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Cadherin-18 loss in prospermatogonia and spermatogonial stem cells enhances cell adhesion through a compensatory mechanism

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Zoological Research 2024年第5期45卷 1048-1060页

作者： Xiao-Xiao li Dan-Chen Zhang Yan Wang Jian Wen Xing-Ju Wang Yu-Lu Cao Ru Jiang Jia-Rui li Yi-Nuo li He-He liu Wen-Hai Xie Zheng-Feng Xu Ping Hu Kang Zou Germline Stem Cells and Microenvironment Lab College of Animal Science and TechnologyNanjing Agricultural UniversityNanjingJiangsu 210095China Stem Cell Research and Translation Center Nanjing Agricultural UniversityNanjingJiangsu 210095China School of life Sciences and Medicine Shandong University of TechnologyZiboShandong 255000China Department of Prenatal Diagnosis Women’s Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China

Extracellular membrane proteins are crucial for mediating cell attachment,recognition,and signal transduction in the testicular microenvironment,particularly germline stem *** 18(CDH18),a type Ⅱ classical cadherin,is primarily expressed in the nervous and reproductive ***,we investigated the expression of CDH18in neonatal porcine prospermatogonia(ProSGs)and murine spermatogonial stem cells(SSCs).Disruption of CDH18 expression did not adversely affect cell morphology,proliferation,self-renewal,or differentiation in cultured porcine ProSGs,but enhanced cell adhesion and prolonged cell *** analysis indicated that the down-regulation of CDH18 in ProSGs significantly up-regulated genes and signaling pathways associated with cell *** further elucidate the function of CDH18 in germ cells,Cdh18 knockout mice were generated,which exhibited normal testicular morphology,histology,*** analysis showed increased expression of genes associated with adhesion,consistent with the observations in porcine *** interaction of CDH18withβ-catenin and JAK2 in both porcine ProSGs and murine SSCs suggested an inhibitory effect on the canonical Wnt and JAK-STAT signaling pathways during CDH18 ***,these findings highlight the crucial role of CDH18 in regulating cell adhesion in porcine ProSGs and mouse *** this regulatory mechanism provides significant insights into the testicular niche.

关键词： Extracellular signal Fertility Quiescency Wnt signaling pathway

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Recent advances in Ir/Ru-based perovskite electrocatalysts for oxygen evolution reaction

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Rare Metals 2024年第7期43卷 2891-2912页

作者： Zhi-Qi Jiang Cheng-Zhen Fan Jun-Yu Pan li Shao Hao Chen Erum Pervaiz Yan Dong Tong-Zhou Wang Xue-Rong Zheng Ji-Hong li Yi-Da Deng School of Materials Science and Engineering Hainan UniversityHaikou570228Chin Department of Chemical Engineering School of Chemical and Materials Engineering(SCME)National University of Sciences&Technology(NUST)Islamabad 44000Pakistan Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071Chin

Oxygen evolution reaction(OER)is a kinetically harsh four-electron anode reaction that requires a large overpotential to provide current and is of great importance in renewable electrochemical ***/Rubased perovskite oxides hold great significance for application as OER electrocatalysts,due to that their multimetal-oxide forms can reduce the use of noble metals,and their compositional tunability can modulate the electronic structure and optimize OER ***,high operating potentials and corrosive environments pose a serious challenge to the development of durable Ir-based and Ru-based perovskite *** efforts have been dedicated to improving the Ir/Ru-based perovskite activity to enhance the efficiency;however,progress in improving the durability of Ir/Ru-based perovskite electrocatalysts has been rather *** this review,the recent research progress of Ir/Ru-based perovskites is reviewed from the perspective of heteroatom doping,structural modulation,and formation of *** dissolution mechanism studies of Ir/Ru and experimental attempts to improve the durability of Ir/Ru-based perovskite electrocatalysts are *** and outlooks for further developing Ru-and Irbased perovskite oxygen electrocatalysts are also presented.

