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Open Journal of Radiology 2013年第3期3卷 112-116页

作者： Masayuki Kanematsu Haruo Watanabe Hiroshi Kondo Satoshi Goshima Hiroshi Kawada yoshifumi Noda Department of Radiology Gifu University Hospital Gifu Japan

Purpose: This study was undertaken to determine if portal-inflow bolus tracking outperforms aortic bolus tracking with respect to the image quality of contrast-enhanced portal venous-phase CT of the liver in patients without chronic liver damage. Materials and Methods: Contrast-enhanced CT of the liver was performed in 132 consecutive patients without chronic liver damage. Patients were prospectively assigned to three protocols: Protocol A—a portal venous-phase scan delay of 6 seconds after superior mesenteric venous (SMV) enhancement increased by 70 HU or 14 seconds after SMV enhancement was visually confirmed, and Protocols B and C—40 and 50 seconds, respectively, after abdominal aortic enhancement increased by 100 HU. Enhancement (ΔHU) of abdominal aorta, portal trunk, and liver parenchyma and diagnostic acceptability were assessed. Results: ΔHU of aorta was higher for protocol A than for protocols B and C (P P Conclusion: Portal-inflow bolus tracking did not outperform aortic tracking in terms of optimization of portal venous-phase CT in patients without chronic liver damage.

关键词： CT Liver Contrast Enhancement Bolus Tracking

Prognostic Significance of Fluorodeoxyglucose Positron Emission Tomography Maximum Standardized Uptake Value in Stage I Ovarian Clear Cell Carcinoma: A Retrospective Observational Study

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Open Journal of Obstetrics and Gynecology 2016年第2期6卷 136-143页

作者： Haruhisa Konishi Kazuhiro Takehara Shinichi Okame Masaaki Komatsu Yuko Shiroyama Takashi Yokoyama yoshifumi Sugawara Department of Gynecologic Oncology National Hospital Organization Shikoku Cancer Center Matsuyama Japan Department of Obstetrics and Gynecology Graduate School of Biomedical Science Hiroshima University Hiroshima Japan Department of Diagnostic Radiology National Hospital Organization Shikoku Cancer Center Matsuyama Japan

Background: Ovarian clear cell carcinoma (CCC) is often diagnosed at stage I. However, because of the poor prognosis of recurrent cases, even for stage Ia CCC, treatment strategies such as expansion of fertility-sparing treatment and omission of adjuvant chemotherapy have been carefully discussed in recent years. We previously reported the possibility of the maximum standardized uptake value (SUVmax) as a biomarker of CCC prognosis prediction at all stages. In this study, we confirmed differences in SUVmax within stage I CCC and considered treatment strategies. Methods: We selected all 31 patients with ovarian CCC stage I who underwent fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) before treatment between 2006 and 2013 at our institution. This retrospective study was based on their medical records. Results: Clinical tumor stage was Ia in 13 patients, and Ic in 18 (Ic (b) in 11, and Ic (1) + Ic (2) in seven). There were no differences in serum CA125 level, maximum tumor diameter or mural nodules. Median SUVmax was significantly higher in stage Ic (5.87) than stage Ia (3.08) cases (P = 0.02). Progression-free survival was longer in the low SUVmax group than the high SUVmax group (P = 0.08). Conclusions: SUVmax for primary lesions in CCC was significantly higher in stage Ic than stage Ia. As SUVmax represents a prognostic factor in stage I CCC, these findings may suggest SUVmax as an indicator for the application of fertility-sparing surgery and omission of adjuvant chemotherapy for stage Ia CCC.

