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Correlation between gut microbiota and tumor immune microenvironment:A bibliometric and visualized study

World Journal of Clinical Oncology 2025年第2期16卷 110-129页

作者： Zheng-Jun Hu Hui-Rong Zhu yong-jie jin Pan Liu Xiao-Wei Yu Yu-Ren Zhang Department of Oncology Shanghai Jiading District Hospital of Traditional Chinese MedicineShanghai 200000China Department of Oncology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200000China School of Chinese Medicine Anhui University of Traditional Chinese MedicineHefei 230000Anhui ProvinceChina

BACKGROUND In recent years,numerous reports have been published regarding the relationship between the gut microbiota and the tumor immune microenvironment(TIME).However,to date,no systematic study has been conducted on the relationship between gut microbiota and the TIME using bibliometric *** To describe the current global research status on the correlation between gut microbiota and the TIME,and to identify the most influential countries,research institutions,researchers,and research hotspots related to this *** We searched for all literature related to gut microbiota and TIME published from January 1,2014,to May 28,2024,in the Web of Science Core Collection *** then conducted a bibliometric analysis and created visual maps of the published literature on countries,institutions,authors,keywords,references,etc.,using CiteSpace(6.2R6),VOSviewer(1.6.20),and bibliometrics(based on R 4.3.2).RESULTS In total,491 documents were included,with a rapid increase in the number of publications starting in *** country with the highest number of publications was China,followed by the United *** has the highest number of citations in *** a centrality perspective,the United States has the highest influence in this *** institutions with the highest number of publications were Shanghai Jiao Tong University and Zhejiang ***,the institution with the most citations was the United States National Cancer *** authors,Professor Giorgio Trinchieri from the National Institutes of Health has the most local impact in this *** most cited author was Fan *** results of journal publications showed that the top three journals with the highest number of published papers were Frontiers in Immunology,Cancers,and Frontiers in *** three most frequently used keywords were gut microbiota,tumor microenvironment,and *** This study systematically elaborates on the research progress re

关键词： Gut microbiota Tumor immune microenvironment Bibliometric CiteSpace VOSviewer R-bibliometrics

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Soil organic carbon contents, aggregate stability,and humic acid composition in different alpine grasslands in Qinghai-Tibet Plateau

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Journal of Mountain Science 2016年第11期13卷 2015-2027页

作者： CAO Zhi-yuan WANG yong LI jie ZHANG jin-jing HE Nian-peng Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China

Alpine grassland soils on Qinghai-Tibet Plateau store approximately 33.5 Pg of organic carbon(C) at 0–0.75 m depth and play an important role in the global carbon *** investigated soil organic C(SOC),water-soluble organic C(WSOC),easily oxidizable organic C(EOC),humic C fractions,aggregate-associated C,aggregate stability,and humic acid(HA) composition along an east-west transect across Qinghai-Tibet Plateau,and explored their spatial patterns and controlling *** contents of SOC,WSOC,EOC,humic C fractions and aggregate-associated C,the proportions of macroaggregates(2-0.25) and micro-aggregates(0.25-0.053 mm),and the aggregate stability indices all increased in the order alpine desert < alpine steppe < alpine *** alkyl C,O-alkyl C,and aliphatic C/aromatic C ratio of HA increased as alpine desert < alpine meadow < alpine steppe,and the trends were reverse for the aromatic C and HB/HI *** annual precipitation and aboveground biomass weresignificantly correlated with the contents of SOC and its fractions,the proportions of macro- and microaggregates,and the aggregate stability indices along this *** all these C fractions,SOC content and aggregate stability were more closely associated with humic C and silt and clay sized C in comparison with WSOC,EOC,and macro- and microaggregate *** results suggested that alpine meadow soils containing higher SOC exhibited high soil aggregation and aggregate *** annual precipitation should be the main climate factor controlling the spatial patterns of SOC,soil aggregation,and aggregate stability in this *** resistant and stable C fractions rather than labile C fractions are the major determinant of SOC stocks and aggregate stability.

关键词： Soil organic carbon Aggregate stability Humic acid Carbon-13 nuclear magnetic resonance Latitudinal transect Qinghai-Tibet Plateau

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Continuous Selections and Fixed Points forφ-maps with Their Applications to Section Problems

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Communications in Mathematical Research 2012年第3期28卷 225-234页

作者： PIAO yong-jie jin HAI-LAN PIAO GUANG-RI Department of Mathematics College of Science Yanbian Universify Yanji Jilin 133002

The concept of finitely continuous topological space is introduced and the basic properties of the space are given. Several continuous selection theorems and fixed point theorems for Ф-maps are established, and as applications of the above fixed point theorems, some section problems are discussed. The results generalize and improve many corresponding conclusions.

