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Treatment and prognosis of cervical cancer associated with pregnancy: analysis of 20 cases from a Chinese tumor institution

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第5期16卷 388-394页

作者： Xiang ZHANG yong-liang GAO Yue yang Department of Gynecological Oncology Zhejiang Cancer Hospital Zhejiang Key Laboratory of Radiation Oncology

This study was designed to investigate the therapeutic approaches and prognosis for cervical cancer associated with pregnancy. Clinical information, therapeutic strategies, and follow-up results of 20 patients with cervical cancer associated with pregnancy from Jan. 2000 to June 2009 in the Zhejiang Cancer Hospital were retrospectively analyzed. The International Federation of Gynecology and Obstetrics （FIGO） stages were： in situ （n=1）, stage IA1 （n=l）, stage IB1 （n=5）, stage ⅠB2 （n=1）, stage ⅡA （n=8）, stage lib （n=3）, and stage ⅢB （n=1）. Eight patients were in the first trimester of pregnancy, four in the second, two in the third, and six at postpartum when diagnosed. The therapeutic strategies were either single or combined modalities, including surgery, radiotherapy, and chemotherapy. Fourteen patients survived, five patients died （four of remote metastasis and one of uremia）, and one patient was lost to follow-up. One newborn from a patient at stage IIA carcinoma in the third trimester with postponed therapy six weeks after diagnosis survived. Retarded fetal growth was observed in one patient receiving neoadjuvant chemotherapy and cesarean section. Out of the six postpartum patients, three underwent cesarean section and survived, whereas only one out of the three who underwent vaginal delivery survived. The remaining two died of remote metastasis. Therefore, personalized treatment is necessary for cervical cancer associated with pregnancy. Cervical cancer patients in the third trimester of pregnancy can continue the pregnancy for a short period of time. There may be potential risk for the fetus by chemotherapy during pregnancy. Cesarean section is the preferred mode of delivery for pregnant cervical cancer patients.

关键词： Cervical cancer Pregnancy Treatment Prognosis

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Effects of Incretin-based Therapies on Weight-related Indicators among Patients with Type 2 Diabetes: A Network Meta-analysis

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Biomedical and Environmental Sciences 2020年第1期33卷 37-47页

作者： XU Lu YU Shu Qing GAO Le HUANG Yi WU Shan Shan yang Jun SUN Yi Xin yang Zhi rong CHAI San Bao ZHANG Yuan JI Li Nong SUN Feng ZHAN Si Yan Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Mathematics and Statistics University of Maryland Baltimore CountyBaltimore MD 21250MarylandUSA National Clinical Research Center of Digestive Diseases Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China The Primary Care Unit School of Clinical MedicineUniversity of CambridgeCambridge CB21TNUK Department of Endocrinology and Metabolism Peking University International HospitalBeijing 102206China Department of Clinical Epidemiology and Biostatistics McMaster UniversityHamilton L8S 4L8OntarioCanada Department of Endocrinology and Metabolism Peking University People’s HospitalBeijing 100044China

Objective To evaluate the effects of incretin-based therapies on body weight as the primary outcome,as well as on body mass index(BMI)and waist circumference(WC)as secondary *** Databases including Medline,Embase,the Cochrane Library,and ***(***)were searched for randomized controlled trials(RCTs).Standard pairwise meta-analysis and network meta-analysis(NMA)were both carried *** risk of bias(ROB)tool recommended by the Cochrane handbook was used to assess the quality of *** analysis,sensitivity analysis,meta-regression,and quality evaluation based on the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)were also *** A total of 292 trials were included in this *** with placebo,dipeptidyl-peptidase IV inhibitors(DPP-4 Is)increased weight slightly by 0.31 kg[95%confidence interval(CI):0.05,0.58]and had negligible effects on BMI and *** with placebo,glucagon-like peptide-1 receptor agonists(GLP-1 RAs)lowered weight,BMI,and WC by-1.34 kg(95%CI:-1.60,-1.09),-1.10 kg/m2(95%CI:-1.42,-0.78),and-1.28 cm(95%CI:-1.69,-0.86),*** GLP-1 RAs were more effective than DPP-4 Is in lowering the three ***,the effects of GLP-1 RAs on weight,BMI,and WC were favorable.