关键词： Ovarian Clear Cell Carcinoma FDG-PET/CT SUVmax Biomarker Prognosis

Comparison of glycemic variability between basal-bolus and premixed insulin therapy

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Journal of Diabetes Mellitus 2013年第2期3卷 45-51页

作者： Satoru Yamada Ryo Hirai Gaku Inoue yoshifumi Yamada Junichiro Irie Koichiro Atsuda Toshikazu Yamanouchi Center for Clinical Pharmacy and Clinical Sciences Kitasato University Tokyo Japan Department of Internal Medicine Keio University School of Medicine Tokyo Japan Department of Medicine Tokyo University School of Medicine Tokyo Japan Diabetes Center Kitasato Institute Hospital Tokyo Japan

Background: Several studies have shown that twice-daily injections of premixed insulin analogs (MIX) could achieve comparable HbA1c levels to basal-bolus (BB) therapy. However, HbA1c does not necessarily reflect short-term glycemic fluctuations that may contribute to the onset or progression of diabetic complications. Therefore, in this study, we compared MIX and BB therapies in terms of their effects on glycemic variability. Methods: We performed a crosssectional observational study of patients attending our outpatient clinics to compare the effects of two insulin regimens on glycemic variability. We recruited patients treated with MIX or BB with HbA1c 180 mg/dL (t > 180) was significantly shorter with BB therapy (88 ± 76 min) than with MIX therapy (145 ± 54 min;p < 0.05). After classification according to HbA1c levels, markers of glycemic variability were better in patients treated with BB than in those treated with MIX in better control group. Conclusion: These results suggest that BB therapy achieves better glucose profiles than MIX therapy in patients with type 2 diabetes, particularly after lunch.

关键词： Glycemic Variability Insulin Therapy Diabetes Continuous Glucose Monitoring

Verifying Stacks and Queues Using Symbolic Simulation Techniques

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湖南大学学报（自然科学版） 2000年第S2期27卷 119-128页

作者： yoshifumi MORIHIRO Tomohiro YONEDA Graduate School of Information Science and Engineering, Department of Computer Science Tokyo Institute of Technology, 2-12-l Ookayama Meguro-ku Tokyo 152, Japan

This paper presents a formal verification method based on logic simulation. In our method, using symbolic values even circuits which include data paths can be verified without abstraction of data paths. Our verifier extracts a transition relation from the state graph (given as a specification) which is expressed using symbolic values, and verifies based on simulation using those symbolic values if the circuit behaves correctly with respect to each transition of the specification. If the verifier terminates with "correct", then we can guarantee that for any applicable input vector sequences, the circuit and the specification behaves identically. We have implemented the proposed method on a Unix workstation and verified some FIFO and LIFO circuits by using it.

关键词： Formal Verification Simulation State Graph Data--Path Abstraction

A new diagnostic feasibility for cardiomyopathy utilizing acoustic microscopy

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World Journal of Cardiovascular Diseases 2013年第1期3卷 22-30页

作者： Yoichi Nakamura Kengo Fukushima Kusano Kazufumi Nakamura Kazuto Kobayashi Naohiro Hozumi yoshifumi Saijo Tohru Ohe Biomedical Imaging Laboratory Graduate School of Biomedical Engineering Tohoku University Sendai Japan Department of Cardiology Sakakibara Heart Institute of Okayama Okayama Japan Department of Cardiovascular Medicine Matsuyama Shimin Hospital Matsuyama Japan Department of Research and Development Honda Electronics Co. Ltd. Toyohashi Japan epartment of Cardiovascular Medicine Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan Toyohashi University of Technology International Cooperation Center for Engineering Education Development Toyohashi Japan

Aims: Dilated cardiomyopathy often shows left ventricular systolic dysfunction, although histologically it always exhibits non-specific abnormality. We hypothesized that myocyte sound speed might be altered due to incomplete protein accumulation in cells. Methods and Results: Ninety eight biopsied samples were obtained from 49 patients comprising 43 with clinical dilated cardiomyopathy and 6 with hypertrophic cardiomyopathy. Sound speed was evaluated in deparaffinized 10 μm thick sections using an acoustic microscope (frequency range: 50 - 105 MHz). Conventional histology revealed 7 cases of persistent myocarditis derived from clinical dilated cardio- myopathy samples. Histology of the remaining dilated cardiomyopathy patients indicated non-specific abnormality. All hypertrophic cardiomyopathy cases exhibited myocardial disarray. Ten normal autopsied hearts were compared as controls. The sound speed of controls was 1627 ± 30m/sec. The sound speed in dilated cardiomyopathy samples (1700 ±51m/sec) was 1.045-fold faster compared to controls. The sound speed in hypertrophic cardiomyopathy samples (1734 ±51m/sec, 1.066-fold compared to controls) was faster than that of the myocarditis group (1672 ±30m/sec, 1.028-fold) (P = 0.0218). Furtheremore, desmin expression was evaluated as extent of emergence (grading 0 - 4). The desmin expression score in hypertrophic cardiomyopathy samples (2.7 ± 0.8) was significantly higher than in other groups (dilated 2.0 ± 1.4, myocarditis 1.6 ± 1.5 vs., controls 0, P ≤ 0.0001, 0.0001, 0.0129, respectively). Conclusion: Cardio-myopathy enhanced the sound speed, which correlated with the elasticity of myocytes, following the impaired compliance of left ventricle, despite the absence of histological changes. The elevation of sound speed of myocytes may be linked to cytoskeletal changes. Myocyte sound speed may be a new diagnostic tool for diagnosis of idiopathic cardiomyopathy independently of conventional histological diagnosis.

