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Coronary bifurcation angle from 3-D predicts clinical outcomes after stenting bifurcation lesions

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Chinese Medical Journal 2012年第12期125卷 2083-2088页

作者： CHEN Shao-liang Teguh Santoso ZHANG Jun-jie YE Fei XU Ya-wei FU Qiang KAN Jing Chitprapai Paiboon ZHOU yong ding Shi-qing Tak W Kwan Department of Cardiology Nanjing First Hospital NanjingMedical University Nanjing Jiangsu 210006 China Department of Cardiology Medistra Hospital University ofIndonesia Medical School Jakarta Indonesia Department of Cardiology Shanghai 10th People＇s HospitalShanghai 200072 China Department of Cardiology Xuzhou Central Hospital XuzhouJiangsu 221009 China Department of Cardiology Bangkok General Hospital BangkokThailand Department of Cardiology Zhangjiagang People＇s HospitalZhangjiagang Jiangsu 215600 China Department of Cardiology Huainan Xinhua Hospital HuainanAnhui 232038 China Department of Cardiology Beth Israel Hospital NewYork USA

Background The predictive value of bifurcation angle （BA） for worse events after stenting bifurcation lesions remains to be unknown. The present study was to investigate the dynamic change of BA and clinical relevance for patients with coronary bifurcation lesions treated by drug-eluting stent （DES）. Methods BA was calculated by 3-D quantitative coronary analysis from 347 patients in DKCRUSH-II study. Primary endpoint was the occurrence of composite major adverse cardiac events （MACE） at 12-month, including cardiac death, myocardial infarction （MI） and target vessel revascularization （TVR）. Secondary end points were the rate of binary restenosis and stent thrombosis at 12-month. Results Stenting was associated with the reduction of distal BA. The cut-off value of distal BA for predicting MACE was 60°. Distal BA in 〈60° group had less reduction after stenting （（-1.96＋13.58）°vs. （-12.12±23.58）°, P 〈0.001）; two-stent technique was associated with significant reduction of distal BA （△（-4.05±14.20）°）, compared to single stent group （4＋1.55±11.73, P=0.003）; the target lesion revascularization （TLR）, TVR and MACE rate was higher in one-stent group （16.5%, 19.0% and 21.5%）, compared to two-stent group （3.8%, P=0.002; 7.5%, P=0.016; and 9.8%, P=0.024）, respectively. Among patients in ≥60° group, there were no significant differences in distal BA, stent thrombosis （ST）, MI, MACE, death, TLR, TVR between one- and two-stent groups; after stenting procedure, there was only slight change of distal BA in left anterior descending （LAD）-Ieft circumflex （LCX） subgroup （from （88.54±21.33）° at baseline to （82.44±31.72）° post-stenting）, compared to either LAD-diagonal branch （Di）, or LCX-obtuse marginal branch （OM）, or IRCA distal （RCAd）（all P 〈0.001 ）. Conclusion Two-stent technique was associated with significant reduction of distal BA. DK crush stenting had reduced rate of MACE in patients in 〈60° group, compared to one-stent technique.

关键词： coronary bifurcation lesions bifurcation angle major adverse cardiac events ROC curve

Synthesis of Olaparib Derivatives and Their Antitumor Activities

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Chemical Research in Chinese Universities 2013年第2期29卷 231-235页

作者： LOU Xi-yu YANG Xuan ding Yi-li WANG jian-jun YAN Qing-yan HUANG Xian-gui GUO Yang-hui WANG Xiang-jing XIANG Wen-sheng Department of Biochemical Engineering Northeast Agricultural University Harbin 150030 P. R. China Zhejiang Hisun Pharmaceutical Co. Ltd. Taizhou 318000 P R. China

A series of Olaparib derivatives was synthesized, and their structures were confirmed by 1H NMR, MS and elemental analysis. Their antitumor activities on breast cancer susceptbility gene 1/2（BRCAl/2）-deficient cancer cell lines including HCC1937, Capan-1 and MDA-MB-436 were evaluated. The antitumor activity of compound Olaparib-1 was better than the positive control Olaparib in BRCAl-deficient cell line HCC1937.