关键词： Oxygen evolution reaction Ir/Ru-based perovskites Stability Electrocatalysts

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Recent advances,challenges,and perspectives on carbon capture

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 75-104页

作者： Shihan Zhang Yao Shen Chenghang Zheng Qianqian Xu Yifang Sun Min Huang Lu li Xiongwei Yang Hao Zhou Heliang Ma Zhendong li Yuanhang Zhang Wenqing liu Xiang Gao Institute of Energy and Sustainable Development Zhejiang University of TechnologyHangzhou 310014China College of Environment Zhejiang University of TechnologyHangzhou 310014China Baima Lake Laboratory Hangzhou 310051China Institute of Carbon Neutrality College of Energy EngineeringZhejiang UniversityHangzhou 310027China State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Key Laboratory of Environmental Optics and Technology Anhui Institute of Optics and Fine MechanicsHFIPSChinese Academy of SciencesHefei 230031China

Carbon capture,utilization and storage(CCUS)technologies play an essential role in achieving Net Zero Emissions *** the lack of timely reviews on the recent advancements in promising CCUS technologies,it is crucial to provide a prompt review of the CCUS advances to understand the current research gaps pertained to its industrial *** that end,this review first summarized the developmental history of CCUS technologies and the current large-scale ***,based on a visually bibliometric analysis,the carbon capture remains a hotspot in the CCUS *** that the materials applied in the carbon capture process determines its *** a result,the state-of-the-art carbon capture materials and emerging capture technologies were comprehensively summarized and *** between state-of-art carbon capture process and its ideal counterpart are analyzed,and insights into the research needs such as material design,process optimization,environmental impact,and technical and economic assessments are provided.

关键词： Carbon capture,utilization and storage Visualization analysis Research hotspots and trends CO_(2)capture technology

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阳离子自交联苯丙聚合物及其改性ASA乳液的制备与性能研究

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中国造纸 2024年第5期43卷 124-129,170页

作者：张勇李小瑞张家口市生态环境局沽源县分局河北沽源076550 陕西科技大学化学与化工学院陕西西安710021

本研究选用甲基丙烯酰氧乙基三甲基氯化铵(DMC)、丙烯酰胺(AM)、苯乙烯(St)、丙烯酸丁酯(BA)、N-羟甲基丙烯酰胺(NMA)为共聚单体,经水溶液共聚方式制得阳离子自交联苯丙聚合物,并对其乳化ASA的实验条件进行了探究。结果表明,功能型单体... 详细信息

本研究选用甲基丙烯酰氧乙基三甲基氯化铵(DMC)、丙烯酰胺(AM)、苯乙烯(St)、丙烯酸丁酯(BA)、N-羟甲基丙烯酰胺(NMA)为共聚单体,经水溶液共聚方式制得阳离子自交联苯丙聚合物,并对其乳化ASA的实验条件进行了探究。结果表明,功能型单体的最佳用量为(相对于共聚单体)DMC 9.5%、NMA 2%,ASA与阳离子自交联苯丙聚合物最佳质量比为4.5∶1,改性后的ASA乳液具有优良的分散性和稳定性;用阳离子淀粉、矾土为双元助留剂,在浆料pH值为6.5,改性ASA乳液用量(相对于阔叶木浆)为0.15%,抄造的纸张施胶度达92 s;与原纸相比,施胶纸张耐折度、撕裂指数、抗张指数、环压指数分别提高41.2%、38.3%、45.6%、58.7%;碳酸钙填料为15%~20%,具有良好的施胶效果,适用于中性施胶。

关键词：阳离子自交联苯丙聚合物改性ASA施胶剂分散性稳定性中性施胶

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5S-Heudelotinone alleviates experimental colitis by shaping the immune system and enhancing the intestinal barrier in a gut microbiota-dependent manner

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2153-2176页

作者： Qing Meng Jianshuang Guo Ke Lv Yang liu Jin Zhang Mingyue li Xirui Cheng Shenghua Chen Xiaoguang Huo Quan Zhang Yue Chen Jing li State Key Laboratory of Medicinal Chemical Biology College of PharmacyNankai UniversityTianjin 300353China College of Chemistry and Frontiers Science Center for New Organic Matter Haihe Laboratory of Sustainable Chemical TransformationsNankai UniversityTianjin 300071China Accendatech Company Ltd.Tianjin 300193China

Aberrant changes in the gut microbiota are implicated in many diseases,including inflammatory bowel disease(IBD).Gut microbes produce diverse metabolites that can shape the immune system and impact the intestinal barrier integrity,indicating that microbe-mediated modulation may be a promising strategy for preventing and treating *** fecal microbiota transplantation and probiotic supplementation are well-established IBD therapies,novel chemical agents that are safe and exert strong effects on the gut microbiota are urgently ***,we report the total synthesis of heudelotinone and the discovery of 5S-heudelotinone(an enantiomer)as a potent agent against experimental colitis that acts by modulating the gut microbiota.5S-Heudelotinone alters the diversity and composition of the gut microbiota and increases the concentration of short-chain fatty acids(SCFAs);thus,it regulates the intestinal immune system by reducing proinflammatory immune cell numbers,and maintains intestinal mucosal integrity by modulating tight junctions(TJs).Moreover,5S-heudelotinone(2)ameliorates colitis-associated colorectal cancer(CAC)in an azoxymethane(AOM)/dextran sulfate sodium(DSS)-induced in situ carcinoma ***,these findings reveal the potential of a novel natural product,namely,5S-heudelotinone,to control intestinal inflammation and highlight that this product is a safe and effective candidate for the treatment of IBD and CAC.

