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Synchronous gastric cancer complicated with chronic myeloid leukemia (multiple primary cancers):A case report

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World Journal of Clinical Cases 2022年第30期10卷 11146-11154页

作者： yong-xun zhao Ze Yang Li-Bin Ma Jia-Yao Dang Hui-Ying Wang The Seventh Department of General Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The First Clinical Medical School The First Clinical Medical School of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND With the advancement of medical technology and improvement in living standards,the incidence of multiple primary cancers has gradually *** particular,tumors of the digestive system account for a large proportion of multiple primary *** diagnosis and treatment of chronic myeloid leukemia,particularly with synchronous gastric cancer,at the first consultation is relatively *** SUMMARY Herein,we present the case of a middle-aged man who was referred to the Department of Hematology owing to an elevated white blood cell *** the examination,he was diagnosed with chronic myeloid leukemia and was administered *** months after the initial diagnosis,he visited our hospital again for abdominal pain,and further examination revealed gastric *** discussion with a multidisciplinary team,S-1(Tegafur,Gimeracil,and Oteracil Potassium Capsules) combined with oxaliplatin—SOX regimen—was ***,the patient’s condition rapidly *** developed colonic obstruction and underwent an ostomy;however,he died less than 6 months after the initial *** Multiple primary cancers are influenced by environmental and genetic factors;a standardized multidisciplinary discussion plays a key role in treatment.

关键词： Multiple primary cancers Gastric cancer Leukemia Leukemia inhibitory factor Case report

Cancerous inhibitor of protein phosphatase 2A enhances chemoresistance of gastric cancer cells to oxaliplatin

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World Journal of Gastrointestinal Oncology 2023年第2期15卷 286-302页

作者： yong-xun zhao Li-Bin Ma Ze Yang Fang Wang Hui-Ying Wang Jia-Yao Dang The Seventh Department of General Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Pathology The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The First Clinical Medical School Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Cancerous inhibitor of protein phosphatase 2A(CIP2A)is a newly discovered *** is an active cell proliferation regulatory factor that inhibits tumor apoptosis in gastric cancer(GC)***2A is functionally related to chemoresistance in various types of tumors according to recent *** underlying mechanism,however,is ***,the primary treatment regimen for GC is oxaliplatin-based ***,it often fails due to chemoresistance of GC cells to *** The goal of this study was to examine CIP2A expression and its association with oxaliplatin resistance in human GC *** Immunohistochemistry was used to examine CIP2A expression in GC tissues and adjacent normal ***2A expression in GC cell lines was reduced using small interfering *** confirming the silencing efficiency,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide tetrazolium and flow cytometry assays were used to evaluate cell proliferation and apoptosis caused by oxaliplatin ***,the key genes and protein changes were verified using realtime quantitative reverse transcription PCR and Western blotting,respectively,before and after *** bioinformatics analysis,we used the R software and Bioconductor *** statistical analysis,we used GraphPad Prism 6.0 and the Statistical Package for the Social Sciences software version 20.0(IBM,Armonk,United States).RESULTS A high level of CIP2A expression was associated with tumor size,T stage,lymph node metastasis,Tumor Node Metastasis stage,and a poor ***,CIP2A expression was higher in GC cells than in normal human gastric epithelial *** small interfering RNA against CIP2A,we discovered that CIP2A knockdown inhibited cell proliferation and significantly increased GC cell sensitivity to ***,CIP2A knockdown enhanced oxaliplatin-induced apoptosis in GC ***,high CIP2A levels in GC may be a factor in chemoresistance

关键词： Cancerous inhibitor of protein phosphatase 2A Gastric cancer Oxaliplatin Chemoresistance Akt

Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression

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World Journal of Gastroenterology 2018年第40期24卷 4565-4577页

作者： Li-Ping Liu Xi-Ping Sheng Tian-Kui Shuai yong-xun zhao Bin Li Yu-Min Li The Second Clinical Medical School of Lanzhou University Lanzhou 730000Gansu ProvinceChina Department of Critical Care Medicine The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Critical Care Medicine The Donggang District of First Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Institute of Epidemiology and Health Statistics School of Public HealthLanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Surgical Oncology The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Key Laboratory of Digestive System Tumors of Gansu Province The Second Clinical Medical School of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

