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Berberine hydrochloride alleviates chronic prostatitis/chronic pelvic pain syndrome by modifying gut microbiome signaling

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Asian Journal of Andrology 2024年第5期26卷 500-509页

作者： yi-Qun Tian Xiang Ren Jing Wang Xing Li yi-Sheng yin Zi-Hao Guo Zhen-Liang Qin Xiao-yong zeng Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Urology of Hubei Province Wuhan 430000China

Chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS)is highly prevalent worldwide and poses a significant threat to men’s health,particularly affecting young ***,the exact causes and mechanisms behind CP/CPPS remain unclear,leading to challenges in its *** this research,a CP/CPPS rat model was established with complete Freund’s adjuvant(CFA),and berberine hydrochloride was administered through daily gavage to assess its therapeutic *** alterations in the gut microbiome induced by CP/CPPS and berberine hydrochloride were investigated through 16S ribosomal RNA sequencing of cecum content and colonic epithelial *** investigate the impact of the gut microbiome on CP/CPPS,a pseudo germ-free rat model was established,and fecal microbiome transplantation(FMT)was performed on these *** all,berberine hydrochloride demonstrated effective reduction of inflammation and oxidative stress in the prostate,offering significant therapeutic advantages for CP/*** analysis of the gut microbiome using 16S ribosome RNA sequencing,distinct differences were observed between CP/CPPS rats and control rats,and Clostridium butyricum was identified as a key *** germ-free rats that underwent FMT from CP/CPPS rats or rats treated with berberine hydrochloride displayed varying levels of inflammatory cytokine production,oxidative stress,and activity of associated signaling *** conclusion,the therapeutic potential of berberine hydrochloride in addressing CP/CPPS is highly *** gut microbiome has emerged as a critical factor in the development of CP/CPPS and plays a pivotal role in mediating the therapeutic effects of berberine hydrochloride.

关键词： berberine hydrochloride chronic prostatitis/chronic pelvic pain syndrome gut microbiome

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Relative Syzygies and Grade of Modules

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Acta Mathematica Sinica,English Series 2013年第3期29卷 489-504页

作者： zeng Feng LIU Zhao yong HUANG Department of Mathematics Nanjing University

Recently, Takahashi established a new approximation theory for finitely generated modules over commutative Noetherian rings, which unifies the spherical approximation theorem due to Auslan- der and Bridger and the Cohen-Macaulay approximation theorem due to Auslander and Buchweitz. In this paper we generalize these results to much more general case over non-commutative rings. As an application, we establish a relation between the injective dimension of a generalized tilting module w and the finitistic dimension with respect to w.

关键词： n-l-Syzygy modules n-w-torsionfree modules approximation presentations grade

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Research progress of m^(6) A methylation in prostate cancer

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Asian Journal of Andrology 2023年第2期25卷 166-170页

作者： Shou-yi Zhang Yu zeng Department of Urology The Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042China

N^(6)-methyladenosine(m^(6)A)is a ubiquitous RNA modification in *** modification is“written”by methyltransferases and then“read”by m^(6)A-binding proteins,followed by a series of regulation,such as alternative splicing,translation,RNA stability,and RNA *** last,the modification is“erased”by demethylases.m^(6)A modification is essential for normal physiological processes in mammals and is also a very important epigenetic modification in the development of *** recent years,cancer-related m^(6)A regulation has been widely studied,and various mechanisms of m^(6)A regulation in cancer have also been *** this review,we summarize the changes of m^(6)A modification in prostate cancer and discuss the effect of m6A regulation on prostate cancer progression,aiming to profile the potential relevance between m^(6)A regulation and prostate cancer *** studies on m^(6)A regulation in prostate cancer may uncover the potential role of m^(6)A methylation in the cancer diagnosis and cancer therapy.

