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Research on automatic high velocity arc spraying technique and metastable coating materials

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Advances in Manufacturing 2013年第1期1卷 97-101页

作者： Xiu-Bing Liang yong-Xiong Chen Zhi-Bin Zhang Shi-Cheng Wei yong-ming guo Bin-Shi Xu National Engineering Research Center for Mechanical Product Remanufacturing The Academy of Armored Forces Engineering National Key Laboratory for Remanufacturing The Academy of Armored Forces Engineering College of Materials Science and Engineering Beijing University of Technology

Into the 21st century, remanufacturing engineering has been accepted by more and more people in China. Remanufacturing is an industrial maintenance technology for worn or waste electro-mechanical products using advanced technology, which means the high-level stage for the maintenance and surface engineering. In this paper, a new automotive high velocity arc spraying system was introduced. And three kinds of advanced amorphous and nanocrystalline metastable coatings were developed, including Fe, Ni and Al-based amorphous and nanocrystalline composite coatings. Their research development and applications were introduced. And the development trends of high velocity arc spraying system and advanced metastable surface protective coating materials on the remanu- facturing engineering were indicated.

关键词： Remanufacturing. Arc spraying. AmorphousNanocrystalline Coating

The mRNA expression patterns of tumor necrosis factor-a and TNFR-I in some vital organs after thermal injury

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World Journal of Gastroenterology 2003年第5期9卷 1038-1044页

作者： Wen-Hui Fang yong-ming Yao Zhi-guo Shi Yan Yu Ye Wu Lian-Rong Lu Zhi-yong Sheng Department of Microbiology and Immunology,Burns Institute,304th Hospital of PLA,Beijing 100037,China Hosp PLA 304th Burns Inst Dept Microbiol & Immunol Beijing 100037 Peoples R China

AIM: To investigate changes of tumor necrosis factor-α (TNFα) and TNFR-Ⅰ expression in vital organs and their significance in the pathogenesis of multiple organ damage associated with endogenous endotoxin following major ***: Wistar rats subjected to a 35 % full-thickness scald injury were sacrificed at 12 h, 24 h, 48 h, and 72 h postburn, respectively. Meanwhile, eight rats were taken as normal controls. Tissue samples from liver, spleen, kidney,lung and intestine were collected to assay tissue endotoxin levels and measure TNF-α and TNFR-Ⅰ expression, In addition, blood samples were obtained for the determination of organ function ***: Endotoxin levels in liver, spleen and lung increased markedly after thermal injury, with the highest level in liver. The gene expression of TNF-α in liver, lung and kidney was up-regulated after thermal injury, while the TNFR-Ⅰ mRNA expression in liver, lung, kidney and intestine was shown decreased throughout the observation period. Thus, the mRNA expression ratio of TNF-α to TNFRⅠ was significantly increased postburn, particularly in pulmonary tissue (67-fold). In addition, the significant correlations between the expression of TNFR-Ⅰ or the expression ratio of TNF-α/TNFR mRNA in liver tissue and serum aspartate aminotransferase levels were noted (P ＜0.05-0.01). Similar results were also obtained between pulmonary TNF-α mRNA expression and myeloperoxidase activities (P＜0.01), whereas there was a highly negative correlation between levels of renal TNFR-Ⅰ mRNA expression and serum ***: Burn injury could result in the translocation of gut-derived endotoxin that was mainly distributed in the liver, spleen and lung. The translocated endotoxin then made the expression of TNF-α and TNFR-Ⅰ mRNA up-regulated and down-regulated respectively in various organs, which might be involved in the pathogenesis of multiple organ damage following burns.

