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Advances in depressants for flotation separation of Cu–Fe sulfide minerals at low alkalinity:A critical review

International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 1-17页

作者： Qicheng feng Wenhang yang Maohan Chang Shuming Wen Dianwen Liu Guang Han State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Faculty of Land Resource EngineeringKunming University of Science and TechnologyKunming 650093China Yunnan Key Laboratory of Green Separation and Enrichment of Strategic Mineral Resources Kunming University of Science and TechnologyKunming 650093China

The flotation separation of Cu–Fe sulfide minerals at low alkalinity can be achieved using selective *** the flotation system of Cu–Fe sulfide minerals,depressants usually preferentially interact with the pyrite surface to render the mineral surface hydrophilic and hinder the adsorption of the *** review summarizes the advances in depressants for the flotation separation of Cu–Fe sulfide minerals at low *** advances include use of inorganic depressants (oxidants and sulfur–oxygen compounds),natural polysaccharides (starch,dextrin,konjac glucomannan,and galactomannan),modified polymers (carboxymethyl cellulose,polyacrylamide,lignosulfonate,and tricarboxylate sodium starch),organic acids (polyglutamic acid,sodium humate,tannic acid,pyrogallic acid,salicylic acid,and lactic acid),sodium dimethyl dithiocarbamate,and *** potential application of specific inorganic and organic depressants in the flotation separation of Cu–Fe sulfide minerals at low alkalinity is *** advances in the use of organic depressants with respect to the flotation separation of Cu–Fe sulfide minerals are comprehensively ***,the depression performances and mechanisms of different types of organic depressants on mineral surfaces are ***,several perspectives on depressants vis-à-vis flotation separation of Cu–Fe sulfide minerals at low alkalinity are proposed.

关键词： Cu–Fe sulfide minerals flotation separation selective depressants depression mechanism

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Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment

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Particuology 2024年第5期88卷 282-289页

作者： feng Li Yuan yang Hua Yue Shuang Wang Xiao Zhang Wei Wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to ***,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based ***,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer ***,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading ***,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target *** released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its *** a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery

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A deep reinforcement learning approach to gasoline blending real-time optimization under uncertainty

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Chinese Journal of Chemical Engineering 2024年第7期71卷 183-192页

作者： Zhiwei Zhu Minglei yang Wangli He Renchu He Yunmeng Zhao feng Qian Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of EducationEast China University of Science and TechnologyShanghai 200237China

The gasoline inline blending process has widely used real-time optimization techniques to achieve optimization objectives,such as minimizing the cost of ***,the effectiveness of real-time optimization in gasoline blending relies on accurate blending models and is challenged by stochastic ***,we propose a real-time optimization algorithm based on the soft actor-critic(SAC)deep reinforcement learning strategy to optimize gasoline blending without relying on a single blending model and to be robust against *** approach constructs the environment using nonlinear blending models and feedstocks with *** algorithm incorporates the Lagrange multiplier and path constraints in reward design to manage sparse product *** abstracted states facilitate algorithm convergence,and the normalized action vector in each optimization period allows the agent to generalize to some extent across different target production *** these well-designed components,the algorithm based on the SAC outperforms real-time optimization methods based on either nonlinear or linear *** even demonstrates comparable performance with the time-horizon based real-time optimization method,which requires knowledge of uncertainty models,confirming its capability to handle uncertainty without accurate *** simulation illustrates a promising approach to free real-time optimization of the gasoline blending process from uncertainty models that are difficult to acquire in practice.

