direct purulent otorrhea smear microscopy revealed no acid-fast bacilli using Ziehl-Neelsen staining, whereas the phagocytosis of gram-negative cocci by white blood cells was confirmed using Gram staining. Otorrhea culture revealed the growth of N. mucosa. Subsequently, M. tuberculosis infection in the otorrhea was identified using a culture-based method. Vigilance is critical for the early detection of TOM to prevent further complications. This report raises awareness regarding TOM and provides insight into the pathogenicity of N. mucosa in otitis media.

关键词： Commensal neisseria Miliary tuberculosis Mycobacterium tuberculosis Neisseria mucosa Tuberculous otitis media

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小鼠胎肝激酶-1阳性细胞向胆管细胞和肝细胞分化

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中华肝脏病杂志 2010年第7期18卷 544-545页

作者：金成豪米满吉和居石克夫时军江西省人民医院血液内科南昌330006 Division of Pathophysiological and ExperimentaJ Pathology Department of Pathology Graduate School of Medical Sciences Kyushu University Fukuoka 812 8582 JapanDepartmentofPathologyGraduateSchoolofMedicalSciencesKyushuUniversityFukuoka812-8582Japan

干细胞对再生医学和人工器官的发展具有巨大潜在应用价值.肝脏可能是再生医学的一个很有吸引力的目标,理由是：（1）肝脏是一种多种遗传性和获得性代谢性疾病的易损器官;（2）增殖肝可接受来自同基因供者的肝细胞.

关键词：干细胞小鼠胎肝激酶-1

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小鼠胎肝中胎肝激酶-1阳性细胞具有血管祖细胞的功能特性

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中华心血管病杂志 2010年第12期38卷 1108-1112页

作者：金成豪米满吉和丁伟荣居石克夫江西省人民医院血液内科南昌330006 日本九州大学医学研究院病理病态学研究室

目的探讨胎肝中胎肝激酶-1（fetla liver kinase 1,FLK-1）阳性细胞的特征和功能.方法免疫磁珠分离胎肝FLK-1阳性细胞,流式细胞术（又称荧光活化细胞分类计数,fluorescence activated cell sorter,FACS）检测胎肝FLK-1阳性细胞.体外... 详细信息

目的探讨胎肝中胎肝激酶-1（fetla liver kinase 1,FLK-1）阳性细胞的特征和功能.方法免疫磁珠分离胎肝FLK-1阳性细胞,流式细胞术（又称荧光活化细胞分类计数,fluorescence activated cell sorter,FACS）检测胎肝FLK-1阳性细胞.体外生长因子诱导培养、测定FLK-1阳性细胞的分化、增殖活性.FLK-1阳性细胞植入75%肝切除的小鼠肝脏模型中,借助荧光解剖显微镜及免疫组织化学方法观察血管形成及细胞分化的情况.结果 FLK-1阳性细胞经生长因子诱导后,可表达典型的血管内皮细胞、平滑肌细胞的标志.75%肝切除的小鼠肝脏模型中,植入的FLK-1阳性细胞在肝脏的纤维囊中分化成血管细胞并形成血管.结论胎鼠肝脏FLK-1阳性细胞具有血管祖细胞的功能,具有潜在的临床应用价值.

关键词：血管内皮生长因子受体2 干细胞细胞分化细胞移植

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Dendritic cell-based vaccine for pancreatic cancer in Japan

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第1期7卷 133-138页

作者： Masato Okamoto Masanori Kobayashi yoshikazu yonemitsu Shigeo Koido Sadamu Homma Department of Advanced Immunotherapeutics Kitasato University School of Pharmacy Oncology Cencer Kitasato Institute Hospital Seren Clinic Nagoya R and D Laboratory for Innovative Biotherapeutics Graduate School of Pharmaceutical Sciences Kyushu University Division of Gastroenterology and Hepatology Department of Internal Medicine the Jikei University School of Medicine Department of Oncology the Jikei University School of Medicine

"Vaccell" is a dendritic cell(DC)-based cancer vaccine which has been established in Japan. The DCs play central roles in deciding the direction of host immune reactions as well as antigen presentation. We have demonstrated that DCs treated with a streptococcal immune adjuvant OK-432, produce interleukin-12, induce Th1-dominant state, and elicit anti-tumor effects, more powerful than those treated with the known DCmaturating factors. We therefore decided to mature DCs by the OK-432 for making an effective DC vaccine, Vaccell. The 255 patients with inoperable pancreatic cancer who received standard chemotherapy combined with DC vaccines, were analyzed retrospectively. Survival time of the patients with positive delayed type hypersensitivity(DTH) skin reaction was significantly prolonged as compared with that of the patients with negative DTH. The findings strongly suggest that there may be "Responders" for the DC vaccine in advanced pancreatic cancer patients. We next conducted a smallscale prospective clinical study. In this trial, we pulsed HLA class Ⅱ-restricted WT1 peptide(WT1-Ⅱ) in addition to HLA class Ⅰ-restricted peptide(WT1-Ⅰ) into the DCs. Survival of the patients received WT1-Ⅰ and-Ⅱ pulsed DC vaccine was significantly extended as compared to that of the patients received DCs pulsed with WT1-Ⅰ or WT1-Ⅱ alone. Furthermore, WT1-specific DTH positive patients showed significantly improved the overall survival as well as progressionfree survival as compared to the DTH negative patients. The activation of antigen-specific immune responses by DC vaccine in combination with standard chemotherapy may be associated with a good clinical outcome in advanced pancreatic cancer. We are now planning a pivotal study of the Vaccell in appropriate protocols in Japan.