关键词：肿瘤坏死因子-α 受体热损伤 mRNA 烧伤细胞因子炎症动物实验

Neuroendocrine-Immune Regulating Mechanisms for the Anti-Inflammatory and Analgesic Actions of Acupuncture

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World Journal of Traditional Chinese Medicine 2020年第4期6卷 384-392页

作者： Zhi-Fang Xu Shou-Hai Hong Shen-Jun Wang Xue Zhao Yang-Yang Liu Sha-Sha Ding Yuan Xu Kuo Zhang Nan-Nan Yu Zhong-Xi Lu Fu-ming Yang Yi-Nan Gong Qin-Qin He Kun Yu Yi-Ping Zhang Bao-Min Dou Lin Yao Ya-Wen Yan Tao Yang Yan-Fang Zhang Bao-Hu Liu yong-ming guo Hsuah-Nee-Connie Wong Yi guo Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese Medicine National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina

Pain and inflammatory diseases are important clinical indications of acupuncture,which have been widely accepted in the international *** studies have been focusing on rapid analgesia of acupuncture through the regulation of nervous system,but few studies on the inflammation regulatory mechanisms in which acupuncture inhibits the peripheral sensitization-induced *** on studies concerning acupoint mechanisms of acupuncture actions and related researches on acupuncture regulating neuroendocrine and immune systems,we put forward the scientific hypothesis that acupuncture regulates neuroendocrine-immune(NEI)network and key response media therein,so as to achieve anti-inflammatory and analgesic effects in target *** have established a platform for acupuncture at ST36 to alleviate inflammatory pain in adjuvant induced arthritic *** on the complex network analysis of multi-dimensional data from multi-time point and multi-site detection of NEI common signaling molecules,we have clarified the regulatory effects of acupuncture on NEI network and corresponding downstream immune *** indicated that monocytes/macrophages are the key targeting cells of acupuncture regulation,and acupuncture may display the anti-inflammatory and analgesic effects by regulating polarization of T cells in lymph nodes and polarization of M1/M2 macrophages in inflamed joints/*** addition,we have spotted a key molecule for acupuncture analgesia,CXCL1,as well as clarified the novel central analgesic mechanism of acupuncture mediated by CXCL1/CXCR2 ***,we have provided novel evidence of the anti-inflammatory and analgesic actions of acupuncture through regulating NEI network and several key substances,highlighting a systemic research paradigm for investigating mechanisms of acupuncture actions.

关键词： Acupuncture anti-inflammation analgesia neuro-endocrine-immune network CXCL1

Analysis of microblog public opinion characteristics on traditional Chinese medicine against COVID-19 based on deep learning

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History & Philosophy of Medicine 2021年第2期3卷 24-35页

作者： Shi-Pian Li Xue-Meng Cai Cheng Chen Ze-Lin Wei Wen-Zong Zhang Dai-Le Zhang yong-ming guo Xin-Ju Li Tianjin University of Traditional Chinese Medicine Tianjin 301617China Central China Normal University Wuhan 430077China Beijing University of Technology Beijing 100081China.

The opinion research on traditional Chinese medicine during the coronavirus disease 2019(COVID-19)pandemic on microblog,a social network,took into account the national people’s fight against COVID-19—the research background—the strength of traditional Chinese medicine during the pandemic—the research topic—and the public opinion—the research *** timeline was divided into three stages according to the overall heat *** order to explore and compare people’s emotion and topics of concern on traditional Chinese medicine during the different stages of the pandemic,deep learning analysis methods such as emotional analysis and Latent Dirichlet Allocation analysis were *** study found that the public’s positive“emotional composition”on traditional Chinese medicine significantly improved within the timeline,while the public’s autonomy was enhanced and the overall public opinion started to show an increased trend.

关键词： Deep learning COVID-19 Public opinion analysis Traditional Chinese medicine

ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China Life Sciences 2025年第1期 272-283页

作者： Yuwei Hua Yizhi Zhang Zhenming guo Shan Bian yong Zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji University

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level, limiting their applications in biological discoveries. Here, we introduce ImSpiRE, an image feature-aided spatial resolution enhancement method for in situ capturing spatial transcriptome. Taking the information stored in histological images, ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution, together with extending the gene expression profiles into unmeasured regions. Applications to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains, signaling communication patterns, and spatiotemporal characterization.

