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Characteristics and predictors of gastric cancer after Helicobacter pylori eradication

World Journal of Gastroenterology 2018年第20期24卷 2163-2172页

作者： Satoki Shichijo yoshihiro hirata Department of Gastrointestinal Oncology Osaka International Cancer Institute Division of Advanced Genome Medicine The Institute of Medical Science The University of Tokyo

Helicobacter pylori(H. pylori) eradication can reduce gastric cancer. However, gastric cancer still develops after eradication, and cases who received eradication therapy are increasing. In this study, we have reviewed the characteristics and predictors of primary gastric cancer developing after H. pylori eradication. In terms of the characteristics, endoscopic, histologic, and molecular characteristics are reported. Endoscopically, gastric cancer after eradication is often depressedtype and shows a gastritis-like appearance, which sometimes makes the diagnosis difficult. Histologically, most gastric cancer after eradication is intestinal type, and non-neoplastic epithelium, also called epithelium with low-grade atypia, is frequently seen over the tumor, which is presumably the cause of the endoscopic gastritis-like appearance. As for molecular characteristics, some markers, such as Ki67, MUC2, and Wnt5a expression, are lower in cancer from patients in whom H. pylori has been eradicated. In terms of predictors, several Japanese studies have reported that severe endoscopic atrophy at eradication is a risk factor for gastric cancer development. Histologic intestinal metaplasia, especially in the corpus, and long-term use of proton pump inhibitors, are also reported as risk factors for gastric cancer after H. pylori eradication. These studies on the characteristics and predictors of gastric cancer development will become the cornerstone for establishing a novel surveillance program based on the gastric cancer risk stratification specific to H. pylori-eradicated patients.

关键词： gastric cancer eradication characteristic Helicobacter pylori predictor

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Initial management for acute lower gastrointestinal bleeding

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World Journal of Gastroenterology 2019年第1期25卷 69-84页

作者： Tomonori Aoki yoshihiro hirata Atsuo Yamada Kazuhiko Koike Department of Gastroenterology Graduate School of Medicine the University of Tokyo Division of Advanced Genome Medicine the Institute of Medical Sciencethe University of Tokyo

Acute lower gastrointestinal bleeding(LGIB) is a common indication for hospital admission. Patients with LGIB often experience persistent or recurrent bleeding and require blood transfusions and interventions, such as colonoscopic,radiological, and surgical treatments. Appropriate decision-making is needed to initially manage acute LGIB, including emergency hospitalization, timing of colonoscopy, and medication use. In this literature review, we summarize the evidence for initial management of acute LGIB. Assessing various clinical factors,including comorbidities, medication use, presenting symptoms, vital signs, and laboratory data is useful for risk stratification of severe LGIB, and for discriminating upper gastrointestinal bleeding. Early timing of colonoscopy had the possibility of improving identification of the bleeding source, and the rate of endoscopic intervention, compared with elective colonoscopy. Contrast-enhanced computed tomography before colonoscopy may help identify stigmata of recent hemorrhage on colonoscopy, particularly in patients who can be examined immediately after the last hematochezia. How to deal with nonsteroidal antiinflammatory drugs(NSAIDs) and antithrombotic agents after hemostasis should be carefully considered because of the risk of rebleeding and thromboembolic events. In general, aspirin as primary prophylaxis for cardiovascular events and NSAIDs were suggested to be discontinued after LGIB. Managing acute LGIB based on this information would improve clinical outcomes. Further investigations are needed to distinguish patients with LGIB who require early colonoscopy and hemostatic intervention.

关键词： Lower gastrointestinal bleeding Predictive model Colonoscopy Computed tomography Medication

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NF-κB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection

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World Journal of Gastroenterology 2005年第39期11卷 6134-6143页

作者： Wataru Shibata yoshihiro hirata Haruhiko Yoshida Motoyuki Otsuka Yujin Hoshida Keiji Ogura Shin Maeda Tomoya Ohmae Ayako Yanai Yuzo Mitsuno Naohiko Seki Takao Kawabe Masao Omata Department of Gastroenterology Graduate School of Medicine University of TokyoJapan Department of Functional Genomics Graduate School of Medicine University of ChibaJapan