关键词： Cardiomyopathy Acoustic Microscopy Heart Failure Myocytes Sound Speed Diagnosis

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加热对65Zn可萃取性的影响

核农学通报 1987年第3期 30-31页

作者： yoshifumi Homma 蔡进

据报道,粘土在70℃下经反复润湿和干燥处理可使 Zn 吸附在斑脱岩和伊利石上。也有报道土壤在40℃下加热可导致 Zn 的可萃取性下降。然而 Molloy 等指出,即使将土壤加热到204℃,用 NH4OAc 萃取的 Zn 量仍未发生变化。由于测定土壤、植株... 详细信息

据报道,粘土在70℃下经反复润湿和干燥处理可使 Zn 吸附在斑脱岩和伊利石上。也有报道土壤在40℃下加热可导致 Zn 的可萃取性下降。然而 Molloy 等指出,即使将土壤加热到204℃,用 NH4OAc 萃取的 Zn 量仍未发生变化。由于测定土壤、植株中有效 Zn 常采用加热方法,本试验研究了加热对土壤 Zn 和施用65Zn 可萃取性的影响。

关键词： Zn 植株放射性活度放射性强度 DTPA

Influence of Adiponectin and Leptin on the Kinetics of Human Pulp Cells

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Open Journal of Stomatology 2020年第12期10卷 360-371页

作者： Isao Tamura Katsura Ueda yoshifumi Matsuda Aiko Kamada Yoshihiro Yoshikawa Eisuke Domae Takashi Ikeo Shunji Kumabe Department of Oral Anatomy School of Dentistry Osaka Dental University 8-1 Kuzuhahanazono-cho Hirakata-shi Osaka Japan Department of Biochemistry School of Dentistry Osaka Dental University 8-1 Kuzuhahanazono-cho Hirakata-shi Osaka Japan

Adipocytokines, such as adiponectin and leptin, are expressed by adipocytes and are known as anti-metabolic syndrome factors. They are also thought to mediate calcification in mineralized tissue. We investigated the effects of adiponectin and leptin on the kinetics of human pulp cells using ELISA and western blot. After gaining informed consent, we obtained human pulp cells from three patients. After cultivation in Dulbecco’s Modified Eagle Medium (DMEM) without serum, cells from the 4th to 6th passages were incubated with various concentrations of adiponectin (1, 10, or 100 ng/mL) in DMEM or leptin (0.1, 1, or 10 ng/mL) in DMEM for 24 h. We confirmed that human pulp cells expressed adiponectin receptor 1 and leptin receptor. Although the proliferation index of these cells as measured by 5-bromo-2'-deoxyuridine (BrdU) incorporation increased in the presence of adiponectin in a dose-dependent manner, pulp cells stimulated with leptin showed no significant changes in BrdU incorporation. Alkaline phosphatase activity showed no significant changes after stimulation with either adipocytokine. Adiponectin induced expression of BMP-2 and osteopontin more strongly than did leptin. In particular, expression of BMP-2 increased in the presence of adiponectin in a dose-dependent manner. In contrast, the expression of dentin sialoprotein increased after stimulation with leptin. The expression of Runx2 was not observed from the cultured pulp cells stimulated with both molecules. These results indicate that adiponectin and leptin contribute to growth and differentiation of human pulp cells and may consequently affect the formation of secondary dentin or reparative dentin in the dentin-pulp complex.