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Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： yong Hou Shuo Zhang Jie Dang Jia guo Hanghang Zhou Xuewei Lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

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针刺电信息的神经编码特性

中西医结合学报 2008年第12期6卷 1300-1304页

作者：周涛郭义郭永明陈泽林天津中医药大学基础医学院生理学教研室天津300193 天津中医药大学针灸系天津300193

针刺作用可产生两类信息，即化学信息和电信息。化学信息是通过一些化学物质（如组织胺、Ca^2＋等）来传递的信息，它的作用通常具有弥散、缓慢和持久的特点。针刺效应的发挥，还依赖于机体神经一内分泌系统结构和功能的完整与完善，在... 详细信息

针刺作用可产生两类信息，即化学信息和电信息。化学信息是通过一些化学物质（如组织胺、Ca^2＋等）来传递的信息，它的作用通常具有弥散、缓慢和持久的特点。针刺效应的发挥，还依赖于机体神经一内分泌系统结构和功能的完整与完善，在这一过程中，针刺刺激转换成相应的神经冲动，即针刺电信息。针剌电信息引发了相应节段内神经递质和生物活性物质的分泌与释放，后者通过靶组织细胞发生一系列生物效应，从而在机体产生相应的针刺效应。近年来针刺以及随之产生的电信息逐渐成为研究热点。

关键词：针刺信号传导神经编码

重金属污染土壤的植物修复研究 Ⅲ.金属富集植物Brassica juncea对锌镉的吸收和积累

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土壤学报 2002年第5期39卷 664-670页

作者：蒋先军骆永明赵其国中国科学院南京土壤研究所南京210008

采用温室盆栽试验研究了印度芥菜对土壤中锌镉污染的忍耐、积累能力 ,以检验这种植物修复Zn、Cd污染土壤的可能性及其潜力。在加入Zn 5 0 0和 1 0 0 0mgkg- 1 的土壤中 ,印度芥菜生长 66天后 ,叶片中积累Zn的平均浓度分别达 2 80和 662m... 详细信息

采用温室盆栽试验研究了印度芥菜对土壤中锌镉污染的忍耐、积累能力 ,以检验这种植物修复Zn、Cd污染土壤的可能性及其潜力。在加入Zn 5 0 0和 1 0 0 0mgkg- 1 的土壤中 ,印度芥菜生长 66天后 ,叶片中积累Zn的平均浓度分别达 2 80和 662mgkg- 1 ,地上部带走的Zn分别为每盆 2 1 95和 341 2 μg。在加入Cd 2 0 0mgkg- 1 的土壤中生长的印度芥菜 ,叶片中积累Cd浓度为 1 61mgkg- 1 ,地上部带走的Cd为每盆 381 μg。和普通植物相比 ,印度芥菜更能将Zn和Cd从根运输到地上部。Zn 5 0 0mgkg- 1 处理的土壤在种植印度芥菜后其NH4NO3提取的Zn显著高于不种植物的处理 ;土壤添加Cd 2 0 0mgkg- 1 的处理NH4NO3提取的Cd也显著高于不种植物的处理 ,可能的原因是植物根分泌出特殊的分泌物 ,专一性地螯合溶解根系附近的难溶态Zn和Cd,从而提高土壤溶液中的浓度。印度芥菜对Zn、Cd有较强的忍耐和富集能力 ,是Zn、Cd污染土壤修复有潜力的植物。

关键词：重金属污染土壤植物修复金属富集植物 Brassica juncea 锌镉吸收积累印度芥菜

Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population： Results from a Nationally Representative Survey

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Chinese Medical Journal 2015年第21期128卷 2843-2850页

