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Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke

Acta Pharmaceutica Sinica B 2024年第9期14卷 3983-4000页

作者： Ru Li Riqing Wei Chenxin Liu Keying Zhang Sixiao He Zhifeng Liu Junhao Huang Youyong Tang Qiyuan An Ligen Lin Lishe Gan Liying zhao Xiaoming Zou Fudi Wang Yuan Ping Qiang Ma The Seventh Affiliated Hospital Southern Medical UniversityFoshan 528244China Department of Biopharmaceutics School of Laboratory Medicine and BiotechnologySouthern Medical UniversityGuangzhou 510000China Medical Critical Care Medicine General Hospital of Southern Theatre Command of PLAGuangzhou 510000China Guangdong Branch Center National Clinical Research Center for Geriatric Diseases(Chinese PLA General Hospital)Guangzhou 510000China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoAvenida da UniversidadeTaip1Macao 999078China School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 311402China Department of General Surgery Nanfang Hospitalthe First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510000China The Fourth Affiliated Hospital the First Affiliated HospitalSchool of Public HealthInstitute of Translational MedicineCancer CenterState Key Laboratory of Experimental HematologyZhejiang University School of MedicineHangzhou 310000China The First Affiliated Hospital the Second Affiliated HospitalBasic Medical SciencesSchool of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang 421200China College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310000China Liangzhu Laboratory Zhejiang University Medical CenterHangzhou 310000China Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy School of Laboratory Medicine and BiotechnologySouthern Medical UniversityGuangzhou 510000China

With the escalating prevalence of global heat waves,heat stroke has become a prominent health concern,leading to substantial liver *** other forms of liver injury,heat strokeinduced damage is characterized by heat cytotoxicity and heightened inflammation,directly contributing to elevated mortality *** clinical assessments have identified elevated bilirubin levels as indicative of Kupffer cell dysfunction,their specific correlation with heat stroke liver injury remains *** hypothesis proposes the involvement of Kupffer cell ferroptosis during heat stroke,initiating IL-1bmediated *** single-cell RNA sequencing of murine macrophages,a distinct and highly susceptible Kupffer cell subtype,Clec4Ft/CD206t,emerged,with heme oxygenase 1(HMOX-1)playing a pivotal ***,heat-induced HMOX-1,regulated by early growth response factor 1,mediated ferroptosis in Kupffer cells,specifically in the Clec4F t/CD206 t subtype(KC2),activating phosphatidylinositol 4-kinase beta and promoting PI4P *** cascade triggered NLRP3 inflammasome activation and maturation of *** findings underscore the critical role of targeted therapy against HMOX-1 in ferroptosis within Kupffer cells,particularly in Clec4F t/CD206 t *** an approach has the potential to mitigate inflammation and alleviate acute liver injury in the context of heat stroke,offering a promising avenue for future therapeutic interventions.

关键词： Heat stroke Liver injury Kupffer cells Ferroptosis Heme oxygenase 1 Phosphatidylinositol 4-kinase beta NLRP3 Early growth response factor 1

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中国蔬菜绿色全要素生产率时空特征与空间错位

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农业工程学报 2024年第2期40卷 344-355页

作者：赵梦璇张军以重庆师范大学地理与旅游学院重庆401331 三峡库区地表过程与环境遥感重庆市重点实验室重庆401331

为评估中国蔬菜绿色生产率,提升蔬菜生产绿色发展水平,推进农业高质量发展。该研究采用超效率SBMML模型、空间错位指数、主成分分析法等方法,探究2011—2020年中国30个省市蔬菜绿色全要素生产率的时空格局演变与空间错位特征,识别影响... 详细信息

为评估中国蔬菜绿色生产率,提升蔬菜生产绿色发展水平,推进农业高质量发展。该研究采用超效率SBMML模型、空间错位指数、主成分分析法等方法,探究2011—2020年中国30个省市蔬菜绿色全要素生产率的时空格局演变与空间错位特征,识别影响中国蔬菜绿色全要素生产率的主要因素。研究结果发现:1)2011—2020年中国蔬菜绿色全要素生产率整体呈下降趋势,由1.023 1降低到0.741 4,蔬菜生产与生态环境可持续发展的协调程度降低,其中技术效率下降和技术退步共同拖累了蔬菜绿色全要素生产率的提高。2)2011—2020年中国蔬菜绿色全要素生产率增长呈“东高西低,南高北低”的空间分布特征。北回归线以南产区蔬菜绿色全要素生产率最高,西北产区蔬菜绿色全要素生产率最低,其差异主要取决于水土资源供给状况与市场需求规模等因素。3)2011—2020年中国蔬菜绿色全要素生产率与技术效率的空间错位由北向南大致呈现“正向错位—负向错位”的变化趋势,整体以低错位为主。东北产区、中部产区地势平坦,农业生产条件良好,有利于蔬菜规模化种植。2011—2020年中国蔬菜绿色全要素生产率与技术进步的空间错位呈显著的“东正西负”的空间分布特征,且空间错位程度较大,负向错位省份数量由13个增至17个。由于蔬菜生产过于追求经济效益,忽视了绿色生产技术的投入。4)经济发展水平、资源环境禀赋和交通通达性是影响中国省域蔬菜绿色全要素生产率变化的主要因素,其中城镇化率和人均可支配收入等经济要素对蔬菜绿色全要素生产率的影响最为明显。研究结果可准确把握现阶段蔬菜绿色生产现状,为农业绿色转型发展提供借鉴。

