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Stage II/III Rectal Cancer Patients Benefit from Extremely Early Initiation of Postoperative Adjuvant Chemotherapy: A Retrospective Study

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Journal of Cancer Therapy 2019年第1期10卷 36-52页

作者： Liuniu Xiao Li Zhu Yingming Chen Zhenlin Hou Lingwei Jia Junbo Hu yongdong feng Department of General Surgery of Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology Wuhan China Center for Experiment Medicine and Molecular Biology Tongji Hospital Affiliated to Tongji Medical College Wuhan China

Background: For Stage II/III rectal cancer patients, curative resection is the primary treatment, prescribing of postoperative adjuvant chemotherapy (PAC) is regarded as a standard therapy. The interval between surgery and the initiation of PAC is usually within 8 weeks. However, the optimal cut-off is still controversial. This study aimed to explore the impact of extremely early initiation of PAC for II/III rectal cancer. Methods: Patients with Stage II/III rectal cancer treated from January 2013 to December 2015 were retrospectively collected at the Department of Tongji Hospital. According to the starting point of PAC, patients were categorized into two groups: extremely early group (The interval of PAC ≤ 2 weeks) and normal group (The interval of PAC within 3 - 5 weeks). For the sake of evaluating the effectiveness of different intervals, Overall Survival rate (OS), Progress-Free Survival rate (PFS) and Recurrence or Metastasis Rate (RMR) were analyzed, as well as the Quality of Life Score. To estimate the safety of the extremely early PAC, we evaluated the first post chemotherapy adverse reactions and defecation ability, and analyzed the variance laboratory indexes around the first postoperative adjuvant chemotherapy. Results: A total of 267 patients were included in this study. Compared to normal group (192 cases), extremely early group (75 cases) of patients attained a better tendency of OS and PFS, although there were no significant statistical differences (OS: P = 0.0930;PFS: P = 0.1058). However, the RMR was significant lower (P = 0.0452) and the Quality of Life Score was significantly higher (P = 0.0090) in extremely early group. Multivariate analysis also showed that extremely early group had better defecation ability (P = 0.0149) and less side reactions of post chemotherapy, such as vomiting (P , got a higher level of inflammatory cells (P Conclusion: For Stage II/III rectal cancer patients, extremely early to start PAC not only might be effectively prol

关键词： Rectal Cancer Postoperative Adjuvant Chemotherapy Prognosis Quality of Life Chemotherapy-Associated Adverse Reaction

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Ensemble learning system to identify nutritional risk and malnutrition in cancer patients without weight loss information

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Science China(Life Sciences) 2023年第5期66卷 1200-1203页

作者： Liangyu Yin Jie Liu Ming Liu Jin Zheng Aiguo Xu Quanjun Lyu yongdong feng Zengqing Guo Hu Ma Jipeng Li Zhikang Chen Hui Wang Zengning Li Chunling Zhou Xi Gao Min Weng Qinghua Yao Wei Li Tao Li Hanping Shi Hongxia Xu Department of Clinical Nutrition Daping HospitalArmy Medical University(Third Military Medical University)Chongqing 400042China Institute of Hepatopancreatobiliary Surgery Southwest HospitalArmy Medical University(Third Military Medical University)Chongqing 400038China Department of General Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of Traditional Chinese Medicine Tangdu HospitalAir Force Medical University(The Fourth Military Medical University)Xi’an 710038China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Nutrition The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of GI Cancer Research Institute Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014China Department of Oncology The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000China Department of Experimental Surgery Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Colorectal and Anus Surgery Xiangya Hospital of Central South UniversityChangsha 410008China Department of Oncology The People’s Hospital of DujiangyanDujiangyan 611830China Department of Clinical Nutrition The First Hospital of Hebei Medical UniversityShijiazhuang 050031China Department of Clinical Nutrition The Fourth Affiliated Hospital of Harbin Medical UniversityHarbin 150001China Department of Oncology Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000China Department of Clinical Nutrition The First Affiliated Hospital of Kunming Medical UniversityKunming 650032China Department of Integrated Chinese and Western Medicine Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Hangzhou 310022China Cancer Center The First Hospital

Dear Editor,Malnutrition is a prevalent disease in oncology practice(Arends et al.,2017).With its cancer-specific prevalence ranging from 21%–72%,malnutrition is responsible for 10%–20% cancer deaths(Yin et al.,2021b).However,malnutrition is often underestimated,misclassified,or left untreated in cancer care(Hébuterne et al.,2014).

