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Effects of maternal methyl donor intake during pregnancy on ileum methylation and function in an intrauterine growth restriction pig model

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1173-1189页

作者： Yan Lin Jiangnan Wu yong Zhuo Bin Feng Zhengfeng Fang Shengyu Xu Jian Li hua Zhao De Wu Lun hua Lianqiang Che Key Laboratory of Animal Disease‑Resistance Nutrition Animal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130SichuanChina

Background Intrauterine growth retardation(IUGR)affects intestinal growth,morphology,and function,which leads to poor growth performance and high *** present study explored whether maternal dietary methyl donor(MET)supplementation alleviates IUGR and enhances offspring’s growth performance by improving intestinal growth,function,and DNA methylation of the ileum in a porcine IUGR *** Forty multiparous sows were allocated to the control or MET diet groups from mating until *** farrowing,8 pairs of IUGR and normal birth weight piglets from 8 litters were selected for sampling before suckling *** The results showed that maternal MET supplementation tended to decrease the IUGR incidence and increased the average weaning weight of ***,maternal MET supplementation significantly reduced the plasma concentrations of isoleucine,cysteine,urea,and total amino acids in sows and newborn *** also increased lactase and sucrase activity in the jejunum of newborn *** addition resulted in lower ileal methionine synthase activity and increased betaine homocysteine S-methyltransferase activity in the ileum of newborn *** methylation analysis of the ileum showed that MET supplementation increased the methyla-tion level of DNA CpG sites in the ileum of newborn ***-regulated differentially methylated genes were enriched in folic acid binding,insulin receptor signaling pathway,and endothelial cell *** contrast,up-regulated methylated genes were enriched in growth hormone receptor signaling pathway and nitric oxide biosyn-thetic *** Maternal MET supplementation can reduce the incidence of IUGR and increase the weaning litter weight of piglets,which may be associated with better intestinal function and methylation status.

关键词： Ileum Intrauterine growth restriction Methyl donor Methylation Sows

Regulation of the quantum barrier and carrier transport toward high-efficiency quasi-2D Dion-Jacobson tin perovskite solar cells

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Journal of Energy Chemistry 2024年第8期95卷 200-207,I0005页

作者： huanhuan Yao Chang Shi Tai Wu Shurong Wang Mingyu Yin Liming Ding yong hua Feng Hao School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Yunnan Key Laboratory for Micro/Nano Materials&Technology School of Materials and EnergyYunnan UniversityKunming 650091YunnanChina Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190China

Quasi-2D Dion-Jacobson(DJ)tin halide perovskite has attracted much attention due to its elimination of Van der Waals gap and enhanced environmental ***,the bulky organic spacers usually form a natural quantum well structure,which brings a large quantum barrier and poor film quality,further limiting the carrier transport and device ***,we designed three organic spacers with different chain lengths(ethylenediamine(EDA),1,3-propanediamine(PDA),and 1,4-butanediamine(BDA))to investigate the quantum barrier *** and experimental characterizations indicate that EDA with short chain can reduce the lattice distortion and dielectric confinement effect,which is beneficial to the effective dissociation of excitons and the inhibition of trap-free non-radiative *** addition,EDA cation shows strong interaction with the inorganic octahedron,realizing large aggregates in precursor solution and high-quality films with improved structural ***,femtosecond transient absorption proves that EDA cations can also weaken the formation of small n-phases with large quantum barrier to achieve effective carrier transport between different ***,the quasi-2D DJ(EDA)FA_(9)Sn_(10)I_(31)solar cells achieves a 7.07%power conversion efficiency with good environment ***,this work sheds light on the regulation of the quantum barrier and carrier transport through the chain length of organic spacer for qua si-2D DJ lead-free perovskites.