关键词： Dendritic cell Cancer vaccine Pancreatic cancer Cancer immunotherapy Anti-cancer immunity

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Predictive factors for efficacy of testosterone replacement therapy for late-onset hypogonadism in Japanese men:a preliminary report

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Asian Journal of Andrology 2023年第5期25卷 587-590页

作者： Nobuyuki Kondoh Yohei Kaizuka Seiji Nagasawa yoshikazu Togo Shingo Yamamoto Department of Urology Kawanishi City Medical CenterKawanishiHyogo 6660017Japan Department of Urology Hyogo Medical UniversityNishinomiyaHyog 6638501Japan

Although testosterone replacement therapy(TRT)is the first-choice method used worldwide for late-onset hypogonadism(LOH),clinical benefits are not seen in all *** study was conducted to determine the predictors of TRT efficacy for ***-six patients who visited our Men’s Health Clinic(Kawanishi City Medical Center,Kawanishi and Hyogo Medical University,Nishinomiya,Hyogo,Japan)between November 2003 and June 2021 with data available before and after TRT were *** were divided into responders(Group 1;n=45,accounting for 80.4%)and nonresponders(Group 2;n=11,accounting for 19.6%)based on the clinical response to TRT,including patient *** noted before TRT included age,body mass index,aging males’symptoms score,sexual health inventory for men,luteinizing hormone,follicular-stimulating hormone,testosterone,free testosterone,prolactin(PRL),estradiol(E2),and testosterone/estradiol(T/E2)ratio in *** statistical analysis,a multivariable logistic regression model was *** analysis revealed PRL(odds ratio TORI:0.9624;95%confidence interval[Cl]:0.9316-0.9943,P<0.05),E2(OR:0.8692;95%Cl:0.7745-0.9754,P<0.05),and T/E2 ratio(OR:1.1312;95%Cl:1.0106-1.2661,P<0.05)to be predictive *** analyses showed that T/E2 ratio was an independent predictive factor(OR:1.1593;95%Cl:1.0438-1.2875,P<0.01).The present results suggest that a low value for T/E2 ratio may predict a reduced response to *** T/E2 ratio threshold to predict nonresponders based on receiver-operating characteristics(ROC)curve analysis was shown to be *** additional studies with larger number of patients are necessary,we propose the determination of serum E2 level and testosterone level prior to performing TRT.

关键词： estradiol late-onset hypogonadism predictive factor testosterone treatment

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A Contribution to Guy's Conjecture

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Acta Mathematica Sinica,English Series 2022年第10期38卷 1856-1886页

作者： Yukio MATSUMOTO yoshikazu MATSUTANI Angel MONTESINOS-AMILIBIA Masami ODA Shuichi OHKI Tsuyoshi SAKAI Department of Mathematics Gakushuin UniversityMejiroToshima-kuTokyo 171-8588Japan 3-21-1-901 Minamimachi KokubunjiTokyo 185-0021Japan Calle Rio Alberche 8.05260 CebrerosSpain Tsuda University 2-1-1Tsuda-choKodairaTokyo 187-8577Japan Tokyo Japanese Language Educational Center 3-22-7Kita ShinjukuShinjuku-kuTokyo 169-0074Japan Department of Mathematics College of Humanities and SciencesNihon UniversitySetagaya-kuTokyo 156-0045Japan

Let Kdenote the complete graph consisting of n vertices,every pair of which forms an *** want to know the least possible number of the intersections,when we draw the graph Kon the plane or on the sphere using continuous arcs for *** a paper published in 1960,Richard *** conjectured that the least possible number of the intersections is 1/64(n-1)^(2)(n-3)^(2) if n is odd,or 1/64 n(n-2)^(2)(n-4)if n is even.A virgin road V_(n)is a drawing of a Hamiltonian cycle in Kconsisting of n vertices and n edges such that no other edge-representing arcs cross V.A drawing of Kis called virginal if it contains a virgin *** drawings considered in this paper will be virginal with respect to a fixed virgin road *** will present a certain drawing of a subgraph of K,for each n(≥5),which is"characteristic"in the sense that any minimal virginal drawing of Kcontaining this subdrawing satisfies Guy’s conjecture.

