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高等工程教育研究 2018年第6期66卷 96-100页

作者：杨勇平华北电力大学

"双一流"背景下高水平行业特色型大学面临诸多挑战。华北电力大学在"双一流"建设中准确把握学科建设定位,从科技创新、师资团队、校企合作、国际化改革等方面对推动高水平行业特色型大学的内涵发展进行了有益探索。

关键词： “双一流” 行业特色型大学学科建设内涵发展

Exploiting the potential of the ubiquitin-proteasome system in overcoming tyrosine kinase inhibitor resistance in chronic myeloid leukemia

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Genes & Diseases 2024年第5期11卷 140-162页

作者： Xudong Li Wei Li Yanli Zhang Linping Xu yongping Song Department of Hematology Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhouHenan 450008China Academy of Medical Sciences Zhengzhou UniversityZhengzhouHenan 450052China Department of Hematology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China

The advent of tyrosine kinase inhibitors(TKI)targeting BCR-ABL has drastically changed the treatment approach of chronic myeloid leukemia(CML),greatly prolonged the life of CML patients,and improved their ***,TKI resistance is still a major problem with CML patients,reducing the efficacy of treatment and their quality of *** resistance is mainly divided into BCR-ABL-dependent and BCR-ABL-independent ***,the main clinical strategy addressing TKI resistance is to switch to newly developed ***,data have shown that these new drugs may cause serious adverse reactions and intolerance and cannot address all resistance ***,finding new therapeutic targets to overcome TKI resistance is crucial and the ubiquitin-proteasome system(UPS)has emerged as a *** UPS mediates the degradation of most proteins in organisms and controls a wide range of physiological *** recent years,the study of UPS in hematological malignant tumors has resulted in effective treatments,such as bortezomib in the treatment of multiple myeloma and mantle cell *** CML,the components of UPS cooperate or antagonize the efficacy of TKI by directly or indirectly affecting the ubiquitination of BCR-ABL,interfering with CML-related signaling pathways,and negatively or positively affecting leukemia stem *** of these molecules may help overcome TKI resistance and treat *** this review,the mechanism of TKI resistance is briefly described,the components of UPS are introduced,existing studies on UPS participating in TKI resistance are listed,and UPS as the therapeutic target and strategies are discussed.

关键词： Chronic myeloid leukemia Deubiquitinases E3 ligase PROTAC TKI resistance Ubiquitin-proteasome system

热力循环流程重构能效分析新方法:循环拆分法

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中国电机工程学报 2021年第20期41卷 7003-7013页

作者：杨勇平辛团团许诚电站能量传递转化与系统教育部重点实验室(华北电力大学) 北京市昌平区102206

流程重构是提高热力循环效率的有效途径,然而重构后的循环流程配置往往较为复杂。为简单直观地揭示热力循环不同流程配置的节能机制,提出一种具有普适性的热力循环能效分析新方法——"循环拆分法"。该方法基于热力学第一定律,将复杂热... 详细信息

流程重构是提高热力循环效率的有效途径,然而重构后的循环流程配置往往较为复杂。为简单直观地揭示热力循环不同流程配置的节能机制,提出一种具有普适性的热力循环能效分析新方法——"循环拆分法"。该方法基于热力学第一定律,将复杂热力循环拆分为基础循环与若干等效"小循环";拆分获得的小循环可直接用于分析热力循环流程重构的节能机制,指导系统流程优化。以蒸汽朗肯循环与超临界二氧化碳布雷顿循环为例,对典型循环的拆分过程进行了图示化描述和公式化表达,并分析了多种流程重构手段的节能效益;基于循环拆分法,对现有超临界二氧化碳布雷顿循环开展流程优化,进一步提高了循环效率。

关键词：热力学分析循环拆分法节能机理蒸汽朗肯循环超临界二氧化碳布雷顿循环化学回热

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多变边界条件下火电机组能耗基准状态诊断

中国电机工程学报 2013年第26期33卷 1-7,3页

作者：王宁玲杨勇平杨志平华北电力大学国家火力发电工程技术研究中心北京市昌平区102206

运行于多变边界条件下给火电机组深度节能理论研究带来新的挑战。针对这一问题,提出了多变条件下火电机组能耗基准状态概念,利用机组的海量实际运行数据,基于模糊粗糙集(fuzzy rough set,FRS)约简和模糊均值聚类(fuzzy C mean,FCM)等数... 详细信息

运行于多变边界条件下给火电机组深度节能理论研究带来新的挑战。针对这一问题,提出了多变条件下火电机组能耗基准状态概念,利用机组的海量实际运行数据,基于模糊粗糙集(fuzzy rough set,FRS)约简和模糊均值聚类(fuzzy C mean,FCM)等数据挖掘方法构建机组性能优化知识库,在可比历史边界条件下动态寻优确定机组能耗基准状态。以某600MW亚临界机组为案例开展了实例研究,结果表明该方法具有快速、自适应性、高度复现性和可动态调整优化等特点,适用于机组在不同工况和边界条件下的能耗分析与节能诊断。

