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Effect of Sim-eui point on causes of nasal obstruction such as allergic rhinitis and rhinosinusitis

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World Journal of Acupuncture-Moxibustion 2010年第4期20卷 53-53页

作者： Kwon.HJ kim.CH kim.Yong-Suk Kyung hee University

Purpose This study was done to verify the effectiveness of acupuncture treatment on nasal obstruction caused by allergic rhinitis or rhinosinusitis, and to know the clinical effect of a novel acupuncture point named Sim-eui. Method Rhinitis patients with at least two visits to the hospital from September, 2009 to November, 2009 were randomized into either experiment or control group. The experiment group were treated with acupuncture on generally used points of rhinitis, that are GV 22, GV 23, GV 24, ST 8 (both sides), BL 2 (both sides), ST 4 (both sides), as well as Sim-eui point. The control group were treated with the general points and LI20(both sides) instead of Sim-eui point. Acupuncture needles were left in for 15 minutes for both groups. The initial and final symptom scores of SNOT-20 and a modified VAS were used to evaluate the effectiveness. The program used for statistical analysis was SPSS 15.0 for window. Wilcoxon Signed Ranks Test was done to analyze the intra-group symptom score change before and after treatment, and Mann-Whitney Test was used to compare inter-group VAS change. All the statistics were verified at a signifi cance level of 5%. Result The SNOT-20 scores before and after acupuncture treatment showed significant changes on both experiment and control groups, but there was no signifi cant difference between the two groups. All categories of the SNOT-20 showed signifi cant result, except the 'Wake up at night' and 'Lack of a good night's sleep' entries. The modifi ed VAS showed significant improvement of symptom in the experiment group compared with control group. Conclusion Acupuncture treatment using Sim-eui point seems to be helpful in improving quality of life by immediate relief of nasal obstruction.

关键词：中医学针灸学针法灸法

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Clinical trial to evaluate the efficacy and safety of Tongxinluo in high risk group of cardiovascular diseases

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Clinical trial to evaluate the efficacy and safety of Tongxi...

不同生长环境下水稻结实率数量性状位点的检测

第二届国际络病学大会

作者： Seong Uk Park Woo Sang Jung Sang Kwan Moon Chang Nam Go Ki Ho Cho Young Suk kim Hyung Sup Bae Department of Cardiovascular ＆ Neurologic Diseases Stroke Center College of Oriental Medicine Kyung Hee University Department of Cardiovascular ＆ Neurologic Diseases Stroke Center College of Oriental Medicine Kyung Hee University Department of Cardiovascular ＆ Neurologic Diseases Stroke Center College of Oriental Medicine Kyung Hee University Department of Cardiovascular ＆ Neurologic Diseases Stroke Center College of Oriental Medicine Kyung Hee University Department of Cardiovascular ＆ Neurologic Diseases Stroke Center College of Oriental Medicine Kyung Hee University Department of Cardiovascular ＆ Neurologic Diseases Stroke Center College of Oriental Medicine Kyung Hee University Department of Cardiovascular ＆ Neurologic Diseases Stroke Center College of Oriental Medicine Kyung Hee University

＜正＞Objective Arterial stiffness is an important, independent determinant of cardiovascular risk. Pulse wave velocity （PWV） has been used as a valuable index of arterial stiffness and as a surrogate marker for atherosclerosis. The Framingham risk score was developed using categorized risk factors to predict the 10 - year absolute risk of developing coronary heart disease （CHD）. This algorithm is established using recommended guidelines for blood pressure, total cholesterol, and high - density lipoprotein cholesterol in addition to age, smoking history and history of diabetes. Tongxinluo（TXL） has been shown to have anti - hyperlipidemic activity and anti - atherogenic effects. To determine its efficacy and safety, we examined whether TXL improves PWV, ABI, Framingham score, blood pressure, and lipid profile in high risk group of cardiovascular diseases. Methods 49 subjects with the high risk of cardiovascular diseases were recruited. Subjects were administered TXL with the dose of 1110mg three times a day for 8 weeks. baPWV, ABI, Framingham risk score, Blood pressure and serum lipid profile were assessed at baseline and after 4 and 8weeks. Results Total cholesterol, LDL cholesterol, triglyceride, total lipid and phospolipid significantly decreased after 4 weeks of medication. Total cholesterol, total lipid and phospolipid significantly decreased after 8 weeks of medication. There were no significant changes in Framingham risk scores, ABI, PWV and blood pressure. On safety assessment, there were no adverse effects, hepatic or renal toxicity. Conclusion We suggest that TXL is a safe and useful herbal medicine for hyperlipidemia and as for anti - atherognic effects, further research would be necessary.

