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Fecal microbiota transplantation in the metabolic diseases:Current status and perspectives

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World Journal of Gastroenterology 2022年第23期28卷 2546-2560页

作者： Lie Zheng yong-yi ji Xin-Li Wen Sheng-Lei Duan Department of Gastroenterology Shaanxi Hospital of Traditional Chinese MedicineXi’an 710003Shaanxi ProvinceChina Department of Neurology Xi’an Hospital of Traditional Chinese MedicineXi’an 710021Shaanxi ProvinceChina

With the development of microbiology and metabolomics,the relationship between the intestinal microbiome and intestinal diseases has been *** microbiota transplantation(FMT),as a new treatment method,can affect the course of many chronic diseases such as metabolic syndrome,malignant tumor,autoimmune disease and nervous system *** the mechanism of action of FMT is now well understood,there is some controversy in metabolic diseases,so its clinical application may be *** transplantation is recommended by clinical medical guidelines and consensus for the treatment of recurrent or refractory Clostridium difficile infection,and has been gradually promoted for the treatment of other intestinal and extraintestinal ***,the initial results are varied,suggesting that the heterogeneity of the donor stools may affect the efficacy of *** success of FMT depends on the microbial diversity and composition of donor ***,clinical trials may fail due to the selection of ineffective donors,and not to faulty indication selection for FMT.A new understanding is that FMT not only improves insulin sensitivity,but may also alter the natural course of type 1 diabetes by modulating *** this review,we focus on the main mechanisms and deficiencies of FMT,and explore the optimal design of FMT research,especially in the field of cardiometabolic diseases.

关键词： Fecal microbiota transplantation Metabolic diseases Inflammatory bowel disease Type 1 diabetes Metabolic syndrome

Network pharmacology and molecular docking reveal zedoary turmeric-trisomes in Inflammatory bowel disease with intestinal fibrosis

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World Journal of Clinical Cases 2022年第22期10卷 7674-7685页

作者： Lie Zheng yong-yi ji Yan-Cheng Dai Xin-Li Wen Shi-Cheng Wu Department of Gastroenterology Shaanxi Hospital of Traditional Chinese MedicineShaanxi Provincial Hospital of Traditional Chinese MedicineXi’an 730000Shaanxi ProvinceChina Department of Neurology Xi’an Hospital of Traditional Chinese MedicineXi’an 710021Shaanxi ProvinceChina Department of Gastroenterology Shanghai Traditional Chinese Medicine Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China Department of Gastroenterology Shaanxi Hospital of Traditional Chinese MedicineXi’an 710003Shaanxi ProvinceChina Department of Proctology Gansu Academy of Traditional Chinese MedicineGanSu Hospital of Traditional Chinese MedicineLanzhou 730050Gansu ProvinceChina

BACKGROUND Inflammatory bowel disease(IBD) is a complex chronic IBD that is closely associated with risk factors such as environment, diet, medications and lifestyle that may influence the host microbiome or immune response to antigens. At present, with the increasing incidence of IBD worldwide, it is of great significance to further study the pathogenesis of IBD and seek new therapeutic targets. Traditional Chinese medicine(TCM) treatment of diseases is characterized by multiple approaches and multiple targets and has a long history of clinical application in China. The mechanism underlying the effect of zedoary turmerictrisomes on inducing mucosal healing in IBD is not *** To explore the effective components and potential mechanism of zedoary turmeric-trisomes in the treatment of IBD with intestinal fibrosis using network pharmacology and molecular docking *** The chemical constituents and targets of Rhizoma zedoary and Rhizoma sanarum were screened using the TCMSP database. The GeneCards database was searched to identify targets associated with intestinal fibrosis in IBD. The intersection of chemical component targets and disease targets was obtained using the Venny 2.1 online analysis platform, and the common targets were imported into the STRING 11.0 database to construct a protein interaction regulatory network. A “zedoary turmeric-trisomes-chemical composition-target-disease” network diagram was subsequently constructed using Cytoscape 3.7.2 software, and the topological properties of the network were analyzed using the “Network Analysis” plug-in. Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analyses of the common targets were performed using the DAVID 6.8 database to elucidate the mechanism of zedoary turmeric-trisomes in the treatment of IBD. Subsequently, molecular docking of the compounds and targets with the highest intermediate values in the “zedoary turmeric-trisomes-chemical composition-target-dis

关键词： Network pharmacology Molecular docking Zedoary turmeric trisomes Inflammatory bowel disease Intestinal fibrosis

Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen Li Leilei Liang Baoshan Zhang yi Yang Guangbin ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

急性癫痫大鼠弓状核Glu和NPY的变化——免疫组织化学研究

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四川大学学报（自然科学版） 2002年第S1期39卷 93-97页

