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World Journal of Pediatrics 2024年第2期20卷 189-200页

作者： Shu-na Sun Yan Zhou Xing Fu Yuan-Zheng Zheng Cao Xie Guo-You Qin Fang Liu Chen Chu Feng Wang Cheng-Long Liu Qing-Tong Zhou De-Hua Yang Di Zhu Ming-Wei Wang yong-Hao Gui Children's Hospital of Fudan University National Children's Medical CenterShanghai 201102China The national Center for Drug Screening Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Accuramed Technology(Shanghai)Ltd. Shanghai 200233China School of Pharmacy Fudan UniversityShanghai 201203China School of Public Health Fudan UniversityShanghai 200032China Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Research Center for Deepsea Bioresources Sanya 572025China Department of Chemistry School of ScienceThe University of TokyoTokyo 113-0033Japan School of Pharmacy Hainan Medical UniversityHaikou 570288China

Kawasaki disease(KD)is a disorder of immune *** prevalence of KD among 100,000 children aged 0-4 years was 71.9-110.0 in China,170.9-194.9 in Korea,and 18.1-21.3 in the USA[1].The most severe complication of KD is coronary artery lesions(CALs),including coronary dilatation and coronary aneurysms,which may even lead to myocardial ischemia,myocardial infarction,and sudden death.

关键词： coronary ischemia differentiated

中草药对多重耐药菌的抑制作用及机制研究进展

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中国感染控制杂志 2024年第4期23卷 530-537页

作者：赵永师杜娜杜艳昆明医科大学第一附属医院检验科云南省检验医学重点实验室云南昆明650032 云南省中医医院检验科云南昆明650021

抗菌药物的过度使用和滥用导致了多重耐药菌的出现。多重耐药菌感染日趋严重,治疗困难,迫切需要寻找多重耐药菌感染治疗的新型药物。中草药是我国特有的天然资源,具有耐药性低、毒性低、价格低廉等优点,对多重耐药菌具有较好的抑菌效果... 详细信息

抗菌药物的过度使用和滥用导致了多重耐药菌的出现。多重耐药菌感染日趋严重,治疗困难,迫切需要寻找多重耐药菌感染治疗的新型药物。中草药是我国特有的天然资源,具有耐药性低、毒性低、价格低廉等优点,对多重耐药菌具有较好的抑菌效果,且中草药能够通过多种机制发挥抑菌作用。本文收集整理了国内外相关文献,从单味中药、中药复方、中药联合抗菌药物对多重耐药菌的抑菌作用及机制方面作一综述,以期为抗多重耐药菌药物研究提供理论依据。

关键词：中草药多重耐药菌抑菌抑菌机制

Review of the potential value of serum interleukin levels as prognostic biomarkers of liver failure

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World Journal of Clinical Cases 2024年第27期12卷 6045-6056页

作者： yong Lin Geng-Jie Yan Mei-Yan Liu Yin Cao Kan Zhang na Wang Fu-Li Long De-Wen Mao Graduate School Guangxi University of Chinese MedicineNanning 530200Guangxi Zhuang Autonomous RegionChina Guangxi School of Chinese Medicine Guangxi University of Traditional Chinese MedicineNanning 530022Guangxi Zhuang Autonomous RegionChina Department of Hepatology The First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530023Guangxi Zhuang Autonomous RegionChina Department of Administration The First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530023Guangxi Zhuang Autonomous RegionChina

Liver failure(LF)is prevalent in China and is characterized by complex path-ogenesis,challenging clinical management,poor prognosis,and rising incidence and mortality *** immune status is an important factor affecting LF ***(Ils)are a type of cytokine that act and interact with multiple cells,including immune *** signaling molecules play important roles in intercellular information transmission,including the regulation of immune cells;mediation of the activation,proliferation,and differentiation of T and B cells;and orchestration of the inflammatory *** date,many studies have explored the correlation between IL expression and liver disease prognosis,but few studies have evaluated Ils as the prognostic biomarkers of *** article reviews the potential use of Ils as the prognostic biomarkers of ***,it evaluates the predictive values of IL-21,IL-22,and IL-31,the three often overlooked yet promising prognostic biomarkers,in predicting suscept-ibility to *** biomarkers for early prognostic insights can facilitate tailored treatment strategies and enhance patient ***,this article focuses on the identification of IL-21,IL-22,and IL-33 as biomarkers in preclinical and clinical studies on LF and reviews their role as biomarkers in the pathogenesis and diagnosis of LF.

