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Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale liu Lei Bai xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

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Dynamically self-adjustable liquid-liquid and self-adaptive softcontact solid-solid triboelectric nanogenerator for wave energy harvesting

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Nano Research 2025年第1期18卷 404-414页

作者： yong Long Bingqi Zhao Jianan Niu Yuxiu liu Wei Sha Jiangwen Wang Zhong Lin Wang Weiguo Hu Guangzhou Institute of Blue Energy Knowledge CityHuangpu DistrictGuangzhou 510555China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China

Water wave energy exhibits great potential toalleviate the global energy crisis. However, harvesting andutilizing wave energy are challenging due to its irregularity,randomness, and low frequency. Triboelectric nanogenerators(TENGs) have gained significant attention for harvesting waveenergy with high efficiency. This study presents a novelellipsoidal, pendulum-like TENG integrating both liquid-liquid(L-L) and solid-solid (S-S) triboelectricity (LS-TENG). Thisinnovative design enables continuous wave energy harvestingand self-powered marine environment monitoring under variousconditions, including temperature, humidity, and light intensity. The binary immiscible liquids within the LS-TENG’s innersoft balloon create dynamic, and self-adjustable L-L contact interfaces, significantly increasing the L-L contact area andenhancing L-L contact electrification (CE). The unique self-adaptive, soft S-S contact increases the S-S contact areacompared to traditional hard point contact, better adapting to the irregular movements of waves and promoting efficient S-SCE. The LS-TENG achieves highly efficient wave energy harvesting by coupling L-L and S-S CE. Furthermore, the uniquesoft contact design protects the S-S interfaces from mechanical wear and damage during long-term work. The LS-TENG’snovel structure provides an innovative and effective way for water wave energy harvesting.

关键词： self-adaptive soft-contact solid-solid liquid-liquid self-adjustable triboelectric nanogenerator

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Laser direct writing of flexible multifunctional airflow sensors on the Kevlar fabric

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Nano Research 2025年第1期18卷 443-454页

作者： Wei Wang Zi-Qing Chen yong-Qi Li Yu-Long Wang Mei-Chen liu Yun-Bo Ruan Yang Zhang Shu-Juan liu Qiang Zhao College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory of Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Zhe Jiang Topsun Logistic Control CO. LTD.Yuhuan 317600China Department of Rehabilitation Medicine School of Acupuncture-Moxibustion and Tuina and School of Health Preservation and RehabilitationNanjing University of Chinese MedicineNanjing 210023China

The growing interest in flexible devices has emerged as a global trend due to their advantages in flexibility,lightweight structure,and wearability,addressing the limitations of traditional *** wearable airflow sensors have been previously reported,the development of flexible fabric-based airflow sensors capable of functioning in environments with open flames—critical for fire rescue operations—has yet to be explored,largely due to the poor fire resistance of conventional *** this work,we first present a flexible,wearable,and multifunctional airflow sensor with excellent fire-resistant properties,fabricated through a simple direct laser writing *** sensor maintains airflow detection capabilities even in the presence of open ***,the fabrication of fabric-based sensors involves complex procedures such as carbon materials doping or vapor-phase deposition,leading to lengthy preparation cycles and high ***,fabric-based devices are inherently prone to *** address these challenges,we introduce twice-vertical laser-induced graphene(TVLIG)as a sensitive and reliable component for fire-resistant airflow *** resulting TVLIG/Kevlar fabric can be integrated into various garments,particularly protective suits,to form sensitive and fire-resistant airflow sensors capable of detecting airflow velocity and direction in both two-dimensional(2D)and three-dimensional(3D)spaces during fire ***,the TVLIG patterns can be expanded to multifunctional platforms,such as glucose detection for injured individuals,offering further applications in rescue *** functional expansion reduces the burden on rescue personnel and streamlines device *** its outstanding sensing capabilities,fire resistance,and expandability,the developed flexible airflow sensor shows great potential for various real-world rescue scenarios,promising advancements in wearable sensing technology for rescue enginee

关键词： flexible airflow sensor direct laser writing twice-vertical laser-induced graphene fire accident rescue Kevlar fabric

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Hydrogen-bonded organic framework-ionic liquid composite quasisolid electrolyte for high-performance lithium battery

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Nano Research 2025年第1期18卷 332-340页

作者： Junmei Zhang Yatao Wu Chenye Wang yong liu Zhirong Yang Shiyue Zhou Wenpeng Li Wenjia Wu Jingtao Wang School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China

