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Preparation of baicalin colon-targeted granules and its intervention effect on ulcerative colitis in rats

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Particuology 2024年第2期85卷 13-21页

作者： yongqing huang Yuxin Zhou Yao Shen Jin Wang Liangliang Zhou Zhenhua Chen Jiangxi Provincial Key Laboratory of Drug Design and Evaluation School of PharmacyJiangxi Science and Technology Normal UniversityNanchang330013China

Baicalin(BA)is a flavonoid extracted from the dried root of Scutellaria baicalensis Georgi with excellent antioxidant and anti-inflammatory biological *** this study,Eudragit S100 was used as the colonic target material to prepare BA colonic targeting granules(EBCGs)based on plasticizer dry powder coating technology to improve the targeting transportation performance of *** vitro studies showed that EBCGs with pH-sensitive properties were successfully prepared by plasticizer dry powder coating,and in vivo animal imaging studies showed that EBCGs could deliver BA to the colon and inhibit the release of BA in the upper gastrointestinal tract(GIT).In vivo studies showed that EBCGs had good therapeutic effects in colitis,which reduced expression levels of tumor necrosis factor alpha(TNF-α)and interleukin-1β(IL-1β)and increased superoxide dismutase(SOD)activities in the colonic tissues of rats with *** conclusion,Eudragit S100 could be used for the preparation of multi-unit oral colon-targeted formulations by plasticizer dry powder coating technology,and our prepared EBCGs had good colon-targeting properties,which could improve the therapeutic effect and provide a potential application for ulcerative colitis(UC).

关键词： Plasticizer dry powder coating Colon-targeted granulesIn vivo imaging Ulcerative colitis

Realizing Zinc Blende GaAs/AlGaAs Axial and Radial Heterostructure Nanowires by Tuning the Growth Temperature

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Journal of Materials Science & Technology 2011年第6期27卷 507-512页

作者： Jingwei Cuo Hui huang Xiaomin Ren Xin Yan Shiwei Cai Wei Wang yongqing huang Qi Wang and Xi Zhang Key Laboratory of Information Photonics & Optical Communications Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 China

Vertical zinc blende GaAs/AlGaAs heterostructure nanowires were grown at different temperatures by metalorganic chemical vapor deposition via Au-assisted vapor-liquid-solid *** was found that radial growth can be enhanced by increasing the growth *** growth of radial heterostructure can be realized at temperature higher than 500℃,while the growth temperature of axial heterostructure is lower than 440℃.The room temperature photoluminescence properties of the nanowires were investigated and the relevant growth mechanism was discussed.

关键词： Nanowire GaAs AlGaAs Heterostructure Zinc blende

All-optical regeneration based on highly nonlinear photonic crystal fiber

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Frontiers of Optoelectronics 2008年第Z1期1卷 79-84页

作者： Yongzhao XU Yanfen WEI Xiaomin REN Xia ZHANG yongqing huang Department of Electronic Engineering Dongguan University of Technology Tianjin Mobile Corporation Company Key Laboratory of Optical Communication and Lightwave Technologies Ministry of Education Beijing University of Posts and Telecommunications

An all-optical regeneration based on selfphase modulation in a highly nonlinear photonic crystal fiber is proposed. The dispersion and nonlinearity properties of a series of photonic crystal fibers are analyzed, and the results show that the nonlinearity coefficient is closely related to the structure of the *** this paper, the nonlinearity coefficient is increased by reducing the effective mode area, and a highly nonlinear photonic crystal fiber with a large air-filling fraction is used as nonlinearity medium in optical regeneration. The numerical results show that good optical regeneration results can be obtained by using a relatively short fiber length due to the high nonlinearity of the fiber. The input peak power launched into the photonic crystal fiber and the parameters of the filter have much influence on optical regeneration. To achieve good optical regeneration, those parameters need to meet certain ***, the transfer characteristic of the regenerator is also discussed. By adjusting the input peak power and filter parameters, the regenerator can deal with input pulses of different pulse widths.

