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Marine red yeast supplementation improves laying performance by regulating small intestinal homeostasis in aging chickens

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Animal Nutrition 2024年第3期18卷 177-190页

作者： Yudian Zhao Sujin Si Yangguang Ren Xing Wu Zihao Zhang Yixiang Tian Jing Li Yijie Li Meng Hou Xueyang yao Zhaoheng Xu Ruirui Jiang Xiangtao Kang Yujie Gong qiang Li Yadong Tian College of Animal Science and Technology Henan Agricultural UniversityZhengzhou 450046China Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources Zhengzhou 450046China Henan College of Animal Husbandry and Economics Zhengzhou 450046China College of Animal Science and Veterinary Medicine Henan Institute of Science and TechnologyXinxiang 453003China AB Vista Marlborough SN84ANUK

Recent studies have shown that age-related aging evolution is accompanied by imbalances in intestinal *** red yeast(MRY)is a functional probiotic that has been shown to have antioxidant,immune and other ***,we chose 900 healthy Hy-Line Brown hens at 433 d old as the research subjects and evaluated the correlation between intestinal health,laying performance,and egg quality in aged hens through the supplementation of *** laying hens were assigned into 5 groups and received diet supplementation with 0%,0.5%,1.0%,1.5%,and 2%MRY for 12 *** results showed that MRY supplementation increased egg production rate,average egg weight,and egg quality,and decreased feed conversion ratio and daily feed intake(P<0.05).The MRY supplement improved antioxidant indicators such as superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GSH-Px),stimulated villus height,and increased the villus height to crypt depth ratio(V/C ratio)in the intestine(P<0.05).It also regulated the expression of intestinal inflammatory factors(transforming growth factor-β[TGF-β],interleukin[IL]-1β,IL-8,tumor necrosis factor-α[TNF-α])while increasing serum immunoglobulin G(IgG)levels(P<0.05).Furthermore,MRY supplementation upregulated the mRNA expression of tight junction proteins(occludin and zonula occludens-1[ZO-1]),anti-apoptotic gene(Bcl-2),and autophagy-related proteins(beclin-1 and light chain 3I[LC3I])in the intestine(P<0.05).The MRY supplement also led to an increase in the concentration of short-chain fatty acids in the cecum,and the relative abundance of the phylum Bacteroidetes,and genera Bacteroides and Rikenellaceae_RC9_gut_*** LEfSe analysis revealed an enrichment of Sutterella and Akkermansia *** conclusion,the results of this experiment indicated that the additional supplementation of MRY can improve the production performance of laying hens and may contribute to the restoration and balance of intestinal homeostasis,which sup

关键词： Marine red yeast Laying hen Senescence Intestinal homeostasis

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Combining genome-wide association study and transcriptome analysis to identify molecular markers and genetic basis of population-asynchronous ovarian development in Coilia nasus

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Zoological Research 2024年第3期45卷 491-505页

作者： Yue Yu Shi-Ming Wan Cheng-You Huang Shuang-Meng Zhang Ai-Li Sun Jun-Qi Liu Shun-yao Li yong-Fu Zhu Shu-Xin Gu Ze-Xia Gao College of Fisheries Hubei Hongshan Laboratory/Key Lab of Freshwater Animal BreedingMinistry of Agriculture and Rural Affairs/Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic BeltMinistry of EducationHuazhong Agricultural UniversityWuhanHubei 430070China Laboratory for Marine Biology and Biotechnology Qingdao Marine Science and Technology CenterQingdaoShandong 266237China Wuhan Hengyuxin Technology Breeding Professional Cooperative WuhanHubei 430117China Hubei Provincial Aquatic Science Research Institute WuhanHubei 430208China Zhenjiang Jiangzhiyuan Fishery Technology Co. Ltd.ZhenjiangJiangsu 212213China

