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天山科其喀尔冰川区复杂下垫面CO2通量贡献区分析

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干旱区研究 2018年第6期35卷 1512-1520页

作者：王建丁永建许民许君利盐城师范学院城市与规划学院江苏盐城224007 中国科学院西北生态环境资源研究院甘肃兰州730000

大气湍流交换过程中CO2有效源（汇）区域即CO2通量贡献区,在冰川作用区不仅受到水化学侵蚀强度的影响,还受区域微气候的影响,另外,动态的下垫面和复杂地形也增加了实际监测的不确定性。为了评估冰川区CO2通量监测结果的空间代表性,在西... 详细信息

大气湍流交换过程中CO2有效源（汇）区域即CO2通量贡献区,在冰川作用区不仅受到水化学侵蚀强度的影响,还受区域微气候的影响,另外,动态的下垫面和复杂地形也增加了实际监测的不确定性。为了评估冰川区CO2通量监测结果的空间代表性,在西天山南坡科其喀尔冰川表碛区利用涡度协方差观测系统进行观测,同时,结合基于KM足迹模型基础上开发的ART Footprint Tool足迹软件对通量贡献区进行分析,结果表明：（1）积雪积累期主风向以NW为主,风向频率占53.31%;积雪消融期和冰川消融初期NW向主风减少,偏北的NNW风逐渐增多,但冰川消融峰期后又逐渐过渡为NW风向。（2）积雪积累期雪冰融水几乎消失,但大气CO2通量平均为-0.07 g·m^-2·d^-1,尤其是白天为-0.88 g·m^-2·d^-1,仍呈没收现象,是由于白天较强辐射下,少量积雪融水引起可溶性物质淋溶过程中水化学反应没收大气CO2所致;而夜间冰川消融峰期CO2通量值平均为0.33 g·m^-2·d^-1,呈释放CO2现象,这可能与夜间区域降温及降水过程中溶解的CO2因地表蒸发返回大气所致。（3）通量贡献率80%以上的各期0.5 h数据占比依次为：积雪积累期（95.80%）〉积雪消融期（93.28%）〉冰川消融峰期（86.13%）〉冰川消融初期（81.88%）,而足迹最远点分布距离顺序与前者几乎相反,但均分布在主风向下的冰川中流线上,说明对CO2通量监测值有显著影响的贡献区比较集中,也意味着冰川末端及两侧山脊草地CO2通量变化的影响可以忽略。（4）白天在大气稳态条件下,贡献区解释的CO2通量为（78.55±2.08）%,略高于夜间的（77.72±1.41）%,但显著低于非稳定条件下白天（89.86±0.22）%和夜间（89.45±0.57）%的解释结果,进一步验证了CO2通量贡献区比较集中。

关键词： CO2通量贡献区涡动相关系统主风向科其喀尔冰川天山

Protein-coding genes combined with long noncoding RNA as a novel transcriptome molecular staging model to predict the survival of patients with esophageal squamous cell carcinoma

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Cancer Communications 2018年第1期38卷 50-62页

作者： Jin-Cheng Guo Yang Wu Yang Chen Feng Pan Zhi-yong Wu Jia-Sheng Zhang jian-Yi Wu Xiu-E Xu jian-Mei Zhao En-Min Li Yi Zhao Li-Yan Xu Key Laboratory of Molecular Biology in High Cancer Incidence Coastal Chaoshan Area of Guangdong Higher Education Institutes Shantou University Medical CollegeShantouGuangdong 515041P.R.China Department of Biochemistry and Molecular Biology Shantou University Medical CollegeShantouGuangdong 515041P.R.China Departments of Oncology Surgery Shantou Central HospitalAffiliated Shantou Hospital of Sun Yat-Sen UniversityShantouGuangdong 515041P.R.China Institute of Oncologic Pathology Shantou University Medical CollegeShantouGuangdong 515041P.R.China Key Laboratory of Intelligent Information Processing Advanced Computer Research CenterState Key Laboratory of Computer ArchitectureInstitute of Computing TechnologyChinese Academy of SciencesBeijing 100190P.R.China

