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Liu-Jun-Zi decoction alleviates chemotherapy-induced anorexia by regulating gut microbiota and TLR4/MyD88/NF-κB p65 signaling pathway

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Traditional Medicine Research 2024年第8期9卷 47-58页

作者： Yu-Jie Gao Xi-Pei Wu Bin-Bin Ye yong-zhao dai Yao-Zhong zhao Xiu-Xiu Liao Ke Nie School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China

Background:Liu-Jun-Zi decoction(LJZD),a classical nourishing formula in China,has been proven to be effective in treating chemotherapy-induced *** this study,the mechanism of LJZD in alleviating chemotherapy-induced anorexia was discussed from the aspects of regulating gut microbiota,repairing intestinal barrier injury and inhibiting inflammatory ***:A rat model of chemotherapy-induced anorexia was established using *** study evaluated the therapeutic effects of LJZD by observing the weight,food intake,and intestinal pathology of *** impact of LJZD on gut microbiota and metabolites,specifically short-chain fatty acids,was investigated through gut microbiota analysis and targeted *** anti-inflammatory and intestinal protective effects of LJZD were assessed by examining the expression of intestinal tight junction proteins associated with the inflammatory ***:LJZD alleviated cisplatin-induced inflammation and intestinal barrier disruption,as evidenced by upregulated expression of tight junction protein 1(TJ-1)and occludin,along with reduced serum levels of interleukin 6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and ***,LJZD alleviated microbiota imbalance and regulated the levels of short-chain fatty acids,especially increased the relative abundance of Coriobacteriales Incertae Sedis,Lactabacillus johnsonii F19785,Parasutterella,and reduced the *** the hypothalamus,LJZD exerts suppressive effects on the toll-like receptor 4(TLR4)/myeloid differentiation factor 88(MyD88)/nuclear factor-κB(NF-κB)p65 signaling pathway,leading to a downregulation in the transcriptional activity of IL-6 and IL-1β,as well as Interleukin 6 receptors(IL-6R)and Interleukin-1βreceptors(IL-1R1)mRNA expression ***:In summary,LJZD alleviate chemotherapy-induced anorexia by modulating the gut microbiota,repairing the intestinal mechanical barriers,and suppressing the TLR4

关键词： Liu-Jun-Zi decoction chemotherapy-induced anorexia cisplatin TLR4/MyD818/NF-κB p65 gut microbiota rat

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State of the art of lightweight aggregates used in lightweight refractories for working lining of high-temperature furnaces

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Journal of Iron and Steel Research International 2024年第6期31卷 1320-1343页

作者： Wei Zhang Wen-yong dai Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina Research and Development Department AGC Plibrico(Dalian)Industries Inc.Dalian 116600LiaoningChina

Lightweight refractories for the working lining of high-temperature furnaces play an important role in the smelting of advanced steels and *** prepare lightweight refractories for the working lining of high-temperature furnaces,the synthesis of lightweight aggregates is the ***,the research on the synthesis of lightweight aggregates with high service temperature,low thermal conductivity,high strength,and good slag resistance has received widespread *** available literature on the synthesis of lightweight aggregates was summarized,including corundum,mullite,mullite-corundum,spinel,corundum-spinel,cordierite,cordierite-mullite,calcium hexaluminate,corundum-calcium hexaluminate,bauxite,magnesia,magnesia-based,and forsterite-based ***,the future development trend of lightweight aggregates was proposed.

关键词： Lightweight aggregate Lightweight refractory Working lining Apparent porosity Closed porosity Thermal conductivity Pore-forming approach

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Source apportionment and suitability evaluation of seasonal VOCs contaminants in the soil around a typical refining-chemical integration park in China

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Journal of Environmental Sciences 2024年第3期137卷 651-663页

作者： Xu zhao Jing Meng Qianqian Li Guijin Su Qifan Zhang Bin Shi Lingwen dai yong Yu Key Laboratory of Environmental Nanotechnology and Health Effects State Key Laboratory of Environmental Chemistry and EcotoxicologyResearch Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China State Environmental Protection Key Laboratory of Quality Control in Environmental Monitoring China National Environmental Monitoring CenterBeijing 100012China