关键词： Complete graph virginal drawing Guy’s conjecture

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Enhanced bifunctional catalytic activities of N-doped graphene by Ni in a 3D trimodal nanoporous nanotubular network and its ultralong cycling performance in Zn-air batteries

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Journal of Energy Chemistry 2022年第3期31卷 466-473,I0013页

作者： Yanyi Zhang Xiang-Peng Kong Xiaorong Lin Kailong Hu Weiwei Zhao Guoqiang Xie Xi Lin Xingjun Liu yoshikazu Ito Hua-Jun Qiu School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen 518055GuangdongChina Shenzhen R&D Center for Al-based Hydrogen Hydrolysis Materials Shenzhen 518055GuangdongChina State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001HeilongjiangChina Blockchain Development and Research Institute Harbin Institute of TechnologyShenzhen 518055GuangdongChina Institute of Applied Physics Graduate School of Pure and Applied SciencesUniversity of TsukubaTsukuba 305-8573Japan

Free-standing and fexible air electrodes with long-lasting bifunctional activities for both the oxygen reduction reaction(ORR)and the oxygen evolution reaction(OER)are crucial to the development of wearable Zn-air rechargeable *** this work,we synthesize a fexible air electrode consisting of 3D nanoporous N-doped graphene with trimodal shells and Ni particles through repeated chemical vapor deposition(CVD)and acidic etching *** results indicate that such trimodal graphene morphology significantly enhances the active N-dopant sites and graphene-coated Ni surface,which consequentially boosts both the ORR and OER activities,as well as catalytic ***-principles density functional theory(DFT)calculations reveal the synergetic effects between the Ni and the N-doped graphene;namely,the Ni nanoparticles boost the bifunctional activities of the coated N-doped graphene,and in turn the graphene-covering layers enhance the stability of *** to the better protection from the triple graphene shells,our trimodal N-doped graphene/Ni-based Zn-air battery can be stably discharged/recharged beyond 2500 h with low *** is reasonable to expect that such freestanding trimodal graphene/Ni would be promising in many fexible energy conversion/storage devices.

关键词： Triple shells Bifunctional Hierarchical Cycling durability ORR/OER

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Extracellular matrix gene expression in human trabecular meshwork cells following mechanical fluid flow stimulation

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 388-393页

作者： Koichi Yoshida Motofumi Kawai Tsugiaki Utsunomiya Akihiro Ishibazawa Young-Seok Song Mariana Sayuri BUdo yoshikazu Tasaki Akitoshi Yoshida Department of Ophthalmology Asahikawa Medical UniversityAsahikawaHokkaido 078-8510Japan Department of Hospital Pharmacy&Pharmacology Asahikawa Medical UniversityAsahikawaHokkaido 078-8510Japan

AIM: To investigate changes in extracellular matrix(ECM) gene expression in human trabecular meshwork(HTM) cells in response to mechanical fluid flow ***: HTM cells were grown on a glass plate coated with 0.02% type Ⅰ collagen(COL) and exposed to shear stress(0, 0.2, 1.0 dyne/cm;) for 12 *** in genes related to the ECM were evaluated by real-time reverse transcriptase-polymerase chain *** of Smad2 protein was investigated by Western ***: After mechanical stimulation, COL type 4 alpha 2, COL type 6 alpha 1, and fibronectin-1 mRNA were significantly higher than the static control(P<0.05, <0.05, and <0.01, respectively).The metalloproteinase-2 and plasminogen activator inhibitor-1 mRNA were significantly higher than the static control(P<0.05 and <0.01, respectively), while the differences in the tissue inhibitors of metalloproteinases-2 mRNA were not *** phosphorylation of Smad2 levels was significantly higher compared to the static control ***: Changes in the expressions of genes associated ECM metabolism result in HTM cells after mechanical *** mechanical stimulation of the aqueous humor to the trabecular meshwork may promote ECM turnover and contribute to intraocular pressure homeostasis.

关键词： trabecular meshwork shear stress aqueous humor extracellular matrix glaucoma intraocular pressure

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Accelerated Gas Carburizing (URX Gas Carburizing)

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材料热处理学报 2004年第5期25卷 378-381页

作者： yoshikazu Shimosato Mamoru Kamitani Hiroyuki Nakatsu Chugai Ro Co. Ltd. Osaka JapanChugai Ro Co. Ltd. Osaka JapanChugai Ro Co. Ltd. Osaka Japan

URX gas Carburizing is an accelerated gas Carburizing method with 50% CO + 50% H2 gas which comes from CFLt gas + CO2 gas. By using this gas composition, the Carburizing reaction rate increases to the maximum and the controllability of carbon potential improves. A carbon mass flow rate is the product of the Carburizing reaction rate multiplied by the difference of carbon percent between carbon potential of the gas and the carbon content of the surface of treated steel parts. We have obtained excellent results from the experimental tests at our laboratory as mentioned bellow. 1) Carburizing time can be shortened by 40% for 0.5 - 0.9 mm effective case depth. 2) Uniform Carburizing case depth 3) Less internal oxidation with the same case depth. We have already developed the new roller hearth type continuous Carburizing furnace and the new URX gas generator .

关键词：气体渗碳内部氧化质量流速反应速率系数

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