关键词： Olaparib derivative BRCA 1/2 Antitumor activity

Expression of multidrug-resistance associated proteins in human retinoblastoma treated by primary enucleation

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International Journal of Ophthalmology(English edition) 2018年第9期11卷 1463-1466页

作者： Li-Juan Tang Li-Jun Zhou Wen-Xin Zhang jian-Yan Lin yong-Ping Li Hua-Sheng Yang Ping Zhang State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University

AIM： To reveal the expression of multidrug-resistance associated proteins： glutathione-S-transferase π（GSTπ）, P-glycoprotein（P-gp） and vault protein lung resistance protein（LRP） in retinoblastoma（RB） without any conservative treatment before primary enucleation and to correlate this expression with histopathological tumor features. METHODS： A total of 42 specimens of RB undergone primary enucleation were selected for the research. Sections from the formalin-fixed, paraffin-embedded specimens were stained with HE and immunohistochemistry to detect the expression of GSTπ, P-gp and ***： GSTπ was expressed in 39/42（92.86%） RBs and in 9/9（100%） well-differentiated RBs. P-gp/GSTπ was found in 30（71.42%） of 42 RBs. Totally 9（21.43%） tumors were well differentiated and 33（78.57%） were poorly differentiated. Totally 15（35.71%） eyes had optic nerve（ON） tumor invasion, 36（85.71%） had choroidal tumor invasion, and 14（33.33%） had simultaneous choroidal and ON invasion. There was no statistically significant relationship between P-gp, GSTπ, LRP positivity and the degree of ocular layer tumor invasion and ON tumor invasion（P〉0.05）. CONCLUSION： RB intrinsically expresses GSTπ, P-gp and LRP. GSTπ expression is positive in 100% welldifferentiation ones, so in which way it is correlated with differentiation. But the other two proteins expressions are not related to tumor differentiation and to the degree of tumor invasion. GSTπ may be a new target of chemotherapy in RB.

关键词： glutathione-S-transferase π P-glycoprotein vault protein lung resistance protein retinoblastoma multidrug-resistance proteins

Using p53-immunostained large specimens to determine the distal intramural spread margin of rectal cancer

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World Journal of Gastroenterology 2006年第10期12卷 1626-1629页

作者： Zhi-Zhong Pan De-Sen Wan Chang-Qing Zhang jian-yong Shao Li-Ren Li Gong Chen Zhi-Wei Zhou Fu-Long Wang Department of Abdominal Surgery Cancer Hospital Sun Yat-Sen University Guangzhou 510060 Guangdong Province China

AIM： To determine the distal intramural spread （DIS） margin of rectal cancer.METHODS： Sixty-one p53-positive specimens of rectal cancer were used. After conventional hematoxylin and eosin （H＆E） staining, the DIS margin of rectal cancer in large specimens was examined by immunohistochemistry. The patients were divided into A, B, C, and D groups. After a long-term follow-up, the survival curves of the four groups were estimated using the life table. RESULTS： Fifty-one of the sixty-one cases （83.6%） had DIS. The extent of DIS ranged 0.11-3.5 cm; meanwhile *** of DIS measured by H＆E staining was 0.13 cm. The significant difference was found between the means （t=5.622, P〈0.0001）. Only 1 of 51 patients had DIS greater than 3 cm. The DIS was less than 1.0 cm in most rectal cancer patients. The long-term results indicated that the survival rate of the patients whose DIS was greater than 1.0 cm was lower than that of the patients whose DIS was less than 0.5 cm. CONCLUSION： Rectal cancer patients with DIS greater than 1.0 cm have poor prognosis.

