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Scaffolds based therapy for osteochondral lesions of the talus:A systematic review

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World Journal of Orthopedics 2017年第10期8卷 798-808页

作者： yoshiharu Shimozono Youichi Yasui Andrew W Ross Wataru Miyamoto John G Kennedy Hospital for Special Surgery New York Department of Orthopaedic Surgery Teikyo University School of Medicine Department of Orthopaedic Surgery Kyoto University Graduate School of Medicine

AIM To clarify the effectiveness of scaffold-based therapy for osteochondral lesions of the talus(OLT). METHODS A systematic search of MEDLINE and EMBASE databases was performed during August 2016 and updated in January 2017. Included studies were evaluated with regard to the level of evidence(LOE) and quality of evidence(QOE) using the Modified Coleman Methodology Score. Variable reporting outcome data, clinical outcomes, and the percentage of patients who returned to sport at previous level were also evaluated. RESULTS Twenty-eight studies for a total of 897 ankles were included; 96% were either LOE Ⅲ or Ⅳ. Studies were designated as either of poor or fair quality. There were 30 treatment groups reporting six different scaffold repair techniques: 13 matrix-induced autologous chondrocyte transplantation(MACT), nine bone marrow derived cell transplantation(BMDCT), four autologous matrixinduced chondrogeneis(AMIC), and four studies of other techniques. The categories of general demographics(93%) and patient-reported outcome data(85%) were well reported. Study design(73%), imaging data(73%), clinical variables(49%), and patient history(30%) were also included. The weighted mean American Orthopaedic Foot and Ankle Society(AOFAS) score at final follow-up was: 86.7 in MACT, 88.2 in BMDCT, and 82.3 in AMIC. Eight studies reported that a weighted mean of 68.3% ofpatients returned to a previous level of sport activity. CONCLUSION Scaffold-based therapy for OLT may produce favorable clinical outcomes, but low LOE, poor QOE, and variability of the data have confounded the effectiveness of this treatment.

关键词： Scaffold Ankle Talar osteochondral lesion Systematic review Cartilage

Influence of Different Plant Materials in Combination with Chicken Manure on Soil Carbon and Nitrogen Contents and Vegetable Yield

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Pedosphere 2016年第4期26卷 510-521页

作者： Richard Ansong OMARI Han Phyo AUNG Mudan HOU Tadashi YOKOYAMA Siaw ONWONA-AGYEMAN Yosei OIKAWA yoshiharu FUJII Sonoko Dorothea BELLINGRATH-KIMURA 1 United Graduate School of Agricultural Science Tokyo University of Agriculture and Technology Saiwaicho 3-5-8 Fuchu Tokyo183-8509 Institute of Agriculture Tokyo University of Agriculture and Technology Saiwaicho 3-5-8 Fuchu Tokyo183-8509 Leibniz Centre for Agricultural Landscape Research Institute of Land Use Systems Eberswalder str. 84 15374 Muencheberg

The use of plant materials as soil amendments is an uncommon practice amongst major farming communities in Ghana, although it is necessary for soil fertility improvement. An examination of the effects of soil amendments is necessary to encourage the use of under-utilized organic resources in Ghana. Thus, a field experiment was conducted using 8 different tropical plant materials mixed with chicken manure as soil amendments for growth of tomato as a test crop. The plant materials included Leucaena leueocephala, Centrosema pubescens, Sesbania sesban, Gliricidia sepium, Mucuna pruriens, Pueraria phaseoloides, Azadirachta indiea, and Theo- broma cacao. There were two other treatments： one with equivalent amounts of chemical fertilizers and the other with no-fertilizer input （control）. Plant materials were mixed with chicken manure to obtain a uniform carbon-to-nitrogen （C：N） ratio of 5：1. Except the no-fertilizer control, all treatments received the same amount of nitrogen （N）. To clarify the decomposition pattern of the plant materials in soil, an incubation experiment was conducted using only the plant materials before the field experiment. The Glirieidia treatment released significantly more mineral N than the other plant materials in the incubation experiment. However, the tomato fruit yield was not enhanced in the Gliricidia treatment in the field experiment. The known quality parameters of the tested plant materials, such as total N, total carbon （C）, C：N ratio, and total polyphenols, had minimal effects on their mineralization dynamics. Azadirachta showed the best synergistic effect with chicken manure through significantly increasing soil microbial biomass and fruit yield of tomato. This result provides insights into the possible adoption of Azadirachta in combination with chicken manure as a soil amendment in small-scale agricultural holdings.