Coilia nasus,a migratory fish species found in the middle and lower reaches of the Yangtze River and along offshore areas of China,possesses considerable aquacultural and economic ***,the species faces challenges due to significant variation in the gonadal development rate among females,resulting in inconsistent ovarian maturation times at the population level,an extended reproductive period,and limitations on fish growth rate due to ovarian *** the present study,we combined genome-wide association study(GWAS)and comparative transcriptome analysis to investigate the potential single nucleotide polymorphisms(SNPs)and candidate genes associated with population-asynchronous ovarian development in *** of the female population based on whole-genome resequencing yielded 2120695 high-quality SNPs,39 of which were suggestively associated with ovarian *** note,a significant SNP peak on LG21 containing 30 suggestively associated SNPs was identified,with cpne5a determined as the causal gene of the ***,single-marker and haplotype association analyses were performed on cpne5a,revealing four genetic markers(P0.9)significantly associated with the *** transcriptome analysis of precociously and normally maturing individuals screened out 29 and 426 overlapping differentially expressed genes in the brain and ovary,respectively,between individuals of different body *** the GWAS and transcriptome analysis results,this study identified genes and pathways related to hypothalamic-pituitary-gonadal axis hormone secretion,extracellular matrix,angiogenesis,and gap junctions involved in population-asynchronous ovarian *** insights gained from this study provide a basis for a deeper understanding of the molecular mechanisms underlying ovarian development in fish and may facilitate the genetic breeding of *** strains exhibiting population-synchronous ovarian

关键词： Coilia nasus GWAS Transcriptome Ovarian development SNP

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复杂石墨阵列快速时变热耦合控制方法

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东南大学学报（自然科学版） 2024年第1期54卷 232-239页

作者：王彬文郑瑶秦强中国飞机强度研究所强度与结构完整性全国重点实验室西安710065

为了在高超声速飞行器结构热试验中准确模拟真实服役热环境,用快速时变热耦合控制方法对复杂石墨阵列进行控制.采用热耦合控制方法将瞬态热损失与瞬态黑体辐射量代入控制方程,实时获取试验件的真实热响应状态;研究了结构热试验热载荷典... 详细信息

为了在高超声速飞行器结构热试验中准确模拟真实服役热环境,用快速时变热耦合控制方法对复杂石墨阵列进行控制.采用热耦合控制方法将瞬态热损失与瞬态黑体辐射量代入控制方程,实时获取试验件的真实热响应状态;研究了结构热试验热载荷典型历程及石墨阵列控制响应特性,设计了基于结构热试验的专家PID控制策略,给出了复杂石墨阵列全历程分段控制参数;研究了石墨阵列的电特性,设计了时变限伏控制策略,提高了石墨阵列的可靠性;设计了一种多温区耦合补偿控制方法,减小了温区间的耦合干扰.结果表明:试验得到的温度曲线与理论计算曲线在快速升温段的最大误差为4.8%,平稳段的最大误差为1.4%,下降段的最大误差为2.3%;有效减小了控制系统的超调量,提高了系统响应速度;使用快速时变热耦合控制方法在某试验中对复杂石墨阵列进行控制,控制误差小于1.2%.

关键词：高超声速飞行器结构热试验复杂石墨阵列专家PID 耦合补偿控制

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远读与元数据:大数据时代翻译知识传播研究

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外国语 2024年第2期47卷 82-95页

作者：耿强王瑶上海外国语大学语料库研究院上海201620

大数据时代翻译知识生产在数量和时间两个维度给翻译知识的跨语言传播带来了挑战:一方面,它使得传统翻译书评这种优选个别文本进行细读的质性研究方法的有效性值得怀疑;另一方面,翻译知识生产所产生的大量元数据乏人问津。本文强调指出... 详细信息

