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Antibody response and therapy in COVID-19 patients: what can be learned for vaccine development?

Science China(life Sciences) 2020年第12期63卷 1833-1849页

作者： ligong Lu Hui zhang Meixiao zhan Jun Jiang Hua Yin Danielle JDauphars Shi-You li yong li You-Wen He Zhuhai Interventional Medical Center Zhuhai Precision Medical CenterZhuhai People's HospitalZhuhai Hospital Affiliated with Jinan UniversityZhuhai 519000China First Affiliated Hospital China Medical UniversityShenyang 110001China tricision Biotherapeutic Inc. Zhuhai 519041China Department of Immunology Duke University Medical University Medical CenterDurhamNC 27710USA

The newly emerged severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has infected millions of people and caused tremendous morbidity and mortality worldwide. Effective treatment for coronavirus disease 2019(COVID-19) due to SARSCoV-2 infection is lacking, and different therapeutic strategies are under testing. Host humoral and cellular immunity to SARSCoV-2 infection is a critical determinant for patients’ outcomes. SARS-CoV-2 infection results in seroconversion and production of anti-SARS-CoV-2 antibodies. The antibodies may suppress viral replication through neutralization but might also participate in COVID-19 pathogenesis through a process termed antibody-dependent enhancement. Rapid progress has been made in the research of antibody response and therapy in COVID-19 patients, including characterization of the clinical features of antibody responses in different populations infected by SARS-CoV-2, treatment of COVID-19 patients with convalescent plasma and intravenous immunoglobin products, isolation and characterization of a large panel of monoclonal neutralizing antibodies and early clinical testing, as well as clinical results from several COVID-19 vaccine candidates. In this review, we summarize the recent progress and discuss the implications of these findings in vaccine development.

关键词： COVID-19 seroconversion neutralizing antibody spike protein SARS-CoV-2 convalescent plasma vaccine

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Study of parachute inflation process using fluid–structure interaction method

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Chinese Journal of Aeronautics 2014年第2期27卷 272-279页

作者： Yu li Cheng Han zhan Ya'nan li Shaoteng College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics

A direct numerical modeling method for parachute is proposed firstly, and a model for the star-shaped folded parachute with detailed structures is established. The simplified arbitrary Lagrangian-Eulerian fluid structure interaction （SALE/FSI） method is used to simulate the infla- tion process of a folded parachute, and the flow field calculation is mainly based on operator split- ting technique. By using this method, the dynamic variations of related parameters such as flow field and structure are obtained, and the load jump appearing at the end of initial inflation stage is cap- tured. Numerical results including opening load, drag characteristics, swinging angle, etc. are well consistent with wind tunnel tests. In addition, this coupled method can get more space-time detailed information such as geometry shape, structure, motion, and flow field. Compared with previous inflation time method, this method is a completely theoretical analysis approach without relying on empirical coefficients, which can provide a reference for material selection, performance optimi- zation during parachute design.

关键词： Empirical formula Fluid-structure interaction Inflation process Opening shockiParachute Wind tunnel test

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Chiral Imidazoline ligands and Their Applications in Metal-Catalyzed Asymmetric Synthesis

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Chinese Journal of Chemistry 2021年第2期39卷 488-514页

作者： Jiajing li Bing Yu zhan Lu Department of Chemistry Zhejiang UniversityHangzhouZhejiang310058 China College of Chemistry Zhengzhou UniversityZhengzhouHenan450001 China

As a structural analog of oxazoline,imidazoline(4,5-dihydroimidazole)has received much attention in the rational design of chiral *** additional N-substituent provides broader space for fine-tuning of electronic and steric effects,and it offers a good handle for immobilizing onto solid *** the past decades,imidazoline ring has emerged as a powerful candidate for the design of chiral nitrogen-containing ligands,as well as a significant alternative for oxazoline *** chiral imidazoline ligands have been designed and utilized in asymmetric organic *** new catalysts can not only be applied in classical reactions,but also be employed to develop new organic reactions with high *** review provides an overview of chiral imidazoline *** applications in asymmetric synthesis are also summarized.

关键词： N ligands Asymmetric catalysis Chiral imidazoline Enantioselectivity Metal catalysis

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Environmental Conditions Conducive to the Formation of Multiple Tropical Cyclones over the Western North Pacific

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Advances in Atmospheric Sciences 2024年第10期41卷 2027-2042页

作者： Yining GU Ruifen zhan Xiaomeng li Department of Atmospheric and Oceanic Sciences/Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China CMA-FDU Joint Laboratory of Marine Meteorology Shanghai 200030China Institute of Desert and Meteorology China Meteorological AdministrationUrumqi 830002China