关键词： Dental Pulp Cells Adiponectin Leptin Bone Morphogenetic Protein-2 Dentin Sialoprotein Osteopontin ECM Formation

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衣物用漂白剂种类及有效使用方法

中国洗涤用品工业 2020年第2期 61-66页

作者： Yamagata yoshifumi 岳霄(译) 日本狮王株式会社不详

综述了消费者对新洗涤标识中漂白记号的认知度以及衣物用漂白剂的种类、特征,重点说明了液体氧系漂白剂与洗涤剂并用的去污效果,确认这是一种提高液体氧系漂白剂效力的有效方法,而且有益于衣物附着细菌的去除。

关键词：衣物用漂白剂氯系漂白剂氧系漂白剂使用方法

Small-bowel mucosal injuries in low-dose aspirin users with obscure gastrointestinal bleeding

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World Journal of Gastroenterology 2014年第36期20卷 13133-13138页

作者： Junichi Iwamoto Yuji Mizokami yoshifumi Saito Koichi Shimokobe Akira Honda Tadashi Ikegami Yasushi Matsuzaki Department of Gastroenterology Tokyo Medical University Ibaraki Medical Center Ibaraki 300-0395 Japan Department of Gastroenterology University of Tsukuba Ibaraki 305-8576 Japan

AIM: To investigate the clinical differences between small intestinal injuries in low-dose aspirin(LDA) users and in non-steroidal anti-inflammatory drug(NSAID) users who were examined by capsule endoscopy(CE) for obscure gastrointestinal bleeding(OGIB). METHODS: A total of 181 patients who underwent CE for OGIB were included in this study. Based on clinical records, laboratory data such as hemoglobin levels, major symptoms, underlying diseases, the types and duration of LDA and NSAID use, and endoscopic characteristics of CE were ***: Out of a total of 45 cases of erosive lesions, 27 cases were taking LDA or NSAIDs(7 were on NSAIDs, 9 were on LDA alone, 9 were on LDA and thienopyridine, and 2 were on LDA and warfarin).The prevalence of ulcers or erosion during chronic use of LDA, LDA and the anti-platelet drug thienopyridine (clopidogrel or ticlopidine), and NSAIDs were 64.3%, 80.0%, and 75.0%, respectively. Erosive lesions were observed predominantly in chronic LDA users, while ulcerative lesions were detected mainly in NSAID users. However, concomitant use of thienopyridine such as clopidogrel with LDA increased the proportion of ulcers. The erosive lesions were located in the whole of the small intestine(jejunum and ileum), whereas ulcerative lesions were mainly observed in the ileum(P < 0.05). CONCLUSION: Our CE findings indicate that chronic LDA users and NSAID users show different types and locations of small-bowel mucosal injuries. The concomitant use of anti-platelet drugs with LDA tends to exacerbate the injuries from LDA-type to NSAID-type injuries.

关键词： Non-steroidal anti-inflammatory drugs Lowdose aspi

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中国宝钢新电镀锡生产线的污泥减低技术

国际冶金设备和技术 2010年第2期 30-32页

作者： Kamio Keiji Ninomiya yoshifumi

中国宝钢集团同时新建两条带钢加工线，一条是电镀锡生产线，另一条是无镶镶层生产线。由新日铁制钢工程公司提供的这两条最先进生产线在投产后不久，很快就达到其生产能力。由于生产线投产成功，宝钢提高了高质量的镀锡板和无锡镶层板... 详细信息

中国宝钢集团同时新建两条带钢加工线，一条是电镀锡生产线，另一条是无镶镶层生产线。由新日铁制钢工程公司提供的这两条最先进生产线在投产后不久，很快就达到其生产能力。由于生产线投产成功，宝钢提高了高质量的镀锡板和无锡镶层板的产量。由于不溶性阳极系统的改进，新日铁制钢工程公司的技术保证了在该生产线的商业生产上达到很低的锡损耗，只有3．2％。

关键词：电镀锡生产线宝钢集团技术中国污泥生产能力阳极系统新日铁