关键词： Tongxinluo Atherosclerosis Hyperlipidemia Cardiovascular disease PWV Framingham risk score

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作物学报 2006年第7期32卷 1024-1030页

作者：韩龙植张三元乔永利金钟焕徐福荣曹桂兰南钟浩戴陆园芮钟斗高熙宗中国农业科学院作物科学研究所/国家农作物基因资源与基因改良重大科学工程/农业部作物种质资源与生物技术重点开放实验室北京100081 吉林省农业科学院水稻研究所吉林公主岭136100 韩国农村振兴厅作物科学院云南省农业科学院生物技术与种质资源研究所云南昆明650205 首尔大学校农业生命科学大学农学科

以籼稻密阳23与粳稻吉冷1号配制所获得的R2：3群体200个家系作为作图群体，在北京、昆明、三亚、公主岭和韩国春川等5个点进行水稻结实率的鉴定，并利用SSR标记对水稻结实率数量性状位点进行检测。结果表明，水稻结实率表型值及其在B家... 详细信息

以籼稻密阳23与粳稻吉冷1号配制所获得的R2：3群体200个家系作为作图群体，在北京、昆明、三亚、公主岭和韩国春川等5个点进行水稻结实率的鉴定，并利用SSR标记对水稻结实率数量性状位点进行检测。结果表明，水稻结实率表型值及其在B家系群中的分布以及所检测到的QTL数目因生长环境不同而有较大差异，说明QTL与环境有明显的互作效应。水稻结实率在F3家系群中呈接近正态或偏态的连续分布，是由多个基因所控制的数量性状。共检测到与水稻结实率相关的QTL14个，分布于第1、2、3、4、6、7、8、10和12染色体上，对表型变异的贡献率为4．9％。15．3％。分别位于第1、2、6和12染色体RM1-RM259、RM263～RM6、RM340-RM30、RM270～RMl7区间的qSSR1、qSSR2、qSSR6和口SSRl2至少在2种生长环境下均检测到，对表型变异的贡献率分别为4．9％～8．4％、4．8％。7．2％、7．6％。10．7％和7．4％。10．4％。以上多数QTL增效等位基因均来自吉冷1号，基因作用方式主要为部分显性或显性或超显性。

关键词：水稻结实率不同生长环境数量性状位点微卫星标记

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血管内皮细胞生长因子和血管发生素-1及其受体在斑马鱼早期胚胎发育过程中的表达

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时珍国医国药 2006年第6期17卷 912-913页

作者：柳明洙张学武高圭永金善姬延边大学基础医学院韩国科学技术大学韩国全北大学校医科大学南开大学吉林延吉133000 韩国大田305-701 韩国全州560-180 天津300071

目的探讨血管内皮细胞生长因子和血管发生素-1及其受体在斑马鱼早期胚胎发育过程中的表达,为构建药物筛选的在体模型提供依据。方法采用多聚酶链式反应,扩增了长约280bp的斑马鱼血管发生素-1 cDNA部分序列,作为探针,以原位杂交法测定了... 详细信息

目的探讨血管内皮细胞生长因子和血管发生素-1及其受体在斑马鱼早期胚胎发育过程中的表达,为构建药物筛选的在体模型提供依据。方法采用多聚酶链式反应,扩增了长约280bp的斑马鱼血管发生素-1 cDNA部分序列,作为探针,以原位杂交法测定了血管内皮细胞生长因子和血管发生素-1及其相应受体flk-1和Tie-2的表达。结果从受精卵胚胎发育第12小时可见血管内皮细胞生长因子和血管发生素-1及其相应受体flk-1和Tie-2的表达;在受精卵胚胎发育的第16小时,血管内皮细胞生长因子和血管发生素-1主要在头部和尾部胚芽表达;第24小时在眼球、视窝、中脑、后脑的腹前侧和肌节中表达,Tie2和F lk-1主要在肌间背部动脉血管、躯干新生血管芽和轴向静脉中表达。结论血管内皮细胞生长因子和血管发生素-1及其受体在斑马鱼胚胎发育早期的血管发生过程中可能相互作用,并协调血管发生过程。斑马鱼是研究胚胎发育早期微血管发生和血管发生的极佳动物模型,可用于促血管发生或抑制血管发生药物筛选。

关键词：斑马鱼血管发生素-1 血管内皮生长因子受体

Surgical outcomes of Korean ulcerative colitis patients with and without colitis-associated cancer