关键词： Rectal cancer Distal intramural spread p53 Immunohistochemistry Large specimen

Induction of apoptosis of human gastric carcinoma SGC-7901 cell line by 5,7-dihydroxy-8-nitrochrysin in vitro

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World Journal of Gastroenterology 2007年第28期13卷 3824-3828页

作者： Xiao-Hong Ai Xing Zheng Xiao-Qing Tang Li Sun Yang-Qin Zhang yong Qin Hua-Qing Liu Hong Xia jian-Guo Cao Department of Oncology First Affiliated Hospital Nahua University Hengyang 421001 Hunan Province China Institute of Oncology Nahua University Hengyang 421001 Hunan Province China Institute of Pharmacology Nahua University Hengyang 421001 Hunan Province China School of Pharmaceutical Science Central South University Changsha 410078 Hunan Province China

AIM： To investigate the effect of 5, 7-dihydroxy-8- nitrochrysin （NOChR） on apoptosis of human gastric carcinoma SGC-7901 cell line.METHODS： SGC-7901 cells were cultured in vitro and the inhibitory effect of NOChR on proliferation of SGC-7901 cells was measured by using an Ml-r assay. NOChR-induced apoptosis rate of SGC-7901 cells was detected using flow cytometry （FCM） with PI staining. DNA ladder bands were observed by DNA agarose gel electrophoresis. The influence of NOChR on the proxisome proliferator-activated receptor-γ （PPARγ）, Bcl-2 and Bax protein expression of SGC-7901 cells was analyzed by Western blot.RESULTS： MIF assay showed that NOChR markedly inhibited proliferation of SGC-7901 cells in a dose- dependent manner, and when ICso was 4.14 μmol/L, the potency of NOChR was 10 times than that of lead compound, chrysin （ChR, IC50 was 40.56 μmol/L）, and was similar to 5-fluorouracil （5-FU, IC50 was 4.51 μmol/L）. FCM with propidium iodide （PI） staining demonstrated that the apoptosis rates of SGC-7901 cells treated with 1.25, 5.00 and 20.00 μmol/L NOChR for 48 h were 9.8% 4- 0.2%, 36.8% 4- 1.9% and 45.5% 4- 3.5%, respectively, and were significantly higher when treated with 5.00 and 20.00 μmol/L NOChR than that with 20.00 μmol/L ChR （12.9% 4- 1.5%）. DNA agarose gel electrophoresis showed that treatment of SGC-7901 cells with 20.00 μmol/L NOChR for 48 h resulted in typical DNA ladder bands of DNA of SGC-7901 cells, which could be eliminated by treating with 10.00 μmol/L GW9662, a blocker of PPARy. Western blot analysis revealed that after 24 h of treatment with 20.00 μmol/L NOChR, PPARgamma and Bax protein expression of SGC-7901 cells increased but Bcl-2 expression decreased; however, pre-incubation with 10.00 μmol/L GW9662 could efficiently antagonize and weaken the regulatory effect of 20.00 μmol/L NOChR on Bax and Bcl-2 protein expression of SGC-7901 cells. CONCLUSION： NOChR induces apoptosis of SGO7901 cell lines by activating PPARy and decreasing rat

关键词： Gastric neoplasm Chrysin Chrysin derivatives Apoptosis Proxisome proliferator-activated receptorγ Bcl-2 Bax

Experimental evidence of the thickness- and electric-field-dependent topological phase transitions intopological crystalline insulator SnTe（111） thin films

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Nano Research 2018年第11期11卷 6045-6050页

作者： Yan Gong Kejing Zhu Zhe Li Yunyi Zang Xiao Feng ding Zhang Canli Song Lili Wang Wei Li Xi Chen Xu-Cun Ma Qi-Kun Xue yong Xu Ke He State Key Laboratory of Low-Dimensional Quantum Physics Department of Physics Tsinghua University Beijing 100084 China Collaborative Innovation Center of Quantum Matter 8eijing 100084 China

Using in situ angle-resolved photoemission spectroscopy, we systematically studied molecular-beam-epitaxy-grown topological crystalline insulator SnTe(111) thin films with varied thicknesses and substrate conditions. An oscillation in the band gap size with an increase in thickness was observed to depend on the electric field perpendicular to the films. The observations are consistent with the theoretically predicted thickness- and electric-field-dependent topological phase transitions between the normal insulator and the quantum spin Hall insulator phases in SnTe(111) films and demonstrate them to be an excellent and electrically tunable quantum spin Hall system.