关键词：火电机组能耗基准状态多变边界数据挖掘

Impact of Initial Soil Conditions on Soil Hydrothermal and Surface Energy Fluxes in the Permafrost Region of the Tibetan Plateau

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Advances in Atmospheric Sciences 2024年第4期41卷 717-736页

作者： Siqiong LUO Zihang CHEN Jingyuan WANG Tonghua WU Yao XIAO yongping QIAO Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Cryosphere Research Station on the Qinghai-Tibet Plateau State Key Laboratory of Cryospheric ScienceNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

Accurate initial soil conditions play a crucial role in simulating soil hydrothermal and surface energy fluxes in land surface process *** study emphasized the influence of the initial soil temperature(ST)and soil moisture(SM)conditions on a land surface energy and water simulation in the permafrost region in the Tibetan Plateau(TP)using the Community Land Model version 5.0(CLM5.0).The results indicate that the default initial schemes for ST and SM in CLM5.0 were simplistic,and inaccurately represented the soil characteristics of permafrost in the TP which led to underestimating ST during the freezing period while overestimating ST and underestimating SLW during the thawing period at the XDT *** the long-term spin-up method to obtain initial soil conditions has only led to limited improvement in simulating soil hydrothermal and surface energy *** modified initial soil schemes proposed in this study comprehensively incorporate the characteristics of permafrost,which coexists with soil liquid water(SLW),and soil ice(SI)when the ST is below freezing temperature,effectively enhancing the accuracy of the simulated soil hydrothermal and surface energy ***,the modified initial soil schemes greatly improved upon the results achieved through the long-term spin-up *** modified initial soil schemes experiments resulted in a 64%,88%,and 77%reduction in the average mean bias error(MBE)of ST,and a 13%,21%,and 19%reduction in the average root-mean-square error(RMSE)of SLW compared to the default simulation ***,the average MBE of net radiation was reduced by 7%,22%,and 21%.

关键词： initial soil conditions soil temperature soil liquid water soil ice surface energy fluxes permafrost

Differences in pseudogene evolution contributed to the contrasting flavors of turnip and Chiifu, two Brassica rapa subspecies

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Plant Communications 2023年第1期4卷 120-135页

作者： Xin Yin Danni yang Youjie Zhao Xingyu yang Zhili Zhou Xudong Sun Xiangxiang Kong Xiong Li Guangyan Wang Yuanwen Duan Yunqiang yang yongping yang Plant Germplasm and Genomics Center Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650204China Institute of Tibetan Plateau Research at Kunming Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China College of Big Data and Intelligent Engineering Southwest Forestry UniversityKunmingYunnanChina University of Chinese Academy of Sciences Beijing 100049China

Pseudogenes are important resources for investigation of genome evolution and genomic diversity because they are nonfunctional but have regulatory effects that influence plant adaptation and ***,few systematic comparative analyses of pseudogenes in closely related species have been ***,we present a turnip(Brassica rapa ***)genome sequence and characterize pseudogenes among diploid Brassica species/*** results revealed that the number of pseudogenes was greatest in Brassica oleracea(CC genome),followed by ***(AA genome)and then Brassica nigra(BB genome),implying that pseudogene differences emerged after species *** Brassica AA genomes,pseudogenes were distributed asymmetrically on chromosomes because of numerous chromosomal insertions/rearrangements,which contributed to the diversity among *** differences among subspecies were reflected in the flavor-related glucosinolate(GSL)***,turnip had the highest content of pungent substances,probably because of expansion of the methylthioalkylmalate synthase-encoding gene family in turnips;these genes were converted into pseudogenes in *** ***(Chiifu).RNA interference-based silencing of the gene encoding 2-oxoglutarate-dependent dioxygenase 2,which is also associated with flavor and anticancer substances in the GSL pathway,resulted in increased abundance of anticancer compounds and decreased pungency of turnip and *** findings revealed that pseudogene differences between turnip and Chiifu influenced the evolution of flavor-associated GSL metabolism-related genes,ultimately resulting in the different flavors of turnip and Chiifu.

关键词： turnip genome comparative genomics pseudogene evolution GSL biosynthesis flavor

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泡沫金属强化石蜡相变蓄热过程可视化实验

化工学报 2015年第2期66卷 497-503页

作者：杨佳霖杜小泽杨立军杨勇平华北电力大学电站设备状态监测与控制教育部重点实验室北京102206

相变材料的低热导率是限制潜热蓄热广泛应用的重要原因。将相变材料石蜡真空条件下注入到泡沫金属铜内制备泡沫金属铜-石蜡复合相变材料,通过铜的高热导率及高孔隙材料的大面体比来强化相变换热过程。采用DSC示差扫描量热法对石蜡进行... 详细信息