关键词： FC-space FC-subset Ф-map continuous selection fixed point section problem

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Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第01期 249-256页

作者： Qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng Yan yong Liang Weipeng Li Chengjian Zhu jie Han jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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Prognostic model for esophagogastric variceal rebleeding after endoscopic treatment in liver cirrhosis: A Chinese multicenter study

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World Journal of Gastroenterology 2025年第2期31卷 85-101页

作者： Jun-Yi Zhan jie Chen jin-Zhong Yu Fei-Peng Xu Fei-Fei Xing De-Xin Wang Ming-Yan Yang Feng Xing Jian Wang yong-Ping Mu Cell Biology Laboratory Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Liver Diseases Shanghai Academy of Chinese MedicineShanghai 201203China Clinical Key Laboratory of Traditional Chinese Medicine of Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Key Laboratory of Liver and Kidney Disease of the Ministry of Education Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Gastroenterology and Hepatology Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Institute of Liver Disease Fudan UniversityShanghai 200032China Evidence-Based Medicine Center Fudan UniversityShanghai 200032China Department of Gastrointestinal Endoscopy Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Hepatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Rebleeding after recovery from esophagogastric variceal bleeding(EGVB)is a severe complication that is associated with high rates of both incidence and *** its clinical importance,recognized prognostic models that can effectively predict esophagogastric variceal rebleeding in patients with liver cirrhosis are *** To construct and externally validate a reliable prognostic model for predicting the occurrence of esophagogastric variceal *** This study included 477 EGVB patients across 2 cohorts:The derivation cohort(n=322)and the validation cohort(n=155).The primary outcome was rebleeding events within 1 *** least absolute shrinkage and selection operator was applied for predictor selection,and multivariate Cox regression analysis was used to construct the prognostic *** validation was performed with bootstrap *** assessed the discrimination,calibration and accuracy of the model,and performed patient risk *** Six predictors,including albumin and aspartate aminotransferase concentrations,white blood cell count,and the presence of ascites,portal vein thrombosis,and bleeding signs,were selected for the rebleeding event prediction following endoscopic treatment(REPET)*** predicting rebleeding within 1 year,the REPET model ex-hibited a concordance index of 0.775 and a Brier score of 0.143 in the derivation cohort,alongside 0.862 and 0.127 in the validation ***,the REPET model revealed a significant difference in rebleeding rates(P<0.01)between low-risk patients and intermediate-to high-risk patients in both *** We constructed and validated a new prognostic model for variceal rebleeding with excellent predictive per-formance,which will improve the clinical management of rebleeding in EGVB patients.

关键词： Esophagogastric variceal bleeding Variceal rebleeding Liver cirrhosis Prognostic model Risk stratification Secondary prophylaxis

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Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： yong Hou Shuo Zhang jie Dang Jia Guo Hanghang Zhou Xuewei Lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

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西准噶尔地区石炭纪残余洋盆充填演化的地层学记录

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地层学杂志 2022年第2期46卷 163-173页

作者：宋永雍锦杰李世鑫任海姣张廷山中国石油新疆油田分公司勘探开发研究院新疆克拉玛依834000 油气藏地质与开发工程国家重点实验室四川成都610500 西南石油大学地球科学与技术学院四川成都610500

准噶尔盆地位于古亚洲洋构造域南部,是中亚造山带的重要组成部分。早石炭世,该盆地继承了晚泥盆世多洋岛的古地理格局,沉积了一套巨厚海相沉积物。随着古准噶尔洋持续收缩,海水逐渐退去,区内形成多个残余洋盆,并最后被充填及消亡。太勒... 详细信息

准噶尔盆地位于古亚洲洋构造域南部,是中亚造山带的重要组成部分。早石炭世,该盆地继承了晚泥盆世多洋岛的古地理格局,沉积了一套巨厚海相沉积物。随着古准噶尔洋持续收缩,海水逐渐退去,区内形成多个残余洋盆,并最后被充填及消亡。太勒古拉组、包古图组和希贝库拉斯组为西准噶尔地区从下到上的石炭纪沉积序列,完整记录了西准噶尔残余洋盆充填消亡的全过程。根据上述三组地层岩性及其组合特征、沉积构造特征,将残余洋盆收缩充填过程分为3个阶段:太勒古拉组以暗色硅质岩、硅质泥岩夹粉砂岩为主,代表着洋盆沉积记录,即盆地阶段;包古图组以硅质岩、粉—细砂岩和含砾砂岩为主,毫米—厘米级鲍马序列极为发育,代表洋盆缓慢收缩充填的开始,即缓慢充填阶段;希贝库拉斯组以含砾砂岩、砾岩、角砾岩夹砂岩和泥岩为主,浊流沉积和风暴沉积较为发育,水体较浅,残余洋盆进入快速充填—消亡阶段。

