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High-strength antiswelling adhesive achieves both hemostasis and wound healing

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Journal of Pharmaceutical Analysis 2024年第6期14卷 781-784页

作者： Xin Zhao Jinlong Luo Ying Huang Lei Mu Jueying Chen Zhen liang Zhanhai Yin Dake Chu yong Han Baolin Guo State Key Laboratory for Mechanical Behavior of Materials Frontier Institute of Science and TechnologyXi'an Jiaotong UniversityXi'an710049China Department of Plastic Surgery Xijing HospitalAir Force Medical UniversityXi'an710032China Department of Orthopaedics The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi'an Jiaotong UniversityXi'an710049China

Skin is one of the most vulnerable tissues,but there is a lack of injectable bioactive hydrogel dressings,which possess high strength,antiswelling capacity,and wet tissue adhesiveness,but also a rapid gelling process to enable rapid hemostasis,sutureless wound closure,and scarless healing of infected skin wounds[1e5].A new injectable,antibacterial,and multifunctional hydrogel dressings based on poly(citric acid-co-polyethylene glycol)-g-dopamine(PCPD)and amino-terminated Pluronic F127(APF)mi-celles loaded with astragaloside IV(AS)was developed for this pur-pose,as shown in Fig.1A[6].

关键词： healing wound stasis

Targeting complement hyperactivation:a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection

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Signal Transduction and Targeted Therapy 2024年第1期9卷 51-54页

作者： Leili Jia Haihua Luo Lizhong Li Mingyao Wang Jiangfeng Liu Yuan liang Shan Li yong Jiang Juntao Yang Hongbin Song Institute for Disease Control and Prevention of PLA BeijingChina Guangdong Provincial Key Laboratory of Proteomics State Key Laboratory of Organ Failure ResearchSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical SciencesChinese Academy of Medical Science and Peking Union Medical College100005 BeijingChina

Dear Editor,Infections by the influenza virus are a significant and widespread global health threat,as these infections have an annual death toll ranging from 290,000 to 650,000.1 A significant proportion of these fatalities are attributed to secondary bacterial pneumonia,a severe complication commonly caused by ubiquitous respiratory pathogens such as Staphylococcus aureus(***).2 Of particular concern is the increased morbidity and mortality rates in individuals infected simultaneously with influenza virus and methicillin-resistant ***(MRSA).3 The concurrent presence of bacteria and influenza virus usually causes acute respiratory distress syndrome(ARDS),which is associated with acute lung injury(ALI),severe lung tissue edema,and widespread ***,determining the complex mechanisms underlying the synergistic interplay will require further investigation with a suitable coinfection mouse *** our previous study,we utilized different sequential coinfections at various time points to model influenza A virus and MRSA coinfection.

关键词： influenza pneumonia lung

Quorum Sensing:An Emerging Role for Vibrio Infection and Host Defense

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Infectious Microbes & Diseases 2024年第2期6卷 47-55页

作者： Hao-Nan Lin Xian-Hui Huang Xin-Jun Miao Wei-Lin Hu yong-liang Lou Dan-Li Xie The School of Laboratory Medicine&Life Sciences Wenzhou Medical UniversityWenzhouChina Key Laboratory of Laboratory Medicine Ministry of Education of ChinaWenzhouChina Wenzhou Key Laboratory of Sanitary Microbiology WenzhouChina Department of Emergency Wenzhou Central HospitalWenzhouZhejiangChina Department of Microbiology School of MedicineZhejiang UniversityHangzhouChina Zhuji Institute of Biomedical Research School of PharmacyWenzhou Medical UniversityZhujiChina

Quorum sensing(QS)is a mechanism that allows bacteria to regulate various physiological and biochemical functions by secreting,sensing and responding to signaling molecules called autoinducers(AIs).In Vibrio species,QS plays a crucial role in modulating different biological *** can influence the formation of biofilms,which are communities of bacteria encased in a protective *** also controls flagella formation and motility,ensuring that Vibrio *** move efficiently in response to environmental ***ally,QS in Vibrio *** the production of different virulence factors based on cell *** enables the bacteria to adjust their virulence strategies accordingly,enhancing *** also influences the interaction between Vibrio *** their ***ing infection by Vibrio spp.,QS can affect the host immune response and colonization *** the role of QS in these interactions is crucial for unraveling the complex dynamics between Vibrio *** the *** summary,research on QS in Vibrio *** revealed its significance in regulating various biological phenotypes,controlling virulence factor production and affecting host de*** provides valuable insights into the intricate mechanisms underlying microbial behavior,host adaptation and Vibrio ***.