Ionic liquids(ILs)hold great promise as highperformance electrolyte material due to their unique advantages including nonvolatility,high thermal stability and high ionic ***,the IL-based electrolytes always suffer from serious ion aggregation and high viscosity at low temperatures,leading to significantly decline in ionic ***,hydrogen-bonded organic framework-ionic liquid composite quasi-solid electrolyte(high temperature treatment(HT)-HOF-IL CQSE)was prepared through confining the IL electrolytes(ILEs)into the pore of HOF lamellar *** weak hydrogen bonding interactions within HOF nanosheets,together with the generated interactions between ILE and HOF,enable uniform and continuous distribution of ILE in HOF lamellar *** effectively inhibits the ion migration of ILE,which meanwhile serves as Li+transfer sites,affording high ionic conductivity of 5.7×10^(-5)S·cm-1 at-60 ℃,with high lithium-ion transference number of 0.69,whereas ILEs usually lose ionic conduction ability at such low *** assembled Li symmetrical cell can stably cycle at 0.2 mA·cm^(-2)and^(-2)0 ℃ for more than 1500 *** LiFePO_(4)|HT-HOF-IL CQSE|Li cell shows excellent cycling performance at 0.5 C at a wide temperature range of^(-2)0 to 60 ℃.This work may pave a new avenue for the development of high-performance IL-based composite electrolytes.

关键词： ionic liquid hydrogen-bonded organic framework low-temperature ionic conductivity lithium-ion transference number quasi-solid electrolyte

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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang Fan Yang Jian-Qin liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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Study on Production Performance of Alfalfa in Yellow River beach areas

Study on Production Performance of Alfalfa in Yellow River b...

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河南省畜牧兽医学会第七届理事会第二次会议暨2008年学术研讨会

作者： Gao yong-ge liu xiang Li Li Li He-ping Zhu wei-ran Wang Lei Wang Yan-hua Forage Grass and Feedstuff Station of Animal Husbandry Bureau of Henan Province,Jing San Road 91,Zhengzhou,Henan 450002,China

In order to study the growth law of alfalfa,and choose suitable varieties with high yield and good quality for cultivation,4 alfalfa varieties,including Liangmu 400,Affinity,Baoding alfalfa and Seven leaves alfalfa were studied in Yellow River beach areas of Zhengzhou,Henan Province,China,in 2004,2005 and 2006 using a randomized block design with three *** plot was cut four times each year over the 3-year period to evaluate production performance of the tested *** results were obtained from the experiment.(1)As alfalfa growth year increased,the dry matter yields *** third year had the highest yield among the three years for the four *** dry matter yield of the four varieties in 2006 were higher than that of ones in 2005, and 2005 were higher than that of ones in 2004,and the third yield’s dry matter yield nearly was the sum of the previous two years. The production performance of Liangmu400 was the best in the four varieties,providing a scientific base for choosing varieties in *** order to increase dry matter yield,we should select Liangmu400 in the industrialization production of alfalfa.(2) Cutting times had significant effect on dry matter herbage yield,the yield of first cutting was the highest,then the second,and the fourth,the third were the lowest,and dry matter yield of the first cutting were extremely significantly higher than that of the other three cuttings except for Seven leaf alfalfa (P<0.01).The dry matter yield was decreased to the lowest value in July among the four cuttings,in order to obtain higher alfalfa yield,we should focus on the management of the spring and autumn.(3)The changes of plant height were different from that of yield,three years average plant height of "Liangmu 400" was the tallest among the four varieties,significantly different from the other three varieties (P<0.05)."Baoding alfalfa"had the lowest height,and was very significantly different from Liangmu 400,Affinity and S

关键词： alfalfa production performance dry matter yield plant height correlation

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芭蕾舞台倾斜台面虚拟铰轴的设计与分析

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演艺科技 2016年第8期 59-61页

作者：张向勇刘斌常江江北京东方舞台科技有限公司北京100028

介绍虚拟铰轴机构在芭蕾舞台倾斜台面中的应用,该机构有效地实现了台面接口在运动过程中始终保持契合,重点对翻转驱动力进行分析,并进一步提出改进与优化措施。

关键词：芭蕾舞台倾斜台面虚拟铰轴翻转驱动力优化措施

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Assessing the corrosion protection property of coatings loaded with corrosion inhibitors using the real-time atmospheric corrosion monitoring technique