Accurate source apportionment of volatile organic compounds(VOCs)in soil nearby petrochemical industries prevailing globally,is critical for preventing ***,in the process,seasonal effect on contamination pathways and accumulation of soil VOCs is often ***,Yanshan Refining-Chemical Integration Park,including a carpet,refining,synthetic rubber,and two synthetic resin zones,was selected for *** variations resulted in a gradual decrease of 31 VOCs in soil from winter to summer.A method of dry deposition resistance model coupling partitioning coefficient model was created,revealing that dry deposition by gas phase was the primary pathway for VOCs to enter soil in winter and spring,with 100 times higher fux than by particle *** profiles for five zones were built by gas sampling with distinct substance indicators screened,which were used for positive matrix factorization factors *** of the five zones were 14.9%,20.8%,13.6%,22.1%,and 28.6%in winter and 33.4%,12.5%,10.7%,24.9%,and 18.5%in spring,*** variation in the soil sorption capacity of VOCs causes inter-seasonal differences in *** better correlation between dry deposition capacity and soil storage of VOCs made root mean square and mean absolute errors decrease averagely by 8.8%and 5.5%in winter compared to *** study provides new perspectives and methods for the source apportionment of soil VOCs contamination in industrial sites.

关键词： Dry deposition resistance model Positive matrix factorization model Partitioning coefficient model Contamination pathway Source profile

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Supramolecular polymer-based gel fracturing fluid with a double network applied in ultra-deep hydraulic fracturing

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Petroleum Science 2024年第3期21卷 1875-1888页

作者： yong-Ping Huang yong Hu Chang-Long Liu Yi-Ning Wu Chen-Wei Zou Li-Yuan Zhang Ming-Wei zhao Cai-Li dai School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China Shandong Key Laboratory of Oilfield Chemistry China University of Petroleum(East China)Qingdao 266580ShandongPR China SINOPEC Petroleum Exploration and Production Research Institute Beijing102206PR China CNOOC China Co Ltd Tianjin BranchTianjin300459PR China

A gel based on polyacrylamide,exhibiting delayed crosslinking characteristics,emerges as the preferred solution for mitigating degradation under conditions of high temperature and extended shear in ultralong *** viscosity/viscoelasticity of the fracturing fluid was required to maintain excellent proppant suspension properties before *** into account both the cost and the potential damage to reservoirs,polymers with lower concentrations and molecular weights are generally *** this work,the supramolecular action was integrated into the polymer,resulting in significant increases in the viscosity and viscoelasticity of the synthesized supramolecular polymer *** double network gel,which is formed by the combination of the supramolecular polymer system and a small quantity of Zr-crosslinker,effectively resists temperature while minimizing permeability damage to the *** results indicate that the supramolecular polymer system with a molecular weight of(268—380)×10^(4)g/mol can achieve the same viscosity and viscoelasticity at 0.4 wt%due to the supramolecular interaction between polymers,compared to the 0.6 wt%traditional polymer(hydrolyzed polyacrylamide,molecular weight of 1078×10^(4)g/mol).The supramolecular polymer system possessed excellent proppant suspension properties with a 0.55 cm/min sedimentation rate at 0.4 wt%,whereas the0.6 wt%traditional polymer had a rate of 0.57 cm/*** comparison to the traditional gel with a Zrcrosslinker concentration of 0.6 wt%and an elastic modulus of 7.77 Pa,the double network gel with a higher elastic modulus(9.00 Pa)could be formed only at 0.1 wt%Zr-crosslinker,which greatly reduced the amount of residue of the fluid after *** viscosity of the double network gel was66 m Pa s after 2 h shearing,whereas the traditional gel only reached 27 m Pa s.

关键词： Ultra-deep reservoir Gel fracturing fluid Double network Supramolecular polymer system Proppant suspension property

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Mechanical Modeling and Analysis of Stability Deterioration of Production Well During Marine Hydrate Depressurization Production

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China Ocean Engineering 2024年第2期38卷 338-351页

作者： SUN Huan-zhao CHANG Yuan-jiang SUN Bao-jiang WANG Kang CHEN Guo-ming LI Hao dai yong-guo Centre for Offshore Engineering and Safety Technology China University of Petroleum(East China)Qingdao 266580China School of Petroleum Engineering China University of Petroleum(East China)Qingdao 266580China Jiangsu Shuguang Oil Tools Co. LtdTaizhou 225532China