关键词： epigenetic N^(6)-methyladenosine methylation molecular biology prostate cancer

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Joint transmit beamforming and power control in multi-user MIMO downlink using a game theoretic approach

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The Journal of China Universities of Posts and Telecommunications 2007年第2期14卷 14-18页

作者： zeng yi ZHANG Zu-fan Special Research Center for Optical Intemet and Wireless Information Networks Chongqing University of Posts and Telecommunications Chongqing 400065 China

This study addresses the problem of jointly optimizing the transmit beamformers and power control in multi-user multiple-input multiple-output （MIMO） downlink. The objective is minimizing the total transmission power while satisfying the signal-to-noise plus interference ratio （SINR） requirement of each user. Before power control, it uses the maximum ratio transmission （MRT） scheme to determine the beamformers due to its attractive properties and the simplicity of handling. For power control it introduces a supermodular game approach and proposes an iterated strict dominance elimination algorithm. The algorithm is proved to converge to the Nash equilibrium. Simulation results indicate that this joint optimization method assures the improvement of performance.

关键词： multi-user MIMO power control transmit beamforming MRT supermodular game

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Male external genitalia growth curves and charts for children and adolescents aged 0 to 17 years in Chongqing, China

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Asian Journal of Andrology 2018年第6期20卷 567-571页

作者： yi-Nan Wang Qmg zeng Feng Xiong Yah zeng Department of Medical Statistics and Information Management School of Public Health and Management Chongqing Medical University Chongqing 400016 China Department of Endocrinology the Children's Hospital of Chongqing Medical University Chongqing 400014 China

Genital size is a crucial index for the assessment of male sexual development, as abnormal penile or testicular size may be the earliest visible clinical manifestation of some diseases. However, there is a lack of data regarding penile and testicular size measurements for Chinese boys at all stages of childhood and puberty. This cross-sectional study aimed to develop appropriate growth curves and charts for male external genitalia among children and adolescents aged 0-17 years in Chongqing, China. A total of 2974 boys were enrolled in the present study. Penile length was measured using a rigid ruler, penile diameter was measured using a pachymeter, and testicular volume was determined using a Prader orchidometer. Age-specific percentile curves for penile length, penile diameter, and testicular volume were drawn using the generalized additive models for location, scale, and shape. Very similar growth curves were found for both penile length and penile diameter. Both of them gradually rose to 10 years of age and then sharply increased from 11 to 15 years of age. However, testicular volume changed little before the age of 10 years. This study contributes to the literature covering age-specific growth curve and charts about male external genitalia in Chinese children and adolescents. These age-related values are valuable in evaluating the growth and development status of male external genitalia and could be helpful in diagnosing genital disorders.

关键词： adolescents children generalized additive model for location scale and shape growth curves penile size testicular volume

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EXISTENCE RESULTS FOR THE KIRCHHOFF TYPE EQUATION WITH A GENERAL NONLINEAR TERM

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Acta Mathematica Scientia 2022年第5期42卷 2063-2077页

作者： Huirong PI yong zeng School of Mathematics and Information Guangci UniversityNanning 530004China

This paper is mainly concerned with existence and nonexistence results for solutions to the Kirchhoff type equation−(a+b∫_(R^(3))|∇u|^(2))Δu+V(x)u=f(u)in R^(3),with the general hypotheses on the nonlinearity f being as introduced by Berestycki and *** analysis introduces variational techniques to the analysis of the effect of the nonlinearity,especially for those cases when the concentration-compactness principle cannot be applied in terms of obtaining the compactness of the bounded Palais-Smale sequences and a minimizing problem related to the existence of a ground state on the Pohozaev manifold rather than the Nehari manifold associated with the equation.

关键词： Kirchhoff type equation general nonlinearity variational methods Pohozaev identity

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Strategy for AIDS Prevention and Treatment

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Virologica Sinica 2007年第6期22卷 419-420页

作者： yi zeng College of Life Science and Bioengineering Beijing University of Technology Beijing 100052 China

HIV/AIDS has been circulating in China for over 25 year. While making achievements on HIV/AIDS prevention, there still are great challenge and difficulties epidemic controlling and vaccine research .