AIM： To elucidate the sequential gene expression profile in AGS cells co-cultured with wild-type Helicobacter pylori （H pylon） as a model of Hpylori-infected gastric epithelium, and to further examine the contribution of cag-pathogenicity islands （cagPAI）-coding type IV secretion system and the two pathways, nuclear factor kappa B （NF-κB） and extracellular signal-regulated kinases （ERK） on wild-type Hpylori-induced gene expression. METHODS： Gene expression profiles induced by Hpylori were evaluated in AGS gastric epithelial cells using cDNA microarray, which were present in the 4600 independent clones picked up from the human gastric tissue. We also analyzed the contribution of NF-κB and ERK signaling on H pylori-induced gene expression by using inhibitors of specific signal pathways. The isogenic mutant with disrupted cagE （△cagE） was used to elucidate the role of cagPAI-encoding type IV secretion system in the gene expression profile. RESULTS： According to the expression profile, the genes were classified into four clusters. Among them, the clusters characterized by continuous upregulation were most conspicuous, and it contained many signal transducer activity-associated genes. The role of cagPAI on cultured cells was also investigated using isogenic mutant cagE, which carries non-functional cagPAI. Then the upregulation of more than 80% of the induced genes （476/566） was found to depend on cagPAI. Signal transducer pathway through NF-κB or ERK are the major pathways which are known to be activated by cagPAI-positive H pylori. The role of these pathways in the whole signal activation by cagPAI-positive H pyloriwas analyzed. The specific inhibitors against NF-κB or ERK pathway blocked the activation of gene expression in 65% （367/566） or 76% （429/566） of the genes whose activation appealed to depend on cagPAI. CONCLUSION： These results suggest that more than half of the genes induced by cayPAI-positive H pylori depend on NF-κB and ERK signaling activation, and thes

关键词： Helicobacter pylort, Cag-pathogenicity islands cDNA microarray, Cluster analysis Signal transduction

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Sessile serrated adenoma detection rate is correlated with adenoma detection rate

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World Journal of Gastrointestinal Oncology 2018年第3期10卷 82-90页

作者： Daisuke Ohki Yosuke Tsuji Tomohiro Shinozaki Yoshiki Sakaguchi Chihiro Minatsuki Hiroto Kinoshita Keiko Niimi Satoshi Ono Yoku Hayakawa Shuntaro Yoshida Atsuo Yamada Shinya Kodashima Nobutake Yamamichi yoshihiro hirata Tetsuo Ushiku Mitsuhiro Fujishiro Masashi Fukayama Kazuhiko Koike Department of Gastroenterology Graduate School of Medicinethe University of Tokyo Department of Biostatistics School of Public Healththe University of Tokyo Center for Epidemiology and Preventive Medicine Graduate School of Medicinethe University of Tokyo Department of Endoscopy and Endoscopic Surgery Graduate School of Medicinethe University of Tokyo Department of Pathology Graduate School of Medicine the University of Tokyo

AIM To investigated the association between adenoma detection rate(ADR) and sessile serrated ADR(SSADR) and significant predictors for sessile serrated adenomas(SSA) *** This study is a retrospective, single-center analysis. Total colonoscopies performed by the gastroenterologists at the University of Tokyo Hospital between January and December 2014 were retrospectively identified. Polyps were classified as low-grade or high-grade adenoma, cancer, SSA, or SSA with cytological dysplasia, and the prevalence of each type of polyp was investigated. Predictors of adenoma and SSA detection were examined using logistic generalized estimating equation models. The association between ADR and SSADR for each gastroenterologist was investigated by calculating a correlation coefficient weighted by the number of each gastroenterologist's *** A total of 3691 colonoscopies performed by 35 gastroenterologists were assessed. Overall, 978 (26.5%) low-and 84 (2.2%) high-grade adenomas, 81 (2.2%) cancers, 66 (1.8%) SSAs, and 2 (0.1%) SSAs with cytological dysplasia were detected. Overall ADR was 29.5%(men 33.2%, women 23.8%) and overall SSADR was 1.8%(men 1.7%, women 2.1%). In addition, 672 low-grade adenomas (68.8% of all the detected lowgrade adenomas), 58 (69.9%) high-grade adenomas, 29 (34.5%) cancers, 52 (78.8%) SSAs, and 2 (100%) SSAs with cytological dysplasia were found in the proximal colon. Adenoma detection was the only significant predictor of SSA detection (adjusted OR: 2.53, 95%CI: 1.53-4.20; P < 0.001). The correlation coefficient between ADR and SSADR weighted by the number of each gastroenterologist's examinations was 0.606(P < 0.001).CONCLUSION Our results demonstrated that ADR is correlated to SSADR. In addition, patients with adenomas had a higher prevalence of SSAs than those without adenomas.

