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3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian liu Jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

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高纯稀土化合物制备的现状与发展

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上海有色金属 2004年第4期25卷 188-191页

作者：梁勇王瑞祥刘俊江西理工大学材料与化学工程学院江西赣州341000

综述了近年来离子交换法、溶剂萃取法和萃取色层法在制备高纯稀土化合物上的应用现状与发展,总结了三种方法在提取高纯稀土化合物上的优缺点,并提出了C272萃取色层制备单一、高纯稀土的设想。

关键词：高纯制备稀土化合物离子交换法溶剂萃取法应用现状设想

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ADAMS在机械原理课程实践教学中的探索

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教育教学论坛 2017年第47期 140-141页

作者：廖达海花拥斌宁翔刘玉涛朱祚祥景德镇陶瓷大学机械电子工程学院江西景德镇333403

将ADAMS软件引入机械原理课程教学,应用该软件对虚拟机构进行三维建模、动态仿真以及运动学分析可有效解决学生对机构组成、运动特性理解掌握困难的问题,同时极大地提高学生学习积极性,从而提高课堂教学效果。

关键词： ADAMS 机械原理课程教学运动学分析

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Limited Fraction of Crystallized Side Chains in Bottlebrush Poly(n-alkyl methacrylate)s

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Chinese Journal of Polymer Science 2021年第9期39卷 1211-1216页

作者： Ming-Yue xiang Dong Lyu Ling-Zhi liu yong-Feng Men State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

Crystallinity of bottlebrush polymers due to side chain crystallization has been considered to be related to the length of the side chains only under the assumption of complete participation of crystallization by all *** experimental results revealed that in poly(n-alkyl methacrylate)s a fraction of side chains could not crystallize due to constraints imposed by the trapped main chain entanglements and required expansi on of main chain-main chain *** result renders the original simplified con sideration of the origin of crystallinity in bottlebrush polymers *** this work,we introduce a new parameter f_(c),the fraction of crystallizable side chains,to better describe the crystallinity of bottlebrush polymers.A lin earrelati on ship between the meltingenthalpy and the number of alkyl groups in side chains for bottlebrush polymers reported repeatedly indicates that f_(c) remains essentially unchanged when bottlebrush polymers had the same main chain structure and grafting degree but different side chain *** slope of the above-mentioned linear relationship is thus △H_(CH2)xf_(c),where △H_(CH2) stands for the melting enthalpy of one mole alkyl group packed into the *** a known value of f_(c),it is possible to estimate the value of △H_(CH_(2)).In case of poly(n-alkyl methacrylate)s,we estimated △H_(CH_(2)) of hexagonal crystal being at most 5.74 kJ/mol with the knowledge of possibly smallest f_(c) of 0.67 obtained from small angle X-ray scattering ***,the crystallinity of bottlebrush polymer would be calculated based on the equati on X_(c)=f_(c)×N_(c)/N with N and N_(c) being the nu mber of alkyl groups in a side chain and those packed in the crystalline structure,*** chemical structure and grafting degree of bottlebrush polymers affect f_(c).

关键词： Poly(n-alkyl methacrylate)s(PMA(n)s) PMA(n)-co-PMMA Crystallization behavior The fraction of crystallizable side chain(fc) Grafting degree(G)

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Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders:Present trends and future directions

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World Journal of Psychiatry 2025年第1期15卷 153-167页

作者： Bo-Fan Chen Li liu Fang-Zhen Lin Hai-Min Zeng Hai-Qiang Huang Chun-Fang Zhang Cong-Cong liu xiang Chen Jie Peng Yun-Fa Wang Zhi-Lin Wang Bin Chen De-Le liu Yun liu Zheng-Zheng Li Xin-Xing Zeng The Second Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second Clinical Medical College Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Rehabilitation Medicine The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Provincial People’s Hospital The First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006Jiangxi ProvinceChina Department of Psychiatry Jiangxi Mental HospitalHospital of Nanchang UniversityNanchang UniversityNanchang 330029Jiangxi ProvinceChina

BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood *** drug treatment modalities are crucial for managing *** To analyze the current status and future trends of global research on BD drug treatment over the last *** The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were *** visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration *** University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this *** Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited *** This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future *** study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.

