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Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism

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Neural Regeneration Research 2024年第3期19卷 650-656页

作者： Jie Li Wen Jiang Yuefang Cai Zhenqiu Ning Yingying Zhou Chengyi Wang Sookja Ki chung Yan Huang Jingbo Sun Minzhen Deng Lihua Zhou Xiao Cheng Guangzhou University of Traditional Chinese Medicine GuangzhouGuangdong ProvinceChina State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Research on Emergency in TCM GuangzhouGuangdong ProvinceChina Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anatomy Sun Yat-Sen School of MedicineSun Yat-Sen UniversityShenzhenGuangdong ProvinceChina Faculty of Medicine Macao University of Science and TechnologyMacao Special Administration RegionChina

Vascular etiology is the second most prevalent cause of cognitive impairment ***-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of ***,the way in which changes in astrocytic endothelin-1 lead to poststroke cognitive deficits following transient middle cerebral artery occlusion is not well ***,using mice in which astrocytic endothelin-1 was overexpressed,we found that the selective overexpression of endothelin-1 by astrocytic cells led to ischemic stroke-related dementia(1 hour of ischemia;7 days,28 days,or 3 months of reperfusion).We also revealed that astrocytic endothelin-1 overexpression contributed to the role of neural stem cell proliferation but impaired neurogenesis in the dentate gyrus of the hippocampus after middle cerebral artery *** proteome profiles and western blot analysis confirmed that levels of glial fibrillary acidic protein and peroxiredoxin 6,which were differentially expressed in the brain,were significantly increased in mice with astrocytic endothelin-1 overexpression in comparison with wild-type mice 28 days after ischemic ***,the levels of the enriched differentially expressed proteins were closely related to lipid metabolism,as indicated by Kyoto Encyclopedia of Genes and Genomes pathway *** chromatography-mass spectrometry nontargeted metabolite profiling of brain tissues showed that astrocytic endothelin-1 overexpression altered lipid metabolism products such as glycerol phosphatidylcholine,sphingomyelin,and phosphatidic ***,this study demonstrates that astrocytic endothelin-1 overexpression can impair hippocampal neurogenesis and that it is correlated with lipid metabolism in poststroke cognitive dysfunction.

关键词： astrocytic endothelin-1 dentate gyrus differentially expressed proteins hippocampus ischemic stroke learning and memory deficits lipid metabolism neural stem cells neurogenesis proliferation

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一种基于风险代码抽取的控制流保护方法

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计算机学报 2024年第6期47卷 1372-1392页

作者：李勇钢钟叶青郑伊健林果园鲍宇中国矿业大学计算机学院信息安全系江苏徐州221116 香港中文大学(深圳)数据科学学院广东深圳518172

代码复用攻击是控制流安全面临的主要威胁之一.虽然地址分布随机化能够缓解该攻击,但它们很容易被代码探测技术绕过.相比之下,控制流完整性方法具有更好的保护效果.但是,现有的方法要么依赖于源码分析,要么采用无差别跟踪的方式追踪所... 详细信息

代码复用攻击是控制流安全面临的主要威胁之一.虽然地址分布随机化能够缓解该攻击,但它们很容易被代码探测技术绕过.相比之下,控制流完整性方法具有更好的保护效果.但是,现有的方法要么依赖于源码分析,要么采用无差别跟踪的方式追踪所有的控制流转移.前者无法摆脱对源码的依赖性,后者则会引入巨大的运行时开销.针对上述问题,本文提出一种新的控制流保护方法MCE(Micro Code Extraction).MCE的保护目标是源码不可用的闭源对象.与现有的方法相比,MCE并不会盲目地追踪所有的控制流转移活动.它实时地检测代码探测活动,并仅将被探测的代码作为保护目标.之后,MCE抽取具有潜在风险的代码片段,以进一步缩小目标对象的大小.最后,所有跳转到风险代码中的控制流都会被追踪和检测,以保护它的合法性.实验和分析表明,MCE对代码探测和代码复用攻击具有良好的保护效果,并在一般场景下仅对CPU引入2%的开销.

