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Osteogenesis stimulation by copper-containing 316L stainless steel via activation of akt cell signaling pathway and Runx2 upregulation

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Journal of Materials Science & Technology 2019年第11期35卷 2727-2733页

作者： yonghui yuan Shujing Jin Xun Qi Xudong Chen Wei Zhang Ke Yang Hongshan Zhong Key Laboratory of Diagnostic Imaging and Interventional Radiology of Liaoning Province Department of RadiologyThe First Affiliated Hospital of China Medical UniversityShenyang 110001China Research and Academic Department Cancer Hospital of China Medical University Liaoning Cancer Hospital&InstituteShenyang 110042China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China First Affiliated Hospital of Southern University of Science and Technology Shenzhen People's Hospital&Shenzhen Interventional Medical Engineering Research and Development CenterShenzhen 518020China

As a metallic orthopedic implant,316L stainless steel(316L SS)is used extensively for its good resistance to corrosion and mechanical ***,it takes a long time to achieve osseointegration between 316L SS and adjacent tissues due to its bio-inert ***,the aim is to improve the bio-adaption of 316L SS.A good approach is to add elements to materials to improve their osteogenic capabilities by the appropriate release of *** copper-containing 316L stainless steel(316L-Cu SS)was investigated in this work,where Cu is an essential trace element that can stimulates *** was found that 316L-Cu SS was bio-safe and did not affect the proliferation of co-cultured osteoblasts in comparison with 316L *** increased cell apoptosis on day 1 but inhibited it on day 3,which cooperates with new bone formation *** extend themselves more quickly and in a better manner on the surface of 316L-Cu SS,wheneven more pseudopodia are ***,the gene expression of alkaline phosphatase,collagen I and runt-related transcription factor 2(Runx2)in osteoblasts cultured with 316L-Cu SS was significantly ***2 protein expression increased,and osteogenesis was stimulated by 316L-Cu SS via an Akt cell signaling *** conclusion,316L-Cu SS stimulates osteogenesis through activation of the Akt cell signaling pathway and the upregulation of ***,316L-Cu SS is a promising material that may be used in surgical implants to stimulate osteogenesis.

关键词： Osteogenesis Cu addition Stainless steel Cell signaling pathway Bone

Biological applications of copper-containing materials

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Bioactive Materials 2021年第4期6卷 916-927页

作者： Peng Wang yonghui yuan Ke Xu Hongshan Zhong Yinghui Yang Shiyu Jin Ke Yang Xun Qi Key Laboratory of Diagnostic Imaging and Interventional Radiology of Liaoning Province Department of RadiologyThe First Affiliated Hospital of China Medical UniversityShenyangLiaoning110001China Clinical Research Center for Malignant Tumor of Liaoning Province Cancer Hospital of China Medical University Liaoning Cancer Hospital&InstituteShenyangLiaoning110042China Institute of Metal Research Chinese Academy of ScienceShenyang 110016China Suzhou Silvan Medical Co. LtdSuzhou 215006China

Copper is an indispensable trace metal element in the human body,which is mainly absorbed in the stomach and small intestine and excreted into the *** is an important component and catalytic agent of many enzymes and proteins in the body,so it can influence human health through multiple *** on the biological functions and benefits of copper,an increasing number of researchers in the field of biomaterials have focused on developing novel copper-containing biomaterials,which exhibit unique properties in protecting the cardiovascular system,promoting bone fracture healing,and exerting antibacterial *** can also be used in promoting incisional wounds healing,killing cancer cells,Positron Emission Tomography(PET)imaging,radioimmunological tracing and radiotherapy of *** the present review,the biological functions of copper in the human body are presented,along with an overview of recent progress in our understanding of the biological applications and development of copper-containing ***,this review also provides the prospective on the challenges of those novel biomaterials for future clinical applications.