关键词： malnutrition cancer

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短肠综合征的治疗及进展

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华中科技大学学报（医学版） 2021年第4期50卷 522-527页

作者：贾凌威王桂华冯永东华中科技大学同济医学院附属同济医院胃肠外科中心武汉430030

短肠综合征严重影响患者生存质量,妨碍正常社交,但病例少见,临床认识普遍不足。补充必须营养成分及促进肠道再适应、营养支持治疗、肠康复治疗以及各种形式的非移植手术是短肠综合征的有效治疗手段,近年来发展迅速。小肠移植是短肠综合... 详细信息

短肠综合征严重影响患者生存质量,妨碍正常社交,但病例少见,临床认识普遍不足。补充必须营养成分及促进肠道再适应、营养支持治疗、肠康复治疗以及各种形式的非移植手术是短肠综合征的有效治疗手段,近年来发展迅速。小肠移植是短肠综合征的挽救性治疗,但手术时间跨度大,移植后急性排斥仍是阻碍其发展的主要原因。该文就短肠综合征的病理生理机制和治疗进展展开综述,为临床医生根据患者病情开展个体化治疗提供理论依据。

关键词：短肠综合征营养支持肠康复治疗手术

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智能热网统一服务平台的架构及建设方案

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煤气与热力 2018年第3期38卷 7-10页

作者：冯用栋北京天时前程自动化工程技术有限公司北京100086

许多供热企业已形成了热网自动化系统、客服系统等应用子系统。分析制约智能热网系统发展的问题,介绍智能热网系统中应用子系统架构的演变。为解决现阶段智能热网存在的问题,在充分利用已有应用子系统的基础上,基于云计算平台、企业服... 详细信息

许多供热企业已形成了热网自动化系统、客服系统等应用子系统。分析制约智能热网系统发展的问题,介绍智能热网系统中应用子系统架构的演变。为解决现阶段智能热网存在的问题,在充分利用已有应用子系统的基础上,基于云计算平台、企业服务总线(ESB)搭建智能热网统一服务平台,对其架构与建设方案进行分析。

关键词：智能热网云计算企业服务总线(ESB) 统一服务平台

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缺血缺氧对体外培养星形胶质细胞细胞活化和细胞周期的影响

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中国组织化学与细胞化学杂志 2006年第5期15卷 481-486页

作者：骆翔喻志源冯永东王伟华中科技大学同济医学院附属同济医院神经内科武汉430030

目的观察缺血缺氧损伤对星形胶质细胞细胞活化和细胞周期的影响。方法用流式细胞仪及BrdU掺入法检测缺血缺氧后不同时间点星形胶质细胞细胞周期变化和细胞的增殖活力;用荧光免疫细胞化学技术测定胶质细胞纤维酸性蛋白(GFAP)及细胞周期蛋... 详细信息

目的观察缺血缺氧损伤对星形胶质细胞细胞活化和细胞周期的影响。方法用流式细胞仪及BrdU掺入法检测缺血缺氧后不同时间点星形胶质细胞细胞周期变化和细胞的增殖活力;用荧光免疫细胞化学技术测定胶质细胞纤维酸性蛋白(GFAP)及细胞周期蛋白cyclinD1的表达水平。结果体外缺血缺氧损伤后星形胶质细胞S期较正常组明显增高,6h达高峰,BrdU掺入法显示损伤后6h星形胶质细胞的增殖活力最高,而随后S期细胞数目及细胞增殖活力都呈下降趋势。在缺血缺氧早期,GFAP阳性染色增强,6h最高;缺血缺氧12h后GFAP阳性染色变弱,而cyclinD1的表达在损伤后逐渐增加,在24h时达高峰。结论缺血缺氧损伤激活星形胶质细胞,使其进入新的细胞周期,出现细胞的增殖反应;cyclinD1参与了损伤后星形胶质细胞的修复和增殖;细胞周期事件与星形胶质细胞的增殖活化密切相关。