关键词： Deep reinforcement learning Gasoline blending Real-time optimization Petroleum Computer simulation Neural networks

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Simulation and analysis of soil homogenization drills based on discrete element method and response surface methodology

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Particuology 2024年第5期88卷 128-148页

作者： Zhipeng Wang Tong Zhu Youzhao Wang Song yang feng Ma Xu Li Institute of Process Equipment and Environmental Engineering School of Mechanical Engineering and AutomationNortheastern UniversityShenyang110819China Liaoning Coning Testing Co. Ltd.Shenyang110170 China

Currently,rotary drilling is one of the main pieces of equipment used for in-situ remediation of contaminated ***,this equipment has problems such as uneven mixing and low utilization efficiency,which affect the efficiency of in-situ soil *** improve the efficiency of in-situ soil remediation,this paper takes contaminated black soil as the research object,and the structural design of the new three-stage soil remediation auger is carried out based on *** mixing process of soil and heavy metal passivator under different motion and structural parameters was investigated by the discrete element method(DEM)and response surface *** experimental design was based on rotational speed,homogenizing mixing time,crushing section pitch,and homogenizing section pitch as factors,and soil fragmentation ratio,the coefficient of dispersion,and torque as optimization *** kinematic and structural parameters of the three-stage auger drill bit were then optimized using the one-factor method,the orthogonal test,and the response surface methodology,*** test method uses a one-way test to determine the central level value of the orthogonal test and a comprehensive balance method to determine the best combination of parameters for the orthogonal test,which is then used as the central value of the response surface test for parameter *** optimal combinations of kinematic and structural parameters of the three-stage auger drill bit are determined and validated using response surface *** optimum combination of parameters was found to be a speed of 129 rpm,a homogenizing mixing time of 24 s,a pitch of 165 mm in the crushing section,and a pitch of 132 mm in the homogenizing *** error between the optimal value of the predicted model using the response surface method and the actual simulated value under the optimal parameters is 4.2%,4.9%,and 5.3%,*** optimized factor parameters provide a refe

关键词： Black soil Mixing homogeneity Orthogonal method Response surface methodology Discrete element method Soil remediation

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Enhancing the mechanical properties of casting eutectic high -entropy alloys via W addition

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1364-1372页

作者： Xu yang Dezhi Chen Li feng Gang Qin Shiping Wu Ruirun Chen National Key Laboratory for Precision Hot Processing of Metals School of Material Science and EngineeringHarbin Institute of TechnologyHarbin 150001China

The effect of W element on the microstructure evolution and mechanical properties of Al_(1.25)CoCrFeNi3 eutectic high-entropy alloy and Al_(1.25)CoCrFeNi_(3-x)W_(x)(x=0,0.05,0.1,0.3,and 0.5;atomic ratio)high-entropy alloys(HEAs)were *** show that the Al_(1.25)CoCrFeNi_(3-x)W_(x) HEAs are composed of face-centered cubic and body-centered cubic(BCC)*** W content increases,the microstructure changes from eutectic to *** addition of W lowers the nucleation barrier of the BCC phase,decreases the valence electron concentration of the HEAs,and replaces Al in the BCC phase,thus facilitating the nucleation of the BCC *** results show that the addition of W greatly improves the mechanical properties,and solid-solution,heterogeneous-interface,and second-phase strengthening are the main strengthening *** yield strength,tensile strength,and elongation of the Al_(1.25)CoCrFeNi2.95W0.05 HEA are 601.44 MPa,1132.26 MPa,and 15.94%,respectively,realizing a balance between strength and *** fracture mode of the Al_(1.25)CoCrFeNi_(3-x)W_(x) HEAs is ductile–brittle mixed fracture,and the crack propagates and initiates in the BCC *** eutectic lamellar structure impedes crack propagation and maintains plasticity.

关键词： high-entropy alloy microstructure mechanical property fracture behavior

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Towards complex scenes: A deep learning-based camouflaged people detection method for snapshot multispectral images

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Defence Technology（防务技术） 2024年第4期34卷 269-281页

作者： Shu Wang Dawei Zeng Yixuan Xu Gonghan yang feng Huang Liqiong Chen School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou 350108China