关键词： Interleukin-21 Interleukin-22 Interleukin-31 Liver failure Biological markers Potential value

基于卫星遥感的辐照度时空关联映射与预测建模

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太阳能学报 2024年第3期45卷 1-9页

作者：王飞李娜苏营孙勇杨恒甄钊华北电力大学电力工程系保定071003 太原工业学院自动化系太原030008 中国长江三峡集团有限公司科学技术研究院北京100074

常规光伏电站仅能依赖局地地表气象观测信息进行辐照度预测,难以挖掘电站周边广域光伏资源的时空关联特性,限制了光伏电站辐照度以及发电功率的预测精度。针对上述问题,该文提出基于卫星遥感的光伏电站广域辐照度空间分布映射方法,并建... 详细信息

常规光伏电站仅能依赖局地地表气象观测信息进行辐照度预测,难以挖掘电站周边广域光伏资源的时空关联特性,限制了光伏电站辐照度以及发电功率的预测精度。针对上述问题,该文提出基于卫星遥感的光伏电站广域辐照度空间分布映射方法,并建立基于图卷积网络(GCN)的地表辐照度超短期时空关联预测模型,在充分利用多通道卫星数据的同时,考虑时空关联特性提高地表辐照度超短期预测精度。通过某光伏场站实例仿真分析,验证地表辐照度反演模型的可行性以及在此基础上所构建的辐照度时空关联预测模型的先进性。

关键词：卫星特征选择辐照度反演图卷积神经网络地表辐照度超短期预测

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学龄前儿童视力发展的影响因素及保护措施

医学信息 2024年第12期37卷 189-192页

作者：崔伟娜牛会勇天津市宝坻区人民医院眼科天津市宝坻区人民医院全科医学科

目前，我国越来越多的学龄前儿童出现视力问题，对其学习和生活均产生不同程度的消极影响。学龄前儿童正处于视力发育的关键时期，若发现其出现视力异常现象需及时采取适当的方法保护视力。本文通过对学龄前儿童视力发展的现状、影响因... 详细信息

目前，我国越来越多的学龄前儿童出现视力问题，对其学习和生活均产生不同程度的消极影响。学龄前儿童正处于视力发育的关键时期，若发现其出现视力异常现象需及时采取适当的方法保护视力。本文通过对学龄前儿童视力发展的现状、影响因素及保护措施进行综述，旨在为后续的视力保护工作提供科学指导。

关键词：学龄前儿童视力发展影响因素保护措施

OCTA characteristics in non-arteritic central retinal artery occlusion and correlation with visual acuity

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 289-296页

作者： Hong-Xia Gong Bin Wu Shi-yong Xie Wei Zhang Song Chen Tianjin Key Lab of Ophthalmology and Visual Science Department of Ophthalmology for Integrated Traditional Chinese and Western MedicineTianjin Eye HospitalTianjin 300020China Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300010China Eye Hospital Affiliated to nankai University Tianjin 300020China

AIM:To observe the retinal and choroidal circulations in patients with non-arteritic permanent central retinal artery occlusion(na-CRAO)via optical coherence tomography angiography(OCTA)and analyze their correlation with visual ***:Sixty-two eyes with clinically confirmed acute na-CRAO were included in the study and divided into:A type(mild n=29),B type(moderate n=27)and C type(severe n=6)based on the degree of visual loss,retinal edema,and arterial blood flow delay in fundus fluorescence angiography(FFA).Contralateral healthy eyes were used as the control ***-corrected visual acuity(BCVA),slit lamp microscopy,indirect ophthalmoscopy,fundus color photography,OCTA,and FFA were ***’s correlation analysis was used to determine the correlations between retinal and choroidal vessels and visual ***:There were no statistically significant differences in age,gender,and intraocular pressure among the three types and the control group(P>0.05).Vessel density in deep capillary plexus(VD-DCP)significantly decreased(Pna-CRAO patients compared to the control *** density in superficial vascular plexus(VD-SVP)significantly decreased(Pnal flow areas significantly increased in the type A(Pnal thickness significantly increased in type C group(Pnasal parafovea in type A and B was significantly lower than type C(Pnalysis showed that the logMAR BCVA was positively correlated with VD-SVP at fovea(r=0.679,P=0.031)and nasal parafovea(r=0.826,P=0.013).CONCLUSION:OCTA is valua