关键词： quorum sensing Vibrio species biological phenotype bacterial virulence host defense

Multimodal abnormalities of brain structures in adolescents and young adults with major depressive disorder:An activation likelihood estimation meta-analysis

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World Journal of Psychiatry 2024年第7期14卷 1106-1117页

作者： Yan-Ping Shu Qin Zhang yong-Zhe Hou Shuang liang Zu-Li Zheng Jia-Lin Li Gang Wu Department of Psychiatry of Women and Children The Second People’s Hospital of Guizhou ProvinceGuiyang 550000Guizhou ProvinceChina Department of Radiology The Second People’s Hospital of Guizhou ProvinceGuiyang 550000Guizhou ProvinceChina Department of Radiology Guizhou Provincial People’s HospitalGuiyang 550000Guizhou ProvinceChina Medical Humanities College Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

BACKGROUND Major depressive disorder(MDD)in adolescents and young adults contributes significantly to global morbidity,with inconsistent findings on brain structural changes from structural magnetic resonance imaging *** likeli-hood estimation(ALE)offers a method to synthesize these diverse findings and identify consistent brain *** We performed a comprehensive literature search in PubMed,Web of Science,Embase,and Chinese National Knowledge Infrastructure databases for neuroi-maging studies on MDD among adolescents and young adults published up to November 19,*** independent researchers performed the study selection,quality assessment,and data *** ALE technique was employed to synthesize findings on localized brain function anomalies in MDD patients,which was supplemented by sensitivity *** Twenty-two studies comprising fourteen diffusion tensor imaging(DTI)studies and eight voxel-based morphome-try(VBM)studies,and involving 451 MDD patients and 465 healthy controls(HCs)for DTI and 664 MDD patients and 946 HCs for VBM,were ***-based ALE demonstrated significant reductions in fractional anisotropy(FA)values in the right caudate head,right insula,and right lentiform nucleus putamen in adolescents and young adults with MDD compared to HCs,with no regions exhibiting increased FA ***-based ALE did not demonstrate significant alterations in gray matter *** analyses highlighted consistent findings in the right caudate head(11 of 14 analyses),right insula(10 of 14 analyses),and right lentiform nucleus putamen(11 of 14 analyses).CONCLUSION Structural alterations in the right caudate head,right insula,and right lentiform nucleus putamen in young MDD patients may contribute to its recurrent nature,offering insights for targeted therapies.

关键词： Major depressive disorder Adolescent Young adults Neuroimaging Diffusion tensor imaging Voxel-based morphometry Activation likelihood estimation Meta-analysis

Outlier item detection in bundle recommendation via the attention mechanism

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High-Confidence Computing

High-Confidence Computing 2024年第3期4卷 51-57页

作者： Yuan liang School of Information Engineering Suqian UniversitySuqian 223800China Guangxi Key Laboratory of Trusted Software Guilin University of Electronic TechnologyGuilin 541004China

Bundle recommendation offers users more holistic insights by recommending multiple compatible items at ***,the intricate correlations between items,varied user preferences,and the pronounced data sparsity in combinations present significant challenges for bundle recommendation ***,current bundle recommendation methods fail to identify mismatched items within a given set,a process termed as‘‘outlier item detection’’.These outlier items are those with the weakest correlations within a *** them can aid users in refining their item *** the correlation among items can predict the detection of such outliers,the adaptability of combinations might not be adequately responsive to shifts in individual items during the learning *** limitation can hinder the algorithm’s *** tackle these challenges,we introduce an encoder–decoder architecture tailored for outlier item *** encoder learns potential item correlations through a self-attention ***,the decoder garners efficient inference frameworks by directly assessing item *** have validated the efficacy and efficiency of our proposed algorithm using real-world datasets.

关键词： Bundle recommendation Outlier item detection Attention mechanism Decoder encoder

Screening of transition metal oxides for electrocatalytic nitrate reduction to ammonia at large currents

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Nano Research 2024年第5期17卷 3902-3910页

作者： Qiongfei Wu Weijie Zhu Dongxu Ma Chao liang Zhoucheng Wang Hanfeng liang State Key Laboratory of Physical Chemistry of Solid Surfaces Tan Kah Kee Innovation LaboratoryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China College of Chemical Engineering Tianjin UniversityTianjin 300072China

Electrochemical nitrate reduction reaction(NO_(3)RR)towards ammonia,as an emerging and appealing technology alternative to the energy-intensive Haber-Bosch process and inefficient nitrogen reduction reaction,has recently aroused wide concern and ***,the current research of the NO_(3)RR towards ammonia lacks the overall performance comparison of various *** this,we here make a comparison of 12 common transition metal oxide catalysts for the NO_(3)RR under a high cathodic current density of 0.25 A·cm^(-2),wherein Co_(3)O_(4) catalyst displays the highest ammonia Faradaic efficiency(85.15%)and moderate activity(ca.-0.25 V *** hydrogen electrode).Other external factors,such as nitrate concentrations in the electrolyte and applied potential ranges,have also been specifically investigated for the NO_(3)RR.