关键词：准噶尔盆地石炭系残余洋盆充填演化

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Recurrent ameloblastoma in the anterior skull base: Report of 3 cases

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中国口腔颌面外科杂志 2005年第4期3卷 307-310页

作者： CHEN Wei-liang YANG Zhao-hui HUANG Zhi-quan WANG yong-jie LI jin-song ZHANG Bin Department of Oral and Maxillofacial Surgery the Second Affiliated Hospital of San Yat-Sen University.Guangzhou 510120 Guangdong Province China

Recurrent ameloblastoma is common following inadequate excision but rarely presents in the anterior skull base. We presented 3 patients with recurrent ameloblastoma in the anterior skull base including the frontotemporal fossa and the pterygomaxillary fossa that occurred following multiple enucleations, segmental mandibulectomy, or partial maxillectomy for ameloblastoma in the jaws. Attenborough approach was used in the exposure of the frontotemporal fossa. Attenborough plus Barbosa approach was used in the exposure of the pterygomaxillary fossa. The patients were treated by radical dissection. Microscopy confirmed that the histopathologic pattern of one case was fixed follicular and plexiform, two cases were follicular. All patients healed without serious complications. The local recurrences of the patients following the operations were found in 3 to 4 years. The present study showed that the tumors in the regions had a greater recurrence potential even when treated with radical dissection, and the original tumors were the high-risk follicular pattern.

关键词： Ameloblastoma Anterior skull base tumors Recurrence Surgical resection

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The Ability of Tissue Engineered Skin Accelerating the Closure of Different Wound

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生物医学工程学杂志 2005年第S1期22卷 158-页

作者： yong-jie ZHANG Yan jin~(△) Xin NIE Yuan LIU Rui DONG Xin-Wen WANG (Tissue Engineering Center, Department of Oral Histopathology, The Fourth Military Medical University, Xi’an 710032,China) Tissue Engineering Center Department of Oral Histopathology The Fourth Military Medical University Xi' an 710032 China

1 IntroductionIn the past several decades, a number of reseacher have described the principal efficacy of tissue engineered skin to promote wound healing of venous and diabetic ulcers. But the true value of tissue-engineered skin products in different wound care remains yet to be more clearly defined. In this trial, we analysis the effective of tissue-engineered skin (ActivSkin) in the management of burns,donor sites and ulcers, which were also the frequently injury caused with warfare, disaster and terrorist incident.

关键词： The Ability of Tissue Engineered Skin Accelerating the Closure of Different Wound

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SMAS folded flap and allograft dermal matrix repairing parotid bed following parotidectomy to prevent facial deformity and Frey's syndrome

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中国口腔颌面外科杂志 2007年第4期5卷 265-269页

作者： CHEN Wei-liang YANG Zhao-hui HUANG Zhi-quan WANG yong-jie LI jin-son ZHANG Bin WANG Jian-guang Department of Oral and Maxillofacial Surgery the Second Affiliated Hospital of Sun Yat-Sen University.Guangzhou 510120 Guangdong Province China

PURPOSE:This study evaluates the outcome of superficial musculoaponeurotic system(SMAS) and allograft dermal matrix(ADM) in preventing facial deformity and Frey's syndrome following ***:Forty-six patients with benign parotid tumors were randomly assigned to 4 *** control group consisted of 12 patients who underwent a total parotidectomy;The AMD group consisted of 10 patients who underwent a total parotidectomy and underwent intraoperative placement of ADM within the parotid bed;SMAS group consisted of 11patients who underwent a total parotidectomy and SMAS folded flaps to repair parotid bed;and SMAS plus AMD group consisted of 13 patients who underwent a total parotidectomy and intraoperative placement of ADM to repair parotid bed with SMAS folded *** 46 patients were evaluated via a short questionnaire regarding perception of a facial contour deformity,Frey's syndrome,modified Minor's starch-Iodine test(MSIT) ,and clinical ***:Twelve months of follow-up was conducted after the treatment,the rates of satisfaction with the post-operative facial contour were 33.3%(4/12) ,40.0%(4/10) ,91.9%(10/11) and 100%(13/13) respectively in the control group,AMD group,SMAS group and SMAS plus AMD group,and the difference between the SMAS plus AMD group and the former two groups was statistically significant(P< 0.05) .The incidences of objective Frey's syndrome by MSIT were 50.0 %(6/12) ,20.0%(2/10) ,27.3%(3/11) and 7.7%(1/13) respectively,and the difference between the SMAS plus AMD group and the control groups was statistically significant(P<0.05) .CONCLUSION:The SMAS folded flap is clinically simple to perform,which can prevent depressed facial *** of SMAS folded flap and ADM can reduce the incidence of Frey's syndrome in patients undergoing parotidectomy.

关键词：腮腺切除术脸部畸形表面肌腱膜系统脱细胞真皮基质 Frey氏综合症

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