关键词：代码探测代码复用攻击控制流劫持代码抽取内存访问控制

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Exploring the Relationship Between Patent Forward Citation and Stock Return Rate Using Empirical Data of China Stock Market

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Management Studies 2024年第2期12卷 67-83页

作者： Hong-Wen Tsai Hui-chung Che National Taiwan University of Science and Technology TaipeiTaiwanChina China Bio-Medical&Technology Applications Associate New TaipeiTaiwanChina

A novel indicator called price-citation was *** on the company integrated patent database of China listed companies of common stocks(A-shares)with the stock price and the stock return rate data,more than two thousand of A-shares from 2017 to 2020 were *** effect of the traditional patent forward citation and the price-citation for discriminating the stock return rate was thoroughly analyzed via *** A-shares of forward citation counts above the average showed higher stock return rate means than the A-shares having patents but receiving no forward *** price-citation,combining both the financial and patent attributes,defined as the multiplication of the current stock price and the currently receiving forward citation count,showed its excellence in discriminating the stock return *** A-shares of higher price-citation showed significantly higher stock return rate means while the A-shares of lower price-citation showed significantly lowest stock return rate *** price-citation effect had not been changed by COVID-19 though COVID-19 affected the social and economic environment to a considerable extent in 2020.

关键词： China A-share patent ANOVA stock return rate forward citation price-citation

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Accelerating Oxygen Electrocatalysis Kinetics on Metal-Organic Frameworks via Bond Length Optimization

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Nano-Micro Letters 2024年第9期16卷 279-290页

作者： Fan He Yingnan Liu Xiaoxuan Yang Yaqi Chen Cheng‑Chieh Yang chung‑Li Dong Qinggang He Bin Yang Zhongjian Li yongbo Kuang Lecheng Lei Liming Dai Yang Hou Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Institute of Zhejiang University-Quzhou Quzhou 324000People’s Republic of China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201People’s Republic of China School of Biological and Chemical Engineering NingboTech UniversityNingbo 315100People’s Republic of China Department of Physics Tamkang UniversityNew Taipei 25137TaiwanPeople’s Republic of China Australian Carbon Materials Centre(A‑CMC) School of Chemical EngineeringUniversity of New South WalesSydneyNSW 2051Australia

Metal-organic frameworks(MOFs)have been developed as an ideal platform for exploration of the relationship between intrinsic structure and catalytic activity,but the limited catalytic activity and stability has hampered their practical use in water ***,we develop a bond length adjustment strategy for optimizing naphthalene-based MOFs that synthesized by acid etching Co-naphthalenedicarboxylic acid-based MOFs(donated as AE-CoNDA)to serve as efficient catalyst for water ***-CoNDA exhibits a low overpotential of 260 mV to reach 10 mA cm^(−2)and a small Tafel slope of 62 mV dec^(−1)with excellent stability over 100 *** integrated AE-CoNDA onto BiVO_(4),photocurrent density of 4.3 mA cm^(−2)is achieved at 1.23 *** investigations demonstrate that the stretched Co-O bond length was found to optimize the orbitals hybridization of Co 3d and O 2p,which accounts for the fast kinetics and high *** calculations reveal that the stretched Co-O bond length strengthens the adsorption of oxygen-contained intermediates at the Co active sites for highly efficient water splitting.

关键词： Metal-organic frameworks Bond length adjustment Spin state transition Orbitals hybridization Water splitting

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Benefit in physical function and quality of life to nonsurgical treatment of varicose veins: Pilot study

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World Journal of Clinical Cases 2024年第3期12卷 517-524页

作者： Gwon-Min Kim BoKun Kim Minwoo Jang Jong-Hwan Park Miju Bae chung Won Lee Jong Won Kim Up Huh Medical Research Institute Pusan National University School of MedicineYangsan 50612South Korea Future Convergence Research Institute Changwon National UniversityChangwon 51140South Korea Department of Convergence Medical Science School of MedicinePusan National UniversityYangsan 50612South Korea Health Convergence Medicine Laboratory Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Thoracic and Cardiovascular Surgery Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea

