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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-jie Quan Hao Liang yong-Hong Tang Li jiang Xiong-Ying ji Feng-Ying zhang Ping zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

学习型组织视角下高校学生组织发展的内驱力研究

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陕西师范大学学报（哲学社会科学版） 2017年第2期46卷 171-176页

作者：王慧刘永栓章集香大连民族大学文法学院辽宁大连116600 对外经济贸易大学党委办公室北京100029 机械工业出版社北京100037

高校学生组织发展对提升大学生综合素质和能力具有不可替代的作用。在学习型组织理论指导下,构建多维互联的组织目标系统、有机灵活的组织结构系统、全面有效的组织学习系统是建设学习型学生组织的应有之义。同时,为进一步激发学生组织... 详细信息

高校学生组织发展对提升大学生综合素质和能力具有不可替代的作用。在学习型组织理论指导下,构建多维互联的组织目标系统、有机灵活的组织结构系统、全面有效的组织学习系统是建设学习型学生组织的应有之义。同时,为进一步激发学生组织发展的内驱力,需要采取建设卓越学生工作团队、改善学生组织管理监督和创新组织文化等措施。

关键词：学习型组织高校学生组织组织学习系统内驱力

Deciphering the role of ultra-low-loaded rhodium in NiFe-MIL-53 for superior oxygen evolution reaction

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Journal of Energy Chemistry 2025年第1期100卷 77-86页

作者： jinzhi jia jinhua zhang Kailu Guo Lanyue zhang Gening Du Hao You Junfeng Huang Mudong Tu Hua Li yong Peng Wei Dou Cailing Xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering School of Materials and Energy Lanzhou University College of Chemistry and Chemical Engineering Luoyang Normal University

Designing highly active and stable electrocatalysts of oxygen evolution reaction （OER） is one of the crucial *** this study,a novel OER electrocatalyst,NiFe-MIL-53 modified with ultra-low rhodium（Rh@NiFe-MIL-53）,is successfully prepared via the hydrothermal ***-situ Raman spectroscopy and electrochemical impedance spectroscopy reveal that the doped Rh accelerates the phase transformation of NiFe-MIL-53 and the in-situ formed Rh@NiFeOOH is the actual active *** importantly,the enhanced reversibility of electrochemical reconstruction between NiFeOOH and NiFe（OH）2after doping Rh is beneficial for improving the electrochemical stability of the catalyst.X-ray photoelectron spectroscopy spectra show the strong electronic interaction between single-atom Rh and Ni/Fe in Rh@***,theoretical calculations confirm that the integration of single-atom Rh into the NiFeOOH successfully reduces the band gap,regulates the d-band center （εd）,accelerates the charge transfer,and optimizes the adsorption behavior of oxygen-containing intermediates,thereby lowering the energy barrier of rate-determining ***,the optimized Rh@NiFe-MIL-53 exhibits excellent OER activity （240 mV） with a small Tafel slope of 48.2 mV dec-1and long-term durability (over1270 h at 10 m A cm-2and 110 h at 200 mA cm-2).This work presents a new perspective on designing highly efficient OER electrocatalysts.

关键词： NiFe-MIL-53 Rh Electrochemical reconstruction Catalytic mechanism Oxygen evolution reaction

Effect of Salt Stress on Ammonium Assimilation Enzymes of the Roots of Rice (Oryza sativa L.) Cultivars Differing in Salinity Resistance

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Effect of Salt Stress on Ammonium Assimilation Enzymes of th...

Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

湖北省暨武汉生物化学与分子生物学学会第八届会员代表大会和第十五次学术年会

作者： Zhou Wei, Sun Qing-jie, zhang Chu-Fu~*, Yuan yong-Ze, zhang ji (Key Laboratory of MOE for Developmental Biology, College of Life Sciences, Wuhan University, Wuhan 430072, China)

The effects of NaCl-stress on ammonia assimilation enzymes and the related parameters were determined in the roots of three rice (Oryza sativa L.) cultivars differing in salt tolerance. The results showed that the activities of glutamine synthetase (GS) and NADH-dependent glutamate synthase (NADH-GOGAT), as well as the levels of soluble protein decreased under high concentration salt. The influence extent was in accordance with Zao-hua 2 (salt-sensitive), jin-zhu 1 (normal cultivar), jin-dao 779 (salt-resistant), which was consistent with their salt-tolerance. Results from native-PAGE and activity dyeing indicated that GSrb by external nitrogen is more sensitive to the change of the external condition. Under the stress of high salt concentration, NADH-dependent glutamate dehydrogenase (NADH-GDH) activity of Zao-hua 2 and jin-zhu 1 was induced significantly, but that of jin-dao 779 did not increased remarkably, NADH-GDH activity had positive correlation with NH accumulation level. The salt stress led to the accumulation of total soluble sugar (TSS) in the root of jin-zhu 1 and jin-dao 779 in different degree. The level of TSS in Zao-hua 2 changed with different NaCl concentration, this suggested that the increase of TSS level would decrease the loss of water to keep the relative balance of ions in tissue, and play a role in making the activity of GOGAT and GS enzymes higher. Among the cultivars observed, content of proline increased in different degree, but under high salt eoncentration, it had a more marked rise in the roots of salt-sensitive cultivars. Effects of Different Lights on Ammonium Assimilation in Rice (Oryza sativa L.) Roots ji-Quan Ou, Chu-Fu zhang, Qing-hua Lin(Key Laboratory of MOE for Developmental Biology, College of Life Sciences, Wuhan University, Wuhan 430072, China)

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： yong Hou Shuo zhang jie Dang jia Guo Hanghang Zhou Xuewei Lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

农学专业《作物生产实践》课程教学体系改革的探索与实践

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西南师范大学学报（自然科学版） 2018年第5期43卷 200-205页

作者：赵勇王季春张建奎唐章林西南大学农学与生物科技学院/西南大学农学基础实验教学中心重庆400715

实践教学是农学专业人才培养的重要环节.在对农学专业实验实践教学现状进行分析的基础上,指出了其中存在的问题,阐述了实践教学改革的必要性,提出了改革的思路与具体措施.重新开设《作物生产实践》课程,确立新的实践教学内容体系和教学... 详细信息

实践教学是农学专业人才培养的重要环节.在对农学专业实验实践教学现状进行分析的基础上,指出了其中存在的问题,阐述了实践教学改革的必要性,提出了改革的思路与具体措施.重新开设《作物生产实践》课程,确立新的实践教学内容体系和教学方法体系,完善和更新实践教学评价体系.通过改革实践,取得了良好的效果,提高了学生专业技能和动手操作能力,训练了学生的创新意识和思维,提升了学生的创新精神和能力,促进了学生科学精神的发展.

关键词：农学专业作物生产实践教学体系改革探索

TWO NEW STEROIDAL ALKALOIDS FROM BULBS OF FRITILLARIA LICHUANENSIS

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TWO NEW STEROIDAL ALKALOIDS FROM BULBS OF FRITILLARIA LICHUA...

致密磷酸钙陶瓷在动态SBF中类骨磷灰石层形成研究

第八届全国中药和天然药物学术研讨会与第五届全国药用植物和植物药学学术研讨会

作者： Hui-Fang Pi, Han-Li Ruan, yong-Hui zhang, ji-Zhou Wu (Faculty of Pharmaceutical Sciences, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China)

Two new steroidal alkaloids lichuanine (1) and lichuanisinine (2) were isolated from the bulbs of Fritillaria Lichuanensis P. Li et C.P. Yang. Their structures were determined to be (205, 25R)-5□.. 14 □-cevanine-3□, 6D-diol (1) and (205, 25S)-5□, 14 D-cevanine-3□, 6□-diol-N-Oxide (2) by means of spectral analysis and chemical evidence.