大数据时代翻译知识生产在数量和时间两个维度给翻译知识的跨语言传播带来了挑战:一方面,它使得传统翻译书评这种优选个别文本进行细读的质性研究方法的有效性值得怀疑;另一方面,翻译知识生产所产生的大量元数据乏人问津。本文强调指出,元数据是大数据时代翻译知识生产的副文本,必须使用技术手段才能将其转化为信息和知识。基于此,本文以远读作为途径和方法,结合现代数字技术手段和质性分析的方法,对近6年国外英语翻译学术论著的元数据进行采集、整理与分析,以便在研究途径、方法和结论方面为研究翻译知识的国际生产与跨文化传播提供一种认知参照和路径借鉴。

关键词：远读大数据时代翻译知识传播元数据翻译书评

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Anion-induced differential assembly and structural transformation of supramolecular coordination cages

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Chinese Chemical Letters 2024年第3期35卷 268-272页

作者： Shao-Ping Zheng yao-Wei Xu Pei-Yang Su Chen-Hui Liu Yin-Hui Huang Yu-Lin Lu Zhang-Wen Wei Zhiwei Jiao Hai-Sen Xu Cheng-yong Su MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional MaterialsSchool of ChemistrySun Yat-sen UniversityGuangzhou 510006China Institute of Environmental Research at Greater Bay Area Guangzhou UniversityGuangzhou 510006China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

The intimate host-anion interactions will regulate thermodynamics and kinetics in the self-assembly of cationic cages mimicking biological ***,we report construction and transformation of three Pd(Ⅱ)-based metal-organic cages(MOCs)depending on different *** conversions of the lantern-shaped MOC-34 into either octahedral MOC-35 or tricapped trigonal prism MOC-36 are induced by BF_(4)^(–)or NO_(3)^(–),***-36 is kinetically favored and can undergo quantitative conversion to the thermodynamically preferred MOC-35 upon heating,accelerated by excess BF_(4)^(–)to motivate dissociative dynamics of Pd-vertices and lower activation barrier of cage *** guest encapsulation behaviors of MOC-35 and MOC-36 have also been *** results manifest a significance of host-anion dynamics beyond complementary anion template,shedding light on the understanding of intricate anion recognition in nature.

关键词： Supramolecular coordination cage Dynamic host-anion interactions Structural transformation Anion receptor Guest inclusion

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Epidemiological and Subtype Characterization of Influenza Viruses Infection in Children in Shenzhen, China during Three Consecutive Seasons (January 2016-December 2018)

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Open Journal of Pediatrics 2024年第5期14卷 851-864页

作者： Yaxian Kuang Ruihong Ma Lei Jia qiang yao Chenhui Zhang Xiaoying Fu Department of Laboratory Medicine Shenzhen Childrens Hospital Affiliated to Shantou University Medical College Shenzhen China The Department of Clinical Laboratory The Sixth Peoples Hospital of Nansha Guangzhou China Guangxi Key Laboratory of Intelligent Precision Medicine Nanning China International Health Medicine Innovation Center Shenzhen University Shenzhen China

Background: Children with seasonal influenza infection cause a significant burden of disease each year in the pediatric clinic. Influenza A and B viruses are the major types responsible for illness. A better understanding of the periodicity facilitates the prevention and control of influenza in children. Objective: This study aims to analyze the epidemiological patterns and subtype characterization of influenza viruses among children in Shenzhen, China. Methods: Influenza samples were collected by nasopharyngeal swabs from influenza like illness patients in Shenzhen Children’s Hospital from January 2016 to December 2018. The positive cases and influenza subtypes were determined by gold labeled antigen detection and reverse transcriptase polymerase chain reaction. The influenza periodicity and age, subtype distribution as well as the association between climate parameters and different influenza subtypes were analyzed by SPSS 22.0. Results: The influenza positive rate during 2016-2018 was 21.0%, with a highest positive rate in the year 2018. The positive rate varied by month, season, and year describing a sequence of peaks presenting primarily in all year including spring, summer and winter. The characteristics of influenza peak were different in each year, with a spring peak in 2016 and a summer plus a winter-spring peaks in 2017 and 2018. In addition, influenza B exhibited a winter-spring seasonal pattern while influenza A displayed a more variable seasonality, highlighting influenza B rather than influenza A which had a negative association with climate parameters. Influenza-positive cases were older than influenza-negative cases (P P Conclusion: Influenza activity in children from Shenzhen typically displays both winter-spring and summer peaks. Influenza A epidemic occurred separately or co-circulated with influenza B, with a winter-spring pattern for influenza B and a much more variable seasonality for influenza A. Influenza B had a negative association with cli