相变材料的低热导率是限制潜热蓄热广泛应用的重要原因。将相变材料石蜡真空条件下注入到泡沫金属铜内制备泡沫金属铜-石蜡复合相变材料,通过铜的高热导率及高孔隙材料的大面体比来强化相变换热过程。采用DSC示差扫描量热法对石蜡进行热物性测量获得准确的石蜡相变温度及相变潜热。以管壳式相变蓄热结构为对象,提取对称结构进行可视化设计,对比纯石蜡及泡沫金属铜-石蜡复合材料在相同运行条件下的相变过程,追踪二者熔化过程的相界面位置随时间的演化过程并布置热电偶准确测量材料内部的温度分布。结果显示加入泡沫金属后的复合材料的内部温差明显减小,温度分布均匀,蓄热热通量显著增大,有效缩短相变时间并缓解了自然对流造成的顶部过热和底部不熔化现象。

关键词：相变多孔介质泡沫金属自然对流可视化实验

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地热源非共沸工质有机朗肯循环发电性能分析

中国电机工程学报 2014年第32期34卷 5701-5708页

作者：郭丛杜小泽杨立军杨勇平电站设备状态监测与控制教育部重点实验室(华北电力大学) 北京市昌平区102206

建立有机朗肯循环热力学模型和蒸发器传热模型;基于工质的实验经验状态方程,利用REFPROP 8.0软件获得非共沸工质物性;以获得最佳的凝汽器温度匹配为原则选择工质。采用种温度的地热能,在给定的蒸发器和凝汽器夹点温差下,分析了采用组分... 详细信息

建立有机朗肯循环热力学模型和蒸发器传热模型;基于工质的实验经验状态方程,利用REFPROP 8.0软件获得非共沸工质物性;以获得最佳的凝汽器温度匹配为原则选择工质。采用种温度的地热能,在给定的蒸发器和凝汽器夹点温差下,分析了采用组分比例为0.64:0.36的R600a/R601非共沸工质的有机朗肯循环发电系统的特性,并与R601纯工质发电循环进行了比较。结果表明:以对外输出功为目标函数的利用地热的中低温有机朗肯循环发电系统中不宜加入回热器;对于蒸发器热源进出口温差较小的工况,如热源来自水蒸气凝结放热,采用混合工质的循环的性能不如纯工质的;有机朗肯循环采用混合工质时其最大对外输出功要高于纯工质的,且热源温度越低时,这种优势越明显。

关键词：有机朗肯循环混合物地热能热力学低温热源

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毛细微结构中延展薄液膜过渡区的蒸发特性

化工学报 2008年第8期59卷 1930-1935页

作者：赵娜杜小泽杨立军杨勇平华北电力大学能源的安全与清洁利用北京市重点实验室北京102206

毛细力驱动下微细通道内延展薄液膜的蒸发是很多高效热控和热沉装置的关键换热环节。借助表观接触角的演化,建立起包含固有弯月面、过渡薄液膜和平衡区三部分的延展薄液膜形状及其表面蒸发的物理数学模型,并考虑液膜的结构、工质物性和... 详细信息

毛细力驱动下微细通道内延展薄液膜的蒸发是很多高效热控和热沉装置的关键换热环节。借助表观接触角的演化,建立起包含固有弯月面、过渡薄液膜和平衡区三部分的延展薄液膜形状及其表面蒸发的物理数学模型,并考虑液膜的结构、工质物性和通道特征尺度,引入分离压力和毛细压力比确定液膜不同区域的范围。分析结果表明,过渡薄液膜区域占整个延展弯月面区的比例很小,但气液界面的温度变化非常明显;薄液膜过渡区对传热的主要贡献不在于增加总换热量,而是通过界面温度变化产生的Marangoni效应,对整个液膜区域的流动产生显著的"泵吸"作用。描述了过渡薄液膜区表面蒸发率和液膜平均速度的变化规律,发现受液膜导热热阻和分离压力产生吸附作用的综合影响,该区域的蒸发率存在局部最大值。

关键词：延展薄液膜接触角蒸发

基于粒子群优化BP神经网络的风电机组齿轮箱故障诊断方法

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太阳能学报 2012年第1期33卷 120-125页

作者：龙泉刘永前杨勇平新能源电力系统国家重点实验室(华北电力大学) 北京102206

提出了一种基于粒子群优化BP神经网络风电机组齿轮箱故障诊断方法。粒子群算法不需要计算梯度,可以兼顾全局寻优和局部寻优。利用粒子群算法对BP网络权值和偏置进行优化,减少了BP神经网络算法陷入局部最优解的风险,提高了神经网络的训... 详细信息

提出了一种基于粒子群优化BP神经网络风电机组齿轮箱故障诊断方法。粒子群算法不需要计算梯度,可以兼顾全局寻优和局部寻优。利用粒子群算法对BP网络权值和偏置进行优化,减少了BP神经网络算法陷入局部最优解的风险,提高了神经网络的训练效率,加快了网络的收敛速度。考虑风电齿轮箱振动信号的不确定性、非平稳性和复杂性,提取功率谱熵、小波熵、峭度、偏度、关联维数和盒维数作为故障特征。经测试,算法诊断结果正确,表明了PSO优化BP神经网络用于风电机组齿轮箱故障诊断的有效性和实用性。

关键词：风电机组齿轮箱故障诊断粒子群优化算法 BP神经网络故障特征