关键词： fiber optics and optical communications photonic crystal fiber optical regeneration self-phase modulation

Effects of Solution Chemistry Conditions and Adsorbent Surface Properties on Adsorption of Ni(Ⅱ) on Laiyang Bentonite

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China Petroleum Processing & Petrochemical Technology 2016年第3期18卷 66-75页

作者： Cao Xiaoqiang Yan Bingqi Xue Jianliang Wang Qian Wang Yaping huang yongqing Zhang Yan Lyu Xianjun College of Chemical and Environmental Engineering Shandong University of Science and Technology Qingdao 266590

The effects of solution chemistry conditions and adsorbent surface properties on the adsorption of Ni(II) on Laiyang bentonite were investigated via the batch technique. Potentiometric and mass titration techniques were employed in the batch experimental methods, and the results showed that the point of zero net proton charge(PZNPC) of bentonite at different ionic strength denoted p HPZNPC to be 8.2±0.1. The removal of Ni(II) from the solution increased with an increasing bentonite dosage, with the maximum removal efficiency equating up to 99%. The adsorption of Ni(II) on bentonite increased with an increasing p H value at a p H value of 99% at a p H value of >10.2. The Ni(II) adsorption performance exhibited different responses to cations(K+, Na+) but was not influenced by the background anions(NO3-, Cl-, and Cl O4-). The adsorption of Ni(II) was dominated by the outer-sphere surface complexation and ion exchange with Na+/H+ on bentonite surface at low p H value, whereas the inner-sphere surface complexation and surface precipitation were the main adsorption mechanisms at high p H value. The adsorption isotherms of Ni(II) on bentonite can be described well by the Langmuir model. The thermodynamic parameters of adsorption, including the Gibbs free energy, the enthalpy change, and the entropy change, at different temperatures indicated that the adsorption of Ni(II) on bentonite was endothermic and spontaneous.

关键词： nickel surface properties adsorption waste catalyst bentonite

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具有新型低损耗电极PIN光探测器的研究

聊城大学学报（自然科学版） 2025年第1期38卷 23-33页

作者：位健牛慧娟陈庆涛李沅昊刘凯段晓峰黄永清聊城大学物理科学与信息工程学院山东聊城252059 聊城大学山东省光通信科学与技术重点实验室山东聊城252059 蒙特利尔综合理工学院电气工程系 Poly-Grames研究中心加拿大蒙特利尔H3T 1J4 北京邮电大学信息光子学与光通信国家重点实验室北京100876

基于一种具有微孔-槽结构的PIN光探测器结构,设计了一种低损耗电极并与之进行联合优化。该方法不但为制备低损耗电极提供了有效的解决方案,还进一步提升了光探测器的3 dB带宽。首先,通过优化电极衬底与厚度、引入绝缘层、增加金属材料... 详细信息

基于一种具有微孔-槽结构的PIN光探测器结构,设计了一种低损耗电极并与之进行联合优化。该方法不但为制备低损耗电极提供了有效的解决方案,还进一步提升了光探测器的3 dB带宽。首先,通过优化电极衬底与厚度、引入绝缘层、增加金属材料以及在衬底中加入矩形槽结构等方式,设计了一款新型低损耗的光探测器电极,降传输损耗降至-1.15 dB。然后,将新型电极与PIN光探测器的等效电路进行联合设计优化。结果表明,与未使用该新型电极相比,光探测器的3 dB带宽提升了近32%。该新型电极的设计可以为不同结构及不同波段光探测器的性能改进提供参考。

关键词：光探测器低损耗电极联合优化 3dB带宽传输损耗

基于CNN-GRU融合网络的情绪脑电信号辨别研究

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传感技术学报 2021年第8期34卷 1109-1116页

作者：黄永庆周强陕西科技大学电气与控制工程学院陕西西安710021

针对当前情绪脑电信号(EM-EEG)辨识方法分辨率低的问题。在分析EM-EEG特征分布规律和单一卷积神经网络(CNN)特性的基础上,与门控循环单元(GRU)相结合,提出了CNN-GRU融合网络用于EM-EEG辨别研究。构建的CNN-GRU网络融合了CNN提取的EM-EE... 详细信息