关键词： C:N ratio microbial biomass mineralization pattern organic material soil amendment synergy

Placement of percutaneous transhepatic biliary stent using a silicone drain with channels

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World Journal of Gastroenterology 2009年第33期15卷 4201-4203页

作者： Hiroshi Yoshida Yasuhiro Mamada Nobuhiko Taniai Sho Mineta Yoshiaki Mizuguchi Yoichi Kawano Junpei Sasaki yoshiharu Nakamura Takayuki Aimoto Takashi Tajiri Department of Surgery Nippon Medical School

This report describes a method for percutaneous transhepatic biliary stenting with a BLAKE Silicone Drain, and discusses the usefulness of placement of the drain connected to a J-VAC Suction Reservoir for the treatment of stenotic hepaticojejunostomy. Percutaneous transhepatic biliary drainage was performed under ultrasonographic guidance in a patient with stenotic hepaticojejunostomy after hepatectomy for hepatic hilum malignancy. The technique used was as follows. After dilatation of the drainage root, an 11-FF tube with several side holes was passed through the stenosis of the hepaticojejunostomy. A 10-Fr BLAKE Silicone Drain is flexible, which precludes onestep insertion. One week after insertion of the 11-Fr tube, a 0.035-inch guidewire was inserted into the tube. After removal of the 11-Fr tube, the guidewire was put into the channel of a 10-Fr BLAKE Silicone Drain. The drain was inserted into the jejunal limb through the intrahepatic bile duct and was connected to a J-VAC Suction Reservoir. Low-pressure continued suction was applied. Patients can be discharged after insertion of the 10-Fr BLAKE Silicone Drain connected to the J-VAC Suction Reservoir. Placement of a percutaneous transhepaUc biliary stent using a 10-Fr BLAKE Silicone Drain connected to a J-VAC Suction Reservoir is useful for the treatment of stenotic hepaticojejunostomy.

关键词： Biliary tract Drainage Hepaticojejunostomy Stenosis Stents

INVASIVE ALIEN PLANTS AND ALLELOPATHY

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INVASIVE ALIEN PLANTS AND ALLELOPATHY

Preoperative, intraoperative and postoperative risk factors for anastomotic leakage after laparoscopic low anterior resection with double stapling technique anastomosis

中国第三届植物化感作用学术研讨会;第八届全国杂草科学大会;联合国粮农组织——中国“水稻化感作用论坛”

作者： yoshiharu FUJII Leader Invasive Alien Species Research ProjectNational Institute for Agro-Environmental Sciences3-1-3 Kan-nondaiTsukubaIbaraki 305-8604Japan

Recently,the movement of people and substances is becoming more active as human activity and living organisms are being introduced into new regions in a manner that exceeds the living organisms’natura

关键词： invasive alien plants allelopathy natural toxin mitigation biodiversity

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World Journal of Gastroenterology 2016年第25期22卷 5718-5727页

作者： Kenji Kawada yoshiharu Sakai Department of Surgery Graduate School of Medicine Kyoto University

Anastomotic leakage(AL) is one of the most devastating complications after rectal cancer surgery. The double stapling technique has greatly facilitated intestinal reconstruction especially for anastomosis after low anterior resection(LAR). Risk factor analyses for AL after open LAR have been widely reported. However, a few studies have analyzed the risk factors for AL after laparoscopic LAR. Laparoscopic rectal surgery provides an excellent operative field in a narrow pelvic space, and enables total mesorectal excision surgery and preservation of the autonomic nervous system with greater precision. However, rectal transection using a laparoscopic linear stapler is relatively difficult compared with open surgery because of the width and limited performance of the linear stapler. Moreover, laparoscopic LAR exhibits a different postoperative course compared with open LAR, which suggests that the risk factors for AL after laparoscopic LAR may also differ from those after open LAR. In this review, we will discuss the risk factors for AL after laparoscopic LAR.

关键词： Risk factor Laparoscopic low anterior resection Anastomotic leakage

Web-Based Sea Level Change Simulation System Using PNG Elevation Tiles and Smart Tile Architecture

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Journal of Geographic Information System 2020年第4期12卷 291-301页

作者： Koki Iwao yoshiharu Nishioka Kaoru Kitao Geological Survey of Japan National Institute of Advanced Industrial Science and Technology Tsukuba Japan CubeWorks Inc. Moriya Japan

We have developed a web-based processing system that can simulate positive and negative sea level changes globally by selecting the best Digital Elevation Model (DEM) for a target region from multiple DEMs. A PNG elevation tile format is used as the DEM format, which reduces the DEM data size. The PNG tile format implements client-based processing, and the DEM data are provided from different websites. In addition, the smart tile architecture is adopted, which enables on-demand simulation by adding a tile conversion process (i.e., a DEM selection process) during image drawing by using JavaScript. To demonstrate the system, we have employed three DEMs, i.e., the Geospatial Information Authority of Japan (GSI) map (~10-m resolution), the ASTER Global Digital Elevation Models (ASTER GDEM version 3) as global land area (~30-m resolution), and the General Bathymetric Chart of the Oceans as bathymetric data (~1000-m resolution). The ASTER Global Water Bodies Database is also used in the data selection process. The GSI provides their DEM in a PNG elevation tile format, and the other data are provided by the Geological Survey of Japan in PNG elevation tile format. We assume the current DEM sea level as 0 m, and the sea level can be changed to an arbitrary integer value (−10,000 to 10,000 m). Combining ASTER GDEM for land and GEBCO for sea makes it possible to target DEM of the whole earth. Moreover, it was shown that if a higher resolution DEM is available, it is possible to combine the higher resolution DEM in that area. The combining the PNG elevation tile format with the smart tile architecture demonstrates the possibilities of a client-based web processing service like that of the server-based OGC Web Processing Service.