AIM To detect the mechanisms of Helicobacter pylori(H. pylori) infection in the invasion and metastasis of gastric cancer(GC).METHODS Specimens from 99 patients with GC were collected. The correlation among H. pylori infection, heparanase(HPA) and mitogen-activated protein kinase(MAPK) expression, which was determined by immunohistochemistry, and the clinical features of GC was analysed using SPSS 22.0. Overall survival(OS) and relapse-free survival(RFS) of GC patients were estimated by the KaplanMeier method. Independent and multiple factors of HPA and MAPK with prognosis were determined with COX proportional hazards models. HPA and MAPK expression in MKN-45 cells infected with H. pylori was analysed using Western blot. RESULTS H. pylori infection was observed in 70 of 99 patients with GC(70.7%), which was significantly higher than that in healthy controls. H. pylori infection was related to lymph metastasis and expression of HPA and MAPK(P < 0.05); HPA expression was relevant to MAPK expression(P = 0.024). HPA and MAPK expression in MKN-45 cells was significantly upregulated following H. pylori infection and peaked at 24 h and 60 min, before decreasing(P < 0.05). SB203580, an inhibitor of MAPK, significantly decreased HPA expression. HPA was related to lymph metastasis and invasive depth. HPA positive GC cases and H. pylori positive GC cases showed poorer prognosis than HPA negative cases(P < 0.05). COX models showed that the prognosis of GC was connected with HPA expression, lymph metastasis, tissue differentiation, and invasive depth. CONCLUSION H. pylori may promote the invasion and metastasis of GC by increasing HPA expression that may associate with MAPK activation, thus causing a poorer prognosis of GC.

关键词： Gastric cancer Helicobacter pylori Heparanase Mitogen-activated protein kinase Overall survival Relapse-free survival

Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression

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World Journal of Gastroenterology 2021年第22期27卷 3138-3141页

作者： Li-Ping Liu Xi-Ping Sheng Tian-Kui Shuai yong-xun zhao Bin Li Yu-Min Li The Second Clinical Medical School of Lanzhou University Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Critical Care Medicine The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Critical Care Medicine The Donggang District of First Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Institute of Epidemiology and Health Statistics School of Public HealthLanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Surgical Oncology The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Key Laboratory of Digestive System Tumors of Gansu Province The Second Clinical Medical School of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

Correction to"Liu LP,Sheng XP,Shuai TK,zhao YX,Li B,Li *** pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase *** J Gastroenterol 2018;24:4565-4577[PMID:30386106 DOI:10.3748/wjg.v24.i40.4565]."In this article,we have identified some of the images in Figure 2A,C,E,G,and I are identical to the images in Figures 1B,2A,3B,3E,and 3G of another paper entitled"Liu L,zhao Y,Fan G,Shuai T,Li B,Li *** pylori infection enhances heparanase leading to cell proliferation via mitogenactivated protein kinase signalling in human gastric cancer cells.",which was published by us in the Molecular Medicine Reports in December,2018[PMID:30320396 DOI:10.3892/mmr.2018.9558].The reason why we asked to replace the pictures was that when we were simultaneously preparing to submit our two different articles to the World Journal of Gastroenterology(WJG)and Molecular Medicine Reports,we uploaded the wrong pictures to the WJG,which were same as those submitted to the Molecular Medicine *** apologize for this negligence and any inconvenience that this may *** would be grateful if you could replace the wrong pictures with the correct ones attached.

关键词： Correction Replace the wrong pictures Gastric cancer Helicobacter pylori

Notch2 regulates matrix metallopeptidase 9 via PI3K/AKT signaling in human gastric carcinoma cell MKN-45

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World Journal of Gastroenterology 2012年第48期18卷 7262-7270页

作者： Ling-Yun Guo Yu-Min Li Liang Qiao Tao Liu Yuan-Yuan Du Jun-Qiang Zhang Wen-Ting He yong-xun zhao Dong-Qiang He the Second Clinical Medical School of Lanzhou University the Second Hospital of Lanzhou University Key Laboratory of Digestive System Tumors Department of General Surgerythe Second Hospital of Lanzhou University Storr Liver Unit at the Westmead Millennium Institute the University of Sydney at Westmead Hospital Key Laboratory of Digestive System Tumors the Second Hospital of Lanzhou University Department of Oncological Surgery the First Hospital of Lanzhou University