关键词： 5S-heudelotinone Total synthesis Inflammatory bowel disease Gut microbiota Short-chain fatty acids Immune system Intestinal barrier Drug discovery

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Dear-DIA^(XMBD): Deep Autoencoder Enables Deconvolution of Data-Independent Acquisition Proteomics

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Research 2024年第1期6卷 707-720页

作者： Qingzu He Chuan-Qi Zhong Xiang li Huan Guo Yiming li Mingxuan Gao Rongshan Yu Xianming liu Fangfei Zhang Donghui Guo Fangfu Ye Tiannan Guo Jianwei Shuai Jiahuai Han Department of Physics and Fujian Provincial Key Laboratory for Soft Functional Materials ResearchXiamen UniversityXiamen 361005China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)and Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China School of life Sciences Xiamen UniversityXiamen 361102China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkXiamen 361102China Department of Computer Science Xiamen UniversityXiamen 361005China National Institute for Data Science in Health and Medicine School of MedicineXiamen UniversityXiamen 361102China Bruker(Beijing)Scientific Technology Co.Ltd. BeijingChina Westlake Laboratory of life Sciences and Biomedicine Key Laboratory of Structural Biology of Zhejiang ProvinceSchool of Life SciencesWestlake University18 Shilongshan RoadHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced Study18 Shilongshan RoadHangzhou 310024China Westlake Omics Ltd. Yunmeng Road 1HangzhouChina Department of Electronic Engineering Xiamen UniversityXiamen 361005China

Data-independent acquisition(DIA)technology for protein identification from mass spectrometry and related algorithms is developing *** spectrum-centric analysis of DIA data without the use of spectra library from data-dependent acquisition data represents a promising *** this paper,we proposed an untargeted analysis method,Dear-DIA^(XMBD),for direct analysis of DIA ***-DIA^(XMBD) first integrates the deep variational autoencoder and triplet loss to learn the representations of the extracted fragment ion chromatograms,then uses the k-means clustering algorithm to aggregate fragments with similar representations into the same classes,and finally establishes the inverted index tables to determine the precursors of fragment clusters between precursors and peptides and between fragments and *** show that Dear-DIA^(XMBD) performs superiorly with the highly complicated DIA data of different species obtained by different instrument platforms.

关键词： Deep Auto Independent

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Knowledge domain and emerging trends in the rupture risk of intracranial aneurysms research from 2004 to 2023

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World Journal of Clinical Cases 2024年第23期12卷 5382-5403页

作者： Jun-Chen Chen Cheng Luo yong li Dian-Hui Tan Department of Neurosurgery The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

BACKGROUND Intracranial aneurysms(IAs)pose significant health risks,attributable to their potential for sudden rupture,which can result in severe outcomes such as stroke and *** extensive research,the variability of aneurysm behavior,with some remaining stable for years while others rupture unexpectedly,remains poorly *** To employ bibliometric analysis to map the research landscape concerning risk factors associated with IAs *** A systematic literature review of publications from 2004 to 2023 was conducted,analyzing 3804 documents from the Web of Science Core Collection database,with a focus on full-text articles and reviews in *** analysis encompassed citation and co-citation networks,keyword bursts,and temporal trends to delineate the evolution of research themes and collaboration *** software tools,CiteSpace and VOSviewer,were utilized for comprehensive data visualization and trend *** Analysis uncovered a total of 3804 publications on IA rupture risk factors between 2006 and *** interest surged after 2013,peaking in *** United States led with 28.97%of publications,garnering 37706 *** United States-China collaborations were *** Medical University produced 184 publications,while Utrecht University boasted a citation average of 69.62 per publication.“World Neurosurgery”published the most papers,contrasting with“Stroke”,the most cited *** PHASES score from“Lancet Neurology”emerged as a vital rupture risk prediction *** research favored endovascular therapy,transitioning to magnetic resonance imaging and flow *** This study assesses global IA research trends and highlights crucial gaps,guiding future investigations to improve preventive and therapeutic approaches.