关键词： HIV/AIDS Prevention and care Infection Vaccine Drugs progress and such as HIV

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Invasion, expansion, and control of Bactrocera dorsalis(Hendel) in China

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Journal of Integrative Agriculture 2019年第4期18卷 771-787页

作者： LIU Huan ZHANG Dong-ju XU yi-juan WANG Lei CHENG Dai-feng QI yi-xiang zeng Ling LU yong-yue Department of Entomology South China Agricultural University

The Oriental fruit fly, Bactrocera dorsalis(Hendel), is among the most destructive fruit/vegetable-eating agricultural pests in the world, particularly in Asian countries such as China. Because of its widespread distribution, invasive ability, pest status, and economic losses to fruit and vegetable crops, this insect species is viewed as an organism warranting severe quarantine restrictions by many countries in the world. To understand the characteristics and potential for expansion of this pest, this article assembled current knowledge on the occurrence and comprehensive control of the Oriental fruit fly in China concerning the following key aspects: invasion and expansion process, biological and ecological characteristics, dynamic monitoring, chemical ecology, function of symbionts, mechanism of insecticide resistance, control index, and comprehensive control and countermeasures. Some suggestions for the further control and study of this pest are also proposed.

关键词： Oriental fruit fly invasion biology ecology management China

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Microstructure and Wear Properties of Laser Coating Reinforced by Ti(C_xN_(1-x)) on Adamite Roller

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Journal of Iron and Steel Research International 2009年第3期16卷 78-82,88页

作者： QI yong-tian ZOU zeng-da School of Material Science and Engineering Shandong University Jinan 250061 Shandong China

Fe-based layer with Ti（CxN1-x） particulates on Adamite roller surface was obtained by a 5 kW traverse-flowing CO2 laser cladding technology. The microstructures of the layer were detected by optical microscopy （OM）,X-ray diffraction （XRD）,scanning electron microscopy （SEM）,and electron probe microscopy analysis （EMPA）. The tests of wear resistance was carried out on the test machine. It was seen that a good metallurgical bonding between the coating and the substrate was achieved. The microstructure contains bulky dendritic crystal and small size Ti（CxN1-x） grains that are uniformly distributed in the solid solution matrix. The wear tests showed that the laser coating provided an excellent wear resistance property at room temperature.

关键词： Ti(CxN1-x) laser cladding in-situ formation adamite roller

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Single-cell RNA Sequencing Deciphers Immune Landscape of Human Recurrent Miscarriage

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Genomics, Proteomics & Bioinformatics 2021年第2期19卷 169-171页

作者： Chunyu Huang yong zeng Wenwei Tu Department of Paediatric and Adolescent Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation Fertility CenterShenzhen Zhongshan Urology HospitalShenzhen 518045China

Introduction Pregnancy is a mysterious biological process that presents great challenges to the maternal immune *** the early 1950s,the‘‘fetal allograft”concept was described for the first time by Peter Medawar,and the unique immunology of the maternal-fetal interface was recognized[1].Correct and precise interaction between mother and fetus plays an important role during pregnancy process,such as the apposition,adhesion,implantation,and growth of embryo in uterus[2].In 1991,Colbern and Main proposed that the maternal immune cells directly interact with placenta but not the fetus[3].Therefore,information concerning the cross-talk between maternal immune cells and placenta during normal pregnancy will provide clues to explore the underlying mechanism of pathological *** cells,such as natural killer(NK),macrophage,T,and dendritic cells,have been demonstrated to play important roles during normal pregnancy[4].With the development of single-cell RNA sequencing(scRNA-seq)technologies,researchers are devoted to providing a whole picture about the immune cellular composition and inter-cellular communication events during normal pregnancy[5,6].These foundational studies reveal that immune cell subsets,which are classified based on different markers at high resolution,exert specific function during pregnancy ***,the panoramic analysis of immune subsets at high resolution in pathological pregnancy remains lacking.

关键词： fetus Immune mother

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