关键词： nitrate reduction reaction ammonia production transition metal oxides Co_(3)O_(4)

Lipid metabolism-related long noncoding RNA RP11-817I4.1 promotes fatty acid synthesis and tumor progression in hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第8期30卷 919-942页

作者： Ren-yong Wang Jia-Ling Yang Ning Xu Jia Xu Shao-Hua Yang Dao-Ming liang Jin-Ze Li Hong Zhu Second Affiliated Hospital of Kunming Medical University Kunming 650106Yunnan ProvinceChina School of Basic Medical Sciences Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina Wuhan Blood Center Wuhan 430030Hubei ProvinceChina Department of Gastrointestinal Surgery The Third People's Hospital of Hubei ProvinceWuhan 430071Hubei ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common types of *** influence of lipid metabolism disruption on the development of HCC has been demonstrated in published *** To establish an HCC prognostic model for lipid metabolism-related long non-coding RNAs(LMR-lncRNAs)and conduct in-depth research on the specific role of novel LMR-lncRNAs in *** Correlation and differential expression analyses of The Cancer Genome Atlas data were used to identify differentially expressed *** real-time polymerase chain reaction analysis was used to evaluate the expression of *** red staining was employed to observe intracellular lipid *** interaction between RP11-817I4.1,miR-3120-3p,and ATP citrate lyase(ACLY)was validated through the performance of dual-luciferase reporter gene and RIP *** Three LMR-lncRNAs(negative regulator of antiviral response,RNA transmembrane and coiled-coil domain family 1 antisense RNA 1,and RP11-817I4.1)were identified as predictive markers for HCC patients and were utilized in the construction of risk ***,proliferation,migration,and invasion were reduced by RP11-817I4.1 *** increase in lipid levels in HCC cells was significantly induced by RP11-817I4.1 through the miR-3120-3p/ACLY *** LMR-lncRNAs have the capacity to predict the clinical characteristics and prognoses of HCC patients,and the discovery of a novel LMR-lncRNAs,RP11-817I4.1,revealed its role in promoting lipid accumulation,thereby accelerating the onset and progression of HCC.

关键词： Hepatocellular carcinoma Lipid metabolism Immune microenvironment Prognostic markers Metabolic reprogramming

An Outbreak of Serogroup Y Meningococcal Meningitis in a Private Secondary Vocational School-Guangzhou City,Guangdong Province,China,2023

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China CDC weekly 2024年第12期6卷 242-246,I0005页

作者： Xiang Zeng Qing He Yilan Li yong Zhou Xiaoping Shao Pei Hu Jian liang Yudan Song Chao Ma Lijie Zhang Limei Sun Lei Luo Chinese Field Epidemiology Training Program Chinese Center for Disease Control and PreventionBeijingChina Zhuhai Center for Disease Control and Prevention Zhuhai CityGuangdong ProvinceChina Guangdong Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Guangzhou Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Institute of Public Health Guangzhou Medical University&Guangzhou Center for Disease Control and PreventionGuangzhou CityGuangdong ProvinceChina Department of the National Immunization Programme Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?The inclusion of meningococcal vaccines in the National Immunization Program(NIP)over several years has significantly reduced the incidence of meningococcal meningitis in China to historic ***,there has been a diversification of meningococcal serogroups,leading to a shift in dominant serogroups in China from serogroup A to serogroups C and B,accompanied by a rise in reports of serogroups Y and *** is added by this report?An outbreak of serogroup Y Neisseria meningitidis(Nm)in a secondary vocational school involved a single confirmed severe case and 24 individuals with laboratory-confirmed Nm *** investigation revealed that the outbreak was localized to the classroom of the confirmed *** close contact within a confined space was identified as a significant risk factor for Nm *** genotype sequence identified was type 1655(ST-1655),which is categorized under clonal complex 23(CC-23)and bears resemblance to 8 previously confirmed cases of serogroup Y meningococcal meningitis within Guangdong *** suggests that serogroup Y infections continue to sporadically emerge and have become prevalent *** are the implications for public health practice?This outbreak underscores the critical need to enhance surveillance of meningococcal serogroups and population carrier,and advocate for vaccination with MenY-containing vaccines.

关键词： break Secondary Guangdong

AFM probe for measuring~10^(−5)ultra-low friction coefficient:Design and application

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Friction 2024年第1期12卷 64-73页

作者： Yushan CHEN liang JIANG Linmao QIAN Tribology Research Institute State Key Laboratory of Traction PowerSouthwest Jiaotong UniversityChengdu 610031China

Superlubricity provides a novel approach to addressing friction and wear issues in mechanical ***,little is known regarding improving the atomic force microscope(AFM)friction coefficient measurement ***,this study established the theoretical formula for the AFM friction coefficient measurement and deduced the measurement ***,the formula was applied to the AFM probe with a rectangular cross-section *** measurement resolution is associated with the dimensional properties of the AFM probe,the mechanical properties of the cantilever material,the properties of the position-sensitive detector(PSD),and probably the anti-vibration performance of the *** is feasible to make the cantilever as short as possible and the tip as high as possible to improve the measurement *** AFM probe for measuring an ultra-low friction coefficient was designed and *** cantilever’s length,width,and thickness are 50,35,and 0.6μm,*** tip height is 23μ*** measurement resolution can reach 7.1×10^(−6) under the maximum normal ***,the AFM probe was applied to measure the superlubricity between graphene *** friction coefficient is 0.00139 under 853.08 *** work provides a promising method for measuring a~10^(−5) friction coefficient of superlubricity.

关键词： atomic force microscope(AFM) superlubricity friction coefficientμ probe