关键词： Sessile serrated adenoma Sessile serrated adenoma detection rate Adenoma detection rate Colonoscopy Interval colorectal cancer

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Impact of fecal occult blood on obscure gastrointestinal bleeding:Observational study

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World Journal of Gastroenterology 2015年第1期21卷 326-332页

作者： Yuka Kobayashi Hirotsugu Watabe Atsuo Yamada Hirobumi Suzuki yoshihiro hirata Yutaka Yamaji Haruhiko Yoshida Kazuhiko Koike Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan

AIM: To elucidate the association between small bowel diseases(SBDs) and positive fecal occult blood test(FOBT) in patients with obscure gastrointestinal bleeding(OGIB).METHODS: Between February 2008 and August 2013, 202 patients with OGIB who performed both capsule endoscopy(CE) and FOBT were enrolled(mean age; 63.6 ± 14.0 years, 118 males, 96 previous overt bleeding, 106 with occult bleeding). All patients underwent immunochemical FOBTs twice prior to CE. Three experienced endoscopists independently reviewed CE videos. All reviews and consensus meeting were conducted without any information on FOBT results. The prevalence of SBDs was compared between patients with positive and negative ***: CE revealed SBDs in 72 patients(36%). FOBT was positive in 100 patients(50%) and negative in 102(50%). The prevalence of SBDs was significantly higher in patients with positive FOBT than those with negative FOBT(46% vs 25%, P = 0.002). In particular, among patients with occult OGIB, the prevalence of SBDs was higher in positive FOBT group than negative FOBT group(45% vs 18%, P = 0.002). On the other hand, among patients with previous overt OGIB, there was no significant difference in the prevalence of SBDs between positive and negative FOBT group(47% vs 33%, P = 0.18). In disease specific analysis among patients with occult OGIB, the prevalence of ulcer and tumor were higher in positive FOBT group than negative FOBT group. In multivariate analysis, only positive FOBT was a predictive factors of SBDs in patients with OGIB(OR = 2.5, 95%CI: 1.4-4.6, P = 0.003). Furthermore, the trend was evidentam on g patients with occult OGIB who underwent FOBT on the same day or a day before CE. The prevalence of SBDs in positive vs negative FOBT group were 54% vs 13% in patients with occult OGIB who underwent FOBT on the same day or the day before CE(P = 0.001), while there was no significant difference between positive and negative FOBT group in those who underwent FOBT two or more d

关键词： Capsule endoscopy Fecal occult blood test Obscure

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Risk factors for small bowel angioectasia:The impact of visceral fat accumulation

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World Journal of Gastroenterology 2015年第23期21卷 7242-7247页

作者： Atsuo Yamada Ryota Niikura Yuka Kobayashi Hirobumi Suzuki Shuntaro Yoshida Hirotsugu Watabe Yutaka Yamaji yoshihiro hirata Kazuhiko Koike Department of Gastroenterology Graduate School of Medicine The University of Tokyo Department of Endoscopy and Endoscopic Surgery The University of Tokyo Hospital

AIM: To investigate visceral fat accumulation in association with the risk of small bowel ***: We retrospectively investigated 198 consecutive patients who underwent both capsule endoscopy and CT for investigation of obscure gastrointestinal bleeding(OGIB) from January 2009 to September 2013. The visceral fat area(VFA) and subcutaneous fat area were measured by CT, and information on comorbidities, body mass index, and medications was obtained from their medical *** regression analysis was used to evaluate ***: Capsule endoscopy revealed small bowel angioectasia in 18/198(9.1%) patients with *** to patients without small bowel angioectasia,those with small bowel angioectasia had a significantly higher VFA(96 ± 76.0 cm2 vs 63.4 ±51.5 cm2, P = 0.016) and a higher prevalence of liver cirrhosis(61% vs 22%, P < 0.001). The proportion of patients with chronic renal failure was higher in patients with small bowel angioectasia(22% vs 9%,P = 0.11). There were no significant differences in subcutaneous fat area or waist circumference. The prevalence of small bowel angioectasia progressively increased according to the VFA. Multivariate analysis showed that the VFA [odd ratio(OR) for each 10-cm2 increment = 1.1; [95% confidence interval(CI):1.02-1.19; P = 0.021] and liver cirrhosis(OR = 6.1,95%CI: 2.2-18.5; P < 0.001) were significant risk factors for small bowel ***: VFA is positively associated with theprevalence of small bowel angioectasia, for which VFA and liver cirrhosis are independent risk factors in patients with OGIB.