Different from oil and gas production,hydrate reservoirs are shallow and unconsolidated,whose mechanical properties deteriorate with hydrate ***,the formations will undergo significant subsidence during depressurization,which will destroy the original force state of the production ***,existing research on the stability of oil and gas production wells assumes the formation to be stable,and lacks consideration of the force exerted on the hydrate production well by formation subsidence caused by hydrate decomposition during *** fill this gap,this paper proposes an analytical method for the dynamic evolution of the stability of hydrate production well considering the effects of hydrate *** on the mechanical model of the production well,the basis for stability analysis has been proposed.A multi-field coupling model of the force state of the production well considering the effect of hydrate decomposition and formation subsidence is established,and a solver is *** analytical approach is verified by its good agreement with the results from the numerical method.A case study found that the decomposition of hydrate will increase the pulling-down force and reduce the supporting force,which is the main reason for the stability *** higher the initial hydrate saturation,the larger the reservoir thickness,and the lower the production pressure,the worse the stability or even *** work can provide a theoretical reference for the stability maintaining of the production well.

关键词： natural gas hydrate production well depressurization production formation deformation stability deterioration

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Reduction of unactivated alkyl chlorides enabled by light-induced single electron transfer

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Science China Chemistry 2024年第2期67卷 471-481页

作者： Lei dai zhao-Fei Zhang Xiang-Yu Chen School of Chemical Sciences University of the Chinese Academy of SciencesBeijing100049China Institute of Chemistry Chinese Academy of SciencesBeijing100190China Binzhou Institute of Technology Weiqiao-UCAS Science and Technology ParkBinzhou256606China

Alkyl chlorides are abundant and easily accessible starting ***,due to the high reduction potentials associated with unactivated alkyl chlorides,achieving their single electron reduction remains a persistent *** challenge has spurred the exploration of efficient activation methods to overcome this *** recent years,photocatalysis has emerged as a mild and potent tool for the single electron reduction of unactivated alkyl chlorides,opening up new possibilities in this *** the rapid advancements in this area,a comprehensive review that provides a conceptual understanding of this emerging field,with a specific focus on reaction design and catalytic mechanisms,would be timely and highly ***,we present an overview of various synthetic techniques for photoinduced single electron reduction of unactivated alkyl ***,we also discuss the limitations of the present methods and future directions that lie ahead in this field.

关键词： photocatalysis unactivated alkyl chlorides single electron transfer radical reactions

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Quantitative characterizations of anisotropic dynamic properties in organic-rich shale with different kerogen content

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Petroleum Science 2024年第2期21卷 855-865页

作者： Jian-yong Xie Yan-Ping Fang Xing-Hua Wu Jian'er zhao Jun-Cheng dai Jun-Xing Cao Ji-Xin Deng State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu610059SichuanChina Key Lab of Earth Exploration&Information Techniques of Ministry of Education Geophysical InstituteChengdu University of TechnologyChengdu610059SichuanChina PetroChina Southwest Oil&Gasfield Company Chengdu610017SichuanChina

Understanding the quantitative responses of anisotropic dynamic properties in organic-rich shale with different kerogen content(KC)is of great significance in hydrocarbon exploration and *** controlled experiments with a single variable is challenging for natural shales due to their high variations in components,diagenesis conditions,or pore *** employed the hot-pressing technique to construct 11 well-controlled artificial shale with varying *** artificial shale samples were successive machined into prismatic shape for ultrasonic measurements along different *** revealed bedding perpendicular P-wave velocities are more sensitive to the increasing KC than bedding paralleling velocities due to the preferential alignments of *** elastic stiffnesses except C_(13)are generally decreasing with the increasing KC,the variation of C_(1) and C_(33)on kerogen content are more sensitive than those of C_(44)and C_(66).Apparent dynamic mechanical parameters(v and E)were found to have linear correlation with the true ones from complete anisotropic equations independent of KC,which hold value towards the interpretation of well logs consistently across formations,Anisotropic mechanical parameters(ΔE and brittlenessΔB)tend to decrease with the reducing KC,withΔB showing great sensitivity to KC *** the range of low KC(10%)shale,compilation of data from natural organic rich-shales globally verified the similar systematic relationships that can be empirically used to predict the fraction of KC in shales.