关键词：蔬菜主成分分析模型绿色全要素生产率超效率SBM-ML指数空间错位

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正交面齿轮传动的两类界线

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哈尔滨工程大学学报 2024年第4期45卷 764-770页

作者：赵亚平娄海青东北大学机械工程与自动化学院辽宁沈阳110004

为了建立系统的正交面齿轮传动啮合界线与曲率干涉界线理论,本文通过求解非线方程组获得了两类界线的数值解。证明了啮合界线在小轮齿面上是渐开线;其共轭线也是渐开线。发现干涉界线一般有2条,近齿面干涉界线存在于面齿轮内端附近,大... 详细信息

为了建立系统的正交面齿轮传动啮合界线与曲率干涉界线理论,本文通过求解非线方程组获得了两类界线的数值解。证明了啮合界线在小轮齿面上是渐开线;其共轭线也是渐开线。发现干涉界线一般有2条,近齿面干涉界线存在于面齿轮内端附近,大致沿齿高走向。近齿面干涉界点存在平凡解,是干涉界线和啮合界线共轭线的交点,位于传动副瞬时相对转动轴上。基于近齿面干涉界线,建立了面齿轮无根切内径公式,通过数值迭代可以获得内径准确值;还导出了无根切内径估算公式,便于设计中应用。

关键词：面齿轮曲率干涉啮合界线渐开线直齿轮根切非线性内径

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中小城市研发投入强度研究——以淮安市为例

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江苏科技信息 2024年第3期41卷 36-38,67页

作者：姚勇唐成蒋洁赵青淮安市科学技术情报研究所江苏淮安223003

中小城市占据我国城市总量的绝大多数,其科技创新水平的提高,对于我国创建世界科技强国和全面建设社会主义现代化强国具有十分重要的意义。文章以淮安市研发投入强度为研究对象,主要介绍2021年以来淮安市通过实施政策奖补、企业梯次培... 详细信息

中小城市占据我国城市总量的绝大多数,其科技创新水平的提高,对于我国创建世界科技强国和全面建设社会主义现代化强国具有十分重要的意义。文章以淮安市研发投入强度为研究对象,主要介绍2021年以来淮安市通过实施政策奖补、企业梯次培育、科技金融扶持、研发投入贯标行动等措施提高研发投入强度,提出可以通过建立激励性政策、发挥企业创新主体作用、适度推广研发投入贯标行动等方法提高中小城市研发投入强度。

关键词：中小城市科技创新淮安市研发投入强度

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倾斜摄影测量技术在城市级实景三维模型生产中的应用研究

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工程与建设 2024年第4期38卷 795-797页

作者：赵鼎杰郑志勇贵州省地质矿产勘查开发局一〇四地质大队贵州都匀558000

本文探讨了倾斜摄影测量技术在城市级实景三维模型生产中的应用。随着城市规划和建设的不断发展,对于城市环境的准确建模需求日益增加。倾斜摄影测量技术以其高精度、高效率和高分辨率等特点,在城市级实景三维模型生产中得到广泛应用。... 详细信息

本文探讨了倾斜摄影测量技术在城市级实景三维模型生产中的应用。随着城市规划和建设的不断发展,对于城市环境的准确建模需求日益增加。倾斜摄影测量技术以其高精度、高效率和高分辨率等特点,在城市级实景三维模型生产中得到广泛应用。本文首先介绍了倾斜摄影测量技术的基本原理和发展历程,随后重点阐述了其在城市级实景三维模型生产中的技术特点及应用方法。接着,文章结合实际案例,分析了倾斜摄影测量技术在城市级实景三维模型生产中的应用效果和优势。最后,文章探讨了该技术在未来的发展方向和应用前景。

关键词：倾斜摄影测量城市级实景三维模型技术应用研究

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Aberrant Hippocampal Development in Early‑onset Mental Disorders and Promising Interventions:Evidence from a Translational Study

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Neuroscience Bulletin 2024年第6期40卷 683-694页