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World Journal of Gastroenterology 2015年第12期21卷 3547-3553页

作者： Yong Sik Yoon Yong Beom Cho Kyu Joo Park Seung Hyuk Baik Sang Nam Yoon Seung-Bum Ryoo Kil Yeon Lee Hungdai kim Ryung-Ah Lee Chang Sik Yu Department of Colon and Rectal Surgery University of Ulsan College of Medicine and Asan Medical Center epartment of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Department of Surgery Seoul National University College of Medicine Department of Surgery Yonsei University College of Medicine Severance Hospital Department of Surgery Kangnam Sacred Heart Hospital Hallym University College of Medicine Department of Surgery Kyung Hee University School of Medicine Department of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Department of Surgery Ewha Womans University School of Medicine

AIM: To determine the clinicopathologic characteristics of surgically treated ulcerative colitis(UC) patients, and to compare the characteristics of UC patients with colitis-associated cancer(CAC) to those without CAC. METHODS: Clinical data on UC patients who underwent abdominal surgery from 1980 to 2013 were collected from 11 medical institutions. Data were analyzed to compare the clinical features of patients with CAC and those of patients without ***: Among 415 UC patients, 383(92.2%) underwent total proctocolectomy, and of these, 342(89%) were subjected to ileal pouch-anal anastomosis. CAC was found in 47 patients(11.3%). Adenocarcinoma was found in 45 patients, and the others had either neuroendocrine carcinoma or lymphoma. Comparing the UC patients with and without CAC, the UC patients with CAC were characteristically older at the time of diagnosis, had longer disease duration, underwent frequent laparoscopic surgery, and were infrequently given preoperative steroid therapy(P < 0.001-0.035). During the 37 mo mean follow-up period, the 3-yearoverall survival rate was 82.2%.CONCLUSION: Most Korean UC patients experience early disease exacerbation or complications. Approximately 10% of UC patients had CAC, and UC patients with CAC had a later diagnosis, a longer disease duration, and less steroid treatment than UC patients without CAC.

关键词： Ulcerative colitis Colorectal neoplasms Colorectal

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TbP_5O_(14)晶体的真空紫外光谱

人工晶体学报 2000年第S1期29卷 183-页

作者： HONG Guang yan 1, ZENG Xiao qing 1, kim Chang hong 2, PYUM Chong hong 2, YU Byung yong 2, BAE Hyum sook 2, PARK Cheal hee 2, KWON I1 eok 2 (1.Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchu n 130022,China

The rare earth pentaphosphates (LnP 5O 14 ) is a kind of functional crysta l with chemical *** have received considerable attention and th e i r crystal growth,structure,absorption and fluorescence spectra,infrared and Rama n spectra,ferroelectric and magnetic properties had been *** 5O 14 can emit strong green *** might be a kind of new crystal luminescenc e *** order to search for new luminescence material of plasma display pa nels (PDP),we have studied the VUV spectra of TbP 5O 14 . TbP 5O 14 crystals were made by evaporation solution *** usual expe rimental condition is as follows:

关键词： TbP 5O 14 crystal luminescence crystal vac uum ultraviolet spectrum

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国际白菜基因组测序项目中的参考遗传图

国际白菜基因组测序项目中的参考遗传图

Phenolic compounds from the Frutits of Capsicum annuum L.（Hot Pepper）

第十二届国际油菜大会

作者： Su Ryun Choi Graham R.Teakle Prikshit Plaha Jeong hee kim Charlotte J.Allender Elena Beynon Zhong Yun Piao Tae Ho Han Graham J.King Guy C.Barker Paul Hand Derek J.Lydiate Jacqui Batley Dave Edwards Thomas C.Osborn Dal Hoe Koo Jae Wook Bang Beom-Seok Park Yong Pyo Lim Department of Horticulture Genome Research CenterChungnam National UniversityDaejeon 305-764Korea Warwick HRI University of WarwickWellesbourneWarwickCV35 9EFUK Department of Horticulture Genome Research CenterChungnam National UniversityDaejeon 305-764Korea Department of Horticulture Genome Research CenterChungnam National UniversityDaejeon 305-764Korea Warwick HRI University of WarwickWellesbourneWarwickCV35 9EFUK Saskatoon Research Centre Agriculture and Agri-Food Canada107 Science PlaceSaskatoonSKS7N3V3Canada Department of Horticulture Genome Research CenterChungnam National UniversityDaejeon 305-764Korea Department of Applied Plant Science Chonnam National UniversityGwangju 500-757Korea Warwick HRI University of WarwickWellesbourneWarwickCV35 9EFUK Warwick HRI University of WarwickWellesbourneWarwickCV35 9EFUK Warwick HRI University of WarwickWellesbourneWarwickCV35 9EFUK Saskatoon Research Centre Agriculture and Agri-Food Canada107 Science PlaceSaskatoonSKS7N3V3Canada Plant Biotechnology Centre Primary Industries Research VictoriaLa Trobe UniversityBundooraVictoria 3086Australia Plant Biotechnology Centre Primary Industries Research VictoriaLa Trobe UniversityBundooraVictoria 3086Australia Seminis Vegetable Seeds Inc. 37437 State Highway 16woodlandCA 95695USA Department of Biology Chungnam National UniversityDaejeon 305-764Korea Department of Biology Chungnam National UniversityDaejeon 305-764Korea Brassica Genomics Team National Institute of Agricultural BiotechnologySuwon 441-707Korea Department of Horticulture Genome Research CenterChungnam National UniversityDaejeon 305-764Korea

我们目前正在构建的大白菜遗传连锁图是国际白菜基因组测序项目作为骨架图,将用来序列重叠群的锚定工作。图谱是基于以遗传差异大的两个中国大白菜品种---“Chiifu”和”Kenshin”杂交得到的F1经花药培养而得到78个DH系构建的。目前,图...

我们目前正在构建的大白菜遗传连锁图是国际白菜基因组测序项目作为骨架图,将用来序列重叠群的锚定工作。图谱是基于以遗传差异大的两个中国大白菜品种---“Chiifu”和”Kenshin”杂交得到的F1经花药培养而得到78个DH系构建的。目前,图谱上一共定位了556个标记,其中包括278个AFLP、235个SSR、25个RAPD和18个ESTP、STS、CAPS标记。对本遗传图谱和甘蓝型油菜遗传图谱中的通用SSR标记进行了位置和方向比较,从而把确定的10个连锁群分别记为R1-R10,并与甘蓝型油菜的N1-N10相对应。同时,通过定位的235个通用SSR标记,我们还可以对来自白菜的A基因组和来自甘蓝型油菜的A基因组进行比较分析。通过与拟南芥基因组序列进行比较,选出了500个BAC克隆,作为部分最小跨度克隆。对这些BAC的测序工作已完成,并成为设计和发展SSR引物的一个重要序列来源。用这些BAC序列发展而来的SSR标记已被定位到了参考遗传图上——CKDH图谱。这些做为锚定用的SSR标记,将在遗传图和物理图的整合中起重要作用,同时也为随后BAC-BY-BAC的测序策略中构建重叠群提供种子BAC。这样一个参考图谱的成功构建将对国际社会中改良白菜以及其它芸薹属作物起重要作用。

关键词：

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Phenolic compounds from the Frutits of Capsicum annuum L.（H...

应用多参数MR成像和18F-FDG-PET对脑胶质瘤分级:一致性与准确性研究

13th Asian Chemical Congress

作者： LEE D.G. LEE D.Y. CHO J.G PARK H.J kim S.Y. RHO Y.D BAEK N.I Graduate School of Biotechnology Kyung-Hee University Department of Oriental Medical Materials and Processing Kyung-hee University

＜正＞Capsicum annuum,the genus Capsicum in the family of Solanaceae,is distributed mainly in tropical America,Korea,and *** the most usually cultivated five species such as ***,C. chinense,***,***,and ***,the last one is cultivated commercially in Korea. *** is used by Korean to give spice to Korean cuisine,kim-Chi and Go-Chu-Jang,and so on.

关键词： Capsicum annuum isodecanoyl-m-anisoylamide 4-O-(6-O-p-hydroxy benzoylβ-D-glucopyranosyl)-cis-p-coumaric acid vanilloylicariside E5.

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国际医学放射学杂志 2014年第2期 197-197页

作者： J.hee.Yoon J.H.kim W.J.Kang C.H.Sohn S.H.Choi T.J.Yun 张倩 Department of Radiology Seoul National University Hospital 101 Daehak-ro Jongno-gu Seoul 110-744Korea

目的回顾性评估多参数MR技术和18F-FDGPET对脑胶质瘤分级的一致性和诊断预测值。方法60例脑胶质瘤的病人(12例低级别和48例高级别胶质瘤)被纳入

关键词：胶质瘤肿瘤分级 MRI 正电子发射体层成像试验预测值