关键词：脑缺血星形胶质细胞细胞周期

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肿瘤相关成纤维细胞通过低氧诱导因子-1通路促进结直肠癌细胞增殖

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中华实验外科杂志 2019年第11期36卷 2022-2025页

作者：姚洋张容圣李庚冯永东华中科技大学同济医学院附属同济医院胃肠外科武汉430030

目的研究结直肠癌中肿瘤相关成纤维细胞促进结直肠癌细胞增殖的机制。方法体外培养原代结直肠癌组织肿瘤相关成纤维细胞(CAF)以及癌旁正常纤维细胞(NF),利用慢病毒高表达人端粒酶反转录酶(hTERT)使其永生化,收集上清处理肿瘤细胞以及将... 详细信息

目的研究结直肠癌中肿瘤相关成纤维细胞促进结直肠癌细胞增殖的机制。方法体外培养原代结直肠癌组织肿瘤相关成纤维细胞(CAF)以及癌旁正常纤维细胞(NF),利用慢病毒高表达人端粒酶反转录酶(hTERT)使其永生化,收集上清处理肿瘤细胞以及将肿瘤相关成纤维细胞或癌旁正常成纤维细胞和肿瘤细胞置入Transwell共培养系统,脂质体介导低氧诱导因子-1(HIF-1α)为靶分子的小干扰RNA(siRNA)转染结肠癌细胞株SW48后,利用细胞核增殖抗原(Ki-67)流式染色、集落形成实验、流式细胞周期检测测定细胞增殖能力的变化,利用细胞计数试剂盒(CCK-8)检测生长曲线,采用蛋白质印迹法(Western blot)检测细胞中HIF-1α的表达。应用SPSS 17.0统计软件分析,计量资料以均值±标准差(Mean±SD)表示,用独立样本t检验来比较组间差异。结果siRNA 1~2组HIF-1α表达水平明显低于阴性对照组,CAF上清处理组较空白对照组克隆生成率明显增高(43.6%比12.4%,t=-12.376,P<0.01),流式细胞周期检测显示CAF共培养组、NF共培养组,HIF-1αsi+CAF共培养组G1~G0期、S期细胞比例分别为(54.6±2.5)%比(65.1±3.0)%比(67.2±1.0)%(F=6.400,P<0.05)、(30.51±2.3)%比(20.3±1.8)%比(21.6±3.8)%(F=4.690,P<0.05),CAF共培养组、NF共培养组、HIF-1αsi+CAF共培养组Ki-67阳性细胞比例分别为(98.4±0.6)%比(95.3±0.8)%比(94.6±0.5)%(F=6.800,P<0.05)。结论肿瘤相关成纤维细胞可以通过间接效应促进结直肠癌肿瘤细胞的增殖,而这一效应可能依赖HIF-1α。

关键词：结直肠癌肿瘤相关成纤维细胞低氧诱导因子-1

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肿瘤相关成纤维细胞上调自噬促进结直肠癌耐药

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中华实验外科杂志 2018年第10期35卷 1878-1880页

作者：张容圣李庚张小超胡俊波冯永东华中科技大学同济医学院附属同济医院胃肠外科武汉430030

目的探讨结直肠癌中肿瘤相关成纤维细胞（CAFs）促进结直肠癌肿瘤细胞（CRC）对5-氟尿嘧啶（5-Fu）耐药及其机制。方法体外培养原代结直肠癌组织CAFs及普通纤维细胞（NFs），收集肿瘤相关成纤维细胞来源上清（CAFCM）或普通纤维细胞来... 详细信息