Background:Esophageal squamous cell carcinoma(ESCC)is the predominant subtype of esophageal carcinoma in *** study was to develop a staging model to predict outcomes of patients with ***:Using Cox regression analysis,principal component analysis(PCA),partitioning clustering,Kaplan-Meier analysis,receiver operating characteristic(ROC)curve analysis,and classification and regression tree(CART)analysis,we mined the Gene Expression Omnibus database to determine the expression profiles of genes in 179 patients with ESCC from GSE63624 and GSE63622 ***:Univariate cox regression analysis of the GSE63624 dataset revealed that 2404 protein-coding genes(PCGs)and 635 long non-coding RNAs(lncRNAs)were associated with the survival of patients with *** categorized these PCGs and lncRNAs into three principal components(PCs),which were used to cluster the patients into three *** analysis demonstrated that the predictive ability of PCG-lncRNA PCs when applied to new patients was better than that of the tumor-node-metastasis staging(area under ROC curve[AUC]:0.69 vs.0.65,P<0.05).Accord-ingly,we constructed a molecular disaggregated model comprising one lncRNA and two PCGs,which we desig-nated as the LSB staging model using CART analysis in the GSE63624 *** LSB staging model classified the GSE63622 dataset of patients into three different groups,and its effectiveness was validated by analysis of another cohort of 105 ***:The LSB staging model has clinical significance for the prognosis prediction of patients with ESCC and may serve as a three-gene staging microarray.

关键词： Long non-coding RNA Protein-coding gene Esophageal squamous cell carcinoma Overall survival Staging model Transcriptome

Impact of obstructive sleep apnea on pulmonary hypertension in patients with chronic obstructive pulmonary disease

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Chinese Medical Journal 2019年第11期132卷 1272-1282页

作者： Wan-Lu Sun jian-Li Wang Guo-Hua Jia Wen-Jun Mi Yi-Xuan Liao yong-Wei Huang Zheng Hu Li-Qiang Zhang Ya-Hong Chen Departm ent of Pulmonary and Critical Care Medicine Peking University Third Hospital Peking University Beijing 100191 China Department of Respiratory Medicine Cixi People's Hospital Cixi Zhejiang 315300 China

Background:Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) syndrome are highly prevalent respiratory conditions. Their coexistence is referred to as the overlap syndrome. They are both related to pulmonary hypertension (PH) development. This study investigated the effects of OSA on PH in patients with COPD and the associated factors. Methods: Consecutive patients with stable COPD were recruited for an observational cross-sectional study from September 2016 to May 2018 at Peking University Third Hospital. In total, 106 patients with COPD were enrolled and performed home portable monitoring and echocardiography. OSA was defined by an apnea hypopnea index (AHI)>10 events/h. Based on OSA absence or presence, patients were divided into the COPD with OSA and COPD without OSA groups. Factors affecting pulmonary artery pressure (PAP) and PH were identified using univariate analysis and logistic regression models. Results: In the 106 patients with COPD, the mean age was 69.52 years, 91.5% were men, and the mean forced expiratory volume in 1 s (FEV!) percentage of predicted was 56.15%. Fifty-six (52.8%) patients with COPD were diagnosed with OSA, and 24 (22.6%) patients with COPD were diagnosed as PH. Compared with COPD without OSA group, the median PAP in COPD with severe OSA group increased by 5 mmHg (36.00 [26.00-50.00] mmHg vs. 31.00 [24.00-34.00] mmHg, P = 0.036). COPD with percent of night-time spent with oxygen saturation below 90%(T90)> 10% group had higher PAP than COPD with T90 < 1 % group (36.00 [29.00-50.00)] mmHg vs. 29.00 [25.50-34.00] mmHg, F = 7.889, P = 0.007). Univariate analysis revealed age, FEVi% predicted, T90, and Charlson index had statistically significant effects on PH. Multiple regression analysis showed a significant and independent effect of both FEVj% predicted (odds ratio [OR]= 3.46;95% confidence interval [Cl]: 1.15-10.46;P = 0.028) and AHI (OR = 3.20;95% Cl: 1.09-19.35;P = 0.034) on PH. Conclusions: Patients with

关键词： Chronic obstructive pulmonary disease Echocardiography Obstructive sleep apnea Pulmonary hypertension

Preparation of LaMgNi_(4-x)Co_x alloys and hydrogen storage properties

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Transactions of Nonferrous Metals Society of China 2013年第8期23卷 2307-2311页

作者：谭剑波曾小勤邹建新吴晓梅丁文江上海交通大学材料科学与工程学院上海市镁材料及应用工程技术研究中心上海200240 上海交通大学材料科学与工程学院金属基复合材料国家重点实验室上海200240

The LaMgNi4xCox （x=0, 0.3, 0.5） compounds were prepared by the method of levitation melting and a subsequent heat treatment at 1073 K for 10 h. XRD analysis shows that the obtained LaMgNia-xCox alloys consist of a single phase with the structure of cubic SnMgCu4 （AuBe5 type）. The hydrogen absorption/desorption properties of LaMgNi4 were investigated by PCI measurement at various temperatures （T=373, 398, 423 K） and the results show that the maximum absorbed hydrogen capacity reaches 1.45% （5.79H/M） under a hydrogen pressure of 4.3 MPa at 373 K. The XRD patterns during absorbing procedure at 373 K indicate the phase structure changing from cubic （a-LaMgNi4） to orthorhombic （fl-LaMgNiaH3.41） and after hydrogenation finally back to cubic （y-LaMgNiaH4.87）, and a partial desorption was also observed under this condition. With increasing temperature, a slight decrease of the absorbed hydrogen content was observed and the number of plateaus reduces from two to one, but the hydrogen absorption kinetics improves. The electrochemical properties of the LaMgNiaxCox were measured by simulated battery test, which shows that the discharge capacity of the alloys significantly improves with the increase of Co content.

