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Transporter-Mediated Organ Toxicity

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毒理学杂志 2005年第S1期 173-174页

作者： Hitoshi Endou,yoshikatsu kanai Department of Pharmacology and Toxicology Kyorin University School of Medicine 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan Department of Pharmacology and Toxicology Kyorin University School of Medicine 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan

CD98 is a promising prognostic biomarker in biliary tract cancer

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Hepatobiliary & Pancreatic Diseases International 2014年第6期13卷 654-657页

作者： Kyoichi Kaira Yutaka Sunose Noboru Oriuchi yoshikatsu kanai Izumi Takeyoshi Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Showa-machi Maebashi Gunma Japan Department of Thoracic and Visceral Surgery Gunma University Graduate School of Medicine Showa-machi Maebashi Gunma Japan Department of Diagnostic Radiology and Nuclear Medicine Gunma University Graduate School of Medicine Showa-machi Maebashi Gunma Japan Division of Biosystem Pharmacology Department of Pharmacology Graduate School of Medicine Osaka University Osaka Japan

ABSTRACT： CD98 has been described to play a crucial role in tumor progression and survival. However, the role of CD98 in biliary tract cancer remains unclear. We found that 36.7% of all patients with biliary tract cancer had a high CD98 expression. Statistical analysis using Spearman＇s rank correlation showed that CD98 was significantly correlated with L-type amino acid transporter 1 （LAT1, r=0.562, P〈0.001）, Ki-67 （r=0.230, P=0.006） and CD34 （r=0.290, P=0.005）. Multivariate analysis confirmed that a high CD98 expression was an independent prognostic factor for predicting poor outcome. CD98 is closely associated with tumor growth, biological aggressiveness, and survival of patients. With these data we proposed that CD98 expression is necessary for the development and pathogenesis of biliary tract cancer.

关键词： CD98 biliary tract cancer amino acid transporter prognostic factor

Transporter-Mediated Organ Toxicity

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Transporter-Mediated Organ Toxicity

A GAN-based temporally stable shading model for fast animation of photorealistic hair

中国毒理学会第四届全国学术会议

＜正＞The absorption, distribution and excretion of most of xenobiotics, drugs, environmental toxins and their metabolites are mediated by membrane transporters. Recent advances in the transporter research have made it possible to investigate the mechanisms of transport of those exogenous compounds and their transporter-mediated organ toxicity at the molecular level. Exogenous compounds including drugs and toxic substances occurring in the environment pass through the transporters with broad substrate selectivity, namely "multispecific" transporters, to enter the cells and exert their toxic effects. The remarkable examples of such transporter-mediated toxicity are l-methyl-4-phenyl-2,3-dihydropyridinium （MPP+）-neurotoxicity mediated by dopamine transporters, cephaloridine-nephrotoxicity and ochratoxin A-nephrotoxicity mediated by organic anion transporters and methylmercury-toxicity mediated by system L amino acid transporters （LATs）.

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Computational Visual Media 2021年第1期7卷 127-138页

作者： Zhi Qiao Takashi kanai Department of General Systems Studies Graduate School of Arts and SciencesThe University of TokyoTokyoJapan

We introduce an unsupervised GANbased model for shading photorealistic hair *** model is much faster than previous rendering algorithms and produces fewer artifacts than other neural image translation *** main idea is to extend the Cycle-GAN structure to avoid semitransparent hair appearance and to exactly reproduce the interaction of the lights with the *** use two constraints to ensure temporal coherence and highlight *** approach outperforms and is computationally more efficient than previous methods.

关键词： hair animation fast shading neural networks

Therapeutic applications of curcumin for patients with pancreatic cancer

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World Journal of Gastroenterology 2014年第28期20卷 9384-9391页

作者： Masashi kanai Department of Clinical Oncology and Pharmacogenomics Graduate School of MedicineKyoto University KyotoJapan Kyoto University Hospital