AIM：To clarify the role of activated Notch2 in the invasiveness of gastric ***：To investigate the invasiveness of silencing Notch2 gene expression,we established a Notch2small interfering RNA（siRNA） transfected cell line using the MKN-45 gastric cancer cell *** the successful transfection confirmed by real-time reverse transcription-polymerase chain reaction（RT-PCR） and Western blotting,migration and invasion assays were employed to evaluate the aggressiveness of the gastric ***-PCR and Western blottings were employed to confirm the down-regulation of Notch2 and to evaluate the expression of epithelial mesenchymal transition-related gene matrix metallopeptidase 9（MMP9）,Akt,*** confirm the relationship between PI3KAkt and MMP9,the PI3K inhibitor LY294002 was used to treat MKN-45 ***：Notch2 expression was dramatically decreased after Notch2 siRNA transfection（100.00% ± 9.74% vs 11.61% ± 3.85%,P 〈 0.01 by qRT-PCR）.There was also a marked reduction of Notch target gene Hes1（100.00% ± 4.74% vs 61.61% ± 3.58%,P 〈 0.05） at the mRNA,indicating an inhibition of Notch *** of Notch signaling was also confirmed by the marked reduction of Notch2 intracellular domain at the protein levels（100.00% ± 9.74% vs 65.61% ± 7.58%,P 〈 0.05）.Down-regulation of Notch2 by siRNA enhanced tumor cell invasion（100.00% ± 21.64% vs 162.22% ± 16.84%,P 〈 0.05） and expression of MMP9（1.56 fold,P 〈 0.05）,and activated the pro-MMP9 protein to its active form（1.48 fold,P 〈 0.05）.There was no significant difference in the protein levels of Akt between the two groups（100.00% ± 10.87% vs 96.61% ± 7.33%,P 〉 0.05）,while down-regulation of Notch2 elevated p-Akt expression（100.00% ± 9.87% vs 154.61% ± 13.10%,P 〈 0.05）.Furthermore,p-Akt and MMP9 was down-regulated in response to the inhibitor LY294002（p-Akt 100.00% ± 8.87% vs 58.27% ± 5.01%,P 〈 0.05;MMP9 100.00% ± 9.17% vs 50.03% ± 4.88%,P 〈 0.05）.CONCLUSION：Notch2 may negatively regulate cell invasion by

关键词： Notch2 Stomach Cancer Invasion Epithelial mesenchymal transition Matrix metallopeptidase 9 RNA interference

Oxygen vacancies enriched Ir/WOx catalysts for the directly chem-catalytic conversion of cellulose to ethanol

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Tungsten 2025年第1期7卷 88-99页

作者： Yu-Jing Weng zhao-Ying Ding Ying-Chao Li Yuan-Feng Wu Yuan-Yang Xu Rui Chen Xiao-Lei zhao Hai-yong Wang Da-Lei Zhang Yu-Long Zhang Henan Key Laboratory of Coal Green Conversion and International Joint Laboratory of Coal Clean Utilization College of Chemistry and Chemical Engineering Henan Polytechnic University Key Laboratory of Renewable Energy Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Liaoning Institute of Energy Technology

Tungsten and its oxides are highly versatile catalysts with unique properties that hold great promise for a wide array of applications,including biological pathways and chemical *** chemo-catalysis of cellulose to ethanol presents a promising avenue for ethanol synthesis with the potential for enhanced efficiency compared to conventional methods,offering a sustainable and carbon-neutral alternative to existing petrochemical and biological ***,Ir/WOxcatalysts enriched with oxygen vacancies were meticulously prepared and demonstrated remarkable catalytic performance in converting cellulose to ethanol directly in the presence of tungstic *** catalyst achieved a high ethanol yield of 66.5%under optimal reaction conditions,approaching the theoretical yield limit of traditional ethanol *** results revealed the presence of oxygen defects,Bronsted/Lewis acidity,and Ir nanoclusters on the catalyst surface,working synergistically to facilitate the cascade catalysis of cellulose hydrolysis,sugar retro-aldol condensation reaction,and C2 intermediate hydrodeoxygenation to *** situ Fourier transform infrared spectrometer analysis confirmed the catalyst's ability to enhance the adsorption and activation of ethylene glycol for ethanol *** manipulating subtle structural features,this study offers a fresh perspective on tungsten group catalyst design and underscores the importance of synergistic effects among catalytic sites for the efficient production of ethanol from cellulose.

关键词： Cellulosic ethanol Chem-catalysis Hydrogenolysis Retro-aldol condensation Tungsten

Impact of Startup Strategy and Buffer Tank Volume on the Compressor Inlet State for a 3-MW sCO2 Brayton Cycle

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Journal of Thermal Science 2025年第1期34卷 159-175页

作者： zhao Decai WANG Bo Key Laboratory of Advanced Energy and Power Institute of Engineering Thermophysics(IET)Chinese Academy of Sciences (CAS) University of Chinese Academy of Sciences