作者： Jingyu Yang Huiling Guo Aoling Cai Junjie Zheng Juan Liu Yao Xiao Sihua Ren Dandan Sun Jia Duan Tongtong zhao Jingwei Tang Xizhe Zhang Rongxin Zhu Jie Wang Fei Wang Early Intervention Unit Department of PsychiatryAffiliated Nanjing Brain HospitalNanjing Medical UniversityNanjing 210029China School of Biomedical Engineering and Informatics NanjingMedical UniversityNanjing 211166China The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University Changzhou Second People’s HospitalChangzhou Medical CenterNanjing Medical UniversityChangzhou 213004China Department of Radiology First Hospital of China Medical UniversityShenyang 110002China Department of Cardiac Function The People’s Hospital of China Medical University and the People’s Hospital of Liaoning ProvinceShenyang 110067China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhan 430064China Institute of Neuroscience and Brain Diseases Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021China Functional Brain Imaging Institute of Nanjing Medical University Nanjing 210029China

Early-onset mental disorders are associated with disrupted neurodevelopmental processes during *** methylazoxymethanol acetate(MAM)animal model,in which disruption in neurodevelopmental processes is induced,mimics the abnormal neurodevelopment associated with early-onset mental disorders from an etiological *** conducted longitudinal structural magnetic resonance imaging(MRI)scans during childhood,adolescence,and adulthood in MAM rats to identify specific brain regions and critical windows for ***,the effect of repetitive transcranial magnetic stimulation(rTMS)intervention on the target brain region during the critical window was *** addition,the efficacy of this intervention paradigm was tested in a group of adolescent patients with early-onset mental disorders(diagnosed with major depressive disorder or bipolar disorder)to evaluate its clinical translational *** results demonstrated that,compared to the control group,the MAM rats exhibited significantly lower striatal volume from childhood to adulthood(all P0.05)but was significantly lower than the control group from adolescence to adulthood(both P0.05).In the clinical trial,adolescents with early-onset mental disorders showed a significant increase in hippocampal volume after rTMS treatment compared to baseline(P<0.01),and these volumetric changes were associated with improvement in depressive symptoms(r=−0.524,P=0.018).These findings highlight the potential of targeting aberrant hippocampal development during adolescence as a viable intervent

关键词： Early-onset Mental disorder Neurodevelopment Animal model Hippocampus Repetitive transcranial magnetic stimulation

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基于地埋液压的可夜视升降安全围栏杆的研究

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机械管理开发 2024年第9期39卷 103-105+131页

作者：蒋嫔赵勇鱼春燕国网甘肃超高压公司

针对变电站大型检修时，运行人员在布置安全措施过程中，面临耗时长、遮拦安装及拆卸耗费人力的现实问题，提出了一种户外地埋液压可夜视升降安全围栏，采用预埋筒将可伸缩液压栏杆预制在变电站内，当需要布置安全措施时只需要按动按钮... 详细信息

针对变电站大型检修时，运行人员在布置安全措施过程中，面临耗时长、遮拦安装及拆卸耗费人力的现实问题，提出了一种户外地埋液压可夜视升降安全围栏，采用预埋筒将可伸缩液压栏杆预制在变电站内，当需要布置安全措施时只需要按动按钮，伸缩套杆将会从预埋筒中伸出，通过液压弹簧作用固定至要求高度，并用夜间发光材质对栏杆表面进行涂刷，起到对现场工作人员的警示作用。从根本上解决了运维人员搬运金属支撑杆这一繁琐步骤，有效提高了变电站人员布置安全措施的效率，缩短检修停电时间，保障电力的可靠供应。

关键词：变电站安全围栏预制地埋式

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Impact of transferred water on the hydrochemistry and water quality of surface water and groundwater in Baiyangdian Lake,North China

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Geoscience Frontiers 2021年第3期12卷 104-112页

作者： yong zhao Jingyan Han Bing Zhang Jiaguo Gong State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin China Institute of Water Resources and Hydropower ResearchBeijing 100038China College ofWater Conservancy Engineering Tianjin Agricultural UniversityTianjin 300384China Tianjin Key Laboratory of Water Resources and Environment Tianjin Normal University300387 TianjinChina

The hydrochemical composition of surface water and groundwater is a key parameter for understanding the evolution of water and its *** particular,little is known about the impact of transferred water on surface water and *** this study,Baiyangdian Lake was selected as a typical area for extensive groundwater exploration and surface water transfer in the North China *** water and groundwater samples were sampled in dry/wet seasons and then analyzed before/after the water transfer,***,surface water and groundwater are extensively hydrologically connected based on hydrochemical *** was found that the hydrochemical composition of the shallow groundwater is affected by the surface water and that the water quality of the deep groundwater is ***,inter-aquifer recharge processes from the shallow groundwater to the deep groundwater existed in the anthropogenic region impacted with high nitrate-ion ***,the hydrochemical composition of the surface water and groundwater was dominated by rock-weathering and evaporation-precipitation *** to the existence of the deep vadose zone in the alluvial fan,Na^(+)was exchanged into soil matrices during the leakage of the surface *** addition,the transferred water resulted in surface water with good quality,and it also played as an important recharge source to *** the most important water resource for irrigation and drinking,deep groundwater should be paid more attention in the alluvial fan with frequent water transfer and extensive groundwater exploration.

