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XELOX(capecitabine plus oxaliplatin)plus bevacizumab(anti-VEGF-A antibody)with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer:a multicenter,open-label,randomized,controlled,phase 3 trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2104-2113页

作者： Qiu-Zhong Pan Jing-Jing Zhao liang liu Dong-Sheng Zhang li-Ping Wang Wen-Wei Hu De-Sheng Weng Xiang Xu Yi-Zhuo li Yan Tang Wei-Hong Zhang Jie-Yao li Xiao Zheng Qi-Jing Wang yong-qiang li Tong Xiang li Zhou Shuang-Ning Yang Chen Wu Rong-Xing Huang Jia He Wei-Jiao Du Lu-Jun Chen Yue-Na Wu Bin Xu Qiong Shen Yi Zhang Jing-Ting Jiang Xiu-Bao Ren Jian-Chuan Xia State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Department of Biotherapy Sun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerTianjin 300060PR China Key Laboratory of Cancer Immunology and Biotherapy Tianjin 300060PR China Department of Biotherapy/Immunology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Oncology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052PR China Department of Tumor Biological Treatment the Third Affiliated Hospital of Soochow UniversityChangzhouJiangsu 213003PR China Jiangsu Engineering Research Center for Tumor Immunotherapy ChangzhouJiangsu 213003PR China Institute for Cell Therapy of Soochow University ChangzhouJiangsu 213003PR China Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042PR China Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060PR China

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer(mCRC),but the prognosis remains *** phase 3 trial(***:NCT03950154)assessed the efficacy and adverse events(AEs)of the combination of PD-1 blockade-activated DC-CIK(PD1-T)cells with XELOX plus bevacizumab as a first-line therapy in patients with mCRC.A total of 202 participants were enrolled and randomly assigned in a 1:1 ratio to receive either first-line XELOX plus bevacizumab(the control group,n=102)or the same regimen plus autologous PD1-T cell immunotherapy(the immunotherapy group,n=100)every 21 days for up to 6 cycles,followed by maintenance treatment with capecitabine and *** main endpoint of the trial was progression-free survival(PFS).The median follow-up was 19.5 *** PFS was 14.8 months(95%CI,11.6-18.0)for the immunotherapy group compared with 9.9 months(8.0-11.8)for the control group(hazard ratio[HR],0.60[95%CI,0.40-0.88];p=0.009).Median overall survival(OS)was not reached for the immunotherapy group and 25.6 months(95%CI,18.3-32.8)for the control group(HR,0.57[95%CI,0.33-0.98];p=0.043).Grade 3 or higher AEs occurred in 20.0%of patients in the immunotherapy group and 23.5%in the control groups,with no toxicity-associated deaths *** addition of PD1-T cells to first-line XELOX plus bevacizumab demonstrates significant clinical improvement of PFS and OS with well tolerability in patients with previously untreated mCRC.

关键词： PD1 immunotherapy bevacizumab

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Antibacterial applications of graphene oxides: structure-activity relationships, molecular initiating events and biosafety

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Science Bulletin 2018年第2期63卷 133-142页

作者： Huizhen Zheng Ronglin Ma Meng Gao Xin Tian yong-qiang li lingwen Zeng Ruibin li School for Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University Institute of Environmental and Food Safety Wuhan Academy of Agricultural Science and Technology Guangzhou Institute of Biomedicine and Health Chinese Academy of Sciences

Bacterial infections may lead to diverse acute or chronic diseases （e.g., inflammation, sepsis and cancer）. New antibiotics against bacteria are rarely discovered in recent years, which necessitates the exploration of new antibacterial agents. Engineered nanomatetials {ENMs） have been extensively studied for antibacterial use because of their long lasting killing effects in wide spectra of bacteria. Graphene oxide （GO） is one of the most widely studied ENMs and exhibit strong bactericidal effects. The physicochemical properties of GO play important roles in bacterial killing by triggering a cascade of toxic events. Many studies have explored the signaling pathways of GO in bacteria. Although molecular initiating events （MIEs） of GO in bacteria dominate its killing efficiency as well as toxicity mechanisms, they have been rarely reviewed. In this report, we discussed the structure-activity relationships （SARs） involved in GOinduced bacterial killing and the MIEs including redox reaction with biomolecules, mechanical destruction of membranes and catalysis of extracellular metabolites. Furthermore, we summarized the clinical or commercial applications of GO-based antibacterial products and discussed their biosafety in mammal. Finally, we reviewed the remaining challenges in GO for antibacterial applications, which may offer new insights for the development of nano antibacterial studies.