关键词： topological crystalline insulator SnTe quantum spin Hall effect field effect

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珠江三角洲软土地基变形的混沌特性研究

岩土力学 2006年第1期27卷 73-76页

作者：刘勇健广东工业大学岩土工程研究所

混沌是非线性系统较普遍存在的一种现象,本文以混沌理论为基础,对珠江三角洲软土地基的变形特性进行了研究。从软土的工程特性和微观结构出发,分析了软土地基变形混沌性的根本原因,并对软土变形混沌性进行了定性判别和基于Lyapunov指数... 详细信息

混沌是非线性系统较普遍存在的一种现象,本文以混沌理论为基础,对珠江三角洲软土地基的变形特性进行了研究。从软土的工程特性和微观结构出发,分析了软土地基变形混沌性的根本原因,并对软土变形混沌性进行了定性判别和基于Lyapunov指数的定量判别。研究结果表明,珠江三角洲地区的天然地基及处理后的复合地基的最大Lyapunov指数λ1均大于0,软土地基的变形具有明显的混沌性。混沌理论为软基变形研究提供了一种新的途径,在工程领域具有广阔的应用前景。

关键词：软土地基变形混沌相空间重构 Lyapunov指数

基于聚类-二叉树支持向量机的砂土液化预测模型

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岩土力学 2008年第10期29卷 2764-2768页

作者：刘勇健广东工业大学广州510006

建立在统计学习理论基础之上的支持向量机(SVM),是一种基于结构风险最小的小样本机器学习方法。经典的支持向量机主要针对二分类问题,而工程实践中遇到的往往是多分类问题。根据影响砂土液化的主要因素,采用聚类分析中的类距离思想,建... 详细信息

建立在统计学习理论基础之上的支持向量机(SVM),是一种基于结构风险最小的小样本机器学习方法。经典的支持向量机主要针对二分类问题,而工程实践中遇到的往往是多分类问题。根据影响砂土液化的主要因素,采用聚类分析中的类距离思想,建立了基于聚类-二叉树的多类支持向量机的砂土液化判别模型。该模型可以通过有限样本的学习,建立砂土液化与各影响因素之间的非线性关系。研究结果表明,基于聚类-二叉树支持向量机的层次结构合理,分类精度高,泛化性好,可对砂土液化等级进行较准确判别。

关键词：支持向量机砂土液化聚类二叉树统计学习预测模型

C-Terminal sequencing of trichosanthin

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Chinese Journal of Chemistry 1988年第4期6卷 341-347页

作者： Wang Yu Zhang Lin‐Hua Sun Xiao‐jian Zhang Li‐Qin Zhou Le Hui yong‐Zheng Shanghai Institute of Organic Chemistry Academia Sinica Shanghai

Preliminary identification of C-terminus of trichosanthin by chemical and enzymic methods,such as hydrazinolysis,thiohydantoin reaction and carboxypeptidase hydrolysis,showed that theremay be the possible presence of more than one terminus,i.e.,Met and Ala but complicated by sidereactions.A computer-assisted carboxypeptidase method was first introduced by the authors to de-termine the C-terminal sequence of trichosanthin,and showed that trichosanthin is heterogeneous at itsC-terminus and has two C-terminal sequences determined as-Arg-Asn-Asn-Met-OH and-Arg-Asn-Asn-Met-Ala-OH *** results have been later unambiguously confirmed by the re-sults from other experiments through the identification of the free alanine always present in the CNBr de-gradation products of trichosanthin,and the actual separation of two fragments from the finger printsas well as from the HPLC fractions of the trypsin digest of this *** shows that their aminoacid sequences,determined by manual DABITC/PITC technique,agree well with those of the twoC-terminal seauences determined by the computer-carboxypeptidase method.

关键词： C-Terminal sequencing of trichosanthin