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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong Lee keun Bon Ku Gun Young yoon Hyun-Woo Moon Chonsaeng Kim Mi-Hwa Kim yoon-Sun Yi Sangmi Jun Bum-Tae Kim Jong-won Oh Aleem Siddiqui Seong-Jun Kim Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research Equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of Microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular alterations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the EGFR-mediated cell survival signal cascade during the early stage of viral ***-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleocapsid cluster,thereby abnormally promoting mitochondrial elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the EGFR signal cascade and subsequently induces mitochondrial EGFR trafficking,contributing to abnormal OXPHOS process and viral *** EGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced EGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACE2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced alterations in mitochondrial dynamics and EGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that EGFR is an attractive host target for combating COVID-19.

关键词： alterations aberrant thereby

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农业文化遗产地土地利用控制优化研究（英文）

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Journal of Resources and Ecology 2016年第3期7卷 180-186页

作者： Park yoon-Ho yoon won-keun Gordon Dabinett 韩国乡村社区法人团体乡村研究所韩国安山市15634 协成大学地域开发系韩国华城市18330 谢菲尔德大学城镇与区域规划系英国谢菲尔德S102TN

近年来,包括韩国、中国、日本在内的东亚地区的全球重要农业文化遗产数量不断增加,且未来仍将会呈持续增加态势。因此,对遗产地尤其是韩国境内遗产地的保护工作变得尤为重要。为避免农业文化遗产地粗放式开发、有效协调保护与开发的关系... 详细信息

近年来,包括韩国、中国、日本在内的东亚地区的全球重要农业文化遗产数量不断增加,且未来仍将会呈持续增加态势。因此,对遗产地尤其是韩国境内遗产地的保护工作变得尤为重要。为避免农业文化遗产地粗放式开发、有效协调保护与开发的关系,解决土地利用冲突问题非常关键。本研究旨在确定农业文化遗产地可持续发展型土地利用管控措施。结果表明,公私合营、地方性法规及综合性计划对农业文化遗产地开展土地利用控制具有重要作用。

关键词：土地利用管控全球重要农业文化遗产(GIAHS) 遗产保护土地利用条例农业遗产系统可持续发展

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A Dynamical System-Based Framework for Dimension Reduction

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Communications on Applied Mathematics and Computation 2024年第2期6卷 757-789页

作者： Ryeongkyung yoon Braxton Ostin Department of Mathematics University of UtahSalt Lake CityUTUSA

We propose a novel framework for learning a low-dimensional representation of data based on nonlinear dynamical systems,which we call the dynamical dimension reduction(DDR).In the DDR model,each point is evolved via a nonlinear flow towards a lower-dimensional subspace;the projection onto the subspace gives the low-dimensional *** the model involves identifying the nonlinear flow and the *** the equation discovery method,we represent the vector field that defines the flow using a linear combination of dictionary elements,where each element is a pre-specified linear/nonlinear candidate function.A regularization term for the average total kinetic energy is also introduced and motivated by the optimal transport *** prove that the resulting optimization problem is well-posed and establish several properties of the DDR *** also show how the DDR method can be trained using a gradient-based optimization method,where the gradients are computed using the adjoint method from the optimal control *** DDR method is implemented and compared on synthetic and example data sets to other dimension reduction methods,including the PCA,t-SNE,and Umap.

关键词： Dimension reduction Equation discovery Dynamical systems Adjoint method Optimal transportation

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通过生态博物馆建设保护韩国乡村农业文化遗产（英文）

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Journal of Resources and Ecology 2016年第3期7卷 163-169页

作者： Lee Jeong-Hwan yoon won-keun Choi Sik-In Ku Jin-Hyuk 韩国乡村社区法人团体乡村研究所韩国安山市15634 国立首尔大学城市规划实验室韩国首尔08826 协成大学地域开发系韩国华城市18330 Nurinet公司韩国安阳市14054

乡村文化遗产包括农业文化遗产,对其进行正确的保护可以增强社区认同感。本文通过对生态博物馆建设等问题进行探索,试图寻找到适合乡村文化遗产保护的方法。文章首先梳理了生态博物馆及乡村文化遗产的基本概念;然后,在分析了生态博物馆... 详细信息