关键词： 2D MaterialsPhysicochemical properties Nanotoxicity Infection Microbe

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Therapeutic advances in non-alcoholic fatty liver disease:A microbiota-centered view

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World Journal of Gastroenterology 2020年第16期26卷 1901-1911页

作者： Hui-Ting Chen Hong-li Huang yong-qiang li Hao-Ming Xu yong-Jian Zhou Department of Gastroenterology and Hepatology Guangzhou First People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180Guangdong ProvinceChina Department of Gastroenterology and Hepatology Guangzhou Digestive Disease CenterGuangzhou First People’s HospitalGuangzhou Medical UniversityGuangzhou 510180Guangdong ProvinceChina

Non-alcoholic fatty liver disease(NAFLD)is a highly prevalent metabolic disorder with steadily increasing incidence rates worldwide,especially in the *** are no drugs available at present to treat NAFLD,and the primary therapeutic options include weight loss and the combination of healthy diet and ***,novel interventions are required that can target the underlying risk *** microbiota is an“invisible organ”of the human body and vital for normal metabolism and *** number and diversity of microbes differ across the gastrointestinal tract from the mouth to the anus,and is most abundant in the *** dysregulated gut microbiota is an underlying pathological factor of NAFLD,it is a viable therapeutic target that can be modulated by antibiotics,probiotics,prebiotics,synbiotics,fecal microbiota transplantation,and microbial *** this review,we summarize the most recent advances in gut microbiota-targeted therapies against NAFLD in clinical and experimental studies,and critically evaluate novel targets and strategies for treating NAFLD.

关键词： Non-alcoholic fatty liver disease Gut microbiota Probiotics Prebiotics Fecal microbiota transplantation Metabolites

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Visual-simulation region proposal and generative adversarial network based ground military target recognition

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Defence Technology（防务技术） 2022年第11期18卷 2083-2096页

作者： Fan-jie Meng yong-qiang li Fa-ming Shao Gai-hong Yuan Ju-ying Dai Department of Space Test and Launch Noncommissioned Officer SchoolSpace Engineering UniversityBeijing102299China Department of Mechanical Engineering College of Field EngineeringArmy Engineering University of PLANanjing210007China

Ground military target recognition plays a crucial role in unmanned equipment and grasping the battlefield dynamics for military applications, but is disturbed by low-resolution and noisyrepresentation. In this paper, a recognition method, involving a novel visual attention mechanismbased Gabor region proposal sub-network(Gabor RPN) and improved refinement generative adversarial sub-network(GAN), is proposed. Novel central-peripheral rivalry 3D color Gabor filters are proposed to simulate retinal structures and taken as feature extraction convolutional kernels in low-level layer to improve the recognition accuracy and framework training efficiency in Gabor RPN. Improved refinement GAN is used to solve the problem of blurry target classification, involving a generator to directly generate large high-resolution images from small blurry ones and a discriminator to distinguish not only real images vs. fake images but also the class of targets. A special recognition dataset for ground military target, named Ground Military Target Dataset(GMTD), is constructed. Experiments performed on the GMTD dataset effectively demonstrate that our method can achieve better energy-saving and recognition results when low-resolution and noisy-representation targets are involved, thus ensuring this algorithm a good engineering application prospect.

关键词： Deep learning Biological vision Military application Region proposal network Gabor filter Generative adversarial network

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Design, Syntheses and Biological Activities of Novel Anthranilic Diamide Insecticides Containing N-Pyridylpyrazole

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Chemical Research in Chinese Universities 2013年第1期29卷 51-56页

作者： ZHAO Yu li yong-qiang XIONG li-xia XU li-ping PENG li-na li Fang li Zheng-ming National Pesticidal Engineering Centre(Tianjin) State Key Laboratory of Elemento-organic Chemistry Nankai University Tianjin 300071 P. R. China

In search of environmentally benign insecticides with high activity, low toxicity and low residue, a series of novel anthranilic diamide derivatives containing N-pyridylpyrazole was designed and synthesized. All the compounds were characterized by H NMR spectroscopy and elemental analysis. The single crystal structure of com pound 8j was determined by X-ray diffraction. The insecticidal activities of the new compounds were evaluated. The results show that some compounds exhibited moderate insecticidal activities against Lepidoptera pests. Among this series of compounds, compounds 80 and 8p showed 100% larvicidal activity against Mythimna separate Walker, Plutella xylostella linnaeus and Laphygma exigua Hubner at a test concentration of 200 mg/kg, which is equal to the commercial chlorantraniliprole.