关键词： Chain lengths Organic spacers Quantum well Carrier transport Lattice distortion

Permian integrative stratigraphy,biotas,paleogeographical and paleoclimatic evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 1107-1151页

作者： Shuzhong SHEN Yichun ZHANG Dongxun YUAN Haipeng XU Qi JU hua ZHANG Quanfeng ZHENG mao LUO Zhangshuai HOU State Key Laboratory for Mineral Deposits Research School of Earth Sciences and Engineering and Frontiers Science Center for Critical Earth Material CyclingNanjing UniversityNanjing 210023China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Nanjing 210049China School of Resources and Geosciences China University of Mining and TechnologyXuzhou 221116China

The Permian Period was a critical time interval during which various blocks of the Qinghai-Tibetan Plateau have experienced profound and complex paleogeographical *** supercontinent Pangea was formed to its maximum during this interval,hampering a global east-to-west trending equatorial warm ocean ***,a semi-closed Tethys Ocean warm pool formed an eastward-opening oceanic embayment of Pangea,and became an engine fostering the evolutions of organisms and environmental changes during the Paleozoic-Mesozoic *** and preserved fossil groups have proved extremely useful in understanding such changes and the evolutionary histories of the Qinghai-Tibetan *** distributed Permian deposits and fossils from various blocks of the Qinghai-Tibetan Plateau exhibited varied characteristics,reflecting these blocks’different paleolatitude settings and drifting *** Himalaya Tethys Zone south to the Yarlung Zangbo suture zone,located in the northern Gondwanan margin,yields fossil assemblages characterized by cold-water organisms throughout the Permian,and was affliated to those of the *** of the exotic limestone blocks within the Yarlung Zangbo suture zone are Guadalupian(Middle Permian)to Early Triassic in *** exotic limestone blocks bear fossil assemblages that have transitional affinities between the warm Tethys and cold Gondwanan regions,suggesting that they most probably represent seamount deposits in the Neo-Tethys *** the Asselian to Sakmarian(Cisuralian,also Early Permian),the Cimmerian microcontinents in the northern part of Gondwana preserved glacio-marine deposits of Asselian to Sakmarian,and contained typical Gondwana-type cold-water *** the middle Cisuralian(~290-280 Ma),the Cimmerian microcontinents rifted off from the Gondwanaland,and drifted northward allometrically due to the active magmatism of the Panjal Traps in the northern margin of the Indian *** slices of micro

关键词： Permian Tethys Ocean Qinghai-Tibetan Plateau Biotas Paleogeography

Investigation of gravity influence on EOR and CO_(2) geological storage based on pore-scale simulation

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Petroleum Science 2024年第2期21卷 987-1001页

作者： yong-mao Hao Gui-Cheng Wu Zong-Fa Li Zhong-Hui Wu yong-Quan Sun Ran Liu Xing-Xing Li Bo-Xin Pang Nan Li Key Laboratory of Unconventional Oil&Gas Development(China University of Petroleum(East China)) Ministry of EducationQingdao266580ShandongChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina School of Petroleum Engineering Yangtze UniversityWuhan430100HubeiChina Dongsheng Jinggong Petroleum Development Group Co. LtdShengli Oilfield CompanySINOPECDongying257001ShandongChina

Gravity assistance is a critical factor influencing CO_(2)-Oil mixing and miscible flow during EOR and CO_(2)geological *** on the Navier-Stokes equation,component mass conservation equation,and fluid property-composition relationship,a mathematical model for pore-scale CO_(2) injection in oilsaturated porous media was developed in this *** model can reflect the effects of gravity assistance,component diffusion,fluid density variation,and velocity change on EOR and CO_(2) *** nonhomogeneous porous media,the gravity influence and large density difference help to minimize the velocity difference between the main flow path and the surrounding area,thus improving the oil recovery and CO_(2) *** CO_(2) injection angles and oil-CO_(2) density differences can increase the oil recovery by 22.6% and 4.2%,respectively,and increase CO_(2) storage by 37.9% and 4.7%,*** diffusion facilitates the transportation of the oil components from the low-velocity region to the main flow path,thereby reducing the oil/CO_(2) concentration difference within the porous *** diffusion can increase oil recovery and CO_(2) storage by 5.7% and 6.9%,*** addition,combined with the component diffusion,a low CO_(2) injection rate creates a more uniform spatial distribution of the oil/CO_(2) component,resulting in increases of 9.5% oil recovery and 15.7% CO_(2) storage,*** study provides theoretical support for improving the geological CO_(2) storage and EOR processes.