关键词： Elastic properties Organic shale Anisotropy Kerogen content Physical modeling

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How plants sense and respond to osmotic stress

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Journal of Integrative Plant Biology 2024年第3期66卷 394-423页

作者： Bo Yu dai-Yin Chao Yang zhao Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesThe Chinese Academy of SciencesShanghai 200032China Key Laboratory of Plant Carbon Capture The Chinese Academy of SciencesShanghai 200032China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyThe Chinese Academy of SciencesShanghai 200032China University of Chinese Academy of Sciences Beijing 100049China

Drought is one of the most serious abiotic stresses to land *** sense and respond to drought stress to survive under water *** have studied how plants sense drought stress,or osmotic stress caused by drought,ever since Charles Darwin,and gradually obtained clues about osmotic stress sensing and signaling in *** stress is a physical stimulus that triggers many physiological changes at the cellular level,including changes in turgor,cell wall stiffness and integrity,membrane tension,and cell fluid volume,and plants may sense some of these stimuli and trigger downstream *** this review,we emphasized water potential and movements in organisms,compared putative signal inputs in cell wall-containing and cell wall-free organisms,prospected how plants sense changes in turgor,membrane tension,and cell fluid volume under osmotic stress according to advances in plants,animals,yeasts,and bacteria,summarized multilevel biochemical and physiological signal outputs,such as plasma membrane nanodomain formation,membrane water permeability,root hydrotropism,root halotropism,Casparian strip and suberin lamellae,and finally proposed a hypothesis that osmotic stress responses are likely to be a cocktail of signaling mediated by multiple *** also discussed the core scientific questions,provided perspective about the future directions in this field,and highlighted the importance of robust and smart root systems and efficient source-sink allocations for generating future high-yield stress-resistant crops and plants.

关键词： cell volume drought membrane tension osmotic stress turgor

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Preparation and performance evaluation of the slickwater using novel polymeric drag reducing agent with high temperature and shear resistance ability

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Petroleum Science 2024年第2期21卷 1113-1121页

作者： Ming-Wei zhao Zhen-Feng Ma Cai-Li dai WeiWu yong-Quan Sun Xu-Guang Song Yun-Long Cheng Xiang-Yu Wang National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina Shandong Key Laboratory of Oilfield Chemistry China University of Petroleum(East China)Qingdao266580ShandongChina Sinopec Shengli Oilfield Dongying257001ShandongChina Department of Chemical and Materials Engineering University of AlbertaEdmontonAB T6G 1H9Canada East China Petroleum Bureau of Sinopec Nanjing210011JiangsuChina

Slickwater fracturing fluids are widely used in the development of unconventional oil and gas resources due to the advantages of low cost,low formation damage and high drag reduction ***,their performance is severely affected at high *** reducing agent is the key to determine the drag reducing performance of *** this work,in order to further improve the temperature resistance of slickwater,a temperature-resistant polymeric drag reducing agent(PDRA)was synthesized and used as the basis for preparing the temperature-resistant *** slickwater system was prepared with the compositions of 0.2 wt%PDRA,0.05 wt%drainage aid nonylphenol polyoxyethylene ether phosphate(NPEP)and 0.5 wt%anti-expansion agent polyepichlorohydrindimethylamine(PDM).The drag reduction ability,rheology properties,temperature and shear resistance ability,and core damage property of slickwater were systematically studied and *** contrast to on-site drag reducing agent(DRA)and HPAM,the temperature-resistant slickwater demonstrates enhanced drag reduction efficacy at 90℃,exhibiting superior temperature and shear resistance ***,the drag reduction retention rate for the slickwater achieved an impressive 90.52%after a 30-min shearing ***,the core damage is only 5.53%.We expect that this study can broaden the application of slickwater in high-temperature reservoirs and provide a theoretical basis for field applications.

关键词： Unconventional resources Polymeric drag reducing agent Slickwater High drag reduction rate Temperature resistance

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Homological Transfer between Additive Categories and Higher Differential Additive Categories

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1325-1344页

作者： Xi TANG zhao yong HUANG School of Science Guilin University of Aerospace TechnologyGuilin 541004P.R.China Department of Mathematics Nanjing UniversityNanjing 210093P.R.China

Given an additive category C and an integer n≥*** higher differential additive category consists of objects X in C equipped with an endomorphism ϵ_(X)satisfying ϵ_(X)^(n).Let R be a,finite-dimensional basic algebra over an algebraically closed field and T the augmenting functor from the category of finitely generated left R-modules to that of finitely generated left R/(t^(n))-*** is proved that a finitely generated left R-module M isτ-rigid(respectively,(support)τ-tilting,almost completeτ-tilting)if and only if so is T(M)as a left R[t]/(t^(n))-***,R isτm-selfinjective if and only if so is R[t]/(t^(n)).

关键词： Higher differential objects Wakamatsu tilting subcategories G_(ω)-projective modules sup-portτ-tilting modules τ_(m)-selfinjective algebras precluster tilting subcategories

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