BACKGROUND Studies on varicose veins have focused its effects on physical function;however,whether nonsurgical treatments alter muscle oxygenation or physical function remains ***,the differences in such functions between individuals with varicose veins and healthy individuals remain *** To investigate changes in physical function and the quality of life(QOL)following nonsurgical treatment of patients with varicose veins and determine the changes in their muscle oxygenation during *** We enrolled 37 participants(those with varicose veins,n=17;healthy individuals,n=20).We performed the following measurements pre-and post-nonsurgical treatment in the varicose vein patients and healthy individuals:Calf muscle oxygenation during the two-minute step test,open eyes one-leg stance,30 s sit-to-stand test,visual analog scale(VAS)for pain,Pittsburgh sleep quality index,physical activity assessment,and QOL *** Varicose veins patients and healthy individuals differ in most variables(physical function,sleep quality,and QOL).Varicose veins patients showed significant differences between pre-and post-nonsurgical treatment—results in the 30 sit-to-stand test[14.41(2.45)to 16.35(4.11),P=0.018],two-minute step test[162.29(25.98)to 170.65(23.80),P=0.037],VAS for pain[5.35(1.90)to 3.88(1.73),P=0.004],and QOL[39.34(19.98)to 26.69(17.02),P=0.005];however,no significant difference was observed for muscle *** Nonsurgical treatment improved lower extremity function and QOL in varicose veins patients,bringing their condition close to that of healthy *** studies should include patients with severe varicose veins requiring surgery to confirm our findings.

关键词： Varicose vein Nonsurgical treatment Physical function Quality of life Near infrared spectroscopy

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基于任务型教学法在越南初级汉语口语线上教学中的行动研究

基于任务型教学法在越南初级汉语口语线上教学中的行动研究

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作者： HOANG THI chung（黄氏钟）华东师范大学

学位级别：硕士

任务型教学法是20世纪80年代以来在对外汉语教学中逐渐形成和应用的一种新的教学方法。此后这种教学方法逐渐发展并在对外汉语教学领域得到广泛应用。由于该教学方法具有许多优点,最突出的优点是促进学生学习的创造力和主动性,提高学生... 详细信息

任务型教学法是20世纪80年代以来在对外汉语教学中逐渐形成和应用的一种新的教学方法。此后这种教学方法逐渐发展并在对外汉语教学领域得到广泛应用。由于该教学方法具有许多优点,最突出的优点是促进学生学习的创造力和主动性,提高学生的语言能力。因此,近年来世界上有很多语言学家对该教学方法从不同角度进行研究。对越南的汉语教学界来说,任务型教学法因为诸多客观条件的限制,并未在汉语教育领域中得到广泛应用,尤其是线上教学形式。本论文在前人语言专家成果的理论基础上,继续对基于任务型教学法应用在越南初级汉语口语线上课堂进行深入研究。本论文分为6章:其中第一章、第二章主要论述基于任务型教学法的理论基础,设计原则以及相关文献综述。第三章的内容是从第二章的理论基础进行教学设计,本论文的研究对象是信锦越南厂责任有限公司的越南人员,使用的教材是速通汉语教程。第四章根据第三章的教学设计进行两轮实施教学,收集学生的反馈。第五章根据教师和学生对初级汉语口语线上课堂设计任务的反馈,进行对任务型初级汉语口语教学的反思。最后,第六章针对任务型教学法在越南汉语初级口语线上课堂的设计任务和编写任务型教学法的口语教材提出建议。本研究的研究方法是行动研究,通过两轮行动研究,实施教学,提出问题,从自己实施教学中的观察和经验提出建议。本研究的教学设计结果包括:速通汉语教程第一册第八课《你的生日是几月几号?》,第十课《你家有几口人?》;第二册第一课《你在听什么?》,第二课《你平时几点起床?》基于任务型教学法设计的教案。通过这篇论文,基于任务型教学法在越南初级汉语口语线上课堂教案设计和两轮实施教学创建一个在信锦越南厂责任有限公司应用的汉语教学模式,任务的设计会考虑到学习者的学习特点。希望未来能够推广在越南河南工业区所有的中国台湾公司应用。