关键词： Copper Biomaterials Angiogenesis Osteogenesis Antibacterial

Crystalline-amorphization-recrystallization structural transition and emergent superconductivity in van der Waals semiconductor SiP under compression

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 115-122页

作者： Chunhua Chen Zhenyu Ding yonghui Zhou Yifang yuan Nixian Qian Jing Wang Shuyang Wang Ying Zhou Chao An Min Zhang Xuliang Chen Xiaoping Yang Mingliang Tian Zhaorong Yang Anhui Key Laboratory of Low-Energy Quantum Materials and Devices High Magnetic Field LaboratoryHFIPSChinese Academy of SciencesHefei 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefei 230026China Key Laboratory of Material Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityHefei 230601China Institutes of Physical Science and Information Technology Anhui UniversityZhengzhou 450001China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

van der Waals(vdW)semiconductors have gained significant attention due to their unique physical properties and promising applications,which are embedded within distinct crystallographic ***,we report a pressure-induced crystallineamorphization-recrystallization transition under compression in binary vdW semiconductor *** compression to 52 GPa,bulk SiP undergoes a consecutive phase transition from pristine crystalline to amorphous phase,ultimately to recrystallized *** employing synchrotron X-ray diffraction experiments in conjunction with high-pressure crystal structure searching techniques,we reveal that the recrystallized Si P hosts a tetragonal structure(space group I4mm)and further transforms partially into a cubic phase(space group Fm3m).Consistently,electrical transport and alternating-current magnetic susceptibility measurements indicate the presence of three superconducting phases,which are embedded in separate crystallographic symmetries—the amorphous,tetragonal,and cubic ***,a high superconducting transition temperature of 12.3 K is observed in its recovered tetragonal phase during *** findings uncover a novel phase evolution path and elucidate a pressure-engineered structure-property relationship in vdW semiconductor *** results not only offer a new platform to explore the transformation between different structures and functionalities,but also provide new opportunities for the design and exploration of advanced devices based on vdW materials.

关键词： recrystallization transition amorphous

Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A_(2)receptors

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Science China(Life Sciences) 2024年第5期67卷 986-995页

作者： yuan Weng Xinyu Yang Qiansen Zhang Ying Chen Yueming Xu Chenyu Zhu Qiong Xie yonghui Wang Huaiyu Yang Mingyao Liu Weiqiang Lu Gaojie Song Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China

The adenosine subfamily G protein-coupled receptors A_(2A)R and A_(2B)R have been identified as promising cancer immunotherapy *** of the A_(2A)R/A_(2B)R dual antagonists,AB928,has progressed to a phaseⅡclinical trial to treat rectal ***,the precise mechanism underlying its dual-antagonistic properties remains ***,we report crystal structures of the A_(2A)R complexed with AB928 and a selective A_(2A)R antagonist *** structures revealed a common binding mode on A_(2A)R,wherein the ligands established extensive interactions with residues from the orthosteric and secondary *** contrast,the cAMP assay and A_(2A)R and A_(2B)R molecular dynamics simulations indicated that the ligands adopted distinct binding modes on A_(2B)*** analysis of their chemical structures suggested that AB928 readily adapted to the A_(2B)R pocket,while 2-118 did not due to intrinsic *** disparity potentially accounted for the difference in inhibitory efficacy between A_(2B)R and A_(2A)*** study serves as a valuable structural template for the future development of selective or dual inhibitors targeting A_(2A)R/A_(2B)R for cancer therapy.

关键词： adenosine receptor A2AR A2BR inhibitor dual-antagonism drug discovery

Robust,self-adhesive,and low-contact impedance polyvinyl alcohol/polyacrylamide dual-network hydrogel semidry electrode for biopotential signal acquisition

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SmartMat 2024年第2期5卷 67-82页

作者： Guangli Li Ying Liu Yuwei Chen yonghui Xia Xiaoman Qi Xuan Wan yuan Jin Jun Liu Quanguo He Kanghua Li Jianxin Tang Hunan Key Laboratory of Biomedical Nanomaterials and Devices College of Life Sciences and ChemistryHunan University of TechnologyZhuzhouChina Department of Neurology Zhuzhou People's HospitalZhuzhouChina Zhuzhou Institute for Food and Drug Control ZhuzhouChina