关键词： Hydrochemical composition Surface water Groundwater Water transfer Baiyangdian Lake

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Multi-objective Optimal Operation of Centralized Battery Swap Charging System with Photovoltaic

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Journal of Modern Power Systems and Clean Energy 2022年第1期10卷 149-162页

作者： Yuanzheng Li Yihan Cai Tianyang zhao Yun Liu Jian Wang Lei Wu yong zhao School of Artificial Intelligence and Automation Ministry of Education Key Laboratory of Image Processing and Intelligence ControlHuazhong University of Science and TechnologyWuhanChina School of Electrical and Electronic Engineering Nanyang Technological UniversitySingaporeSingapore College of Mechatronics and Control Engineering Shenzhen UniversityShenzhenChina Department of Electrical&Computer Engineering Stevens Institute of TechnologyHobokenUSA

Electric vehicles(EVs)are widely deployed throughout the world,and photovoltaic(PV)charging stations have emerged for satisfying the charging demands of EV *** paper proposes a multi-objective optimal operation method for the centralized battery swap charging system(CBSCS),in order to enhance the economic efficiency while reducing its adverse effects on power *** proposed method involves a multi-objective optimization scheduling model,which minimizes the total operation cost and smoothes load fluctuations,***,we modify a recently proposed multi-objective optimization algorithm of non-sorting genetic algorithm III(NSGA-III)for solving this scheduling ***,simulation studies verify the effectiveness of the proposed multi-objective operation method.

关键词： Multi-objective optimization electric vehicle battery swap charging system scheduling photovoltaic

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The light and hypoxia induced gene ZmPORB1 determines tocopherol content in the maize kernel

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Science China(Life Sciences) 2024年第3期67卷 435-448页

作者： Nannan Liu Yuanhao Du Shijuan Yan Wei Chen Min Deng Shutu Xu Hong Wang Wei Zhan Wenjie Huang Yan Yin Xiaohong Yang Qiao zhao Alisdair R.Fernie Jianbing Yan National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China Agro-biological Gene Research Center Guangdong Academy of Agricultural SciencesGuangzhou 510640China College of Agronomy Hunan Agricultural UniversityChangsha 410128China College of Agronomy Northwest A&F UniversityXi'an 710000China State Key Laboratory of North China Crop Improvement and Regulation Hebei Sub-center of National Maize Improvement Center of ChinaCollege of AgronomyHebei Agricultural UniversityBaoding 071001China College of Life Sciences South-Central Minzu UniversityWuhan 430070China Plant Science Facility of the Institute of Botany Chinese Academy of SciencesBeijing 100093China National Maize Improvement Center of China Beijing Key Laboratory of Crop Genetic ImprovementChina Agricultural UniversityBeijing 100093China Shenzhen Key Laboratory of Synthetic Genomics Guangdong Provincial Key Laboratory of Synthetic GenomicsShenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Max Planck Institute of Molecular Plant Physiology Potsdam-Golm 14476Germany

Tocopherol is an important lipid-soluble antioxidant beneficial for both human health and plant growth. Here, we fine mapped a major QTLqVE1 affecting γ-tocopherol content in maize kernel, positionally cloned and confirmed the underlying gene ZmPORB1(por1), as a protochlorophyllide oxidoreductase. A 13.7 kb insertion reduced the tocopherol and chlorophyll content, and the photosynthetic activity by repressing ZmPORB1 expression in embryos of NIL-K22, but did not affect the levels of the tocopherol precursors HGA(homogentisic acid)and PMP(phytyl monophosphate). Furthermore, ZmPORB1 is inducible by low oxygen and light, thereby involved in the hypoxia response in developing embryos. Concurrent with natural hypoxia in embryos, the redox state has been changed with NO increasing and H_(2)O_(2) decreasing, which lowered γ-tocopherol content via scavenging reactive nitrogen species. In conclusion, we proposed that the lower lightharvesting chlorophyll content weakened embryo photosynthesis, leading to fewer oxygen supplies and consequently diverse hypoxic responses including an elevated γ-tocopherol consumption. Our findings shed light on the mechanism for fine-tuning endogenous oxygen concentration in the maize embryo through a novel feedback pathway involving the light and low oxygen regulation of ZmPORB1 expression and chlorophyll content.

关键词： maize tocopherol hypoxia photosynthesis ZmPORB1

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