Camouflaged people are extremely expert in actively concealing themselves by effectively utilizing cover and the surrounding environment. Despite advancements in optical detection capabilities through imaging systems, including spectral, polarization, and infrared technologies, there is still a lack of effective real-time method for accurately detecting small-size and high-efficient camouflaged people in complex real-world scenes. Here, this study proposes a snapshot multispectral image-based camouflaged detection model, multispectral YOLO(MS-YOLO), which utilizes the SPD-Conv and Sim AM modules to effectively represent targets and suppress background interference by exploiting the spatial-spectral target information. Besides, the study constructs the first real-shot multispectral camouflaged people dataset(MSCPD), which encompasses diverse scenes, target scales, and attitudes. To minimize information redundancy, MS-YOLO selects an optimal subset of 12 bands with strong feature representation and minimal inter-band correlation as input. Through experiments on the MSCPD, MS-YOLO achieves a mean Average Precision of 94.31% and real-time detection at 65 frames per second, which confirms the effectiveness and efficiency of our method in detecting camouflaged people in various typical desert and forest scenes. Our approach offers valuable support to improve the perception capabilities of unmanned aerial vehicles in detecting enemy forces and rescuing personnel in battlefield.

关键词： Camouflaged people detection Snapshot multispectral imaging Optimal band selection MS-YOLO Complex remote sensing scenes

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Successful Treatment with Triple Therapy of Amphotericin B, Voriconazole and Flucytosine on an AIDS Patients with Severe Cryptococcal Meningitis

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国际感染病学（电子版） 2012年第2期1卷 110-113页

作者： Zhi-liang Hu Hong-xia Wei Wen-hu Yao yong-feng yang Department of Infectious Diseases the Second Affiliated Hospital of the Southeast University

A 35-year-old man(body weight=63 kg)with AIDS complaining fever and headache after having commenced anti-retroviral therapy(ART)for a week was admitted to our *** lumbar punctures performed during38 days could not confirm a cryptococcal meningitis(CM)based on staining or culture methods for cerebrospinal fluid(CSF).The disease quickly progressed with serious hearing/vision impairment and frequent onset of seizure and coma after being treated with corticosteroids for five days,and then CM was *** lumbar puncture showed elevated intracranial pressure as high as 870 mm H2O,even though treated with standard antifungal regimens for *** disease was finally controlled by a new triple therapy with amphotericin B(0.7mg?kg-1?day-1,intravenously),flucytosine(100 mg/kg perday,orally in four divided doses),and voriconazole(200mg every 12 hours)and ART containing lamivudine(300 mg/day),stavuding(30 mg,twice a day)and efavirenz(300 mg,orally every night).Although it is rare,negative CSF stain or culture for cryptococci in AIDS patients with CM can persist for a long *** should be used cautiously when an effective anti-fungal therapy is not *** therapy with amphotericin B,flucytosine and voriconazole may be selectively applied in severe *** can be co-administered with efavirenz with modified dosing.

关键词： Cryptococcal meningitis Anti-retroviral therapy Corticosteroids Voriconazole Efavirenz

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Fabrication of AZ31/Mg3Y Composites with Excellent Strength and Plasticity via Accumulated Rolling Bonding and Diffusion Annealing

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 339-352页

作者： yang feng Wenhuan Chen Zheng Xu Weijun He Bin Jiang Fusheng Pan College of Materials Science and Engineering Chongqing UniversityChongqing400044China International Joint Laboratory for Light Alloys(Ministry of Education) Chongqing UniversityChongqing400044China

AZ31/Mg3Y composites with a layer thickness of 100-200μm were fabricated by accumulated rolling bonding(ARB),which was followed by diffusion annealing at 300℃ for 0-32 *** interface layer,containing numerous Al-Y precipitates,is formed in the Mg3Y layer that is adjacent to the interface as a result of Al diffusing from the AZ31 layers into the Mg3Y *** thickness of the interface layer gets increased and more precipitates are formed in the interface layer with the extension of the annealing *** microhardness of the AZ31 and Mg3Y layer decreases firstly and then reaches a stable value,while the microhardness of the interface layer increases gradually with the extension of the annealing *** AZ31/Mg3Y composites exhibit equivalent strength but increased ductility after diffusion annealing,in comparison to the as-rolled AZ31/Mg3Y *** addition,the AZ31/Mg3Y composites after annealing always present higher strength and ductility than AZ31/AZ31 composite,which was fabricated by the same process as that for the AZ31/Mg3Y ***-deformation induced strengthening also plays an important role in the excellent strength and ductility of the annealed AZ31/Mg3Y *** study can provide a direction for improving the plasticity and strength of magnesium alloys synergistically.