关键词： non-arteritic central retinal artery occlusion fundus fluorescence angiography optical coherence tomography angiography retinal vessel density visual acuity

Regulating the intrinsic electronic structure of carbon nanofibers with high-spin state Ni for sodium storage with high-power density

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Journal of Materials Science & Technology 2024年第4期171卷 16-23页

作者： Zhijia Zhang Gang Xie Yuefang Chen Yanhao Wei Mengmeng Zhang Shulei Chou Yunxiao Wang Yifang Zhang yong Jiang School of Materials Science and Engineering Institute of Quantum Materials and DevicesState Key Laboratory of Separation Membrane and Membrane ProcessesTiangong UniversityTianjin 300387China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China Institute for Superconducting and Electronic Materials University of WollongongWollongongNSW 2522Australia

Carbon nanofibers(CNFs)with high specific surface area show great potential for sodium storage as a hard carbon ***,CNFs anchored with Ni nanoparticles(CNFs/Ni)were prepared through chemical vapor deposition and impregnation reduction methods,in situ growing on the three-dimensional porous copper current collector(3DP-Cu).The coupling effect of high-spin state Ni nanopar-ticles leads to the increase of defect density and the expansion of lattice spacing of ***,the 3DP-Cu ensures a high loading capacity of CNFs and short ion/electron transport *** an integral binder-free anode,the 3DP-Cu/CNFs/Ni exhibits excellent electrochemical performance,which demon-strates a high specific capacity with 298.5 mAh g^(-1)at 1000 mA g^(-1)after 1500 cycles,and a high power density with 200 mAh g^(-1)over 1000 cycles at 5000 mA g^(-1).Density functional theory calculation re-sults show that the high-spin state Ni regulates the electronic structure of CNFs,which significantly reduces the adsorption energy for na^(+)(-2.7 Ev)and thus enables high-rate *** regulation of the electronic structure of carbon materials by high-spin state metal provides a new strategy for developing high-power carbonaceous anode materials for sodium-ion batteries.

关键词： Carbon nanofibers Ni nanoparticles High-spin state Sodium-ion batteries Anode materials Density functional theory calculation

司美格鲁肽与沙格列汀分别联合二甲双胍治疗2型糖尿病伴腹型肥胖患者的临床研究

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中国临床药理学杂志 2024年第10期40卷 1400-1404页

作者：刘永菊李瑞郝娜娜李婉婉安徽医科大学附属阜阳医院内分泌科安徽阜阳236000

目的观察司美格鲁肽和沙格列汀分别与二甲双胍联用治疗2型糖尿病(T2DM)伴腹型肥胖(AO)的疗效和安全性。方法回顾性分析T2DM伴AO患者的病历资料,按队列法分为司美格鲁肽组和沙格列汀组。2组患者均口服二甲双胍,每次0.5 g,每天3次;司美格... 详细信息

目的观察司美格鲁肽和沙格列汀分别与二甲双胍联用治疗2型糖尿病(T2DM)伴腹型肥胖(AO)的疗效和安全性。方法回顾性分析T2DM伴AO患者的病历资料,按队列法分为司美格鲁肽组和沙格列汀组。2组患者均口服二甲双胍,每次0.5 g,每天3次;司美格鲁肽组在二甲双胍治疗的基础上注射司美格鲁肽,每次0.25 mg,2周后调整剂量为每次0.5 mg,均每周1次;沙格列汀组在二甲双胍治疗的基础上口服沙格列汀,每次5 mg,每天1次,均治疗3个月。比较2组患者的糖代谢指标、胰岛功能指标、脂肪因子及药物不良反应。结果司美格鲁肽组48例和沙格列汀组49例。治疗后,司美格鲁肽组和沙格列汀组的空腹血糖(FPG)分别为(7.45±1.22)和(7.98±1.30)mmol·L^(-1),餐后2 h血糖(2 hPG)分别为(9.78±1.64)和(10.55±1.82)mmol·L^(-1),糖化血红蛋白(HbA1c)分别为(5.66±0.94)%和(6.25±0.87)%,空腹胰岛素(FINS)分别为(29.12±6.46)和(34.34±7.15)pmol·L^(-1),空腹C肽(FC-P)分别为(292.66±67.53)和(319.03±77.92)pmol·L^(-1),胰岛素抵抗指数(HOMA-IR)分别为2.51±0.78和2.94±0.89,胰岛素分泌指数(HOMA-β)分别为51.74±15.31和43.72±14.56,血清鸢尾素(Irisin)分别为(4.56±0.32)和(4.17±0.54)ng·L^(-1),血清神经肽(SPX)分别为(0.71±0.15)和(0.64±0.17)ng·mL^(-1),血清白脂素(ASP)分别为(1.22±0.16)和(1.34±0.25)μg·L^(-1),在统计学上差异均有统计学意义(均P0.05)。结论司美格鲁肽联合二甲双胍治疗T2DM伴AO患者可以更显著地降低血糖,改善胰岛功能和脂肪因子,安全性良好。