关键词： Anthranilic diamide Ryanodine receptor Insecticidal activity

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Role of relaxin in diastasis of the pubic symphysis peripartum

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World Journal of Clinical Cases 2021年第1期9卷 91-101页

作者： Yan Wang yong-qiang li Mei-Rong Tian Nan Wang Zun-Cheng Zheng Rehabilitation Medicine Taian City Central HospitalTaian 271000Shandong ProvinceChina Department of Otolaryngology Taian City Central HospitalTaian 271000Shandong ProvinceChina Department of Obstetrics Taian City Central HospitalTaian 271000Shandong ProvinceChina Rehabilitation Centre Qingdao Fuwai Cardiovascular HospitalQingdao 266034Shandong ProvinceChina Department of Rehabilitation Taian City Central HospitalTaian 271000Shandong ProvinceChina

BACKGROUND Separation of the pubic symphysis can occur during the peripartum ***(RLX)is a hormone primarily secreted by the corpus luteum that can mediate hemodynamic changes during pregnancy as well as loosen the pelvic ***,it is unknown whether RLX is associated with peripartum pubic symphysis separation and if the association is affected by other *** To study the association between RLX and peripartum pubic symphysis separation and evaluate other factors that might affect this *** We performed a cross-sectional study of pregnant women between April 2019 and January *** demographic characteristics,including gestational age,weight,neonatal weight,delivery mode and duration of the first and second stages of labor,were *** clinical symptoms were used as a screening index during pregnancy,and the patients with pubic symphysis and inguinal pain were examined by color Doppler ultrasonography to determine whether there was pubic symphysis *** RLX concentrations were evaluated 1 d after delivery using an enzyme-linked immunosorbent assay,and pubic symphysis separation was diagnosed based on postpartum X-ray *** used an independent-sample t test to analyze the association between serum RLX levels and peripartum pubic symphysis *** regression analysis was used to evaluate whether the association between RLX and peripartum pubic symphysis separation was confounded by other factors,and the association between RLX and the severity of pubic symphysis separation was also *** used Pearson correlation analysis to determine the factors related to RLX levels as well as the correlation between the degree of pubic symphysis separation and activities of daily living(ADL)and *** A total of 54 women were enrolled in the study,with 15 exhibiting(observational group)and 39 not exhibiting(control group)peripartum pubic symphysis *** were no statistica

关键词： Pregnancy Pubic symphysis separation Relaxin Neonatal weight Crosssectional study Activities of daily living

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Energy consumption optimization for edge computing-supported cellular networks based on optimal transport theory

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Science China(Information Sciences) 2024年第2期67卷 201-218页

作者： Xiangyu LV Xiaohu GE Yi ZHONG qiang li yong XIAO School of Electronic Information and Communications Huazhong University of Science and Technology

With advancements in mobile communication technologies, there have been multiple user device(UD) connections to cellular networks. Because of changes in the spatial distribution of UDs and application requirements, the traditional offloading mechanism based on the nearest distance will result in heavy loads for some base stations(BSs). Because there is a high-order relationship between the energy consumption of the BS processing tasks and the number of computing tasks, the traditional offloading mechanism will result in high energy consumption, and UD’s offloading decision must be dynamically adjusted. The offloading decision of UDs is optimized based on detailed information about various parameters associated with a network from the standpoint of distribution. This information includes details regarding the spatial distribution of UDs,application requirements, and the offloading period of computing tasks. Based on optimal transport theory,an energy consumption optimization algorithm is suggested to lower the total amount of energy consumed by the offloading process of UDs’ computing tasks by reasonably planning the offloading BSs of the UDs in the networks. The simulation results show that the proposed offloading mechanism based on energy consumption optimization reduces the total energy consumption of the offloading process by 28.09% when compared to the traditional offloading mechanism, and the traffic managed by each BS is balanced.

关键词： optimal transport theory edge computing energy consumption reduction dynamic voltage frequency scaling

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Triclosan-conjugated,lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms

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Chinese Journal of Polymer Science 2024年第6期42卷 718-728页

作者： Yan-qiang Huang Yuan-Feng li yong liu lin-Qi Shi Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise533000China Translational Medicine Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325035China Wenzhou Institute University of Chinese Academy of SciencesWenzhou325001China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of Educationand Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071China

Bacterial biofilms present a significant challenge in treating drug-resistant infections,necessitating the development of innovative *** this study,we introduce triclosan-conjugated,lipase-responsive polymeric micelles designed to exploit biofilm properties and serve as a responsive drug delivery *** micelles were created using an amphiphilic block polymer synthesized via ring-opening polymerization ofε-caprolactone(CL)and triclosan-containing cyclic trimethylene carbonate(MTC-Tri).Poly(ethylene glycol)(PEG-OH)acted as the macro-initiator,resulting in micelles with a PEG shell that facilitated their penetration into bacterial *** important advantage of our micelles lies in their interaction with local bacterial lipases within *** lipases triggered rapid micelle degradation,releasing triclosan in a controlled *** liberated triclosan effectively eliminated bacteria embedded in the ***,the triclosan-conjugated micelles displayed minimal toxicity to murine fibroblasts,indicating their biocompatibility and *** finding emphasizes the potential application of these micelles in combatting drug resistance observed in bacterial *** triclosan-conjugated,lipase-responsive polymeric micelles exhibit promising characteristics for addressing drug resistance in bacterial *** harnessing biofilm properties and implementing a responsive drug delivery system,we seek to provide an effective solution in the fight against drug-resistant bacteria.