There is limited understanding regarding the formation of multiple tropical cyclones(MTCs).This study explores the environmental conditions conducive to MTC formation by objectively determining the atmospheric circulation patterns favorable for MTC formation over the western North *** on 199 MTC events occurring from June to October 1980–2020,four distinct circulation patterns are identified:the monsoon trough(MT)pattern,accounting for 40.3%of occurrences,the confluence zone(CON)pattern at 26.2%,the easterly wave(EW)pattern at 17.8%,and the monsoon gyre(MG)pattern at 15.7%.The MT pattern mainly arises from the interaction between the subtropical high and the monsoon trough,with MTCs forming along the monsoon trough and its *** CON pattern is affected by the subtropical high,the South Asian high,and the monsoon trough,with MTCs emerging at the confluence zone where the prevailing southwesterly and southeasterly flows *** EW pattern is dominated by easterly flows,with MTCs developing along the easterly wave *** in the MG pattern arise within a monsoon vortex characterized by strong southwesterly flows.A quantitative analysis further indicates that MTC formation in the MT pattern is primarily governed by mid-level vertical velocity and low-level vorticity,while mid-level humidity and vertical velocity are significantly important in the other *** meridional shear and convergence of zonal winds are essential in converting barotropic energy from the basic flows to disturbance kinetic energy,acting as the primary source for eddy kinetic energy growth.

关键词： multiple tropical cyclones western North Pacific circulation pattern monsoon trough barotropic energy conversion

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High resolution bathymetry of China seas and their surroundings

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Chinese Science Bulletin 2001年第19期46卷 1661-1664页

作者： yong Wang Houze Xu Jigang zhan Chinese Acad Sci Inst Geodesy & Geophys Wuhan Peoples R China

Based on the oceanic lithospheric flexure and the worldwide bathymetric data ETOPO5, the high resolution bathymetry of the China seas and their surroundings is computed from altimeter derived gravity anomalies. The new bathymetry obtained by this study is higher resolution and accuracy than the widely used ETOPO5 data, meanwhile it shows clearly the seafloor, the tectonic characteristics and the geodynamical processes in the China seas.

关键词： China seas altimetry gravity anomalies bathymetry.

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Paragorgia papillata ***.,a new bubblegum coral(Octocorallia:Paragorgiidae)from a seamount in the tropical Western Pacific

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Journal of Oceanology and limnology 2021年第5期39卷 1758-1766页

作者： Yang li Zifeng zhan Kuidong XU Laboratory of Marine Organism Taxonomy and Phylogeny Shandong ProvinceKey Laboratory of Experimental Marine BiologyInstitute of OceanologyCenter for Ocean Mega-ScienceChineseAcademy of SciencesQingdao 266071China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China University of Chinese Academy of Sciences Beijing 100049China

A new species of bubblegum coral,Paragorgia papillata ***.,discovered from a seamount located on the Caroline Ridge at the water depth of 858 m,is studied using morphological and molecular *** new gorgonian is white-colored,uniplanar with prominent autozooids,and measures about670-mm high and 690-mm *** genetic distance and phylogenetic analysis showed that *** *** closely related to *** Bayer,1993,but the former differs morphologically from the latter by its prominent calyces(diameter 2.0-4.0 mm and height 1.5-3.0 mm *** diameter and height about 1 mm),white cortex(***),regular 8-radiates in surface cortex(*** 8-radiate derived globular radiates)and highly ornate medullar spindles(length 185-400μm *** more than 150μm).*** *** the third known white-colored species of the genus,and the fifth species found in the tropical Western Pacific.

关键词： Paragorgia gorgonian Scleraxonia Cnidaria new species seamount

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Establishment of Alloptilella splendida *** *** resurrection of Scytalium veneris(Thomson&Henderson,1906),two sea pens(Cnidaria:Pennatulacea)from seamounts in the tropical Western Pacific

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Journal of Oceanology and limnology 2021年第5期39卷 1790-1804页

作者： Yang li Zifeng zhan Kuidong XU Laboratory of Marine Organism Taxonomy and Phylogeny Shandong Province Key Laboratory of Experimental Marine BiologyInstitute of OceanologyCenter for Ocean Mega-ScienceChineseAcademy of SciencesQingdao 266071China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China University of Chinese Academy of Sciences Beijing 100049China

Sea pens are a highly specialized and morphologically distinct group of octocorallians,but many taxa were poorly described and their phylogenetic relationships are still poorly *** describe two species of sea pens collected from the tropical Western Pacific:Alloptilella splendida *** *** Scytalium veneris(Thomson&Henderson,1906).Alloptilella splendida *** *** with the definition of the recently resurrected genus Ptilella Gray,1870 in most characters,but differs from the latter in the arrangement of autozooids and the location of *** new species mostly resembles Pennatula naresi K(o|")lliker(1880),but differs by the location of me sozooids and the reddish color of sclerite s surrounding *** generic separation is also well supported by their genetic distances and the molecular phylogenetic trees constructed by the concatenated mtMutS-COI-28 S,where Alloptilella clustered with Scytalium Herklots,1858 and formed a clade with the cluster of Ptilella and *** veneris,usually considered as a junior synonym of Scytalium sarsii Herklots,1858,is resurrected by recognizing their distinctive *** is the first record of Scytalium veneris outside its type locality,and the phylogenetic analysis indicates that Scytalium is a monophyletic *** the families Pennatulidae and Virgulariidae are polyphyletic,and more morphological and molecular data are needed to clarify the phylogenetic positions of pennatulacean families and genera.