关键词： Bipolar disorder Drug treatment Bibliometric analysis Visualization Mental disorder

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Shape formation of closed-cell aluminum foam in solid–liquid–gas coexisting state

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International Journal of Minerals,Metallurgy and Materials 2018年第8期25卷 974-980页

作者： Zhi-yong liu Ying Cheng Yan-xiang Li Xu Zhou xiang Chen Ning-zhen Wang School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology of Ministry of Education Beijing 100084China

The mold pressing process was applied to investigate the formability of closed-cell aluminum foam in solid–liquid–gas coexisting *** show that the shape formation of closed-cell aluminum foam in the solid–liquid–gas coexisting state was realized through cell wall deformation and cell movement caused by primary α-Al grains that slid,rotated,deformed,and ripened within cell *** formation,characteristic parameters of closed-cell aluminum foam were almost *** proper forming conditions,shaped products of closed-cell aluminum foam could be fabricated through mold pressing.

关键词： closed-cell aluminum foam shape forming microstructure solid–liquid–gas coexisting state

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Recrystallization behavior of Ti40 burn-resistant titanium alloy during hot working process

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International Journal of Minerals,Metallurgy and Materials 2016年第5期23卷 581-587页

作者： Yun-jin Lai She-wei Xin Ping-xiang Zhang yong-qing Zhao Fan-jiao Ma xiang-hong liu yong Feng State Key laboratory of Solidification Processing Northwestern Polytechnical University Xi'an 710072 China Western Superconducting Technologies Co. Ltd. Xi'an 710018 China Northwest Institute for Nonferrous Metal Research Xi'an 710016 China

The recrystallization behavior of deformed Ti40 alloy during a heat-treatment process was studied using electron backscatter dif- fraction and optical microscopy. The results show that the microstructural evolution of Ti40 alloy is controlled by the growth behavior of grain-boundary small grains during the heating process. These small grains at the grain boundaries mostly originate during the forging proc- ess because of the alloy＇s inhomogeneous deformation. During forging, the deformation first occurs in the grain-boundary region. New small recrystallized grains are separated from the parent grains when the orientation between deformation zones and parent grains exceeds a certain threshold. During the heating process, the growth of these small recrystallized grains results in a uniform grain size and a decrease in the av- erage grain size. The special recrystallization behavior of Ti40 alloy is mainly a consequence of the alloy＇s high β-stabilized elemeutal con- tent and high solution strength of the β-grains, which partially explains the poor hot working ability of Ti-V-Cr-type bum-resistant titanium alloys. Notably, this study on Ti40 bum-resistant titanium alloy yields important information related to the optimization of the microstruc- tures and mechanical properties.

关键词： titanium alloys hot working recrystallization microstructural evolution

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Sacrificial microgel‑laden bioink‑enabled 3D bioprinting of mesoscale pore networks

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Bio-Design and Manufacturing 2020年第1期3卷 30-39页

作者： Lei Shao Qing Gao Chaoqi Xie Jianzhong Fu Meixiang xiang Zhenjie liu liulin xiang yong He State Key Laboratory of Fluid Power and Mechatronic Systems College of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Department of Cardiology The Second Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhou 310009China Department of Vascular Surgery The Second Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhou 310009China Zhejiang University Hospital Zhejiang UniversityHangzhou 310027ZhejiangChina Key Laboratory of Materials Processing and Mold Zhengzhou UniversityZhengzhou 450002China

Three-dimensional(3D)bioprinting is a powerful approach that enables the fabrication of 3D tissue constructs that retain complex biological ***,the dense hydrogel networks that form after the gelation of bioinks often restrict the migration and proliferation of encapsulated ***,a sacrificial microgel-laden bioink strategy was designed for directly bioprinting constructs with mesoscale pore networks(MPNs)for enhancing nutrient delivery and cell *** sacrificial microgel-laden bioink,which contains cell/gelatin methacryloyl(GelMA)mixture and gelled gelatin microgel,is first thermo-crosslinked to fabricate temporary predesigned cell-laden constructs by extrusion bioprinting onto a cold ***,the construct is permanently stabilized through photo-crosslinking of *** MPNs inside the printed constructs are formed after subsequent dissolution of the gelatin *** MPNs allowed for effective oxygen/nutrient diffusion,facilitating the generation of bioactive ***,osteoblast and human umbilical vein endothelial cells encapsulated in the bioprinted large-scale constructs(≥1 cm)with MPNs showed enhanced bioactivity during *** 3D bioprinting strategy based on the sacrificial microgel-laden bioink provided a facile method to facilitate formation of complex tissue constructs with MPNs and set a foundation for future optimization of MPN-based tissue constructs with applications in diverse areas of tissue engineering.

