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Journal of Energy and Power Engineering 2014年第5期8卷 785-793页

作者： Kenji Kamiyama yoshiharu Tobita Tohru Suzuki Ken-ichi Matsuba Japan Atomic Energy Agency Ibaraki 311-1393 Japan

The purpose of the present study is to develop a methodology to evaluate fuel discharge through the CRGT （control-rod guide tube） during CDAs （core-disruptive accidents） of SFRs （sodium-cooled fast reactors）, since fuel discharge will decrease the core reactivity and CRGTs have a potential to provide an effective discharge path. Fuel discharge contains multi-component fluid dynamics with phase changes, and, in the present study, the SFR safety analysis code SIMMER （Sn, implicit, multifield, multicomponent, Eulerian recriticality） was utilized as a technical basis. First, dominant phenomena affecting fuel discharge through the CRGT are identified based on parametric calculations by the SIMMER code. Next, validations on the code models closely relating to these phenomena were carried out based on experimental data. It was shown that the SIMMER code with some model modifications could reproduce the experimental results appropriately. Through the present study, the evaluation methodology for the molten-fuel discharge through the CRGT was successfully developed.

关键词： Sodium-cooled fast reactor, core disruptive accident molten-fuel discharge, FBR (fast breeder reactor) safety analysis code SIMMER.

Angiodysplasia Presenting with Multiple Polypoid Lesions: An Unusual Cause of Small Bowel Obstruction

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Case Reports in Clinical Medicine 2014年第11期3卷 592-595页

作者： yoshiharu Takenaka Takahiro Sasaki Nobuyoshi Miyajima Takehito Otsubo Department of Gastroenterological Surgery St. Marianna University School of Medicine Toyoko Hospital Kanagawa Japan

Angiodysplasia (AD), a morphologic vascular abnormality, is a common cause of gastrointestinal bleeding. We present a rare case of polypoid AD lesions. Three years after treatment for adhesive bowel obstruction, a 57-year-old man was admitted with recurrent abdominal distension, anorexia, and lower extremity edema. Computed tomography showed his dilated proximal and collapsed distal small bowel loops had disparate calibers. The transition point demonstrated mucosal enhancement and mesenteric lymphadenopathy. We observed small intestinal wall outpouching with strong mucosal enhancement and polypoid lesions dotting the dilated intestine. Intraoperative findings revealed a hard but elastic intraluminal nodule causing small bowel obstruction and the outpouching’s occurrence on the ileum’s antimesenteric border. We performed partial resection of the small intestine involving the nodule and Meckel’s diverticulum. Macroscopically, the nodule, diverticulum, and intestinal mucosa had polypoid lesions. Histopathologically, these lesions had foci within dilated thin- or thick-walled vascular channels in the submucosa, without specific histological abnormalities. These features led to a diagnosis of AD.

关键词： Angiodysplasia Polipoid Lesions Small Bowel Obstruction Meckel’s Diverticulum

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人物访谈

世界建筑导报 2022年第3期37卷 4-7页

作者：刘珩塚本由晴不详

刘珩:感谢塚本由晴先生欣然接受《世界建筑导报》的采访。您能将研究、学术和实践结合,这对于建筑师来说并不常见。许多年来,您已经有许多关于共有性(commonality)、地质学以及东京城市研究的出版物。您对“非对称化”的表达已被我们所... 详细信息

刘珩:感谢塚本由晴先生欣然接受《世界建筑导报》的采访。您能将研究、学术和实践结合,这对于建筑师来说并不常见。许多年来,您已经有许多关于共有性(commonality)、地质学以及东京城市研究的出版物。您对“非对称化”的表达已被我们所熟知,这种特殊的风格将您的研究转化为图示。谈到您在日本的建筑设计实践,一些建筑师非常注重在构造方面的钻研,但您将以上种种进行融合,形成社会性的、富有逻辑的且富有成效的表达。这与日本的其他建筑非常不同。请问您如何考量工具、研究和实践的关系,您的研究与实践如何相互影响?塚本由晴:我在东京工业大学师承坂本一成学习建筑,在那里他既是设计教授,也是建筑师和学者,同时进行学术写作、研究与设计实践,这个方向确立于谷口吉郎创建之初。我意识到两者兼顾是件很有趣的事。我想要建立一个研究的游乐场,寻找建筑设计游乐场的途径。建筑实践将会拓展游乐场的领域,因此研究和实践并不矛盾。