目的探讨结直肠癌中肿瘤相关成纤维细胞（CAFs）促进结直肠癌肿瘤细胞（CRC）对5-氟尿嘧啶（5-Fu）耐药及其机制。方法体外培养原代结直肠癌组织CAFs及普通纤维细胞（NFs），收集肿瘤相关成纤维细胞来源上清（CAFCM）或普通纤维细胞来源上清（NFCM）与5-Fu共同处理人类结肠癌细胞株SW48，利用Hoeehst33342染色观察凋亡细胞形态变化、膜联蛋白V-异硫氰酸荧光素（AnnexinV-FITC）／碘化丙锭（PI）双染检测肿瘤细胞早期凋亡比例的变化，细胞计数试剂盒（CCKl8）绘制毒性曲线，Westernblot法检测甘油醛-3-磷酸脱氢酶（GAPDH）、LC3、Beelin-1的表达水平，利用自噬抑制剂3-甲基腺嘌呤（3-MA）检测自噬在此过程中的作用。结果Hoechst33342染色显示，肿瘤细胞5-Fu较空白对照组及5-Fu＋CAFCM组凋亡细胞比例明显上升，AnnexinV-FITC／PI双染示，3-MA组、***组、5-Fu＋CAFCM组、5-Fu＋CAFCM＋3-MA组凋亡百分比分别为（7．21±1．3）％、（35．4％±2．6）％、（19．1±0．5）％、（30．4±2．1）％，Western法检测发现5-Fu＋CAFCM组较5-Fu＋NFCM组的LC3-B上升（1．52±0．4）倍、beclin-1表达水平上升（1．76±0．3）倍，与5-Fu比较，5-Fu＋CAFCM组在各时问点细胞活性均明显上升，而5-Fu＋CAFCM＋3-MA组与5-Fu组比，细胞活力差异无统计学意义。以上结论显示CAFCM＋5-Fu组凋亡率较5-Fu组明显减少，差异有统计学意义（P=0．000），3-MA＋CAFCM＋***组凋亡率较CAFCM＋5-Fu组明显上升，差异有统计学意义（P=0．008），CAFCM＋5-Fu组较NFCM＋5-Fu组LC3-B、beclin-l表达增强，差异统计学意义（P=0．040、0．001）。结论肿瘤相关成纤维细胞可以减少结直肠癌对5-Fu的药物敏感性，而这-效应可能依赖保护性自噬的增强。

关键词：结直肠癌肿瘤相关成纤维细胞 5-氟尿嘧啶自噬

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Effects of Ischemia and Anoxia on Cell Activation and Cell Cycle of Cultured Astrocytes in vitro

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2006年第1期26卷 21-24页

作者：骆翔喻志源冯永东王伟 Department of Neurology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

To examine the effects of ischemia and anoxia on cell activation and cell cycle of astrocytes in vitro, the cell cycles and the proliferation of astrocytes in different time points after ischemia and anoxia were studied by flow cytometry and BrdU labeling and the expression of GFAP and cyclin D1 was detected by the fluorescence immunochemistry. After ischemia and anoxia in vitro, the astrocytes in S phase were significantly increased as compared with those in the normal group and the proliferating ability of the astrocytes was highest 6 h after the treatment as revealed by BrdU pulse labeling, but the astrocytes in S phase and proliferating ability were decreased after 6 h. At the early stages of ischemia and anoxia, the positive staining intensity of GFAP was increased, peaked at 6th h, while 12 h after the ischemia and anoxia, the positive staining intensity of GFAP became weak, and the expression of cyclin D1 was gradually increased after the ischemic and anoxic damage. It is concluded that astrocytes are activated to proliferate and enter new cycle events by ischemia and anoxia, and cyclin D1 is implicated in the proliferation and repair of astrocytes. The cell cycle events are closely associated with the proliferation and activation of astrocytes.