Herein,we fabricated a flexible semidry electrode with excellent mechanical performance,satisfactory self-adhesiveness,and low-contact impedance using physical/chemical crosslinked polyvinyl alcohol/polyacrylamide dual-network hydrogels(PVA/PAM DNHs)as an efficient saline *** resultant PVA/PAM DNHs showed admirable adhesive and compliance to the hairy scalp,facilitating the establishment of a robust electrode/skin interface for biopotential signal ***,the PVA/PAM DNHs steadily released trace saline onto the scalp to achieve the minimized potential drift(1.47±0.39 mV/min)and low electrode–scalp impedance(18.2±8.9 kΩ@10 Hz).More importantly,the application feasibility of real-world brain−computer interfaces(BCIs)was preliminarily validated by 10 participants using two classic BCI *** mean temporal cross-correlation coefficients between the semidry and wet electrodes in the eyes open/closed and the N200 speller paradigms are 0.919±0.054 and 0.912±0.050,*** electrodes demonstrate anticipated neuroelectrophysiological responses with similar *** semidry electrode could also effectively capture robust P-QRS-T peaks during electrocardiogram *** their outstanding advantages of fast setup,user-friendliness,and robust signals,the proposed PVA/PAM DNH-based electrode is a promising alternative to wet electrodes in biopotential signal acquisition.

关键词： brain-computer interface dual-network hydrogel electrocardiogram signals electroencephalography signals semidry electrode

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一种改良的猪肺动脉干平滑肌细胞培养方法

同济医科大学学报 2000年第5期29卷 383-384页

作者：袁永辉同济医科大学基础医学院病理学教研室武汉430030

在本室已建立的肺动脉平滑肌细胞 (PASMC)培养方法的基础上作了改进 :1用含 40 0 ml/ L PASMC条件培养液和 10 0 ml/ L胎牛血清 (FBS)的 PASMC混合培养液 (PASMCMM)代替含 10 0 m l/ L FBS的 M199培养液 ;2传代时间选在 90 %长满 ,即 PA... 详细信息

在本室已建立的肺动脉平滑肌细胞 (PASMC)培养方法的基础上作了改进 :1用含 40 0 ml/ L PASMC条件培养液和 10 0 ml/ L胎牛血清 (FBS)的 PASMC混合培养液 (PASMCMM)代替含 10 0 m l/ L FBS的 M199培养液 ;2传代时间选在 90 %长满 ,即 PASMC处在对数生长期末而停滞期前 ;3用 5～ 8滴 /瓶混合消化液传代 ,然后用含 10 0m l/ L小牛血清的 M199培养液终止反应 ,并使其贴壁 ,第 2 d改换成 PASMCMM。经此法培养的 PASMC具有生长快、分散更均匀的特点。细胞倍增时间 (4 5 .6 h)较改进前 (5 6 .8h)缩短 11.2 h。改进后的培养方法更加简便、实用、高效。因此是一种快速、并可大量获取优质

关键词：肺动脉干平滑肌细胞培养 DASMC

Effects of DDPH on HECCM-induced Proliferation and Immunophenotypes of the Pulmonary Vascular Pericytes

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2001年第3期21卷 184-187页

作者：袁永辉车东媛熊密 Department of Pathology School of Basic Medical Sciences Tongji Medical College Huazhong University of Science and Technology Wuhan 430030

