检索结果-南通市图书馆

A new triterpenoid from Kadsura coccinea

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2010年第11期21卷 1352-1354页

作者： Yan Song Qing Jie Zhao yong sheng jin Chuan Wei Feng Hai sheng Chen Department of Phytochemistry School of Pharmacy Second Military Medical University Shanghai 200433 China Department of Organic Chemistry School of Pharmacy Second Military Medical University Shanghai 200433 China

A new triterpenoid,possessing a lanost-9（11）-3-one skeleton,was isolated from the roots of Kadsura coccinea,based on the spectral analysis,its structure was elucidated as 3-hydroxy-12-acetoxycoccinic acid.

关键词： Kadsura coccinea Triterpene Coccinic acid

A comprehensive overview on antiviral effects of baicalein and its glucuronide derivative baicalin

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2024年第6期22卷 621-636页

作者： Xin-yang Liu Wei Xie He-yang Zhou Hui-qing Zhang yong-sheng jin School of Basic Medicine Naval Medical University Faculty of Traditional Chinese Medicine Naval Medical University School of Pharmacy Naval Medical University

Natural product-based antiviral candidates have received significant ***,there is a lack of sufficient research in the field of antivirals to effectively combat patterns of drug *** and its glucuronide derivative baicalin are two main components extracted from Scutellaria baicalensis *** have proven to be effective against a broad range of viruses by directly killing virus particles,protecting infected cells,and targeting viral antigens on their surface,among other *** natural products,they both possess the advantage of lower toxicity,enhanced therapeutic efficacy,and even antagonistic effects against drug-resistant viral *** and baicalin exhibit promising potential as potent pharmacophore scaffolds,demonstrating their antiviral ***,to date,no review on the antiviral effects of baicalein and baicalin has been *** review summarizes the recent research progress on antiviral effects of baicalein and baicalin against various types of viruses both in vitro and in vivo with a focus on the dosages and underlying *** aim is to provide a basis for the rational development and utilization of baicalein and baicalin,as well as to promote antiviral drug research.

关键词： Baicalin Baicalein Antiviral effects Influenza virus Flavivirus Hepatitis B virus Mechanism

Investigating the Mechanism of Qu Du Qiang Fei 1 Hao Fang Formula against Coronavirus Disease 2019 Based on Network Pharmacology Method

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2024年第1期10卷 93-103页

作者： Yuan-Hua Wang He-Yang Zhou jin-Yun Ma Gui-Qing Ding Hua Yu yong-sheng jin Xiao-Dong Cheng Institute of Clinical Immunology Yue-Yang Hospital of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghaiChina School of Pharmacy Naval Medical UniversityShanghaiChina

Objective:Qu Du Qiang Fei 1 Hao Fang(QDQF1)is a novel Chinese herbal medicine formula used to treat coronavirus disease 2019(COVID-19).However,the pharmacological mechanisms of action of QDQF1 remain *** objective of this study was to identify the effective ingredients and biological targets of QDQF1 for COVID-19 *** and Methods:The effective ingredients and mechanisms of action of QDQF1 were analyzed by using network pharmacology methods,which included an analysis of the effective ingredients and corresponding targets,COVID-19-related target acquisition,compound-target network analyses,protein-protein interaction network analysis,Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene Ontology(GO)enrichment analyses,and molecular docking ***:In total,288 effective QDQF1 ingredients were *** identified 51 core targets from the 148 targets through an overlap between putative QDQF1 targets and COVID-19-related *** key components,including formononetin,kaempferol,luteolin,naringenin,quercetin,and wogonin were identified through component-target network *** functional enrichment analysis of the core targets revealed 1296 items,while KEGG pathway enrichment analysis identified 148 signaling *** central targets(CCL2,CXCL8,IL1B,IL6,MAPK1,MAPK3,MAPK8,STAT3,and TNF)related to the COVID-19 pathway were identified in the KEGG pathway enrichment ***,molecular docking analysis suggested that the docking scores of the six key components to the nine central targets were better than those to ***:QDQF1 may regulate multiple immune-and inflammation-related targets to inhibit the progression of severe acute respiratory syndrome coronavirus 2,and thus,may be suitable for the treatment of COVID-19.

关键词： Coronavirus disease 2019 molecular docking molecular mechanism network pharmacology Qu Du Qiang Fei 1 Hao Fang formula

A STUDY ON THE WATER—SOLUBLE PEPTIDES IN RAPE POLLEN:EXTRACTION,PURIFICATION,SEQUENCE DETERMINATION AND MEASUREMENT OF IMMUNOPROMOTIVE ACTIVITY

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1990年第1期1卷 85-86页

作者： yong Liang ZHANG sheng jin Department of Chemistry Peking University Beijing 100871

Four peptide components RP1,RP2,RP3Ⅰ and RP3Ⅱ were purified from the water—ex- tract of rape(Brassica campestris L.)*** primary sequence of RP3I,with 12 amino acid residues,has been determined by Edman degradation—N—terminal *** immunopro- motive activities of the initially separated sample and RP3I have been also observed in vitro.