The supercritical carbon dioxide（sCO2） Brayton cycle system has become an emerging and highly promising method of thermal power conversion due to its efficiency advantage,system compactness,and excellent adaptability of the heat *** the low carbon sCO2Brayton cycle testbed with cycle output power approaching 3 MW,a relatively detailed dynamic simulation model of the entire system is constructed to explore the dynamic response characteristics of the system with different startup strategies and different buffer tank volumes during the startup *** simulation results indicate that the smaller the volume of the buffer tank,the more rapid and obvious the parameter fluctuation in the buffer tank during the *** the allowable relative deviation limit of density is 5%,then the ratio of the buffer tank volume to the volume of the entire closed loop should not be lower than 36.80%.The strategy of simultaneous temperature and speed increase during turbine bypass start can effectively reduce the fluctuation of compressor inlet parameters and reach the steady-state more *** paper provides the recommended matching table for the opening of the turbine bypass valve（TBV） and the main regulating valve（MGV） to reduce the parameter fluctuation during the bypass *** effectiveness of the proposed turbine bypass and bypass switching startup strategy is verified by simulation,which may be used as a reference for test bench's future debugging and operation.

关键词： buffer tank dynamic characteristic dynamic model sCO2 Brayton cycle startup strategy

Laser assisted phase transformation of carbon-based transition metal oxide electrode for high-performance supercapacitor application

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Science China Chemistry 2025年

作者： Mingzhen Xiu Jianghong Zhang Yu Lu xun Cao Kang Huang Siyu Zhu Bowei Zhang Yu Liang Chunwang zhao Junsheng Wu Yizhong Huang School of Materials Science and Engineering Nanyang Technological University Energy Research Institute Interdisciplinary Graduate Programme Nanyang Technological University Institute of Sustainability for Chemicals Energy and Environment Agency for Science Technology and ResearchSingapore Institute of Advanced Materials and Technology University of Science and Technology Beijing School of Materials Science and Technology Shenyang University of Chemical Technology School of Materials Science and Hydrogen Energy Foshan University

Transitional metal oxides have a wide range of applications due to their superior *** enhanced performance of metal oxide relies on their desirable oxidation states,which is challenging to achieve and requires complex *** study demonstrates a facile strategy enabling rapid phase transformation of transition metal *** approach involves synthesis of a tetragonal Mn3O4/carbon cloth composite using the liquid plasma discharge deposition （LPDD） technique,followed by laser irradiation with the presence of ethylene glycol under an N2gas *** resulting face-centered cubic MnO/carbon cloth electrode exhibits an excellent capacitance of 1,125 F g-1at 2 A g-1,with remarkable capacitance retention of 95%after10,000 *** approach can be extended to other transition metals including Co,Cu,Cr,Fe,Ni,and *** simulations reveal the significance of ethylene glycol and the underlying mechanism associated with the phase transformation of transition metal *** present study offers a powerful technique for the phase transformation of transition metal oxide which can guide the development of new electrode materials with enhanced electrochemical properties for high-performance energy storage applications.

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LiDAR-Visual SLAM with Integrated Semantic and Texture Information for Enhanced Ecological Monitoring Vehicle Localization

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Computers, Materials & Continua 2025年第1期82卷 1401-1416页

作者： Yiqing Lu Liutao zhao Qiankun zhao Foreign Environmental Cooperation Center Ministry of Ecology and Environment of PRCBeijing100035China Beijing Computing Center Co. Ltd.Beijing Academy of Science and TechnologyBeijing100083China Beijing Guyu Interactive Artificial Intelligence Application Co. Ltd.Beijing100024China

Ecological monitoring vehicles are equipped with a range of sensors and monitoring devices designed to gather data on ecological and environmental *** vehicles are crucial in various fields,including environmental science research,ecological and environmental monitoring projects,disaster response,and emergency management.A key method employed in these vehicles for achieving high-precision positioning is LiDAR(lightlaser detection and ranging)-Visual Simultaneous Localization and Mapping(SLAM).However,maintaining highprecision localization in complex scenarios,such as degraded environments or when dynamic objects are present,remains a significant *** address this issue,we integrate both semantic and texture information from LiDAR and cameras to enhance the robustness and efficiency of data ***,semantic information simplifies the modeling of scene elements,reducing the reliance on dense point clouds,which can be less ***,visual texture information complements LiDAR-Visual localization by providing additional contextual *** incorporating semantic and texture details frompaired images and point clouds,we significantly improve the quality of data association,thereby increasing the success rate of *** approach not only enhances the operational capabilities of ecological monitoring vehicles in complex environments but also contributes to improving the overall efficiency and effectiveness of ecological monitoring and environmental protection efforts.

关键词： LiDAR-Visual simultaneous localization and mapping integrated semantic texture information