作者： De-Wei Zhao Mang Yu Kai Hu Wei Wang Lei Yang Ben-Jie Wang Xiao-Hong Gao yong-ming guo yong-Qing Xu Yu-Shan Wei Si-Miao Tian Fan Yang Nan Wang Shi-Bo Huang Hui Xie Xiao-Wei Wei Hai-Shen Jiang Yu-Qiang Zang Jun Ai Yuan-Liang Chen Guang-Hua Lei Yu-Jin Li Geng Tia Zong-Sheng Li yong Cao Li Ma Orthopedic Medical Research Center Dalian University Dalian Liaoning 116001 China Department of Orthopaedics Affiliated Zhongshan Hospital of Dalian University Dalian Liaoning 116001 China Department of Pathology Stanford University School of Medicine Stanford CA USA Medical Clinic I University Hospital Wurzburg Worzburg Germany Department of Epidemiology and Statistics School of Public Health Dalian Medical University Oalian Liaoning 116044 China Department of Orthopaedics Xi'an 521 Hospital Xi'an Shaanxi 710065 China Department of Orthopaedics Kunming General Hospital of Chengdu Military Region Kunming Yunnan 650032 China Department of Clinical Laboratory Affiliated Zhongshan Hospital of Dalian University Dalian Liaoning 116001 China Department of Orthopaedics The First People's Hospital of Horqin District Tongliao Inner Mongolia 028000 China Department of Orthopaedics The People's Hospital of Changhai County Dalian Liaoning 116500 China Department of Health Kunming Kun Lu Hospital Kunming Yunnan 650217 China Department of Orthopaedics The People's Hospital of Haikou Haikou Hainan 570208 China Department of Orthopaedics Xiangya Hospital of Central South University Changsha Hunan 410008 China Department of Orthopaedics The People's Hospital of Fangzheng County Harbin Heilongjiang 150800 China Department of Orthopaedics The People's Hospital of Qionghai Qionghai Hainan 571400 China Department of Imaging Traditional Chinese Medicine Orthopedics Hospital of Xiaoshan Hangzhou Zhejiang 311261 China Department of Imaging Red Star Hospital of Agricultural Thirteen Division of Hami Hami Xinjiang 839000 China

Background： Nontraumatic osteonecrosis of the femoral head （NONFH） is a debilitating disease that represents a significant financial burden for both individuals and healthcare systems. Despite its significance, however, its prevalence in the Chinese general population remains unknown. This study aimed to investigate the prevalence of NONFH and its associated risk factors in the Chinese population. Methods： A nationally representative survey of 30,030 respondents was undertaken from June 2012 to August 2013. All participants underwent a questionnaire investigation, physical examination of hip, and bilateral hip joint X-ray and/or magnetic resonance imaging exalnination. Blood samples were taken after overnight fasting to test serum total cholesterol, triglyceride, and high-density lipoprotein （HDL） and low-density lipoprotein （LDL） levels. We then used multivariate logistic regression analysis to investigate the associations between various metabolic, demographic, and lifestyle-related variables and NONFH. Results： NONFH was diagnosed in 218 subjects （0.725%） and the estimated NONFH cases were 8.12 million among Chinesepeople aged 15 years and over. The prevalence of NONFH was significantly higher in males than in females （1.02% vs. 0.51%, x^2 = 24.997, P 〈 0.001 ）. Among NONFH patients, North residents were subjected to higher prevalence of NONFH than that of South residents （0.85% vs. 0.61%,x^2= 5.847, P = 0.016）. Our multivariate regression analysis showed that high blood levels oftriglycerides, total cholesterol, LDL-cholesterol, and non-H DL-cholesterol, male, urban residence, family history of osteonecrosis of the femoral head. heavy smoking, alcohol abuse and glucocorticoid intake, overweight, and obesity were all significantly associated with an increased risk of NONFH. Conclusions： Our findings highlight that NONFH is a significantpublic health challenge in China and underscore the need for policy measures on the national level. Furthermore, NONFH shares a n

关键词： Nontraumatic Osteonecrosis of the Femoral Head Prevalence Risk Factors