关键词： Capsule endoscopy Obscure gastrointestinalbleeding Small bowel angioectasia Visceral fataccumulation

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Depositional condition of Paleoproterozoic Francevillian carbonate rocks revisited from rare earth element contents

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Geoscience Frontiers 2024年第3期15卷 31-49页

作者： Satoshi Yoshida Karen Bakakas Mayika Yuki Ishihara Mathieu Moussavou Hisashi Asanuma Tomohiko Sato Takafumi hirata Cédric Ligna Yusuke Sawaki Amboise Edou-Minko Department of Earth Science and Astronomy The University of Tokyo3-8-1 Komaba Meguro-kuTokyo 153-8902Japan Center for Northeast Asian Studies Tohoku University41 KawauchiAoba-kuSendai 980-8576Japan Department of Geology Universitédes Sciences et Techniques de MasukuBP:90190025 FrancevilleGabon Department of Earth and Planetary Science The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan Geochemical Research Center The University of Tokyo7-3-1HongoBunkyo-kuTokyo 113-0033Japan Graduate School of Human and Environmental Studies Kyoto UniversityYoshida-nihonmatsuSakyo-kuKyoto 606-8501Japan Center for Fundamental Education Okayama University of Science1-1Ridai-choKita-kuOkayama CityOkayama 700-0005Japan

The Paleoproterozoic Francevillian Group in the eastern Gabonese Republic has been recently attracting increasing attention because it includes distinctive macroscopic structures interpreted as eukaryotic ***,its depositional setting and associated redox conditions need to be clearly *** clarify these,petrological studies and rare earth element(REE)abundances of carbonate rocks of the Francevillian Group in the Lastoursville basin were determined with ICP-MS coupled with a laser ablation sampling *** microscopic observations indicate that dolostones in this basin underwent the complicated diagenetic history,including sparitization,decomposition of organic matter,reduction of ferromanganese oxides,silicification,and later *** dolostones of lower Francevillian B(FB)Formation show heterogeneous textures formed by alterations during *** the alterations,changes of REE abundances and degrees of positive Y anomalies appear to have *** indicates that REE signatures in carbonate rocks can vary during *** high Mn contents in the dolostones of upper FB Formation were derived from the reduction of ferromanganese oxides in *** signatures of REE abundance in dolostones can be explained by the mixing of seawater and ferromanganese oxide *** that sense,the dolostones inherited the trace element characteristics of precursor ferromanganese oxides even after the diagenesis.Y/Ho values of the most primary parts of each sample exceed 33,the newly determined threshold value for marine carbonate rocks based on our *** magnitude of the La anomaly values also falls within the range of that of Holocene reefal *** indicate that a precursor of the dolostone of the Francevillian Group was deposited in a marine *** addition,presence of Ce anomalies in the upper FB Formation suggests that the Paleoproterozoic ocean was oxidized to such an ex

关键词： Carbonate diagenesis Francevillian Group LA-ICP-MS Seawater composition Y/Ho fractionation

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Physicochemical properties of Li_(3)Ba_(2)La_(3)(MoO_(4))_(8):Eu,Tb red-emitting phosphor for solid state white lamps

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稀土学报:英文版 2023年第9期41卷 1279-1287,I0001页

作者： Kora Lu Rojas Baldivia Gustavo A.hirata Center for Scientific Research and Higher Education of Ensenada Ensenada Baja California 22860Mexico Center for Nanoscience and Nanotechnology National Autonomous University of Mexico EnsenadaBaja Califomia 22860Mex