A number of preclinical studies have demonstrated anticancer effects for curcumin in various types of tumors, including pancreatic cancer. Curcumin has anticancer effects both alone and in combination with other anticancer drugs (e.g., gemcitabine, 5-fluorouracil, and oxaliplatin), and it has been shown to modulate a variety of molecular targets in preclinical models, with more than 30 molecular targets identified to date. Of these various molecules, NF-κB is thought to be one of the primary targets of curcumin activity. Based on these promising preclinical results, several research groups, including our own, have progressed to testing the anticancer effects of curcumin in clinical trials; however, the poor bioavailability of this agent has been the major challenge for its clinical application. Despite the ingestion of gram-level doses of curcumin, plasma curcumin levels remain at low (ng/mL) levels in patients, which is insufficient to yield the anticancer benefits of curcumin. This problem has been solved by the development of highly bioavailable forms of curcumin (THERACURMIN®), and higher plasma curcumin levels can now be achieved without increased toxicity in patients with pancreatic cancer. In this article, we review possible therapeutic applications of curcumin in patients with pancreatic cancer.

关键词： Curcumin Pancreatic cancer Nuclear factor-kappa B Bioavailability THERACURMIN

Chronic atrophic gastritis detection with a convolutional neural network considering stomach regions

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World Journal of Gastroenterology 2020年第25期26卷 3650-3659页

作者： Misaki kanai Ren Togo Takahiro Ogawa Miki Haseyama Graduate School of Information Science and Technology Hokkaido UniversitySapporo 0600814HokkaidoJapan Education and Research Center for Mathematical and Data Science Hokkaido UniversitySapporo 0600812HokkaidoJapan Faculty of Information Science and Technology Hokkaido UniversitySapporo 0600814HokkaidoJapan

BACKGROUND The risk of gastric cancer increases in patients with Helicobacter pylori-associated chronic atrophic gastritis(CAG).X-ray examination can evaluate the condition of the stomach,and it can be used for gastric cancer mass ***,skilled doctors for interpretation of X-ray examination are decreasing due to the diverse of *** To evaluate the effectiveness of stomach regions that are automatically estimated by a deep learning-based model for CAG *** We used 815 gastric X-ray images(GXIs)obtained from 815 *** ground truth of this study was the diagnostic results in X-ray and endoscopic *** a part of GXIs for training,the stomach regions are manually annotated.A model for automatic estimation of the stomach regions is trained with the *** the rest of them,the stomach regions are automatically ***,a model for automatic CAG detection is trained with all GXIs for *** In the case that the stomach regions were manually annotated for only 10 GXIs and 30 GXIs,the harmonic mean of sensitivity and specificity of CAG detection were 0.955±0.002 and 0.963±0.004,*** By estimating stomach regions automatically,our method contributes to the reduction of the workload of manual annotation and the accurate detection of the CAG.

关键词： Gastric cancer risk Chronic atrophic gastritis Helicobacter pylori Gastric Xray images Deep learning Convolutional neural network Computer-aided diagnosis

Hypoxia and fatty liver

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World Journal of Gastroenterology 2014年第41期20卷 15087-15097页

作者： Tomohiro Suzuki Satoko Shinjo Takatomo Arai Mai kanai Nobuhito Goda Department of Life Science and Medical BioScience Waseda University School of Advanced Science and Engineering

The liver is a central organ that metabolizes excessive nutrients for storage in the form of glycogen and lipids and supplies energy-producing substrates to the peripheral tissues to maintain their function,even under starved *** processes require a considerable amount of oxygen,which causes a steep oxygen gradient throughout the hepatic *** consumption and/or excessive food intake can alter the hepatic metabolic balance drastically,which can precipitate fatty liver disease,a major cause of chronic liver diseases worldwide,ranging from simple steatosis,through steatohepatitis and hepatic fibrosis,to liver *** hepatic metabolism and tissue remodeling in fatty liver disease further disrupt hepatic oxygen homeostasis,resulting in severe liver *** master regulators of adaptive responses to hypoxic stress,hypoxia-inducible factors(HIFs) modulate various cellular and organ functions,including erythropoiesis,angiogenesis,metabolic demand,and cell survival,by activating their target genes during fetal development and also in many disease conditions such as cancer,heart failure,and *** the past decade,it has become clear that HIFs serve as key factors in the regulation of lipid metabolism and fatty liver *** review discusses the molecular mechanisms by which hypoxia and HIFs regulate lipid metabolism in the development and progression of fatty liver disease.