关键词：任务型教学法初级汉语口语越南学生线上教学

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Unique anti-angiogenic effects,pharmacological targets and therapeutic mechanisms of Chinese herbal medicines for endometriosis

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Genes & Diseases 2024年第5期11卷 63-65页

作者： Bo Liang Rui Dong Sze Wan Hung Yiran Li Yuezhen Lin Ling Wu Tao Zhang Gene Chi Wai Man Hui Xu Jacqueline Pui Wah chung Chi Chiu Wang Guangdong Provincial Key Laboratory of Marine Biotechnology Institute of Marine SciencesShantou UniversityShantouGuangdong 515063China Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong Kong SARChina Reproduction and Development Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina Chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong Kong SARChina

Endometriosis is a common and benign angiogenesisdependent gynecological disorder,which refers to the proliferation and growth of endometrium-like tissues with neovasculature formation outside of the uterus.1 Available medical treatments for endometriosis containing hormonal and non-hormonal treatments had been limited for longterm usage by their side effects.2 Ideal medical treatment for endometriosis with efficacy to relieve symptoms and suppress endometriotic lesion growth and minimal side effects has been longing for decades.3 Angiogenesis is a promising therapeutic target for endometriosis.

关键词： therapeutic endometriosis herbal

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Prostate health index can stratify patients with Prostate Imaging Reporting and Data System score 3 lesions on magnetic resonance imaging to reduce prostate biopsies

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Asian Journal of Andrology 2024年第1期26卷 20-24页

作者： John Shung-Lai Leung Wai-Kit Ma Brian Sze-Ho Ho Stacia Tsun-Tsun Chun Rong Na yongle Zhan Chi-Yuen Ng Chi-Ho Ip Ada Tsui-Lin Ng Yiu-chung Lam Division of Urology Department of SurgeryQueen Mary HospitalUniversity of Hong KongHong KongChina Division of Urology Department of SurgeryPrincess Margaret HospitalHongKongChina

We aim to evaluate prostate health index as an additional risk-stratification tool in patients with Prostate Imaging Reporting and Data System score 3 lesions on multiparametric magnetic resonance *** with biochemical or clinical suspicion of having prostate cancer who underwent multiparametric magnetic resonance imaging in two tertiary centers(Queen Mary Hospital and Princess Margaret Hospital,Hong Kong,China)between January 2017 and June 2022 were ***-magnetic resonance imaging fusion biopsies were performed after prostate health index *** who only had Prostate Imaging Reporting and Data System score 3 lesions were further stratified into four prostate health index risk groups and the cancer detection rates were *** of the 747 patients,47.3%had Prostate Imaging Reporting and Data System score 3 lesions *** detection rate of clinically significant prostate cancer in this group was 15.0%.The cancer detection rates of clinically significant prostate cancer had statistically significant differences:5.3%in prostate health index<25.0,7.4%in prostate health index 25.0-34.9,17.9%in prostate health index 35.0-54.9,and 52.6%in prostate health index≥55.0(P<0.01).Among the patients,26.9%could have avoided a biopsy with a prostate health index<25.0,at the expense of a 5.3%risk of missing clinically significant prostate *** health index could be used as an additional risk stratification tool for patients with Prostate Imaging Reporting and Data System score 3 *** could be avoided in patients with low prostate health index,with a small risk of missing clinically significant prostate cancer.