关键词：建筑设计东京工业大学塚本由晴坂本一成共有性游乐场学术写作人物访谈

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一期前路病灶清除加植骨术治疗化脓性脊椎炎

中华骨科杂志 2005年第11期25卷 700-701页

作者：刘洪 Hirokazu Ishihara 马忠泰 yoshiharu Kawaguchi 北京大学第一医院骨科 100034 日本富山医科药科大学骨科

抗生素效力的高度发展已使化脓性脊椎炎患者相对少见.然而,随着糖尿病、恶性肿瘤及滥用毒品等患者的增多,化脓性脊椎炎在这些患者中的发病日益增加[1,2].传统的治疗包括卧床、支具外固定以及静脉应用抗生素;但上述治疗周、期较长,且仍... 详细信息

抗生素效力的高度发展已使化脓性脊椎炎患者相对少见.然而,随着糖尿病、恶性肿瘤及滥用毒品等患者的增多,化脓性脊椎炎在这些患者中的发病日益增加[1,2].传统的治疗包括卧床、支具外固定以及静脉应用抗生素;但上述治疗周、期较长,且仍有相当一部分患者治疗无效,病变进行性发展,出现明显的脊柱不稳定及神经压迫症状.1980年8月至1998年8月,日本富山医科药科大学骨科采用一期前路病灶清除加植骨术治疗化脓性脊椎炎48例,取得良好效果。

关键词：化脓性脊椎炎前路病灶清除治疗包植骨术进行性发展脊柱不稳定滥用毒品恶性肿瘤静脉应用压迫症状

Studies on Composting Spent Coffee Grounds by <i>Aspergillus sp</i>and <i>Aspergillus sp</i>in Aerobic Static Batch Temperature Control

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Journal of Agricultural Chemistry and Environment 2021年第1期10卷 91-112页

作者： Asmak Afriliana Endar Hidayat yoshiharu Mitoma Taizo Masuda Hiroyuki Harada Faculty of Environmental Science Prefectural University of Hiroshima Shobara Japan Faculty of Agricultural Product Technology University of Jember Jember Indonesia

Spent Coffee Ground (SCG) is characterized by high organic content, in the form of insoluble polysaccharides bound and phenol compounds. Phenol compounds are toxic to nature and are a cause of environmental pollution. Composting method of this study is aerobic static batch composting with temperature control with adding activators of some fungi such as Aspergillus sp, and Penicillium sp. The purpose of the research is to fill the research gap from previous studies of spent coffee grounds compost, which requires a long time in composting, so that if it is used directly on the soil and plants, the positive effect also requires a long time. The result of composting for 28 days with this method is that mature compost has black crumb and normal pH, with characteristics of C/N ratio below 10: C1 (7.06), C2 (6.99). This value is far from the control with a C/N ratio of 8.33. Decompose rate of macromolecule are above 40% for lignin and 70% for cellulose. Implementation of compost in radish plants, resulting Germination Index above 80% which indicates that the compost is ripe: control (92.39%), C1 (183.88%), C2 (191.86%). The results of the analysis with FTIR also showed that the compost was mature and stable, and rich in minerals. So, it can be concluded that this composting method can speed up composting time and optimize the results of compost produced.

关键词： Spent Coffee Ground (SCG) Aspergillus sp Aspergillus sp Aerobic Static Batch Temperature Control

Evaluation of Isoflavones as Allelochemicals with Strong Allelopathic Activities of Kudzu Using Protoplast Co-Culture Method with Digital Image Analysis

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American Journal of Plant Sciences 2021年第3期12卷 376-393页

作者： Kentaro Kobayashi Hamako Sasamoto Yutaka Sasamoto Akifumi Sugiyama yoshiharu Fujii Department of International Environmental and Agricultural Science Faculty of Agriculture Tokyo University of Agriculture and Technology Fuchu Japan Research Institute for Sustainable Humanosphere (RISH) Kyoto University Uji Japan