关键词：司美格鲁肽注射液沙格列汀片二甲双胍片腹型肥胖 2型糖尿病

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基础外语教学中的中华文化融入与呈现研究

赤峰学院学报（哲学社会科学版） 2024年第1期45卷 91-94页

作者：许永娜赤峰学院外国语学院内蒙古赤峰024000

基础外语教学应该在夯实语言技能的基础上,重视提升学生的人文素养,学习者不仅要学习西方文化,也应加强中华文化的渗透,提高中华文化知识的建构,树立中华文化的形象,增强中华文化的认同感和自豪感,传播和弘扬中华特色文化。本文剖析阐... 详细信息

基础外语教学应该在夯实语言技能的基础上,重视提升学生的人文素养,学习者不仅要学习西方文化,也应加强中华文化的渗透,提高中华文化知识的建构,树立中华文化的形象,增强中华文化的认同感和自豪感,传播和弘扬中华特色文化。本文剖析阐述基础外语教学的现状及其存在的问题并找出其产生的原因,提出基础外语教学应渗透中华文化内容,论述中华文化融入基础外语教学的重要性及意义,从多维度出发探讨基础外语教学中可实行的中华文化教学范畴和中华文化教学策略,旨在传承和弘扬中国特色文化,促进实施高效的双向文化导入、提升文化教学质量,真正落实素质教育内涵。

关键词：基础外语中华文化策略

Interface engineering of Co_(9)S_(8)/SnS heterostructure as a high-performance anode for lithium/sodium-ion batteries

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Rare Metals 2024年第2期43卷 612-623页

作者： Jia Luo Shi-Li Xiang Dan-Yang Han An Liu João Cunha Gang-yong Li Zhao-Hui Hou Hong Yin School of Chemistry and Chemical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional MaterialsHunan Institute of Science and TechnologyYueyang414006China Hubei Jiufengshan Laboratory Wuhan430206China International Iberian nanotechnology Laboratory(INL) Av.Mestre Jose Veiga4715-330BragaPortugal

Transition metal sulfide(TMS)anodes exhibit the characteristics of phase stability and high capacity for lithium/sodium-ion batteries(LIBs/SIBs).However,the TMS anodes often suffer from poor electronic conductivity,low ionic diffusion and large volume expansion during Li/na-ion intercalation significantly impairing the Li/na-storage ***,a long chain heterostructure composed of the Co_(9)S_(8) and SnS are first reported,which can generate rich phase interfaces,and small crystal *** unique structure can facilitate the properties of reactivity,conductivity and ionic *** addition,the heterostructure surface is modified by the N-doped carbon(N-DC@(CoSn)S),successfully improving the structural *** synergistic effects of Co_(9)S_(8)/SnS heterostructure and coated carbon layer effectively increase the capacity and cycling *** N-DC@(CoSn)S anode delivers enhanced high specific capacities of 820.6 mAh·g^(−1) at 1.0 A·g^(–1) after 500 cycles for LIBs and 339.2 mAh·g^(–1)at 0.5 A·g^(–1) after 1000 cycles for SIBs,*** work is expected to provide a material design idea for preparing LIBs/SIBs with high capacity and long cycling life.

关键词： Interface engineering Long chain heterostructure High capacity Cycling stability Li na-ion batteries