关键词： biopsy fusion biopsy magnetic resonance imaging prostate cancer prostate health index

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Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis

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Journal of Pharmaceutical Analysis 2024年第1期14卷 100-114页

作者： Sze Wan Hung Massimiliano Gaetani Yiran Li Zhouyurong Tan Xu Zheng Ruizhe Zhang Yang Ding Gene Chi Wai Man Tao Zhang Yi Song Yao Wang Jacqueline Pui Wah chung Tak Hang Chan Roman A.Zubarev Chi Chiu Wang Department of Obstetrics&Gynaecology The Chinese University of Hong KongHong KongChina Division of Physiological Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Chemical Proteomics Core Facility Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Unit of Chemical Proteomics Science for Life Laboratory(SciLifeLab)StockholmSE 17177Sweden Center for Reproductive Medicine Henan Key Laboratory of Reproduction and GeneticsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450003China Department of Chemistry McGill UniversityMontrealH3A2K6Canada Department of Pharmacological&Technological Chemistry I.M.Sechenov First Moscow State Medical UniversityMoscow119146Russia Reproduction and Development Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChina School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong KongChina

Endometriosis is a common chronic gynecological disease with endometrial cell implantation outside the *** is a major pathophysiology in *** previous studies have demonstrated that the prodrug of epigallocatechin gallate(ProEGCG)exhibits superior anti-endometriotic and anti-angiogenic effects compared to epigallocatechin gallate(EGCG).However,their direct binding targets and underlying mechanisms for the differential effects remain *** this study,we demonstrated that oral ProEGCG can be effective in preventing and treating ***,1D and 2D Proteome Integral Solubility Alteration assay-based chemical proteomics identified metadherin(MTDH)and PX domain containing serine/threonine kinase-like(PXK)as novel binding targets of EGCG and ProEGCG,*** simulation and BioLayer interferometry were used to confirm their binding *** results showed that MTDH-EGCG inhibited protein kinase B(Akt)-mediated angiogenesis,while PXK-ProEGCG inhibited epidermal growth factor(EGF)-mediated angiogenesis via the EGF/hypoxia-inducible factor(HIF-1a)/vascular endothelial growth factor(VEGF)*** vitro and in vivo knockdown assays and microvascular network imaging further confirmed the involvement of these signaling ***,our study demonstrated that ProEGCG has superior therapeutic effects than EGCG by targeting distinct signal transduction pathways and may act as a novel antiangiogenic therapy for endometriosis.

关键词： Molecular targets ProEGCG EGCG Angiogenesis Treatment Endometriosis

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Connection Between Damping Torque Analysis and Energy Flow Analysis in Damping Performance Evaluation for Electromechanical Oscillations in Power Systems

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Journal of Modern Power Systems and Clean Energy 2022年第1期10卷 19-28页

作者： yong Hu Siqi Bu Xin Zhang Chi Yung chung Hui Cai Department of Electrical Engineering and Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHong KongChina Shenzhen Research Institute The Hong Kong Polytechnic UniversityShenzhenChina Centre for Energy Systems and Strategy Cranfield UniversityCranfieldUK Department of Electrical and Computer Engineering University of SaskatchewanSaskatoonCanada State Grid Jiangsu Economic Research Institute NanjingChina

The damping performance evaluation for electromechanical oscillations in power systems is crucial for the stable operation of modern power *** this paper,the connection between two commonly-used damping performance evaluation methods,i.e.,the damping torque analysis(DTA)and energy flow analysis(EFA),are systematically examined and revealed for the better understanding of the oscillatory damping ***,a concept of the aggregated damping torque coefficient is proposed and derived based on DTA of multi-machine power systems,which can characterize the integration effect of the damping contribution from the whole power ***,the pre-processing of measurements at the terminal of a local generator is conducted for EFA,and a concept of the frequency-decomposed energy attenuation coefficient is defined to screen the damping contribution with respect to the interested *** this basis,the frequency spectrum analysis of the energy attenuation coefficient is employed to rigorously prove that the results of DTA and EFA are essentially equivalent,which is valid for arbitrary types of synchronous generator models in multi-machine power ***,the consistency between the aggregated damping torque coefficient and frequency-decomposed energy attenuation coefficient is further verified by the numerical calculation in case *** relationship between the proposed coefficients and the eigenvalue(or damping ratio)is finally revealed,which consolidates the application of the proposed concepts in the damping performance evaluation.

关键词： Electromechanical oscillation damping performance damping torque analysis(DTA) energy flow analysis(EFA) frequency spectrum

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