关键词： Gravity Flow simulation CO_(2)-oil mixing Enhanced oil recovery(EOR) Geological storage

Cisplatin-based miRNA delivery strategy inspired by the circCPNE1/miR-330-3p pathway for oral squamous cell carcinoma

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2748-2760页

作者： hua-yang Fan Ming-da Zhao Hong-jie Jiang Zhen-wei Yu Yu-jiang Fan Xin-hua Liang Ya-ling Tang yong Sun State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Oral and Maxillofacial Surgery West China Hospital of StomatologySichuan UniversityChengdu 610041China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610065China State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Oral Pathology West China Hospital of StomatologySichuan UniversityChengdu 610041China

Circular RNAs(circRNAs)are ideal biomarkers of oral squamous cell carcinoma(OSCC)because of their highly stable closed-loop structure,and they can act as microRNA(miRNA)sponges to regulate OSCC *** analyzing clinical samples,we identified circCPNE1,a dysregulated circRNA in OSCC,and its expression level was negatively correlated with the clinical stage of OSCC ***-of-function assays revealed the tumor-suppressive effect of circCPNE1,which was then identified as a miR-330-3p ***-330-3p was recognized as a tumor promoter in multiple studies,consistent with our finding that it could promote the proliferation,migration,and invasion of OSCC *** results indicated that selective inhibition of miR-330-3p could be an effective strategy to inhibit OSCC ***,we designed cationic polylysine-cisplatin prodrugs to deliver antagomiR-330-3p(a miRNA inhibitory analog)via electrostatic interactions to form PP@miR nanoparticles(NPs).Paratumoral administration results revealed that PP@miR NPs effectively inhibited subcutaneous tumor progression and achieved partial tumor elimination(2/5),which confirmed the critical role of miR-330-3p in OSCC *** findings provide a new perspective for the development of OSCC treatments.

关键词： Oral squamous cell carcinoma CircRNA MiRNA sponge Antagomir MiRNA delivery Cisplatin-based nanoparticles Drug delivery systems Tumor elimination

Gas sensor array based on carbon-based thin-film transistor for selective detection of indoor harmful gases

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Rare Metals 2024年第9期43卷 4401-4411页

作者： Can Liu Yu Sun Jia-Yi Guo Xiu-Lei Li Lu Tao Jin-yong Hu Jue-Xian Cao Ping-hua Tang yong Zhang School of Electrical and Information Engineering Hunan Institute of Engineering Physics and Optoelectronics&Hunan Institute of Advanced Sensing and Information Technology Xiangtan University

The identification of indoor harmful gases is imperative due to their significant threats to human health and *** achieve accurate identification,an effective strategy of constructing a sensor array combined with the pattern recognition algorithm is ***-based thin-film transistors are selected as the sensor array unit,with semiconductor carbon nanotubes （CNTs） within the TFT channels modified with different metals （Au,Cu and Ti） for selective responses to NH3,H2S and HCHO,*** accurate gas species identification,an identification mode that combines linear discriminant analysis algorithms and logistic regression classifier is *** test results demonstrate that by preprocessing the sensor array’s sensing data with the LDA algorithm and subsequently employing the LR classifier for identification,a 100% recognition rate can be achieved for three target gases （NH3,H2S and HCHO）.This work provides significant guidance for future applications of chip-level gas sensors in the realms of the Internet of Things and Artificial Intelligence.

关键词： Carbon-based thin-film transistors Gas sensor arrays Linear discriminant analysis Multi-gas detection Semiconductor carbon nanotubes

Clinical efficacy and mechanism study of mid-frequency anti-snoring device in treating moderate obstructive sleep apnea-hypopnea syndrome

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World Journal of Clinical Cases 2024年第5期12卷 942-950页

作者： Bao Qian Zhan-Jun Chen yong-Sheng Wang Xiao-Yan Hu Xiao-Biao Hu yong-hua Zheng Pulmonary Medicine Shanghai Jinshan Tinglin HospitalShanghai 201505China Radiology Medicine Shanghai Jinshan Tinglin HospitalShanghai 201505China