关键词： Hypoxia Fatty liver disease Hypoxia-inducible factor Lipid metabolism Obstructive sleep apnea

Automatic registration of MLS point clouds and SfM meshes of urban area

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Geo-Spatial Information Science 2016年第3期19卷 171-181页

作者： Reiji Yoshimura Hiroaki Date Satoshi kanai Ryohei Honma Kazuo Oda Tatsuya Ikeda Graduate School of Information Science and Technology Hokkaido UniversitySapporoJapan Asia Air Survey Co. LtdKawasakiJapan

Recent advances in 3D scanning technologies allow us to acquire accurate and dense 3D scan data of large-scale environments ***,there are various methods for acquiring largescale 3D scan data,such as Mobile Laser Scanning(MLS),Airborne Laser Scanning,Terrestrial Laser Scanning,photogrammetry and Structure from Motion(SfM).Especially,MLS is useful to acquire dense point clouds of road and road-side objects,and SfM is a powerful technique to reconstruct meshes with textures from a set of digital *** this research,a registration method of point clouds from vehicle-based MLS(MLS point cloud),and textured meshes from the SfM of aerial photographs(SfM mesh),is proposed for creating high-quality surface models of urban areas by combining *** general,SfM mesh has non-scale information;therefore,scale,position,and orientation of the SfM mesh are adjusted in the registration *** our method,first,2D feature points are extracted from both SfM mesh and MLS point *** process consists of ground-and building-plane extraction by region growing,random sample consensus and least square method,vertical edge extraction by detecting intersections between the planes,and feature point extraction by intersection tests between the ground plane and the ***,the corresponding feature points between the MLS point cloud and the SfM mesh are searched efficiently,using similarity invariant features and ***,the coordinate transformation is applied to the SfM mesh so that the ground planes and corresponding feature points are ***,scaling Iterative Closest Point algorithm is applied for accurate *** results for three data-sets show that our method is effective for the registration of SfM mesh and MLS point cloud of urban areas including buildings.

关键词： Registration MLS point clouds SfM mesh urban area hash similarity invariant feature

Sunitinib-induced hyperammonemic encephalopathy in metastatic gastrointestinal stromal tumors:A case report

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World Journal of Clinical Cases 2023年第31期11卷 7629-7634页

作者： Takaoki Hayakawa Shinsuke Funakoshi Yasuo Hamamoto Kenro Hirata Takanori kanai Department of Internal Medicine Division of Gastroenterology and HepatologyKeio University School of MedicineShinjuku-ku 160-8582TokyoJapan Division of Medical Oncology Department of Internal MedicineTokyo Saiseikai Central HospitalMinato-ku 108-0073TokyoJapan Keio Cancer Center Keio University School of MedicineShinjuku-ku 160-8582TokyoJapan Department of Internal Medicine Keio University School of MedicineShinjuku-ku 160-8582TokyoJapan

BACKGROUND Sunitinib,a multi-targeted tyrosine kinase inhibitor(TKI),has been approved for the salvage treatment of gastrointestinal stromal tumors(GIST).Hyperammonemic encephalopathy is a rare but severe complication of sunitinib ***,we present the case of a 66-year-old male with metastatic GIST without underlying liver cirrhosis who developed sunitinib-induced hyperammonemic *** SUMMARY A 66-year-old male with metastatic GIST was admitted because of reduced *** was administered as the first-line systemic *** experienced repeated episodes of peritonitis due to tumor perforation,and surgery was *** disease was confirmed based on increased liver metastasis,and sunitinib was initiated as a salvage ***,23 d after the third course of sunitinib,he presented to the emergency room with an episode of altered consciousness and behavioral *** on the patient clinical history and examination findings,sunitinib-induced encephalopathy was *** was discontinued,and the patient was treated for *** patient had a normal level of consciousness four days later,and the serum ammonia level gradually *** further neurological symptoms were reported in subsequent *** TKI-induced hyperammonemic encephalopathy is potentially *** receiving TKIs experiencing adverse reactions should undergo systemic evaluation and prompt treatment.

关键词： Tyrosine protein kinase inhibitors Sunitinib malate Hyperammonemic encephalopathy Gastrointestinal stromal tumors Case report