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 119-126页

作者： Xiaoxue Wang Lulu Jin Jinke Wang Rongqiao Wang Xiuchun liu Kai Gao Jingli Sun yong Yuan Lingwei Ma Hongchang Qian Dawei Zhang School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Institute of Space Long March Vehicle Beijing 100076China National Materials Corrosion and Protection Data Center University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal ***,limited studies have applied ACM to the corrosion protection properties of organic *** study compared a bare epoxy coating with one containing zinc phosphate corrosion inhibitors,both applied on ACM sensors,to observe their corrosion protection properties over *** with artificial damage via scratches were exposed to immersion and alternating dry and wet environments,which allowed for monitoring galvanic corrosion currents in *** the corrosion tests,the ACM currents of the zinc phosphate/epoxy coating were considerably lower than those of the blank epoxy *** trend in ACM current variations closely matched the results obtained from regular electrochemical tests and surface *** alignment highlights the potential of the ACM technique in evaluating the corrosion protection capabilities of organic *** with the blank epoxy coating,the zinc phosphate/epoxy coating showed much-decreased ACM current values that confirmed the effective inhibition of zinc phosphate against steel corrosion beneath the damaged coating.

关键词： atmospheric corrosion monitoring technology corrosion inhibitor coating carbon steel corrosion protection

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“寒门贵子”是“补偿”还是“选拔”出来的?——对两所精英大学2018—2023年高校专项计划招生的追踪研究

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华东师范大学学报（教育科学版） 2025年第1期43卷 113-126页

作者：金文旺柳夕浪北京师范大学中国教育与社会发展研究院北京100875 山东师范大学教育学部济南250014

高校专项计划是我国促进高质量教育公平、破解农村学生上好大学难而出台的一项入学机会补偿政策。综合运用描述性统计方法,本研究对两所精英大学2018—2023年间高校专项计划的选录情况进行了持续追踪研究。从初审、降分、录取人数的总... 详细信息

高校专项计划是我国促进高质量教育公平、破解农村学生上好大学难而出台的一项入学机会补偿政策。综合运用描述性统计方法,本研究对两所精英大学2018—2023年间高校专项计划的选录情况进行了持续追踪研究。从初审、降分、录取人数的总体规模及变化趋势看,近几年高校专项计划政策力度不断加大,越来越多的寒门子弟进入精英高校。同时,精英大学高校专项计划实际招生呈现“补偿不均,选拔有余”的鲜明特点,经济欠发达、教育发展水平薄弱省域的农村学生和学校在该计划中并未获得更多优质高校入学机会的补偿,一个重要原因在于他们在高校自主选拔和高考选拔中处于劣势。为此,应调整高校专项计划招生办法及相关政策,确立“补偿为主,兼顾选拔”的价值导向并切实付诸实践,推进“实质的公平”。

关键词：高校专项计划补偿选拔教育公平精英大学

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FATOC:Bug Isolation Based Multi-Fault Localization by Using OPTICS Clustering

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Journal of Computer Science & Technology 2020年第5期35卷 979-998页

作者： yong-Hao Wu Zheng Li yong liu xiang Chen College of Information Science and Technology Beijing University of Chemical TechnologyBeijing 100029China School of Information Science and Technology Nantong UniversityNantong 226019China State Key Laboratory of Information Security.Institute of Information Engineering Chinese Academy of Sciences Beijing 100093China

Bug isolation is a popular approach for multi-fault localization(MFL),where all failed test cases are clustered into several groups,and then the failed test cases in each group combined with all passed test cases are used to localize only a single ***,existing clustering algorithms cannot always obtain completely correct clustering results,which is a potential threat for bug isolation based MFL *** address this issue,we first analyze the influence of the accuracy of the clustering on the performance of MFL,and the results of a controlled study indicate that using the clustering algorithm with the highest accuracy can achieve the best performance of ***,previous studies on clustering algorithms also show that the elements in a higher density cluster have a higher *** on the above motivation,we propose a novel approach FATOC(One-Fault-at-a-Time via OPTICS Clustering).In particular,FATOC first leverages the OPTICS(Ordering Points to Identify the Clustering Structure)clustering algorithm to group failed test cases,and then identifies a cluster with the highest *** clustering is a density-based clustering algorithm,which can reduce the misgrouping and calculate a density value for each *** a density value of each cluster is helpful for finding a cluster with the highest clustering *** then combines the failed test cases in this cluster with all passed test cases to localize a single-fault through the traditional spectrum-based fault localization(SBFL)*** this fault is localized and fixed,FATOC will use the same method to localize the next single-fault,until all the test cases are *** evaluation results show that FATOC can significantly outperform the traditional SBFL technique and a state-of-the-art MFL approach MSeer on 804 multi-faulty versions from nine real-world ***,FATOC’s performance is 10.32%higher than that of traditional SBFL when using Ochiai formul

关键词： bug isolation multiple-fault localization ordering points to identify the clustering structure(OPTICS)clustering empirical study

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