The inhibitory allelopathic activity of Pueraria montana (Kudzu), and activities of two putative allelochemical isoflavones, puerarin and daidzein, were evaluated using the protoplast co-culture method with digital image analysis using lettuce as a recipient (DIA-PP method). Cotyledon protoplasts of Kudzu were isolated using Cellulase R10 and Driselase 20 in 0.6 M mannitol solution. Optimal hormonal condition and density for growth of Kudzu protoplasts were surveyed. Medium for co-culture of Kudzu or isoflavones with lettuce protoplasts was 50 μl liquid MS basal medium containing 1 μM 2,4-dichlorophenoxyacetic acid, 0.1 μM benzyladenine, 3% sucrose, and 0.4 M or 0.6 M mannitol. Protoplast division of lettuce was strongly inhibited by Kudzu at a low density (104/ml). Slightly less inhibition by Kudzu on cell wall formation and yellow pigment accumulation stages of lettuce growth was also observed. Puerarin did not inhibit the growth of lettuce protoplasts at three growth stages but slightly stimulated growth at high concentrations. By contrast, daidzein, aglycon of puerarin, inhibited growth at three stages of lettuce protoplast growth and strongly inhibited cell division at 100 μM. Daidzein might be one cause of the strong inhibitory allelopathic activity of Kudzu. Grade of inhibitory activities was compared with that of other allelopathic plants including an invader plant and their allelochemicals studied using the DIA-PP method.

关键词： Allelopathy Bioassay Daidzein Isoflavone Protoplast Culture Puerarin

Recovery of Biomass Incinerated as Struvite-K Precipitates Followed Aluminium Removal

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Green and Sustainable Chemistry 2021年第3期11卷 96-106页

作者： Endar Hidayat Hadi Imran A. Halem yoshiharu Mitoma Hiroyuki Harada Department of Environmental Science Prefectural University of Hiroshima Hiroshima Japan

Phosphorus (P) and potassium (K) are non-renewable materials and widely in many industries such as agricultural sectors. On the other hand, the demand of P and K as fertilizers increases which following global population. The nutrient source of P and K which get from biomass waste i.e. incinerated of activated sludge and coffee husk biochar, respectively. The present study was conducted recovery of P and K as struvite-K (KMgPO4·6H2O) precipitates. The results showed that aluminium was released simultaneously with P from incinerated activated sludge with precipitate of Al:P of 1:1, K:P of 0.5, and Mg:P of 3. However, aluminium was inhibited to form struvite-K. Then, we examined cation removal especially for removed Al by dissolved 0.5 M HNO3 and the solution was mixed with KH2PO4 and MgCl2

关键词： Struvite-K Recovery of Biomass Waste Coffee Husk Sludge Waste Precipitates

Detectability of simulated microcalcifications of digital mammography with magnification technique

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Detectability of simulated microcalcifications of digital ma...

Effects of Pre-Schooler Lifestyle on the Circadian Rhythm of Secretory Immunoglobulin A

2010中华医学会影像技术分会第十八次全国学术大会

作者： Nobukazu Tanaka yoshiharu Higashida Masafumi Ohki Junji Morishita Department of Health Sciences Graduate School of Medical SciencesKyusyu UniversityFukuokaJapan Department of Health Sciences Faculty of Medical SciencesKyusyu UniversityFukuokaJapan

Objective:Our purpose in this study was to investigate the usefulness of digital magnification mammography under the same incident exposure to the breast with contact mammography by evaluating its physical imaging pro...

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Health 2021年第2期13卷 178-187页

作者： Takaaki Miyake yoshiharu Tanaka Haruka Kawabata Shinya Saito Megumi Oda Faculty of Liberal Arts and Sciences Osaka Prefecture University Osaka Japan Graduate School of Health Sciences Okayama University Okayama Japan