乡村文化遗产包括农业文化遗产,对其进行正确的保护可以增强社区认同感。本文通过对生态博物馆建设等问题进行探索,试图寻找到适合乡村文化遗产保护的方法。文章首先梳理了生态博物馆及乡村文化遗产的基本概念;然后,在分析了生态博物馆的概念、全球重要农业文化遗产的内涵、欧洲乡村文化遗产保护政策以及韩国农业文化遗产基本特征的基础上,定义了韩国乡村生态博物馆的概念与内涵。本研究提出了适用于韩国乡村生态博物馆建设的一系列具体方法,包括具体的组成与分类等。最后,本文尝试将生态博物馆的理念与方法应用于韩国农业文化遗产地,选取了韩国青山岛地区和Gurae地区的两个试验地进行尝试。结果表明,生态博物馆建设不仅可以保护农业文化遗产,而且可以扩大应用到更大范围的乡村文化遗产保护。因此,可以说乡村生态博物馆建设不仅有助于农业文化遗产的保护,而且对其周边地区的资源保护也具有不可忽略的重要作用。另外,生态博物馆建设还可以增强社区认同感,促进当地经济的发展。

关键词：乡村文化遗产农业文化遗产生态博物馆保护

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Negative Stiffness Mechanism on An Asymmetric Wave Energy Converter by Using A Weakly Nonlinear Potential Model

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China Ocean Engineering 2024年第4期38卷 689-700页

作者： Sunny Kumar POGULURI Dongeun KIM yoon Hyeok BAE Department of Ocean Engineering IIT MadrasChennaiIndia Multidisciplinary Graduate School Program for Wind Energy Jeju National UniversityJejuRepublic of Korea Mechanical and System Design Engineering Hongik UniversitySeoulRepublic of Korea

Salter's duck,an asymmetrical wave energy converter(WEC)device,showed high efficiency in extracting energy from 2D regular waves in the past;yet,challenges remain for fluctuating wave *** can potentially be addressed by adopting a negative stiffness mechanism(NSM)in WEC devices to enhance system efficiency,even in highly nonlinear and steep 3D waves.A weakly nonlinear model was developed which incorporated a nonlinear restoring moment and NSM into the linear formulations and was applied to an asymmetric WEC using a time domain potential flow *** model was initially validated by comparing it with published experimental and numerical computational fluid dynamics *** current results were in good agreement with the published *** was found that the energy extraction increased in the range of 6%to 17%during the evaluation of the effectiveness of the NSM in regular *** irregular wave conditions,specifically at the design wave conditions for the selected test site,the energy extraction increased by 2.4%,with annual energy production increments of approximately *** findings highlight the potential of NSM in enhancing the performance of asymmetric WEC devices,indicating more efficient energy extraction under various wave conditions.

关键词： asymmetric wave energy converter negative stiffness mechanism weakly nonlinear potential flow power

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100 W-class green hydrogen production from ammonia at a dual-layer electrode containing a Pt-Ir catalyst for an alkaline electrolytic process

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Journal of Energy Chemistry 2024年第6期93卷 352-360,I0009页

作者： Donghyun yoon Sunki Chung Minjun Choi Eunhyeok Yang Jaeyoung Lee School of Earth Sciences and Environmental Engineering Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea International Future Research Center of Chemical Energy Storage and Conversion Processes GISTGwangju 61005Republic of Korea Ertl Center for Electrochemistry and Catalysis GISTGwangju 61005Republic of Korea TKG Huchems Co.Ltd 963Sangam-roYeosu-siJeollanam-do 59614Republic of Korea

Ammonia allows storage and transport of hydrogen over long distances and is an attractive potential hydrogen *** decomposition has recently been used for the conversion of ammonia to hydrogen and is regarded as a future technology for production of CO_(2)-free pure ***,a heterostructural Pt-Ir dual-layer electrode is developed and shown to achieve successful long-term operation in an ammonia electrolyzer with an anion exchange membrane(AEM).This electrolyzer consisted of eight membra ne electrode assemblies(MEAs)with a total geometric area of 200 cm~2 on the anode side,which resulted in a hydrogen production rate of 25 L h~(-1).We observed the degradation in MEA performance attributed to changes in the anode catalyst layer during hydrogen production via ammonia ***,we demonstrated the relationship between the ammonia oxidation reaction(AOR)and the oxygen evolution reaction(OER).

