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Irradiation effects on nanocrystalline materials

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Frontiers of Materials Science 2013年第2期7卷 143-155页

作者： yong-qin chang Qiang GUO Jing ZHANG Lin CHEN Yi LONG Fa-Rong WAN School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

In recent years, nanocrystalline materials with grain size below 100 nm have attracted much interest due to their excellent chemical, physical, and optical properties. This review focuses on the irradiation effects of nanocrystalline materials. It has been generally believed that nanocrystalline materials have a great potential to increase irradiation resistance in the future reactor because of a large fraction of grain boundaries or interfaces that could absorb and annihilate mobile defects which produced during irradiation. Some calculation results and experiment results revealed that nanocrystalline materials can enhance irradiation resistance, while some reports showed that nanocrystalline materials exhibit worse irradiation resistance, or even amorphous at a lower irradiation dose compared with their bulk materials. During the irradiation process, the grain growth dominated by irradiation dose, thermal effect or defects was also disputed. Irradiation is also an important tool to tailor the grain size, phase structure and physical properties of the materials.

关键词： nanocrystalline material irradiation resistance grain growth

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian qin Yuxin Jin Yiming qin Feifei Yuan Hongbin Lu Jianzhong Hu yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： yong-chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He chang-qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

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World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： Yu-qin Li Wen-Tao Kuai Lin Chen Ming-Hui Zeng Xue-Mei Tao Jia-Xin Han Yue-Kui Wang Lian-Xin Xu Li-Ying Ge yong-Gang Liu Shuang Li Liang Xu Yu-Qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

Multiquadric Finite Difference (MQ-FD) Method and its Application

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Advances in Applied Mathematics and Mechanics 2009年第5期1卷 615-638页

作者： yong Yuan Shan chang Shu Ning qin Department of Mechanical Engineering National University of Singapore10 Kent Ridge CrescentSingapore 119260Singapore Department of Mechanical Engineering University of SheffieldMappin StreetSheffield S13JDUnited Kingdom

The conventional finite difference(FD)schemes are based on the low order polynomial approximation in a local *** paper shows that when the polynomial approximation is replaced by the multiquadric(MQ)function approximation in the same region,a new FD method,which is termed as MQ-FD method in this work,can be *** paper gives analytical formulas of the MQ-FD method and carries out a performance study for its derivative approximation and solution of Poisson equation and the incompressible Navier-Stokes *** addition,the effect of the shape parameter c in MQ on the formulas of the MQFD method is *** approximation in one-dimensional space and Poisson equation in two-dimensional space are taken as model problems to study the accuracy of the MQ-FD ***,a lid-driven flow problem in a square cavity is simulated by the MQ-FD *** obtained results indicate that this method may solve the engineering problem very accurately with a proper choice of the shape parameter c.

关键词： MQ-FD method shape parameter central FD method

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广西百色马生长激素基因的克隆与序列分析

黑龙江畜牧兽医 2010年第2期 11-13页

作者：蒋钦杨何山红阮栋俭韦英明 AL-KAL Abakar 陈宝剑覃永长蒋和生广西大学动物科学技术学院广西南宁530004 田阳县水产畜牧兽医局广西田阳533600 广西科学院广西南宁530007

为了丰富优良地方品种百色马的分子遗传学基础数据,试验设计1对特异性引物,利用PCR技术成功克隆百色马的生长激素基因全序列。结果表明:百色马GH基因碱基序列全长1922bp(GenBank登录号为FJ604598),包含完整的5个外显子和4个内含子;与蒙... 详细信息

为了丰富优良地方品种百色马的分子遗传学基础数据,试验设计1对特异性引物,利用PCR技术成功克隆百色马的生长激素基因全序列。结果表明:百色马GH基因碱基序列全长1922bp(GenBank登录号为FJ604598),包含完整的5个外显子和4个内含子;与蒙古马比较,百色马GH基因DNA序列出现12个碱基的变异,有3个变异位点处于编码区,均为有义突变,突变方式都为G→A的转换,其中第981位碱基G→A致使第89位氨基酸由Arg突变为Lys,第1739位碱基G→A使第185位氨基酸由Gly→Arg,第1764位碱基G→A使第193位氨基酸由Gly→Asp。基于GH基因构建的不同,动物亲缘进化树的拓扑结构与物种树一致,哺乳动物的GH基因在进化中比较保守。

关键词：百色马生长激素基因克隆序列分析

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng Wen qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

SAGE based iterative receiver for joint synchronization and channel estimation in uplink MIMO-OFDMA systems

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The Journal of China Universities of Posts and Telecommunications 2008年第3期15卷 100-104页

作者： JIANG Zheng qin Xiao-fang ZHANG Xin chang yong-yu Wireless Theories and Technologies Laboratory Beijing University of Posts and Telecommunications Beijing 100876 China

A new Turbo iterative receiver structure is proposed for the uplink multiple-input multiple-output orthogonal frequency division multiple access （MIMO-OFDMA） systems. The space-alternating generalized expectation-maximization （SAGE） algorithm is naturally embedded in the framework of iterative receiver to perform synchronization and detection usin~ the Turbo detector outputs. In each iteration, the expectation step intends to remove the multiple access interference （MAI） caused by other asynchronous users, and the maximization step is utilized to estimate the required parameters （i.e., timing offset, carrier frequency offset, channel state information, etc.） sequentially for each user. Simulation results show that the proposed algorithm can approach the performance of ideal receiver closely, while the processing complexity is rather lower than the conventional detectors.

关键词： SAGE iterative receiver synchronization channel estimation

Influence of crucible material on inclusions in 95Cr saw-wire steel deoxidized by Si–Mn

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International Journal of Minerals,Metallurgy and Materials 2020年第8期27卷 1083-1099页

作者： Yang Li chang-yong Chen Guo-qing qin Zhou-hua Jiang Meng Sun Kui Chen School of Metallurgy Northeasten UniversityShenyang 110819China

To investigate the interaction mechanism between 95 Cr saw-wire steel and different refractories,we conducted laboratory experiments at 1873 *** crucible materials(SiO2,Al2 O3,MgO·Al2 O3,MgO,and MgO-CaO)were *** results indicate that SiO2,Al2 O3,and MgO·Al2 O3 are not suitable for smelting low-oxygen,low-[Al]s 95 Cr saw-wire steel,mainly because they react with the elements in the molten steel and pollute the steel *** contrast,MgO-CaO is an ideal choice to produce 95 Cr saw-wire *** offers three advantages:(ⅰ)It does not decompose by itself at the steelmaking temperature of 1873 K because it exhibits good thermal stability;(ⅱ)[C],[Si],and[Mn]in molten steel cannot react with it to increase the[O]content;and(ⅲ)it not only desulfurizes and dephosphorizes but also removes Al2 O3 inclusions from the steel *** a result,the contents of the main elements([C],[Si],[Mn],[Cr],N,T.O(total oxygen))in the steel are not affected and the content of impurity elements([Al]s,P,and S)can be perfectly controlled within the target ***,the number and size of inclusions in the steel samples decrease sharply when the MgO-CaO crucible is used.

关键词： nonmetallic inclusions 95Cr saw-wire steel crucible material MgO–CaO refractory