关键词： Body mass index Body weight Diabetes mellitus Dipeptidyl-peptidase IV inhibitors Glucagon-like peptide-1 receptor agonists Network meta-analysis Waist circumference

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Delivering quantum dots to lubricants: Current status and prospect

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Friction 2022年第11期10卷 1751-1771页

作者： Wenling ZHANG Tianhao LI rong AN Jiong WANG Yu TIAN School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China Herbert Gleiter Institute of Nanoscience School of Material Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China

Very recently,two-dimensional quantum dots(2D QDs)have been pioneeringly investigated as lubricant additives,which exhibit superior friction-reducing and wear *** with 2D nanoparticles,2D QDs possess small size(~10 nm)and abundant active *** distinguished advantages enable them to quickly disperse into common lube mediums and maintain long-term storage *** good dispersion stability of 2D QDs not only effectively improves their embedding capacity,but also enables continuous supplements of lubricants during the sliding ***,2D QDs are attracting increasing research interest as efficient lubricants with desirable service *** this review,we focus on the latest studies of 2D QDs as liquid lubricant additives(both in polar and nonpolar mediums),self-lubricating solid coatings and gels,*** advanced strategies for synthesis and modification of 2D QDs are summarized.A comprehensive insight into the tribological behavior of a variety of 2D QDs together with the associated mechanism is reviewed in *** superior lubricating performances of 2D QDs are attributed to various mechanisms,including rolling effect,self-mending performance,polishing effect,tribofilm formation,nanostructure transfer and synergistic effects,*** for friction modulation of 2D QDs,including internal factors(surface modification,elemental doping)and extrinsic factors(counter surfaces,test conditions)are discussed,special attentions for achieving intelligent tribology toward superlubricity and bio-engineering,are also ***,the future challenges and research directions regarding QDs as lubricants conforming to the concept of“green tribology”toward a sustainable society are discussed.

关键词： quantum dots(QDs) design diversity dispersibility embedding stability lubrication

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Antithymocyte globulin treatment at the time of transplantation impairs donor hematopoietic stem cell engraftment

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Cellular & Molecular Immunology 2017年第5期14卷 443-450页

作者： Feng Jin Jin He Chunhui Jin Wei Fan Yanhong Shan Zhefeng Zhang Liguang Sun Zheng Hu yong-Guang yang The First Hospital of Jilin University Changchun China Institute of Immunology Jilin University Changchun China Columbla uenter for Translational Immunology Columbia University College of Physicians and Surgeons New York NY USA

Antithymocyte globulin （ATG） is often included in the conditioning regimen to prevent graft vs. host disease in allogeneic hematopoietic stem cell （HSC） transplantation. However, because ATG contains antibodies targeting a wide range of antigens on human cells, its potential off-target effects remain a concern. Here, we explored this question in humanized mice that permit the analysis of human cell depletion in tissues. We showed that ATG binds to almost all lineages of human hematopoietic cells including HSCs, and accordingly it is capable of depleting almost all human hematopoietic cells. Interestingly, the efficacy of ATG was highly variable depending on the tissue of residence, with human cells in bone marrow significantly less susceptible than those in the blood and spleen. Recovery of multilineage human lymphohematopoietic reconstitution in humanized mice that received ATG 3 weeks after HSC transplantation indicates that ATG had a minimal effect on human HSCs that have settled in bone marrow niches. However, efficient human HSC depletion and engraftment failure were seen in mice receiving ATG at the time of transplantation. Our data indicate that the efficacy of ATG is tissue-dependent, and suggest a potential risk of impairing donor hematopoietic engraftment when ATG is used in preparative conditioning regimens.