In order to study the effects of 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino) propane hydrochloride (DDPH) on proliferation and immunophenotypes of newborn rat pulmonary vascular pericytes induced by hypoxic endothelial cell conditioned medium (HECCM) from porcine pulmonary arteries, the cultured pericytes were divided into 4 groups according to the endothelial cell conditioned medium (ECCM) used: normoxic ECCM (NECCM) group, NECCM+DDPH group, HECCM group and HECCM+DDPH group. Cell culture, immunocytochemical staining, image analysis and flow cytometric method were used to investigate the effects of HECCM and DDPH on the expression of α-smooth muscle actin (α-SM-Actin) antigen, CD34 antigen, S-100 antigen and proliferating cell nuclear antigen (PCNA) and cell cycle in pericytes. The results showed that the α-SM-Actin antigen in the pericytes in HECCM group was stronger positively expressed than in the other three groups, but CD34 antigen and S-100 antigen were negatively expressed. The expression of α-SM-Actin antigen, CD34 antigen and S-100 antigen was positive in the groups of NECCM, NECCM+DDPH and HECCM+DDPH; The expression of α-SM-Actin and PCNA in HECCM group was 1.32 times (P<0.01) and 1.24 times (P<0.05) that in NECCM group, 1.30 times (P<0.01) and 1.21 times (P<0.05) that in HECCM+DDPH group, respectively. The percentage of the cells in the GO-G1 phase in the HECCM group was lower by 11.7 % and 9.1 %, in S phase higher by 5.6 % and 4.2 %, in G2-M phase higher by 6.1 % and 4.9 % than in the groups of NECCM,HECCM+DDPH, respectively. The inhibitory rate of DDPH on the increased α-SM-Actin and PCNA syntheses in pericytes induced by HECCM were 23.4 % and 17.1 % respectively. The inhibitory rate on the increased pericytes from GO-G1 phase to S phase was 8.3 %. These results suggest that DDPH can directly inhibit pericytes from proliferation and immunophenotypical transformation of smooth muscle-like cells induced by HECCM.

关键词： DDPH pericyte immunophenotypes HECCM hypertension, pulmonary

超声场“聚能效应”的研究——超声场对氢键缔合的负载固定相解吸平衡的影响

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清华大学学报（自然科学版） 1998年第2期38卷 84-87,90页

作者：秦炜原永辉戴猷元清华大学化学工程系

以ＮＫＡ－Ⅱ树脂／ＴＢＰ／５０％乙醇和ＣＬ－ＴＢＰ树脂／苯酚／水为实验对象，测定了超声场条件下树脂吸附物解吸过程的动力学曲线，讨论了超声功率密度和温度对平衡条件下解吸物浓度的影响。结果表明，随着温度的升高和超声功率密... 详细信息

以ＮＫＡ－Ⅱ树脂／ＴＢＰ／５０％乙醇和ＣＬ－ＴＢＰ树脂／苯酚／水为实验对象，测定了超声场条件下树脂吸附物解吸过程的动力学曲线，讨论了超声功率密度和温度对平衡条件下解吸物浓度的影响。结果表明，随着温度的升高和超声功率密度的增大，平衡解吸物浓度呈上升趋势。超声场作用下的平衡解吸物浓度比无超声场同温度下的一般解吸过程的平衡解吸物浓度高。这反映了超声场“聚能效应”的强化作用。

关键词：超声场聚能效应解吸氢键缔合

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“乡村名师工作站”有效运行的思考及对策

教师教育学报 2020年第2期7卷 89-94页

作者：袁永惠云南师范大学云南西南联大干部教育学院

要保证和提升“乡村名师工作站”建设和运行的有效性,就必须清晰地认识乡村地域背景及其基本特征。借鉴“中小学幼儿园名师工作室”建设的成功经验,提出建设中小学“乡村名师工作站”要着力解决好“主持人的遴选”“内部管理机制的完善... 详细信息

要保证和提升“乡村名师工作站”建设和运行的有效性,就必须清晰地认识乡村地域背景及其基本特征。借鉴“中小学幼儿园名师工作室”建设的成功经验,提出建设中小学“乡村名师工作站”要着力解决好“主持人的遴选”“内部管理机制的完善”“学习资源的整合和利用”“网络平台的建设与使用”“特色亮点的打造”“建设经费的落实”和“乡村教师的时间安排”等关键问题,同时给出了相应的对策和建议。另外,本文还探讨了课例分享、考察学习、互助交流、强化研修、案例实践等学习方式对“乡村名师工作站”的作用和意义。

关键词：乡村名师工作站有效运行关键问题学习方式