关键词： brain ischemia astrocytes cell cycle

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Mesozoic uplift of the Dabashan and Micangshan-Hannan Dome in the South Qinling orogenic belt

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Science China Earth Sciences 2022年第3期65卷 426-436页

作者： yongdong LI Xiong XIONG Yashan feng School of Geophysics and Geomatics University of GeosciencesWuhan 430074China

The topographic evolution of continental orogens is important for understanding continental orogenic processes,geodynamic mechanisms,and climatic and environmental *** Qinling Orogen is a major orogenic belt in China,and its uplift history can provide insights into the tectonic configuration and geodynamics of China and East *** studies have shown that the Dabashan and Micangshan-Hannan Dome(MHD)in the South Qinling orogenic belt were uplifted during the ***,the magnitude of the uplift remains *** this study,using sedimentary records in the northern Sichuan Basin and lithospheric flexural modeling,we estimated the magnitude of Mesozoic uplift of the Dabashan and MHD,along with the effective elastic thickness(Te)of the Sichuan *** Dabashan and MHD were uplifted by approximately 1220 and 880 m during the Middle Jurassic and Early Cretaceous,***,we propose that the present-day elevation of the Dabashan and MHD is primarily the result of Mesozoic *** differences in the duration and amount of uplift between different tectonic units indicate that the uplift processes and driving mechanisms in the South Qinling orogenic belt were different in the Mesozoic and *** uplift was the result of convergence of the North China and South China blocks advanced from east to west,whereas Cenozoic uplift was driven by ongoing indentation of the Indian Plate into Eurasia from southwest to *** lithospheric strength of the northern Sichuan Basin was weakened from the Middle Jurassic to Early Cretaceous,and Tedecreased from 73 to 57 *** may have been caused by the flexure-related bending stresses in the lithosphere that developed due to the large topographic loading.

关键词： South Qinling orogenic belt Dabashan Micangshan-Hannan Dome Mesozoic Uplift

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成人十二指肠异物27例手术治疗临床分析

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临床外科杂志 2021年第3期29卷 278-281页

作者：贾凌威冯永东陈礼升华中科技大学同济医学院附属同济医院胃肠外科武汉430000

目的总结十二指肠异物的临床特征和规范化外科治疗经验。方法2008年1月~2020年9月经术前检查(腹部平片、腹部CT和/或胃镜)证实为十二指肠异物并接受手术治疗的病人27例,主要手术方式包括十二指肠切开术、胃窦切开术和空肠切开术,附加手... 详细信息

目的总结十二指肠异物的临床特征和规范化外科治疗经验。方法2008年1月~2020年9月经术前检查(腹部平片、腹部CT和/或胃镜)证实为十二指肠异物并接受手术治疗的病人27例,主要手术方式包括十二指肠切开术、胃窦切开术和空肠切开术,附加手术方式包括喂养性空肠造瘘术、胃造瘘术。同时收集一般临床特征、手术时间、出血量、术后住院时间、并发症等资料。结果十二指肠异物主要包括柿石等植物性结石10例(37%),牙签4例(15%),刀片3例(12%)等。27例病例中,采取十二指肠切开术16例,胃窦切开术8例,空肠切开术3例。每种术式适合处理十二指肠不同部位(球部,降部,水平部和升部)的异物,十二指肠切开修补术平均手术时间(144±57)分钟,平均出血量(112±105)ml,平均术后住院时间(13.4±19.0)天。胃窦切开术和空肠切开术手术时间、出血量、术后住院时间均较十二指肠切开术有减少趋势。主要并发症为十二指肠肠漏1例,肺部感染2例,切口感染2例,再剖腹探查1例。结论十二指肠切开术主要针对水平部异物,胃窦切开术和空肠切开术分别适合十二指肠球降范围内和升部附近的异物。3种术式均安全可靠,临床上应针对异物滞留部位选择手术方式。

关键词：十二指肠消化道异物手术

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