关键词： ATG transplantation hematopoietic stem cell humanized mice

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Evaluation on the Essentiality Grades of Water Conserving in Tibet, China

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Wuhan University Journal of Natural Sciences 2005年第4期10卷 628-634页

作者： H_EXiao-rong ZHONGXiang-hao FANJian-rong FANJi-hui LIHui-xia InstituteofMountainChineseAcademyofSciences ChinaHazardsandEnvironmentChengdu610041Sichuan／／GraduatedSchoolofChineseAcademyofSciencesBeijing100039China InstituteofMountainHazardsandEnvironment ChineseAcademyofSciencesChengdu610041SichuanChina DepartmentofResourceandEnvironment FoshanUniversityFoshan528000GuangdongChina

Taking Tibet as an example, the functional essentiality degrees of water resources conserving of regions were discussed in this paper. At first, based on the status of regional vegetation, whether the region has the function of water conserving was made certain. And then, according to the impacted objects of water resources conserving, taking into account the demands for water and regional supply capacities of water and the requirement of environmental protection, the functional grades of regional water resources conserving of Tibet were evaluated in this paper.

关键词： Tibet function of water resources conserving evaluation

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Skyrmion-(non)crystal structure stabilized by dipolar interaction

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Rare Metals 2022年第9期41卷 3160-3169页

作者： Ming-Xiu Sui yong Hu Department of Physics College of SciencesNortheastern UniversityShenyang110819China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819China

We report a numerical study on the role of longrange dipolar interaction played on the creation and stabilization of skyrmion-(non)crystal structure in chiral ferromagnetic thin films without any anisotropies,based on a Monte-Carlo simulation *** the increase of external magnetic field,the microscopic spin configuration is transformed from a spin-spiral stripe or labyrinth structure,depending on the strength of dipolar interaction,into a skyrmion-(non)crystal structure,and then into a skyrmiongas structure,and finally into a ferromagnetic ***,with the increase of dipolar interaction,the skyrmion-crystal structure evolves from a triangular arrangement into a square arrangement with the change of skyrmion shape from circle to *** larger dipolar interactions,the skyrmion-crystal structure loses the regular arrangements and the skyrmions,remaining topological,exhibit different shapes and sizes and squeeze with each other,whose distributions are analogous to a non-crystal ***,different skyrmion-(non)crystal structures are stabilized in different ranges of dipolar interactions,which further promotes the applications of skyrmions as non-volatile information carriers.

关键词： Chiral ferromagnetic thin film Skyrmion(non)crystal structure Interfacial Dzyaloshinskii-Moriya interaction Dipolar interaction Monte-Carlo simulation

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Cage-like radiotherapy system for noncoplanar radiotherapy

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Nuclear Science and Techniques 2021年第2期32卷 1-10页

作者： Chuan-Meng Niu Ming-Hui Li Jian-rong Dai Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

The aim of this study was to design a cage-like radiotherapy system(CRTS)to further promote the clinical application of noncoplanar *** CRTS comprises two stands,two O-rings,several arc girders,an X-ray head,an imaging subsystem,and a treatment *** X-ray head rotates with O-rings around the patient’s body and slides along the arc *** with the C-arm linear accelerator(C-Linac),the clinically available spatial irradiation angle ranges(SIARs)of the CRTS for the head,chest,and abdomen were 33%,63.6%,and 62.6%larger,***,according to a preliminary planning comparison based on the dose distribution simulation method,the CRTS achieved much better protection of normal tissue than the ***,the CRTS enabled accurate noncoplanar irradiation without movement of the body being irradiated,allowed automatic control of the movements of different parts without risk of collisions,and provided continuous radiation over an angle that considerably exceeded a full *** advantages make CRTS very promising for noncoplanar radiotherapy.