In this work,combustion synthesis was used for the first time to fabricate a phosphor material with red emission for applications in solid-state white-light *** synthesized a material with emission wavelength at λ_(em)=617 nm,excited under long UV-blue wavelength based on Eu^(3+),Tb^(3+)-activated molybdates Li_(3)Ba_(2)(La_(1-x-y)Eu_(x)Tb_(y))_(3)(MoO_(4))_(8) with 0 ≤ x ≤1 and 0 ≤ y ≤ 1.A series of powder samples were produced by the combustion method and post-annealed at 800℃ in *** crystalline phase formation was investigated by X-ray diffraction,which reveals the monoclinic C2/c(15) space *** is observed that crystalline structure and morphology are preserved when the host lattice is doped with Eu^(3+) or Tb^(3+) single ions and co-doped with both ions at different doping concentrations.A detailed characterization by scanning electron microscopy(SEM) and transmission electron microscopy(TEM)shows a similar morphology in all samples:rather large(1-7 μm) agglomerate particles with irregular shapes and surrounded by smaller nanoparticles of 50 nm in ***-visible absorption spectra confirm the presence of Eu^(3+) and Tb^(3+) *** luminescent properties of the obtained phosphors were studied in *** measurements indicate that the best emission intensity is for Eu^(3+):Tb^(3+)doping ratios of 80:0,90:0 and 20:*** the other hand,samples with 80:0,60:40,and 20:80 doping ratios show the highest intensity in a detailed photoluminescence analysis and they exhibit the highest quantum yield values.A complete and efficient energy transfer from the sensitizer Tb^(3+) to the activator Eu^(3+) is observed in all co-doped phosphors post-annealed at 800℃ for 4 ***,the Li_(3)Ba_(2)La_(3)(MaO_(4))_(8):Eu^(3+),Tb^(3+) materials fabricated by combustion synthesis are excellent phosphors for being applied as red-emitting component in solid-state white-light lamps due to an improved color rendering index(CRI) that can be obtained under lo

关键词： Molybdate Europium Terbium Luminescence Phosphor-converted LED Rare earths

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Two-degree-of-freedom H-infinity control of combustion in diesel engine using a discrete dynamics model

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Control Theory and Technology 2017年第2期15卷 109-116页

作者： Mitsuo hirata Sota ISHIZUKI Masasyasu SUZUKI Department of Electrical and Electronic Systems Engineering Utsunomiya University 7-1-2 Yoto Utsunomiya Tochigi 321-8585 Japan

This paper proposes an H-infinity combustion control method for diesel engines. The plant model is the discrete dynamics model developed by Yasuda et al., which is implementable on a real engine control unit. We introduce a two-degree-of-freedom control scheme with a feedback controller and a feedforward controller. This scheme achieves both good feedback properties, such as disturbance suppression and robust stability, and a good transient response. The feedforward controller is designed by taking the inverse of the static plant model, and the feedback controller is designed by the H-infinity control method, which reduces the effect of the trubocharger lag. The effectiveness of the proposed method is evaluated in simulations using the nonlinear discrete dynamics model.

关键词： Combustion control diesel engines H-infinity control two-degree-of-freedom control

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Decolorization of Orange Ⅱ using an anaerobic sequencing batch reactor with and without co-substrates

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Journal of Environmental Sciences 2012年第2期24卷 291-296页

作者： Soon-An Ong Eiichi Toorisaka Makoto hirata Tadashi Hano Department of Applied Chemistry OitaUniversity School of Environmental Engineering University Malaysia Perlis

We investigated the decolorization of Orange Ⅱ with and without the addition of co-substrates and nutrients under an anaerobic sequencing batch reactor（ASBR）.The increase in COD concentrations from 900 to 1750 to 3730 mg/L in the system treating 100 mg/L of Orange Ⅱ-containing wastewater enhanced color removal from 27% to 81% to 89%,*** the absence of co-substrates and nutrients,more than 95% of decolorization was achieved by the acclimatized anaerobic microbes in the bioreactor treating 600 mg/L of Orange Ⅱ.The decrease in mixed liquor suspended solids concentration by endogenous lysis of biomass preserved a high reducing environment in the ASBR,which was important for the reduction of the Orange Ⅱ azo bond that caused *** maximum decolorization rate in the ASBR was approximately 0.17 g/hr in the absence of co-substrates and nutrients.

关键词： anaerobic reduction azo dye decolorization rate endogenous lysis Orange Ⅱ

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