关键词： hydrogen storage alloy electrochemical properties LaMgNi4-xCox

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和谐社会建设需要构建合理的社会保障制度

人口与经济 2009年第3期 73-78页

作者：丁建定华中科技大学社会学系湖北武汉430074

本文采用文献研究的方法,并基于社会保障制度的社会功能理论,从社会保障制度体系、发展道路、水平指标以及基本目标等方面,论述我国和谐社会建设需要建立一种合理的社会保障制度,这种社会保障制度的体系应该是内容、结构与层次体系的相... 详细信息

本文采用文献研究的方法,并基于社会保障制度的社会功能理论,从社会保障制度体系、发展道路、水平指标以及基本目标等方面,论述我国和谐社会建设需要建立一种合理的社会保障制度,这种社会保障制度的体系应该是内容、结构与层次体系的相互协调,发展道路必须注意统一与差别的相互结合,水平指标应该是一种综合性的指标体系,基本目标应该是政治、经济、社会与道德目标的协调一致。

关键词：和谐社会社会保障合理性

Cloning and Expression of Gene Responsible for High-Tillering Dwarf Phenotype in Indica Rice Mutant gsor23

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Rice science 2013年第5期20卷 320-328页

作者： YUAN Shou-jiang WANG Tao YIN Liang ZHAO Jin-feng WAN jian-min LI Xue-yong National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop ScienceChinese Academy of Agriculture Sciences Shandong Rice Research Institute National Key Laboratory for Crop Genetics and Germplasm Enhancement Jiangsu Plant Gene Engineering Research CenterNanjing Agricultural University

High-tillering dwarf mutant gsor23 was generated from an indica rice variety Indica9 radiatied by y-ray. Genetic analysis showed that this phenotype was controlled by one single recessive gene, which was mapped within a physical distance of 386 kb between two insertion-deletion （InDel） markers CI-WT2 and C1-WT4 on the long arm of chromosome 1. There is a known gene DIO within this region, the mutation of which causes high-tillering in rice. Sequence analysis of the DIO allele in gsor23 revealed that the base cytosine （C） at the 404th position in the coding region was deleted, which would cause frameshift mutation after the 134th amino acids. The mutation site and indica background of gsor23 were different from the previously reported japonica mutants d10-1 and d10-2. Therefore, gsor23 is a novel allelic mutant of D10 which encodes the carotenoid-cleaving dioxygenase 8 （CCD8）, a key enzyme involved in the biosynthesis of the new plant hormone strigolactones （SLs）. After treatment with GR24, a synthetic analogue of SLs, the high-tillering phenotype of gsor23 was restored to normal. Real-time RT-PCR analysis showed that D10 expression was high in roots, but low in leaves. Compared with the wild type Indica9, the expression of the SL biosynthesis gene DIO was upregulated, while genes likely involved in the SL signal transduction pathway such as D3 and D14 were down-regulated in the gsor23 mutant.

关键词： high-tillering dwarf mutant strigolactone carotenoid-cleaving dioxygenase feedback regulation positional cloning rice

Prognostic impact of the red cell distribution width in esophageal cancer patients: A systematic review and meta-analysis

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World Journal of Gastroenterology 2018年第19期24卷 2120-2129页

作者： Wei-Yu Xu Xiao-Bo Yang Wen-Qin Wang Yi Bai Jun-Yu Long jian-Zhen Lin jian-Ping Xiong yong-Chang Zheng Xiao-Dong He Hai-Tao Zhao Xin-Ting Sang Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