关键词： Radiotherapy system Noncoplanar radiotherapy Spatial irradiation angle range Spherical surface area

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Stability for a competing system of hierarchical age-structured populations

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International Journal of Biomathematics 2020年第7期13卷 325-345页

作者： Ze-rong He Nan Zhou Institute of Operational Research and Cybernetics Hangzhou Dianzi University Hangzhou 310018P.R.China

In this paper,we are concerned with the stability for a model in the form of system of integro-partial differential equations,which governs the evolution of two competing age-structured *** age-specified environment is incorporated in the vital rates,which displays the hierarchy of *** a non-zero fixed-point result,we show the existence of positive *** conditions for the stability of steady states are derived by means of semigroup ***,numerical experiments are also presented.

关键词： Dominance rank population system equilibria stability semigroup of linear operators

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Crack buckling in soft gels under compression

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Acta Mechanica Sinica 2012年第4期28卷 1098-1105页

作者： rong Long Chung-Yuen Hui Department of Biological and Environmental Engineering Cornell University Ithaca 14853 New York USA Field of Theoretical and Applied Mechanics Cornell University Ithaca 14850 New York USA

Recent interest in designing soft gels with high fracture toughness has called for simple and robust methods to test fracture behavior. The conventional method of applying tension to a gel sample suffers from a difficulty of sample gripping. In this paper, we study a possible fracture mechanism of soft gels under uni-axial compression. We show that the surfaces of a pre-existing crack, oriented parallel to the loading axis, can buckle at a critical compressive stress. This buckling instability can open the crack surfaces and cre- ate highly concentrated stress fields near the crack tip, which can lead to crack growth. We show that the onset of crack buckling can be deduced by a dimensional argument com- bined with an analysis to determine the critical compression needed to induce surface instabilities of an elastic half space. The critical compression for buckling was verified for a neo- Hookean material model using finite element simulations.

关键词： Fracture mechanics. Soft gels. Buckling. Crack Compression

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Relations of Uranium Enrichment and Metal Sulfides within the Shuanglong Uranium Deposit,Southern Ordos Basin

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Journal of Earth Science 2022年第2期33卷 395-408页

作者： Yuhan Sun yangquan Jiao LiqunWu Hui rong Key Laboratory of Tectonics and Petroleum Resources China University of GeosciencesMinistry of EducationWuhan 430074China School of Earth Resources China University of GeosciencesWuhan 430074China

Large quantities of metal sulfides are widely distributed in uranium ores from the Middle Jurassic Zhiluo Formation of the Shuanglong uranium deposit,southern Ordos Basin,providing a convenient condition to study the relationship between metal sulfides and uranium *** morphology and composition of uranium minerals and metal sulfides are illustrated to study uranium mineralization and mechanisms of *** minerals can be broadly categorized as pitchblende,coffinite and *** sulfides associated with uranium minerals are pyrite,sphalerite,chalcopyrite and *** assemblages of various metal sulfides and uranium minerals indicate that they are coeval,but the order of formation is *** on mineralogical observations,paragenetic sequences for mineral assemblages are *** of Fe-Ti oxides forms Ti oxides,brannerite and *** formation of chalcopyrite was later than that of ***(Pb Se)replaces sphalerite or shows isomorphism with *** are three genetic types of galena,of which typeⅠis related to tectonic thermal events and can interact with uranyl ions to form uranium oxides and Pb;.When sulfur activity is relatively high,Pb;can form new anhedral galena,that is,typeⅡ.TypeⅢof galena is related to the decay of uranium *** genetic order of the main minerals was determined as follows:Fe-Ti oxides>Ti oxides/sphalerite/pyrite>clausthalite/galenaⅠ/chalcopyrite>galenaⅡ/uranium minerals>galenaⅢduring the diagenetic *** sulfide(H;S)is a decisive factor in the interaction between metal sulfides and *** ions can react with H;S,accompanied by precipitation and enrichment of uranium minerals.

关键词： uranium mineralization metal sulfides hydrogen sulfide paragenetic sequences Shuanglong uranium deposit ore deposit geology

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