关键词： Influenza Influenza Like Illness Gold Labeled Antigen Detection Reverse Transcriptase Polymerase Chain Reaction Influenza A Influenza B

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Clinical Study of Shentong Zhuyu Decoction Combined with Massage Therapy in the Treatment of Exertional Chronic Lumbar Muscle Strain

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Medicinal Plant 2024年第2期15卷 65-68页

作者： Lijun HAN Pengjun QIN Junbao KE qiang yao yongzhi LI Shangluo Hospital of Traditional Chinese Medicine Shangluo 726000China Shanyang County People s Hospital Shangluo 726400China

[Objectives]To explore the effects of Shentong Zhuyu decoction combined with massage therapy in the treatment of exertional chronic lumbar muscle strain.[Methods]Sixty-four cases of exertional chronic lumbar muscle strain were randomly divided into two groups(32 cases each group).The patients in the control group only took celecoxib capsules,and those in the treatment group additionally took Shentong Zhuyu decoction combined with massage *** syndrome score,lumbar function,hemorrheology index and clinical effect were compared between the two groups before and after treatment.[Results]After treatment,the TCM syndrome scores of lumbar distension/dull pain,tingling-like lumbago,adverse lateral turn,body weight loss,dark purple tongue,slow or astringent pulse,and Oswestry disability index(ODI)score in the treatment group were lower than those in the control group,and the levels of plasma viscosity,red blood cell aggregation index,platelet aggregation rate(PAG)and fibrinogen(Fib)were lower than those in the control group,showing statistical significance(P<0.05).The overall clinical effect distribution of the treatment group was better than that of the control group,and the difference was statistically significant(P<0.05).[Conclusions]Shentong Zhuyu decoction combined with massage therapy can effectively relieve the symptoms of patients with lumbago and improve the lumbar mobility function and hemorrheology,with obvious therapeutic effects in the treatment of exertional chronic lumbar muscle strain.

关键词： Chronic lumbar muscle strain Exertional Massage Shentong Zhuyu decoction

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Liu-Jun-Zi decoction alleviates chemotherapy-induced anorexia by regulating gut microbiota and TLR4/MyD88/NF-κB p65 signaling pathway

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Traditional Medicine Research 2024年第8期9卷 47-58页

作者： Yu-Jie Gao Xi-Pei Wu Bin-Bin Ye yong-Zhao Dai yao-Zhong Zhao Xiu-Xiu Liao Ke Nie School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China

Background:Liu-Jun-Zi decoction(LJZD),a classical nourishing formula in China,has been proven to be effective in treating chemotherapy-induced *** this study,the mechanism of LJZD in alleviating chemotherapy-induced anorexia was discussed from the aspects of regulating gut microbiota,repairing intestinal barrier injury and inhibiting inflammatory ***:A rat model of chemotherapy-induced anorexia was established using *** study evaluated the therapeutic effects of LJZD by observing the weight,food intake,and intestinal pathology of *** impact of LJZD on gut microbiota and metabolites,specifically short-chain fatty acids,was investigated through gut microbiota analysis and targeted *** anti-inflammatory and intestinal protective effects of LJZD were assessed by examining the expression of intestinal tight junction proteins associated with the inflammatory ***:LJZD alleviated cisplatin-induced inflammation and intestinal barrier disruption,as evidenced by upregulated expression of tight junction protein 1(TJ-1)and occludin,along with reduced serum levels of interleukin 6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and ***,LJZD alleviated microbiota imbalance and regulated the levels of short-chain fatty acids,especially increased the relative abundance of Coriobacteriales Incertae Sedis,Lactabacillus johnsonii F19785,Parasutterella,and reduced the *** the hypothalamus,LJZD exerts suppressive effects on the toll-like receptor 4(TLR4)/myeloid differentiation factor 88(MyD88)/nuclear factor-κB(NF-κB)p65 signaling pathway,leading to a downregulation in the transcriptional activity of IL-6 and IL-1β,as well as Interleukin 6 receptors(IL-6R)and Interleukin-1βreceptors(IL-1R1)mRNA expression ***:In summary,LJZD alleviate chemotherapy-induced anorexia by modulating the gut microbiota,repairing the intestinal mechanical barriers,and suppressing the TLR4