BACKGROUND Obstructive sleep apnea-hypopnea syndrome(OSAHS)is primarily caused by airway obstruction due to narrowing and blockage in the nasal and nasopha-ryngeal,oropharyngeal,soft palate,and tongue base *** mid-frequency anti-snoring device is a new technology based on sublingual nerve *** principle is to improve the degree of oropharyngeal airway stenosis in OSAHS patients under mid-frequency wave ***,there is a lack of clinical application and imaging *** We selected 50 patients diagnosed with moderate OSAHS in our hospital between July 2022 and August *** underwent a 4-wk treatment regimen involving the mid-frequency anti-snoring device during nighttime *** the treatment,we monitored and assessed the sleep apnea quality of life index and Epworth Sleepiness Scale ***,we performed computed tomo-graphy scans of the oropharynx in the awake state,during snoring,and while using the mid-frequency anti-snoring ***-sectional area measurements in different states were taken at the narrowest airway point in the soft palate posterior and retrolingual *** Compared to pretreatment measurements,patients exhibited a significant reduction in the apnea-hypopnea index,the percentage of time with oxygen saturation below 90%,snoring frequency,and the duration of the most prolonged apnea *** lowest oxygen saturation showed a notable increase,and both sleep apnea quality of life index and Epworth Sleepiness Scale scores *** computed tomography scans revealed that in OSAHS patients cross-sectional areas of the oropharyngeal airway in the soft palate posterior area and retrolingual area decreased during snoring compared to the awake ***,during mid-frequency anti-snoring device treatment,these areas increased compared to *** The mid-frequency anti-snoring device demonstrates the potential to enhance various sleep parameters in pat

关键词： Mid-frequency anti-snoring device Obstructive sleep apnea-hypopnea syndrome Sleep monitoring Oropharyngeal computed tomography Curative effect

The hard X-ray nanoprobe beamline at the SSRF

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Nuclear Science and Techniques 2024年第7期35卷 79-88页

作者： Yan He Hui Jiang Dong-Xu Liang Zhi-Sen Jiang huai-Na Yu hua Wang Cheng-Wen mao Jia-Nan Xie Ai-Guo Li Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China

The hard X-ray nanoprobe beamline BL13U is a phase-Ⅱ beamline project at the Shanghai Synchrotron Radiation *** beamline aims to enable comprehensive experiments at high spatial resolutions ranging from 50 to 10 nm. The X-ray energy range of the beamline, 5–25 keV, can detect most elements in the periodic table. Two operating modes were designed to accommodate the experimental requirements of high-energy resolution or high photon flux, respectively. X-ray nanofluorescence, nanodiffraction, and coherent diffraction imaging are developed as the main experimental techniques for BL13U. This paper describes the beamline optics, end station configurations, experimental methods under development, and preliminary test results. This comprehensive overview aims to provide a clear understanding of the beamline capabilities and potential applications.

关键词： Shanghai synchrotron radiation facility Hard X-ray nanoprobe X-ray nanofocusing

Hydrophobic long-chain two-dimensional perovskite scintillators for underwater X-ray imaging

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Rare Metals 2024年第1期43卷 175-185页

作者： Jin-Xiao Zheng Zi-An Zhou Tiao Feng Hui Li Cheng-hua Sun NüWang Yang Tian yong Zhao Shu-Yun Zhou Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Laboratory of Bioinspired Smart Interfacial Science and Technology of the Ministry of Education Beijing Key Laboratory of Bioinspired Energy Materials and DevicesSchool of ChemistryBeijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing 100191China Department of Engineering Physics Tsinghua University and Key Laboratory of Particle and Radiation Imaging Ministry of EducationTsinghua UniversityBeijing 100084China e-mail:yangt@***

The underwater X-ray imaging technology development is significant to subaqueous target reconnaissance/detection/identification, subfluvial archaeology,submerged resource exploration, etc. As the core of X-ray imaging detection, the scintillator has been plagued by inherent moisture absorption and decomposition, and strict requirements for seamless packaging and ***, we designed a manganese-doped two-dimensional(2D) perovskite scintillator modified by hydrophobic longchain organic amine through the combination of component and doping engineering. The modified perovskites show high water repellency that can be used as an underwater X-ray scintillator. X-ray images of aquatic organisms or other objects with a high spatial resolution of10 lp·mm^(-1) at a big view field(32 mm × 32 mm) were obtained by scintillation screen. This hydrophobic perovskite scintillator based on molecular design is of great promise in underwater X-ray nondestructive testing technology development.

关键词： Two-dimensional perovskite Hydrophobic Scintillators Underwater X-ray imaging Underwater nondestructive testing technology