作者：刘广益郭勇韩艺黄吉春泸州医学院组织学与胚胎学教研室四川泸州646000

目的　探讨急性癫痫大鼠 (SD)弓状核Glu和NPY的变化及其作用 .方法　用 2 0只SD大鼠随机分为对照组 (C)和癫痫组 (E) ,采用免疫组织化学 (ABC法 )和图象分析技术 ,对急性癫痫大鼠弓状核Glu和NPY的变化进行定量研究 .结果　 1.E组的Glu... 详细信息

目的　探讨急性癫痫大鼠 (SD)弓状核Glu和NPY的变化及其作用 .方法　用 2 0只SD大鼠随机分为对照组 (C)和癫痫组 (E) ,采用免疫组织化学 (ABC法 )和图象分析技术 ,对急性癫痫大鼠弓状核Glu和NPY的变化进行定量研究 .结果　 1.E组的Glu阳性反应区面积明显增加 (P 0 .0 5 ) ;3.E组Glu和NPY阳性反应神经元的面数密度明显增加 (P <0 .0 5 ) ,灰度明显下降 (P <0 .0 5 ) .结论　急性癫痫大鼠弓状核Glu和NPY免疫反应增强 ,说明急性癫痫发作可能与Glu和NPY的增加有关 .

关键词：急性癫痫弓状核谷氨酸神经肽Y 免疫组织化学大鼠

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： yi Wang Yuning Li Yakun Gu Wei Ma Yuying Guan Mengyuan Guo Qianqian Shao Xunming ji jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： yi ji Chaoyi Yang Xuerui Pang yibing Yan Yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

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前路与后路术式治疗单节段腰椎结核的比较

中国矫形外科杂志 2018年第9期26卷 792-797页

作者：徐用亿季峰王守国孙进岳海涛唐洪辉南京医科大学附属淮安第一医院 223300

[目的]分析比较一期前路病灶清除植骨内固定术和一期后路病灶清除植骨内固定术治疗单节段腰椎结核的临床效果,探讨单节段腰椎结核手术方式的选择。[方法]回顾分析2008年6月~2015年6月在本科手术治疗的40例单节段腰椎结核患者。按手术入... 详细信息

[目的]分析比较一期前路病灶清除植骨内固定术和一期后路病灶清除植骨内固定术治疗单节段腰椎结核的临床效果,探讨单节段腰椎结核手术方式的选择。[方法]回顾分析2008年6月~2015年6月在本科手术治疗的40例单节段腰椎结核患者。按手术入路分为两组:前路组18例,行前路一期病灶清除植骨内固定术;后路组22例,行经后路一期病灶清除植骨内固定术。采用腰痛VAS、JOA评分、节段后凸Cobb角和其他临床指标评估治疗效果。[结果]前路组与后路组在手术时间上差异无统计学意义[(202.50±40.95)min vs(181.14±46.88)min,P>0.05],在失血量上差异无统计学意义[(627.83±261.87)ml vs(570.52±250.09)ml,P>0.05]。40例均获得24~36个月的随访,所有患者在末次随访时病灶均获得骨性融合。与术前相比,术后和末次随访时两组的ESR、CRP、腰痛VAS评分和节段后凸Cobb角均显著减小,差异有统计学意义(P0.05),但前路组的后凸矫正丢失角度显著大于后路组,差异有统计学意义[(5.28±2.40)°vs(1.91±1.60)°,P<0.05]。此外,前路组总并发症发生率明显高于后路组,差异有统计学意义[44.44%(8/18)vs 13.64%(3/22),P<0.05]。[结论]在标准抗结核化疗基础上一期前路病灶清除内固定术与后路病灶清除内固定术治疗单节段腰椎结核可取得同样的满意疗效,但后路手术相比前路手术并发症更少,后凸矫正丢失更少。

关键词：腰椎结核前路后路病灶清除融合

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一种压电换能器辐射阻抗变换器

声学学报 1985年第6期 329-337页

作者：赵松龄袁益镛同济大学

本文介绍一种借助穿孔板变换压电换能器辐射阻抗的装置。根据严格的声学理论阐明了这种变换器的工作原理和声学特性,导出了共振频率、品质因子、辐射阻和辐射效率增大倍数等重要参数的理论公式。文中还介绍了夹心式压电换能器采用这种... 详细信息

本文介绍一种借助穿孔板变换压电换能器辐射阻抗的装置。根据严格的声学理论阐明了这种变换器的工作原理和声学特性,导出了共振频率、品质因子、辐射阻和辐射效率增大倍数等重要参数的理论公式。文中还介绍了夹心式压电换能器采用这种变换器时的一系列对比试验,表明理论计算与实验结果良好相符。

关键词：阻抗变换器辐射阻抗穿孔板共振频率装置有源网络压电换能器辐射效率

Brain age estimation:premise,promise,and problems

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Neural Regeneration Research 2025年第8期20卷 2313-2314页

作者： Jarrad Perron ji Hyun Ko Graduate Program in Biomedical Engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro Research Centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell Science Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North *** old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.

关键词： estimation providing birth