关键词： Bibliometric VOSviewer CiteSpace Intracranial aneurysm Risk factor

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Research on the Cultivation of Aesthetics among Art Students under the New Era Background

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Journal of Contemporary Educational Research 2024年第10期8卷 69-74页

作者： Yanmeng Fan Zhu liu yong Guo Nan li Zhiheng Guo Harbin University of Science And Technology Rongcheng Campus Rongcheng 264300Shandong ProvinceChina

Through understanding the history and current situation of aesthetic education in China,this paper explains some misunderstandings in the aesthetics of contemporary university art students,such as the insufficiency of aesthetic value and ability,as well as the inadequacy of students’creativity due to traditional art *** is also pointed out that the cultivation of core literacy of art students is a multidimensional and comprehensive process,and these problems need to be solved by schools,teachers,and students,so as to strengthen the inner aesthetic education of students and improve their aesthetic awareness and *** education is not only an important part of the art classroom but also a key part of fostering students’all-round development and enhancing their humanistic *** is necessary to cultivate students’observation,imagination,image-thinking ability,and creativity,so that they can become artistic talents with independent thinking and innovation.

关键词： Aesthetics Core literacy Art education Creativity Talent cultivation

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Intense Intramolecular Charge Transfer Endows Cyanated Polymer with Broad Absorption,Intensified light-Harvesting,Long-lived Exciton,and Superior Photovoltaic Property

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CCS Chemistry 2024年第9期6卷 2318-2332页

作者： Jinming Chen Huijuan Wang Songmin Mo Hui Chen Xinyu He Mingbin Su Dongyan li yonghong Xiao Zhiqi Wang Fanwei Ye Mingde li li Dang Xiao-Chun Huang Chang-Zhi li Feng He Qinghe Wu Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Department of ChemistryShantou UniversityShantou 515063 Department of Chemistry Shenzhen Grubbs InstituteSouthern University of Science and TechnologyShenzhen 518055 Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310027 Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515063 Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and TechnologyShenzhen 518055

The donor–acceptor(D–A)copolymers,which exhibit wide broad absorption and intensified light-harvesting,are highly captivating for applications in solar conversion and ***,designing a polymer structure that can achieve these photophysical properties simultaneously remains a ***,we report two novel cyanated units 4-cyanobenzo[1,2-b:6,5-b′:3,4-c″]trithiophene(CBT)and 4,6-dicyanobenzo[1,2-b:6,5-b′:3,4-c″]trithiophene(C2BT)and their corresponding polymers,PCBT and *** interestingly,the PC2BT exhibited a broad absorption band with full width at half maxima(FWHM)of its absorption spectra,almost twice wider than PCBT and benchmark polymers PM6 and ***,the PC2BT demonstrated intensified light-harvesting and long-lived *** in-depth investigation unveiled that the presence of dicyano substitutions induced a strong intramolecular charge transfer(ICT),which,in turn,resulted in the formation of favorable photophysical ***,PC2BT-based polymer solar cells(PSCs)exhibited an efficiency of 18.06%,which was a record-setting efficiency for cyanated *** study suggests an efficient strategy for enhancing ICT to design polymers toward favorable photophysical properties and excellent photovoltaic performance.

关键词： intramolecular charge transfer broad absorption band dicyanobenzotrithiophene cyanated polymer polymer solar cell

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Effect of Deposition Temperature on Optical Properties of Porous Amorphous SiC Film

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 839-844页

作者：徐吉祥 TAO Weijie liU Canhui XU Haoyao li lixuan 贺振华 School of Information Engineering Wuhan University of TechnologyWuhan 430070China

To study the effect of different deposition temperatures on the optical properties of porous SiC films,single crystal Si was used as the substrate,a layer of anodic aluminum oxide(AAO)film was transferred on the Si substrate by chemical method,and then a layer of SiC was deposited on anodic aluminum oxide(AAO)template to prepare porous fluorescent SiC film by magnetron *** deposition temperature was ranged from 373 to 873 *** thickness of the porous SiC film coated on the AAO surface was around 283 *** is found that the porous SiC with the deposition temperature of 873 K has the strongest photoluminescence(PL)intensity excited by 375 nm *** time-resolved PL spectra prove that the PL is mainly from intrinsic light emitting of *** the optimized process,porous amorphous SiC film may have potential applications in the field of warm white LEDs.

关键词： porous SiC film fluorescent SiC anodic aluminum oxide magnetron sputtering time-resolved spectrum

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