关键词： Sacrificial microgel Gelatin methacryloyl(GelMA) 3D bioprinting Mesoscale pore networks(MPNs) Tissue engineering

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Temperature prediction model in multiphase flow considering phase transition in the drilling operations

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Petroleum Science 2024年第3期21卷 1969-1979页

作者： Yang Zhang yong-An Li xiang-Wei Kong Hao liu Teng-Fei Sun College of Mechanical and Electrical Engineering Beijing University of Chemical TechnologyBeijing 100027China School of Petroleum Engineering Yangtze UniversityWuhan430000HubeiChina

The study considers gas compression properties,gas slippage,back pressure(BP),phase transition(PT),well depth,and differences in gas-liquid physical properties.A new temperature model for multiphase flow is proposed by considering phase transition in the drilling *** mathematical model of multiphase flow is solved using the finite difference method with annulus mesh division for grid nodes,and a module for multiphase flow calculation and analysis is *** results indicate that the temperature varies along the annulus with the variation of gas influx at the bottom of the *** the process of controlled pressure drilling,as gas slips along the annulus to the wellhead,its volume continuously expands,leading to an increase in the gas content within the annulus,and consequently,an increase in the pressure drop caused by gas *** temperature increases with the increase in BP and decreases in gas influx rate and wellbore *** gas influx,the thermal conductivity coefficient for the gas-drilling mud two phases is significantly weakened,resulting in a considerable change in temperature along the *** the context of MPD,the method of slightly changing the temperature along the annulus by controlling the back pressure is feasible.

关键词： Managed pressure drilling Phase transition Temperature Gas-drilling mud two phase

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核因子I-C调控人根尖牙乳头干细胞的分化

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中国组织工程研究 2025年第31期29卷 6667-6673页

作者：吴越朱永娜葛翔刘樊何泽禹刘茜蚌埠医科大学口腔医学院蚌埠医科大学第二附属医院口腔科安徽省蚌埠市233000

背景:体外过表达核因子I-C基因可促进人根尖牙乳头干细胞的分化,Wnt/β-catenin信号通路的激活也可促进人根尖牙乳头干细胞的分化,而且核因子I-C对间充质干细胞中Wnt/β-catenin通路具有调节作用。然而,核因子I-C能否通过激活人根尖牙... 详细信息

背景:体外过表达核因子I-C基因可促进人根尖牙乳头干细胞的分化,Wnt/β-catenin信号通路的激活也可促进人根尖牙乳头干细胞的分化,而且核因子I-C对间充质干细胞中Wnt/β-catenin通路具有调节作用。然而,核因子I-C能否通过激活人根尖牙乳头干细胞中Wnt/β-catenin通路进而影响细胞分化,目前尚未见报道。目的:探讨核因子I-C通过Wnt/β-Catenin信号通路调控人根尖牙乳头干细胞分化的作用。方法:玻片覆盖组织块法培养人根尖牙乳头干细胞,慢病毒转染过表达核因子I-C基因。①设置对照组、空载体组和过表达核因子I-C组,Western blot检测β-Catenin、LRP5和TCF7L2的表达。②设置对照组、空载体组、过表达核因子I-C组和过表达核因子I-C+DKK-1(Wnt通路抑制剂)组,细胞成骨诱导7 d后进行碱性磷酸酶染色及活性定量,细胞成骨诱导14 d后qPCR和Western blot检测Runt相关转录因子2、牙本质涎磷蛋白、骨钙素mRNA及蛋白的表达,茜素红染色观察矿化结节形成情况。结果与结论:①与对照组、空载体组相比,过表达核因子I-C组人根尖牙乳头干细胞中Wnt/β-Catenin通路相关蛋白β-Catenin、LRP5、TCF7L2表达显著升高(P<0.01);②与对照组、空载体组相比,过表达核因子I-C组人根尖牙乳头干细胞中碱性磷酸酶活性显著升高(P<0.01),Runt相关转录因子2、牙本质涎磷蛋白、骨钙素mRNA及蛋白表达均显著升高(P<0.01),矿化结节数量显著增加(P<0.01);③与过表达核因子I-C组相比,过表达核因子I-C+DKK-1组人根尖牙乳头干细胞中碱性磷酸酶活性、Runt相关转录因子2、牙本质涎磷蛋白、骨钙素mRNA及蛋白表达显著下降(P<0.05),矿化结节数量显著减少(P<0.05)。结果表明:核因子I-C能够激活人根尖牙乳头干细胞中Wnt/β-catenin信号通路,介导人根尖牙乳头干细胞的成骨/成牙分化。

关键词：人根尖牙乳头干细胞核因子I-C Wnt 信号通路分化成骨 DKK-1 工程化干细胞

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