关键词： Ammonia oxidation Dual-layer catalyst Green hydrogen Electrolytic process Oxygen evolution reaction

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Modification strategies improving the electrochemical and structural stability of high-Ni cathode materials

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Journal of Energy Chemistry 2024年第9期96卷 185-205页

作者： yoon Bo Sim Hami Lee Junyoung Mun Ki Jae Kim Department of Energy Science Sungkyunkwan UniversitySuwon 16419Republic of Korea School of Advanced Materials Sciencend Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Institute of Energy Sciencend Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

With the increasing spotlight in electric vehicles,there is a growing demand for high-energy-density batteries to enhance driving ***,several studies have been conducted on high-energy-density LiNi_(x)Co_(y)Mn_(z)O_(2)***,there is a limit to permanent performance deterioration because of side reactions caused by moisture in the atmosphere and continuous microcracks during cycling as the Ni content to express high energy increases and the content of Mn and Co that maintain structural and electrochemical stabilization *** direct modification of the surface and bulk regions aims to enhance the capacity and long-term performance of high-Ni cathode ***,an efficient modification requires a study based on a thorough understanding of the degradation mechanisms in the surface and bulk *** this review,a comprehensive analysis of various modifications,including doping,coating,concentration gradient,and single crystals,is conducted to solve degradation issues along with an analysis of the overall degradation mechanism occurring in high-Ni cathode *** also summarizes recent research developments related to the following modifications,aims to provide notable points and directions for post-studies,and provides valuable references for the commercialization of stable high-energy-density cathode materials.

关键词： High energy density High-Ni cathode materials Degradation Structural stability Lithium-ion battery

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Advances in Wireless,Batteryless,Implantable Electronics for Real‑Time,Continuous Physiological Monitoring

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Nano-Micro Letters 2024年第3期16卷 254-302页

作者： Hyeonseok Kim Bruno Rigo Gabriella wong yoon Jae Lee Woon‑Hong Yeo IEN Center for Wearable Intelligent Systems and Healthcare Georgia Institute of TechnologyAtlantaGA 30332USA George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Computer Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Georgia Tech and Emory University School of MedicineAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Institute for MaterialsInstitute for Robotics and Intelligent MachinesGeorgia Institute of TechnologyAtlantaGA 30332USA

This review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous physiological signal monitoring,focusing on advancing human health *** considerations,such as biological constraints,energy sourcing,and wireless communication,are discussed in achieving the desired performance of the devices and enhanced interface with human *** addition,we review the recent achievements in materials used for developing implantable systems,emphasizing their importance in achieving multi-functionalities,biocompatibility,and *** wireless,batteryless devices offer minimally invasive device insertion to the body,enabling portable health monitoring and advanced disease ***,we summarize the most recent practical applications of advanced implantable devices for human health care,highlighting their potential for immediate commercialization and clinical uses.

关键词： Implantable electronics Biomedical systems Batteryless devices Wireless electronics Physiological signal monitoring

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Biochemical consequences of glucocerebrosidase 1 mutations in Parkinson’s disease

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Neural Regeneration Research 2024年第4期19卷 725-727页

作者： Jeong Hyun yoon Chiao-Yin Lee Anthony HV Schapira Department of Clinical and Movement Neurosciences University College London Institute of Neurology Faculty of Medicine Imperial College London Aligning Science Across Parkinson's(ASAP)Collaborative Research Network

Parkinson’s disease(PD,OMIM#168600)is a common neurodegenerative disorder with a global prevalence of approximately 8.5 *** is characterized by four cardinal motor symptoms:bradykinesia,rigidity,resting tremor,and subsequently by postural *** usually involves non-motor symptoms such as rapid eye movement sleep disorder,dementia,anosmia,and autonomic *** gene glucocerebrosidase 1(GBA1),which encodes the lysosomal enzyme glucocerebrosidase(GCase)(IUBMB:EC 3.***.1.45),shows strong linkage with PD;variants of GBA1 are the commonest genetic association with PD(Sidransky et al.,2009).Several mechanisms may underlie the relationship between GBA1 mutations/variants and the molecular pathology of PD(Figure 1A and B).

关键词： cerebro consequences

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A novel AIE-NIR-II nano-contrast agent for monitoring and evaluating kidney transplant

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National Science Review 2024年第4期11卷 15-16页

作者： Yuan-Yuan Zhao Bokyeong Hwang Yeju Lee Juyoung yoon Department of Chemistry and Nanoscience Ewha Womans University

Kidney transplantation is a life-saving approach for treating end-stage renal diseases (ESRDs)[1]. However, the scarcity of donor kidneys has resulted in an increasing number of ESRD patients being stuck on the transp... 详细信息

关键词： TIME

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