关键词： Liu-Jun-Zi decoction chemotherapy-induced anorexia cisplatin TLR4/MyD818/NF-κB p65 gut microbiota rat

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加筋材料的格形模型和统计数值方法

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力学季刊 2002年第3期23卷 315-322页

作者：陈永强姚振汉郑小平清华大学工程力学系北京100084

本文采用格形化方法和统计技术建立加筋复合材料有限元力学模型,使用自动选取载荷步长方法和非平衡迭代技术,对加筋复合材料的宏观等效模量和破坏全过程进行了数值模拟。分析了材料分布的非均匀程度、相对体积比和横截面加筋分布方式等... 详细信息

本文采用格形化方法和统计技术建立加筋复合材料有限元力学模型,使用自动选取载荷步长方法和非平衡迭代技术,对加筋复合材料的宏观等效模量和破坏全过程进行了数值模拟。分析了材料分布的非均匀程度、相对体积比和横截面加筋分布方式等对加筋复合材料整体宏观等效模量和承载力的影响。

关键词：加筋材料格形模型非均匀性统计分布数值模拟有限元方法非平衡迭代

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Therapeutic potential of urine-derived stem cells in renal regeneration following acute kidney injury:A comparative analysis with mesenchymal stem cells

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World Journal of Stem Cells 2024年第5期16卷 525-537页

作者： Fang Li Bin Zhao Lei Zhang Guo-Qing Chen Li Zhu Xiao-Ling Feng Meng-Jia Gong Cheng-Chen Hu Yuan-Yuan Zhang Ming Li yong-qiang Liu Department of General Surgery Chongqing General HospitalChongqing 401147China Department of Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqing 401147China

BACKGROUND Acute kidney injury(AKI)is a common clinical syndrome with high morbidity and mortality *** use of pluripotent stem cells holds great promise for the treatment of ***-derived stem cells(USCs)are a novel and versatile cell source in cell-based therapy and regenerative medicine that provide advantages of a noninvasive,simple,and low-cost approach and are induced with high multidifferentiation *** these cells could serve as a potential stem cell source for the treatment of AKI has not been *** Stem cell markers with multidifferentiation potential were isolated from human amniotic *** severe combined immune deficiency(SCID)mice models were induced by means of an intramuscular injection with *** isolated from human-voided urine were administered via tail *** functional changes in the kidney were assessed by the levels of blood urea nitrogen and serum *** histologic changes were evaluated by hematoxylin and eosin staining and transferase dUTP nick-end labeling ***,we compared the regenerative potential of USCs with bone marrow-derived mesenchymal stem cells(MSCs).RESULTS Treatment with USCs significantly alleviated histological destruction and functional *** renal function was rapidly restored after intravenous injection of 5×105 human USCs into SCID mice with glycerol-induced AKI compared with injection of *** from secretion assays conducted in vitro demonstrated that both stem cell varieties released a wide array of cytokines and growth *** suggests that a mixture of various mediators closely interacts with their biochemical *** types of stem cells showed enhanced tubular cell prolif-eration and decreased tubular cell apoptosis,although USC treatment was not more effective than MSC *** found that USC therapy significantly improved renal function and histological damage,inhibited inflammation and apoptosis processes in the kid

关键词： Urine-derived stem cells Regenerative medicine Acute kidney injury Renal function recovery Cell therapy

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