针对当前情绪脑电信号(EM-EEG)辨识方法分辨率低的问题。在分析EM-EEG特征分布规律和单一卷积神经网络(CNN)特性的基础上,与门控循环单元(GRU)相结合,提出了CNN-GRU融合网络用于EM-EEG辨别研究。构建的CNN-GRU网络融合了CNN提取的EM-EEG频域、空域特征与GRU提取的EM-EEG时域特征,在构造的EM-EEG时-频-空域特征空间上进行情绪状态辨识;另外利用自己搭建的数据采集平台,设计情绪诱导实验生成新的情绪状态数据集。经过实验探究,结果表明:所提网络模型分别在SEED IV数据集、自采数据集上训练获得的辨识率为89.2%和83.76%,均能有效的对四种不同情绪进行判别,验证了该网络良好的泛化能力;而使用SEED IV数据集训练得到的模型在自采情绪数据集上的预测实验则验证了该网络拥有较强的鲁棒性。

关键词：脑电信号情绪辨别 CNN-GRU融合网络自采数据集泛化能力鲁棒性

Flat transmitted serrated-phase high-contrast-index subwavelength grating beam splitter

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Chinese Optics Letters 2020年第11期18卷 22-26页

作者： Gongqing Li Xiaofeng Duan yongqing huang Kai Liu Xiaomin Ren State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China

We proposed a method to form a flat transmitted serrated-phase(SP) high-contrast-index subwavelength grating(HCG) beam splitter(HBS) for all dielectric materials, which is to alternately arrange two kinds of grating bars with a phase difference of π. Compared to the typical linear-phase(LP) HBS, which consists of two symmetrical deflecting gratings, the SP-HBS is extensible in size, and can achieve excellent splitting ability regardless of normal incidence or small-angle oblique incidence with large deflection angles, higher diffraction efficiency,lower energy loss, and higher tolerance of fabrication accuracy. Furthermore, the incident light can be split in half at any part of the SP-HBS, and the output beams of light maintain the original shape. In this Letter, we designed an SP-HBS with a 44.8° deflection angle and a 90.28% transmissivity.

关键词： beam splitter high-contrast-index subwavelength grating serrated-phase profile splitting ability

InGaAs/InAlAs SAGCMCT avalanche photodiode with high linearity and wide dynamic range

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Chinese Optics Letters 2022年第2期20卷 153-159页

作者： Yu Li Weifang Yuan Ke Li Xiaofeng Duan Kai Liu yongqing huang State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China

Linearity is a very important parameter to measure the performance of avalanche photodiodes(APDs) under high input optical power. In this paper, the influence of the absorption layer on the linearity of APDs is carefully studied by using bandgap engineering with the structure model of separated absorption, grading, charge, multiplication, charge, and transit(SAGCMCT). The simulated results show that in the hybrid absorption layer device structure the 1 d B compression point can be improved from-9 d Bm to-2.1 d Bm by increasing the proportion of the p-type absorption layer. In the device structure with only one absorption layer, increasing the doping level of the absorption layer can also improve the 1 d B compression point from-8.6 d Bm to 1.43 d Bm at a gain of 10. Therefore, the absorption layer is very critical for the linearity of APDs.

关键词： linearity avalanche photodiode dynamic range

中国人群非综合征型唇腭裂易感基因的研究进展

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中华口腔医学杂志 2017年第4期52卷 223-228页

作者：黄永清宁夏医科大学附属口腔医院·宁夏医科大学总医院口腔颌面外科银川750004

唇腭裂是人类常见的先天性出生缺陷疾病。该畸形病因复杂，被认为是由遗传因素和环境因素共同作用导致。为更好地探索唇腭裂发生的易感基因，笔者综述了近年来对中国人群进行的唇腭裂遗传病因学研究进展，包括对已报道的候选基因进行的... 详细信息

唇腭裂是人类常见的先天性出生缺陷疾病。该畸形病因复杂，被认为是由遗传因素和环境因素共同作用导致。为更好地探索唇腭裂发生的易感基因，笔者综述了近年来对中国人群进行的唇腭裂遗传病因学研究进展，包括对已报道的候选基因进行的验证、对中国人群唇腭裂进行全基因组关联分析筛查并验证中国人群新的易感基因。这些研究不仅验证了国际上报道过的易感基因，并在第16号染色体16p13-3区域首次鉴定出一个与中国人群非综合征型唇腭裂显著关联的位点：rs8049367。笔者对唇腭裂研究中常用的遗传分析法进行总结，同时进一步对未来唇腭裂病因学研究方向进行展望，以期为唇腭裂遗传病因学研究提供更多启发。

关键词：唇裂腭裂全基因组关联研究危险因素人群监测