关键词： SOLUBLE PEPTIDES IN RAPE POLLEN A STUDY ON THE WATER Pro

串联亲和纯化(TAP)技术在蛋白质组学中的应用

在线全文

学校读者我要写书评

暂无评论

生物化学与生物物理进展 2004年第4期31卷 379-383页

作者：程永升刘进元清华大学生物科学与技术系分子生物学实验室北京100084

蛋白质是各种生命活动的主要执行者 ,因此构建蛋白质相互作用的网络图对于准确理解蛋白质功能、揭开各种细胞活动的奥秘十分重要 .串联亲和纯化 (TAP) ,是近年来发展出来的一种能够快速研究在生理条件下蛋白质相互作用 ,揭示蛋白质复合... 详细信息

蛋白质是各种生命活动的主要执行者 ,因此构建蛋白质相互作用的网络图对于准确理解蛋白质功能、揭开各种细胞活动的奥秘十分重要 .串联亲和纯化 (TAP) ,是近年来发展出来的一种能够快速研究在生理条件下蛋白质相互作用 ,揭示蛋白质复合体相互作用网络的新技术 ,已成为研究蛋白质组学的一个重要工具 .随着该技术的不断完善 ,TAP技术在认识蛋白质相互作用的过程中必将发挥越来越重要的作用 .

关键词：串联亲和纯化 TAP 蛋白质组学网络图免疫共沉淀纯化

经济外交与“经济全球化”——机遇与挑战、竞争与合作

在线全文

学校读者我要写书评

暂无评论

外交学院学报 2003年第4期 58-64页

作者：周永生刘锦明外交学院北京100037 国家发展和改革委员会对外经济研究所北京100038

经济全球化是指市场经济在世界各地普及的过程,也是市场经济在新的历史时期获得空前发展的过程。经济全球化所带来的不仅仅有发展机遇,也有严峻的挑战。国际社会成员通过激烈的竞争和密切的合作,彼此的联系也将更加密切。经济外交在经... 详细信息

经济全球化是指市场经济在世界各地普及的过程,也是市场经济在新的历史时期获得空前发展的过程。经济全球化所带来的不仅仅有发展机遇,也有严峻的挑战。国际社会成员通过激烈的竞争和密切的合作,彼此的联系也将更加密切。经济外交在经济全球化中具有不可替代的作用,为使经济全球化不被少数国家和少数垄断资本控制,有必要通过经济外交,建立新的经济外交机制,促进经济全球化向着既注重效益又兼顾公平的方向发展。这是21世纪各国对外政策和外交活动所面临的崭新课题。

关键词：经济外交经济全球化经济竞争经济合作跨国公司

在线全文

学校读者我要写书评

暂无评论

轮腿式机器人倾覆稳定性分析与仿真

系统仿真学报 2009年第13期21卷 4032-4037页

作者：田海波方宗德周勇李声晋张国胜西北工业大学机电学院西安710072

在复杂的三维地形中,移动机器人的抗倾覆能力非常关键。针对非结构化环境对小型移动机器人的运动要求,设计了一种具有多驱动模式的轮腿式机器人。该机器人采用对称结构,有四个独立的运动单元,能够变化多种构型。采用动态能量稳定锥方法... 详细信息

在复杂的三维地形中,移动机器人的抗倾覆能力非常关键。针对非结构化环境对小型移动机器人的运动要求,设计了一种具有多驱动模式的轮腿式机器人。该机器人采用对称结构,有四个独立的运动单元,能够变化多种构型。采用动态能量稳定锥方法和倾覆稳定性指数对机器人的稳定性进行综合评价。分析了机器人变形过程中的稳定性变化,以及存在路面干扰和惯性力干扰时机器人六种典型能动构形的动态倾覆稳定性。仿真试验表明,该机器人的多种能动构型有利于提高其倾覆稳定性。

关键词：轮腿式机器人可变构形倾覆稳定性指数仿真分析非结构化环境

Two new triterpenoid acids from Kadsura coccinea

在线全文

学校读者我要写书评

暂无评论

Two new triterpenoid acids from Kadsura coccinea

Constituents of Bidens bipinnata and theirα-amylase inhibitory activity

中国医药教育协会成人教育委员会三届五次理事大会暨医药教...

作者： Yan Song~a,Qing-Jie Zhao~b,yong-sheng jin~b,Chuan-Wei Feng~a,Hai-sheng Chen~(a*) a Department of Phytochemistry,School of Pharmacy,Second Military Medical University,Shanghai 200433,China b Department of Organic Chemistry,School of Pharmacy,Second Military Medical University,Shanghai 200433,China

＜正＞An investigation of EtOAc extracts of Kadsura coccinea has led to the isolation of two new compounds characterized as 3-hydroxy-12-hydroxyl coccinic acid 1 and 3-hydroxy-neokadsuranic acid A *** structures were ... 详细信息

关键词： Kadsura coccinea triterpenoid coccinic acid neokadsuranic acid A

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Constituents of Bidens bipinnata and theirα-amylase inhibit...