关键词： Self-assembly Polymer prodrug Ring-opening polymerization Biofilm eradication Cytotoxicity

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Tuning the Water Desalination Performance of Graphenic Layered Nanomaterials by Element Doping and Inter-Layer Spacing

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Chinese Physics Letters 2020年第11期37卷 48-54页

作者： Fuxin Wang Chao Zhang Yanmei Yang Yuanyuan Qu yong-qiang li Baoyuan Man Weifeng li School of Physics and State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China Collaborative Innovation Center of light Manipulations and Applications Shandong Normal UniversityJinan 250358China College of Chemistry Chemical Engineering and Materials ScienceCollaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of ShandongKey Laboratory of Molecular and Nano Probes(Ministry of Education)Shandong Normal UniversityJinan 250014China

Through atomic molecular dynamics simulations,we investigate the performance of two graphenic materials,boron(BC3)and nitrogen doped graphene(C3 N),for seawater desalination and salt rejection,and take pristine graphene as a *** of inter-layer separation have been *** water is filtered along the transverse directions of three-layered nanomaterials,the optimal inter-layer separation is 0.7–0.9 nm,which results in high water permeability and salt obstruction *** water permeability is considerably higher than porous graphene filter,and is about two orders of magnitude higher than commercial reverse osmosis(RO)*** changing the inter-layer spacing,the water permeability of three graphenic layered nanomaterials follows an order of C3 N≥GRA>BC3 under the same working *** three nanomaterials,BC3 is more sensitive to inter-layer separation which offers a possibility to control the water desalination speed by mechanically changing the membrane *** is caused by the intrinsic charge transfer inside BC3 that results in periodic distributed water clusters around the layer *** present results reveal the high potentiality of multi-layered graphenic materials for controlled water *** is hopeful that the present work can guide design and fabrication of highly efficient and tunable desalination architectures.

关键词： separation layer filtered

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Ectomycorrhizal fungi and dark septate endophyte inoculation improve growth and tolerance of Pinus tabulaeformis under cadmium stress

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Pedosphere 2024年第2期34卷 473-483页

作者： yong ZHOU Yanyan ZHENG Pengwei li lingjie XU qiang FU College of Landscape Architecture and Tourism Hebei Agricultural UniversityBaoding 071000China

Forest trees can establish symbiotic associations with dark septate endophytes(DSEs)and ectomycorrhizal fungi(ECMF)***,the combined effects of these two fungi on the growth and cadmium(Cd)tolerance of host plants remain largely *** address this knowledge gap,a pot experiment was conducted to examine the effects of the interaction between an ECMF strain(Suillus granulatus)and a DSE strain(Pseudopyrenochaeta sp.)on Pinus tabulaeformis under Cd stress,by assessing plant growth and physiological parameters,nutrient uptake,and soil ***,the colonization rates of both fungal strains were found to increase in response to Cd stress,with the extent of this increase being influenced by the specific fungal species and the Cd level in the *** to the non-inoculation treatment,single inoculation with fungal strain resulted in enhanced biomass,root development,and nutrient contents in *** seedlings under Cd ***,a synergistic effect was observed when these seedlings were co-inoculated with *** and Pseudopyrenochaeta sp.,as indicated by significantly greater measurements in various indicators compared to both the single and non-inoculation *** inoculation effectively regulated the antioxidant defense responses and photosynthesis of *** seedlings subjected to Cd stress,particularly in the co-inoculation *** addition,fungal inoculation facilitated the Cd accumulation in ***,suggesting a promising potential for the implementation of bioremediation strategies in the areas contaminated with heavy *** findings from this study indicate that the utilization of root symbiotic fungi obtained from stress environments could potentially enhance the growth performance and tolerance of *** towards heavy metals,and co-inoculation of both fungal groups may result in even more pronounced synergistic effects on the overall fitness of the plant.

关键词： antioxidant defense response colonization rate fungal inoculation heavy metal tolerance physiological parameter root symbiotic fungi soil property

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