关键词： DEM Sea Level PNG Elevation Tile Smart Tile Architecture Web Processing

Systematic review of bone marrow stimulation for osteochondral lesion of talus-evaluation for level and quality of clinical studies

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World Journal of Orthopedics 2017年第12期8卷 956-963页

作者： Youichi Yasui Laura Ramponi Dexter Seow Eoghan T Hurley Wataru Miyamoto yoshiharu Shimozono John G Kennedy 2~(nd) Department of Orthopaedic Surgery Teikyo University School of Medicine Hospital for Special Surgery New York 2~(nd) Rizzoli Orthopaedic Institute 2~(nd) Royal College of Surgeons in Ireland Department of Orthopaedic Surgery Teikyo University School of Medicine

AIM To clarify the quality of the studies indicating lesion size and/or containment as prognostic indicators of bone marrow stimulation(BMS) for osteochondral lesions of the talus(OLT). METHODS Two reviewers searched the Pub Med/MEDLINE and EMBASE databases using specific terms on March 2015 in accordance with the Preferred Reporting Items for Systemic Reviews and Meta-Analyses guidelines. Predetermined variables were extracted for all the included studies. Level of evidence(LOE) was determined using previously published criteria by the Journal of Bone and Joint Surgery and methodological quality of evidence (MQOE) was evaluated using the Modified Coleman Methodology Score. RESULTS This review included 22 studies. Overall, 21 of the 22(95.5%) included studies were level Ⅳ or level Ⅲ evidences. The remaining study was a level Ⅱ evidence. MQOE analysis revealed 14 of the 22(63.6%) included studies having fair quality, 7(31.8%) studies having poor quality and only 1 study having excellent quality. CONCLUSION The evidence supporting the use of lesion size and containment as prognostic indicators of BMS for OLTs has been shown to be of low quality.

关键词： Osteochondral lesion of talus Arthroscopy Bone marrow stimulation Systematic review

Mechanisms underlying ^(18)F-fluorodeoxyglucose accumulation in colorectal cancer

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World Journal of Radiology 2016年第11期8卷 880-886页

作者： Kenji Kawada Masayoshi Iwamoto yoshiharu Sakai Department of Surgery Graduate School of MedicineKyoto University

Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) is a diagnostic tool to evaluate metabolic activity by measuring accumulation of FDG, an analogue of glucose, and has been widely used for detecting small tumors, monitoring treatment response and predicting patients’ prognosis in a variety of cancers. However, the molecular mechanism of FDG accumulation into tumors remains to be investigated. It is well-known that most cancers are metabolically active with elevated glucose metabolism, a phenomenon known as the Warburg effect. The underlying mechanisms for elevated glucose metabolism in cancer tissues are complex. Recent reports have indicated the potential of FDG-PET/CT scans in predicting mutational status (e.g., KRAS gene mutation) of colorectal cancer (CRC), which suggests that FDG-PET/CT scans may play a key role in determining therapeutic strategies by non-invasively predicting treatment response to anti-epidermal growth factor receptor (EGFR) therapy. In this review, we summarize the current findings investigating the molecular mechanism of 18F-FDG accumulation in CRC.

关键词： ^(18)F-fluorodeoxyglucose-positron emission tomography Colorectal cancer Glucose metabolism Mutational status KRAS

Logical hypothesis:Low FODMAP diet to prevent diverticulitis

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第4期7卷 503-512页

作者： yoshiharu Uno Jennifer C van Velkinburgh Office Uno Column(Medical Science Publisher) Initiative for Collaboratory Biomedical Research

Despite little evidence for the therapeutic benefits of a high-fiber diet for diverticulitis, it is commonly recommended as part of the clinical management. The ongoing uncertainty of the cause(s) of diverticulitis confounds attempts to determine the validity of this therapy. However, the features of a high-fiber diet represent a logical contradiction for colon diverticulitis. Considering that Bernoulli’s principle, by which enlarged diameter of the lumen leads to increased pressure and decreased fluid velocity, might contribute to development of the diverticulum. Thus, theoretically, prevention of high pressure in the colon would be important and adoption of a low FODMAP diet (consisting of fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) may help prevent recurrence of diverticulitis.

关键词： Diverticular disease High-fiber diet Low FODMAP diet Bernoulli&rsquo s principle Irritable bowel syndrome