关键词： AZ31/Mg3Y composite Accumulated rolling bonding Diffusion annealing Precipitates Strengthening

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Enhanced boron neutron capture therapy(BNCT)through controlled drug release via boron-loaded nanofiber mats

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Nano Research 2024年第8期17卷 7479-7492页

作者： Wenyong Huang yongjin yang yong Pan Shiwei Jing Yanxin Qi Yubin Huang Faculty of Chemistry Northeast Normal UniversityChangchun 130024China Key Laboratory of Sustainable Advanced Functional Materials of Jilin Province Changchun 130024China School of Physics Northeast Normal UniversityChangchun 130024China

Boron neutron capture therapy(BNCT)is a novel binary therapy combining boron targeted drugs and neutron irradiation,which can selectively and effectively kill cancer cells at the cellular *** release of boron drug and its accumulation in tumor sites are the crux of ***,we developed a^(10)B-boric acid(^(10)BA)-loaded nanofiber applying for BNCT by in situ *** nanofibers were obtained by electrospinning technique using polyethylene glycol/polylactide(PEO/PLA)block *** changing the ratio of hydrophilicity to hydrophobicity of the nanofibers,the controlled release and the effective accumulation of boron 10 isotope(^(10)B)were achieved in ***^(10)B content in tumor could reach to 2540μg/g,significantly exceeding the required level of 20–50μg/g for BNCT *** pertinent DNA damage experiments,direct evidence and quantified data of BNCT-induced DNA damage in tumor cells were obtained for the first *** sequencing was employed to predict the molecular mechanisms and potential signaling pathways of BNCT,providing theoretical basis for future combined *** antitumor efficiency of BNCT was demonstrated by establishing mice model of subcutaneous tumor and tumor *** research presents a novel boron-loaded nanofiber mats for BNCT,which enables controlled drug release and holds significant potential in the treatment of unresectable or postoperative residual tumors.

关键词： boron neutron capture therapy nanofibers controlled release in situ administration

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Is appendoscope a new option for the treatment of acute appendicitis?

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World Journal of Gastroenterology 2024年第28期30卷 3386-3392页

作者： Shu-Jiong feng Yi-feng Zhou Jian-feng yang Hong-Zhang Shen Guang-Xing Cui Xiao-feng Zhang Department of Gastroenterology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang ProvinceHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology Hangzhou Institute of Digestive DiseasesHangzhou 310000Zhejiang ProvinceChina

Acute appendicitis is a common surgical *** is commonly caused by obstruction of the appendiceal lumen due to fecaliths,tumors,or lymphoid *** over a century,appendectomy has been the primary treatment for acute *** Groves performed the first open appendectomy in *** 1983,Kurt Semm completed the first laparoscopic appendectomy,heralding a new era in ***,appendectomy is associated with certain complications and a rate of negative *** have suggested controversy over the impact of appendectomy on the development of inflammatory bowel disease and Parkinson’s disease,but an increasing number of studies indicate a possible positive correlation between appendectomy and colorectal cancer,gallstones,and cardiovascular *** the recognition that the appendix is not a vestigial organ and the advancement of endoscopic technology,Liu proposed the endoscopic retrograde appendicitis *** is an effective minimally invasive alternative for treating uncomplicated acute *** team has developed an appendoscope with a disposable digital imaging system operated through the biopsy channel of a colonoscope and successfully applied it in the treatment of *** article provides an overview of the progress in endoscopic treatment for acute appendicitis and offers a new perspective on the future direction of appendiceal disease treatment.

关键词： Acute appendicitis Endoscopic technology Endoscopic retrograde appendicitis therapy Appendoscope Appendiceal disease treatment

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