Assuming that secretory immunoglobulin A (s-IgA) in pre-schoolers is influenced by wake-up time, bedtime, sleeping duration and activity, the current study examined the influence of basic pre-schooler lifestyle on the circadian rhythm of s-IgA. We conducted a questionnaire survey on lifestyle and measured steps, heart rate and salivary s-IgA in 44 pre-schoolers aged 4 or 5 years old. Saliva was collected over 2 days at six time points: bedtime, upon waking up, upon arriving at nursery school, before lunch, after lunch and upon going home. To obtain relatively reliable s-IgA values, the s-IgA concentration/total protein concentration ratio (referred to as s-IgA/T.P.) was calculated. Relationship between the s-IgA/T.P. and heart rate, steps, wake-up time, bedtime and sleeping duration was then examined using Pearson’s correlation coefficient. Accordingly, pre-schooler lifestyle had the following effect on circadian rhythm of s-IgA: 1) s-IgA/T.P. values were higher upon waking up than at other measurement time points;2) pre-schoolers with considerable physical activity had high s-IgA/T.P. at bedtime and upon waking up;and 3) pre-schoolers with long sleeping durations and early bedtime had high s-IgA/T.P. upon waking up. Thus, our results confirmed that pre-schoolers’ lifestyle habits, such as bedtime, sleeping duration, physical activity, had an effect on the circadian rhythm of s-IgA.

关键词： Pre-Schooler s-IgA Lifestyle Activity Sleep

A nomogram to preoperatively predict 1-year disease-specific survival in resected pancreatic cancer following neoadjuvant chemoradiation therapy

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Chinese Journal of Cancer Research 2020年第1期32卷 105-114页

作者： Ho Kyoung Hwang Keita Wada Ha Yan Kim Yuichi Nagakawa Yosuke Hijikata Yota Kawasaki yoshiharu Nakamura Lip Seng Lee Dong Sup Yoon Woo Jung Lee Chang Moo Kang Division of HBP Surgery Department of SurgeryYonsei University College of MedicineSeoul 03722Korea Pancreatobiliary Cancer Clinic Yonsei Cancer CenterSeverance HospitalSeoul 03722Korea Department of Surgery Teikyo University School of MedicineTokyo 173-8605Japan Biostatistician Biostatistics Collaboration UnitDepartment of Biomedical Systems InformaticsYonsei University College of MedicineSeoul 03722Korea Department of Gastrointestinal and Pediatric Surgery Tokyo Medical UniversityTokyo 160-8402Japan Department of Digestive Surgery Breastand Thyroid SurgeryGraduate School of Medical SciencesKagoshima UniversityKagoshima 890-0065Japan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical SchoolTokyo 890-0065Japan Department of General Surgery Changi General HospitalSingapore 529889Singapore

Objective: This study aimed to develop a nomogram to predict the 1-year survival of patients with pancreatic cancer who underwent pancreatectomy following neoadjuvant treatment with preoperatively detectable clinical parameters. Extended pancreatectomy is necessary to achieve complete tumor removal in borderline resectable and locally advanced pancreatic cancer. However, it increases postoperative morbidity and mortality rates, and should be balanced with potential benefit of long-term ***: The medical records of patients who underwent pancreatectomy following neoadjuvant treatment from January 2005 to December 2016 at Severance Hospital were retrospectively reviewed. Medical records were collected from five international institutions from Japan and Singapore for external ***: A total of 113 patients were enrolled. The nomogram for predicting 1-year disease-specific survival was created based on 5 clinically detectable preoperative parameters as follows: age(year), symptom(no/yes), tumor size at initial diagnostic stage(cm), preoperative serum carbohydrate antigen(CA) 19-9 level after neoadjuvant treatment(<34/≥34 U/m L), and planned surgery [pancreaticoduodenectomy(PD)(pylorus-preserving PD)/distal pancreatectomy(DP)/total pancreatectomy]. Model performance was assessed for discrimination and *** calibration plot showed good agreement between actual and predicted survival probabilities;the the Greenwood-Nam-D’Agostino(GND) goodness-of-fit test showed that the model was well calibrated(χ~2=8.24,P=0.5099). A total of 84 patients were used for external validation. When correlating actual disease-specific survival and calculated 1-year disease-specific survival, there were significance differences according to the calculated probability of 1-year survival among the three groups(P=0.044).Conclusions: The developed nomogram had quite acceptable accuracy and clinical feasibility in the decision-making process for the management of p

关键词： Pancreatic cancer neoadjuvant treatment pancreatectomy survival nomogram