AIM To clarify the previous discrepant conclusions, we performed a meta-analysis to evaluate the prognostic value of red cell distribution width(RDW) in esophageal cancer(EC). METHODS We searched the PubM ed, EMBASE, Web of Science and Cochrane Library databases to identify clinical studies, followed by using STATA version 12.0 for statistical analysis. Studies that met the following criteria were considered eligible:(1) Studies including EC patients who underwent radical esophagectomy;(2) studies including patients with localized disease without distant metastasis;(3) studies including patients without preoperative neoadjuvant therapy;(4) studies including patients without previous antiinflammatory therapies and with available preoperative laboratory outcomes;(5) studies reporting association between the preoperative RDW and overall survival(OS)/disease-free survival(DFS)/cancer-specific survival(CSS); and(6) studies published in *** A total of six articles, published between 2015 and 2017, fulfilled the selection criteria in the end. Statistical analysis showed that RDW was not associated with the prognosis of EC patients, irrespective of OS/CSS [hazard ratio(HR) = 1.27, 95% confidence interval(CI): 0.97-1.57, P = 0.000] or DFS(HR = 1.42, 95%CI: 0.96-1.88, P = 0.000). Subgroup analysis indicated that elevated RDW was significantly associated with worse OS/CSS of EC patients when RDW > 13%(HR = 1.45, 95%CI: 1.13-1.76, P = 0.000), when the patient number ≤ 400(HR = 1.45, 95%CI: 1.13-1.76, P = 0.000) and when the study type was retrospective(HR = 1.42, 95%CI : 1.16-1.69, P = 0.000).CONCLUSION Contrary to our general understanding, this meta-analysis revealed that RDW cannot serve as an indicator of poor prognosis in patients with EC. However, it may still be a useful predictor of unfavorable prognosis using an appropriate cut-off value.

关键词： Red cell distribution width Prognostic impact Systematic review Meta-analysis

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静力弹塑性分析方法在高层建筑结构中的应用

南京理工大学学报 2008年第6期32卷 672-675页

作者：丁建国南京理工大学理学院江苏南京210094

为了使静力弹塑性分析方法应用于高层结构的弹塑性变形计算,该文根据静力弹塑性分析的基本原理并结合高层建筑结构特点,通过理论分析,得到了既考虑多阶振型组合又能反映结构瞬时动力特性的静力弹塑性分析改进方法。算例计算表明:文中提... 详细信息

为了使静力弹塑性分析方法应用于高层结构的弹塑性变形计算,该文根据静力弹塑性分析的基本原理并结合高层建筑结构特点,通过理论分析,得到了既考虑多阶振型组合又能反映结构瞬时动力特性的静力弹塑性分析改进方法。算例计算表明:文中提出的改进的静力弹塑性分析方法可以适用于高层建筑结构在地震作用下的弹塑性变形计算;并且由于高层结构抗侧移刚度较小,在地震作用下侧向位移曲线受高阶振型影响明显。

关键词：多阶振型瞬时动力特性侧向变形抗侧移刚度静力弹塑性

刃针结合电针治疗对膝关节骨关节炎患者膝关节功能的影响

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针刺研究 2024年第4期49卷 398-402页

作者：马洁褚晓彦刘伙生孙吉雅詹红生徐建德何天峰丁金磊周丽艳段希栋王茜邴兴红陶善平上海市嘉定区中医医院针灸科上海201800

目的:比较刃针结合电针与单纯电针治疗膝关节骨关节炎(KOA)的临床疗效及对膝关节功能的影响。方法:将68例KOA患者运用随机数字表法随机分为两组,分别为刃针组34例和电针组34例。其中刃针组采用刃针结合电针治疗,电针组采用单纯电针治疗... 详细信息

目的:比较刃针结合电针与单纯电针治疗膝关节骨关节炎(KOA)的临床疗效及对膝关节功能的影响。方法:将68例KOA患者运用随机数字表法随机分为两组,分别为刃针组34例和电针组34例。其中刃针组采用刃针结合电针治疗,电针组采用单纯电针治疗,两组电针治疗均隔日1次,每周治疗3次,共治疗4周;刃针组在电针基础上增加刃针治疗,每周治疗1次,共治疗4周。治疗前、治疗后、治疗后1个月、治疗后3个月进行计时起立-步行测验(TUG)、9台阶-楼梯攀登测试(9-SCT)、膝关节功能[西安大略和麦马斯特大学骨关节炎指数可视化量表(WOMAC)]评分。结果:通过意向性分析,与治疗前比较,两组患者治疗后、随访1个月和随访3个月时的TUG结果、9-SCT结果、WOMAC评分均显著降低(P<0.05);与同时间点电针组相比,刃针组治疗后和随访1个月时的TUG结果显著降低,刃针组治疗后的WOMAC评分显著降低(P<0.05);与本组治疗后比较,刃针组随访1个月时的WOMAC评分显著降低(P<0.05)。结论:两种治疗均能改善患者膝关节功能,但是刃针结合电针更能明显提高患者的步速,改善患者的关节疼痛、晨僵等不适症状。刃针结合电针治疗KOA安全有效,并且有较好的远期疗效。

关键词：膝关节骨关节炎刃针电针临床疗效关节功能