关键词： Fritillaria Lichuanensis Liliaceae Steroidal alkaloid Lichuanine Lichuanisinine

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无机材料学报 2002年第3期17卷 552-558页

作者：段友容王朝元陈继镛张兴栋四川大学生物材料工程研究中心成都610064

磷酸钙陶瓷植入体内后其表面类骨磷灰石层的形成是诱导成骨的先决条件.本实验在模拟体液(simulated body fluid, SBF)以人体骨骼肌组织内体液的正常生理流率(2mL/***)和偏离正常生理流率流动的动态条件下,研究在动态SBF中影响致密磷酸... 详细信息

磷酸钙陶瓷植入体内后其表面类骨磷灰石层的形成是诱导成骨的先决条件.本实验在模拟体液(simulated body fluid, SBF)以人体骨骼肌组织内体液的正常生理流率(2mL/***)和偏离正常生理流率流动的动态条件下,研究在动态SBF中影响致密磷酸钙陶瓷表面类骨磷灰石层形成的因素.结果表明:在生理流率条件下,材料的粗糙表面有利于类骨磷灰石的形成,加大SBF中Ca2+、HPO2-4离子浓度,类骨磷灰石层的形成速度加快.比起通常使用的静态浸泡试验,SBF以生理流率流动的动态试验能够更好地模拟类骨磷灰石生长的体内环境.动态SBF对了解类骨磷灰石形成,进而了解磷酸钙陶瓷在体内诱导成骨机理是十分有用的.

关键词：致密磷酸钙陶瓷动态SBF 类骨磷灰石生物陶瓷生物材料

痛风患者外周血中炎症因子IL-18、IL-1β、TNF-α的变化

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中华全科医学 2017年第9期15卷 1487-1489页

作者：黄继勇张艳浙江中医药大学附属第二医院风湿免疫科浙江杭州310005 浙江中医药大学附属第三医院ICU 浙江杭州310005

目的了解痛风患者外周血中炎症因子IL-18、IL-1β、TNF-α的变化,探讨其在痛风发病中的作用。方法病例选自2013年8月—2014年10月浙江中医药大学附属第二医院门诊及病房就诊患者,痛风组共49例(急性期24例、间歇期25例),正常对照组为同... 详细信息

目的了解痛风患者外周血中炎症因子IL-18、IL-1β、TNF-α的变化,探讨其在痛风发病中的作用。方法病例选自2013年8月—2014年10月浙江中医药大学附属第二医院门诊及病房就诊患者,痛风组共49例(急性期24例、间歇期25例),正常对照组为同期门诊健康体检人群,共16例。均抽空腹外周静脉血,检测血尿酸、C反应蛋白(CRP)、白细胞介素-1β(interleukin-1 beta,IL-1β)、白细胞介素-18(interleukin-18,IL-18)、肿瘤坏死因子-α(tumor necrosis factor-alpha,TNF-α)。结果痛风组与正常对照组血清IL-18分别是[105.66(43.32,190.83)]pg/ml、[0.00(0.00,0.00)]pg/ml,IL-1β分别是[0.00(0.00,0.15)]pg/ml、[0.03(0.00,0.30)]pg/ml,TNF-α分别是[0.00(0.00,4.60)]pg/ml、[0.00(0.00,6.77)]pg/ml,2组相比IL-18差异有统计学意义(P0.05)。痛风患者血尿酸与炎症因子关联性分析结果表明:尿酸与IL-18呈正相关(rs=0.497,P0.05)。急性期尿酸与TNF-α呈负相关(r=-0.431,P=0.036);间歇期,IL-18与IL-1β呈负相关(rs=-0.402,P=0.046),尿酸与炎症因子不相关,尿酸与CRP不相关。结论痛风患者外周血中IL-18显著增高,IL-18可能参与痛风的慢性炎症过程,并与尿酸的升高相关。

关键词：痛风尿酸白细胞介素-18 白细胞介素-1β 肿瘤坏死因子-α