关键词： sea pen Pennatulidae Alloptilella new species Scytalium seamount

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Preparation of ultrafine WC-Co powder via fluidized bed

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Chinese Journal of Chemical Engineering 2024年第9期73卷 15-26页

作者： Huijun Shang Hengli li Weijun li Feng Pan zhan Du State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of Sciences(CAS)Beijing 100190China College of Chemistry and Chemical Engineering Shihezi UniversityShihezi 832003China College of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Chinalco Environmental Protection and Energy Conservation Group Co. Ltd.Xiong'an 071700China

In this study,the effects of reaction parameters on the deep-reduction and carbonization process of WO_(2)-Co to WC-Co were *** results indicate that the oxygen loss rate of WO_(2) is positively correlated with temperature and methane partial *** partial pressure of methane has no significant effect on the formation rate of *** carbon content and particle size of the product increase with the increase of CH_(4) partial *** synergistically regulating the reaction temperature to 950℃,the CH_(4) partial pressure to 1.25%,and the reaction time to 60 min,ultrafine WC-Co powder without η phase can be *** particle size of the composite powder is 128 nm,with total carbon content of 6.16%,free carbon content of 0.4%,and residual oxygen content of 0.05%,*** growth rate relationship of tungsten carbide is as follows:δ(t)=1.21×10^(-13)exp(-12809.72/T)√t.

关键词： Ultrafine WC-Co powder Gas-solid reaction Fluidization Reaction process regulation Growth rate equation

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17.1%-Efficiency organic photovoltaic cell enabled with two higher-LUMO-level acceptor guests as the quaternary strategy

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Science China Chemistry 2020年第4期63卷 490-496页

作者： Kun li Yishi Wu Xuemei li Hongbing Fu Chuanlang zhan Department of Chemistry Capital Normal UniversityBeijing 100048China School of Chemistry&Chemical Engineering Linyi UniversityLinyi 276000China CAS Key Laboratory of Photochemistry Institute of ChemistryChinese Academy of SciencesBeijing 100190China

Quaternary blended organic solar cells utilize four blended material components(one donor plus three acceptors, two donors and two acceptors, or three donors plus one acceptor) as the active layer materials. The use of four material components allows us to have more material selections and more mechanism choices to improve the photon-to-electron conversion efficiency. In this contribution, we present a new case of quaternary material system, that shows 17.1% efficiency obtained by adding IDIC and PC71BM as the guest acceptors of the host binary of PM6:Y6. The lowest unoccupied molecular orbital(LUMO) levels of IDIC and PC71BM are both higher than that of Y6, which is one reason to obtain increased open-circuit voltage(Voc) in the quaternary device. Upon introduction of IDIC and PC71BM as the acceptor guests, the hole and electron mobilities are both increased, which contributes to the increased short-circuit current-density(Jsc). Effects of the weight ratios of the three acceptor components are investigated, which demonstrates that the increased hole and electron mobilities, the accelerated hole-transfer, and the reduced monomolecular recombination are the factors contributing to the increased Jscand fill-factor. This case of quaternary device demonstrates the applicability of the quaternary strategy in increasing the device functions and hence the efficiencies in the field of organic photovoltaic cells.

关键词： quaternary solar cell organic photovoltaic small-molecule acceptor nonfullerene fullerene

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Multiarm Star Poly(ε-caprolactone) with Hyperbranched Polyamidoamine as Core Capable of Selective Accommodating Cationic or Anionic Guests

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Chinese Journal of Polymer Science 2015年第6期33卷 920-930页

作者： Chen zhan Si li Jin Cui 陈宇 Department of Chemistry School of SciencesTianjin Universityand Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) National Foodstuff Inspection Center Tianjin Product Quality Inspection Technology Research Institute

Hyperbranched polyamidoamines （HPAs） were directly employed as macroinitiators to initiate the Sn（Oct）2 catalyzed ring-opening polymerization of ε-caprolactone （CL）, resulting in multiarm star copolymers with poly（6- caprolactone）（PCL） as shells and HPA as core （HPA-b-PCL）. From 1H-NMR characterization it was deduced that both the primary amines and the secondary amide groups of HPAs could initiate the CL polymerization, and the initiation efficiency increased when more CL monomers were fed. The average arm-numbers of the obtained stars were in the range of 115-353. Differential scanning calorimetry measurements demonstrated that the melting and crystallization temperatures, fusion and crystallization enthalpy and the degree of crystallinity of the star polymers increased as the PCL arm length increased. HPA- b-PCL stars could be used as nanocarriers to efficiently accommodate anionic dyes at acidic condition, while load cationic dyes at basic condition. Compared with the dye-loading behavior of multiarrn star PCL with the neutral hyperbranched polyglycerol as core, it was deduced that HPA-b-PCL nanocarriers accommodated anionic dyes using the HPA core, while loaded cationic dyes using both the HPA core and the PCL shell. Dynamic light scattering analyses also supported such deduction. Furthermore, HPA-b-PCL nanocarriers could selectively load the anionic Eosin Y or the cationic methylene blue from their mixture at pH = 6 or 9, respectively, realizing their separation.

关键词： Nanocarrier Hyperbranched Polyamidoamine Poly(ε-caprolactone) Star polymers.

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