检索结果-南通市图书馆

Chinese Physics B 2024年第2期33卷 577-585页

作者：马志伟孙蕾丁智国黄宜真胡兆龙 Zhejiang Normal University School of Computer Science and TechnologyJinhua 321004China Shanghai Business School School of Business and EconomicsShanghai 200235China Jinhua Polytechnic School of Information EngineeringJinhua 321016China

While progress has been made in information source localization,it has overlooked the prevalent friend and adversarial relationships in social *** paper addresses this gap by focusing on source localization in signed network *** the topological characteristics of signed networks and transforming the propagation probability into effective distance,we propose an optimization method for observer ***,by using the reverse propagation algorithm we present a method for information source localization in signed *** experimental results demonstrate that a higher proportion of positive edges within signed networks contributes to more favorable source localization,and the higher the ratio of propagation rates between positive and negative edges,the more accurate the source localization ***,this aligns with our observation that,in reality,the number of friends tends to be greater than the number of adversaries,and the likelihood of information propagation among friends is often higher than among *** addition,the source located at the periphery of the network is not easy to ***,our proposed observer selection method based on effective distance achieves higher operational efficiency and exhibits higher accuracy in information source localization,compared with three strategies for observer selection based on the classical full-order neighbor coverage.

关键词： complex networks signed networks source localization effective distance

PSME2和STAT3双重抑制通过合成致死效应诱导食管鳞癌细胞死亡

在线全文

学校读者我要写书评

暂无评论

中国生物化学与分子生物学报 2024年第4期40卷 534-543页

作者：孙魁陈攀刘永萱康永安吴晓爽程月月程浩东刘其伟高社干齐义军河南科技大学临床医学院河南科技大学第一附属医院肿瘤医院省部共建食管癌防治国家重点实验室河南省微生态与食管癌防治重点实验室河南省肿瘤表观遗传重点实验室河南洛阳471003 许昌学院医学院细胞行为学重点实验室河南许昌461000

蛋白酶体激活物复合物亚基2(proteasome activator complex subunit 2,PSME2)表达异常与多种肿瘤发生发展密切相关,但在食管鳞癌(esophageal squamous cell carcinoma,ESCC)中功能及临床意义尚不明确。本研究分析了TCGA-ESCC和GSE53625数据库中ESCC转录物组数据,发现PSME2高表达组ESCC患者预后不良,且ESCC组织中PSME2蛋白表达水平高于癌旁组织。沉默KYSE30细胞和NE6-T细胞中PSME2表达,ESCC细胞的增殖、侵袭、迁移和克隆能力均显著下降,同时伴随着LC3-II/LC3-I蛋白表达明显升高、p62蛋白表达降低和自噬激活。GSEA富集分析表明,PSME2低表达组IL-6/STAT3信号通路激活,沉默KYSE30细胞和NE6-T细胞诱导了IL-6分泌和p-STAT3表达增加。上述PSME2沉默诱导的分子变化,能够被LMT28或WP1066逆转。PSME2沉默联合WP1066,使KYSE30与NE6-T细胞培养上清中LDH含量明显升高,Calcein/PI染色表明,死亡细胞率分别为36.69%和32.55%,显著高于PSME2沉默(6.78%和6.74%)或WP1066单独处理组(18.34%和9.70%)。本研究表明,PSME2促进ESCC恶性进展,PSME2沉默通过IL-6/STAT3信号通路代偿性激活ESCC自噬,联合PSME2沉默和STAT3抑制通过合成致死效应诱导食管鳞癌细胞死亡,表明PSME2是ESCC潜在分子治疗靶点,联合抑制PSME2和STAT3是ESCC治疗的新选择。

关键词：蛋白酶体激活物复合物亚基2 食管鳞癌 STAT3 自噬合成致死

Comparative efficacy and safety between endoscopic submucosal dissection,surgery and definitive chemoradiotherapy in patients with cT1N0M0 esophageal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2024年第2期16卷 72-82页

作者： Shu-Ai Luo Yu-Ying sun Ya-Ting Zeng Chun-Yu Huang State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Endoscopic submucosal dissection(ESD)and surgical resection are the standard of care for cT1N0M0 esophageal cancer(EC),whereas definitive chemoradiotherapy(d-CRT)is a treatment ***,the comparative efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 EC remain *** To compare the efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 *** We retrospectively analyzed the hospitalized data of a total of 472 consecutive patients with cT1N0M0 EC treated at sun Yat-sen University Cancer center between 2017-2019 and followed up until October 30th,*** analyzed demographic,medical recorded,histopathologic characteristics,imaging and endoscopic,and follow-up *** Kaplan-Meier method and Cox proportional hazards modeling were used to analyze the difference of survival outcome by *** probability of treatment weighting(IPTW)was used to minimize potential confounding *** We retrospectively analyzed patients who underwent ESD(n=99)or surgery(n=220)or d-CRT(n=16)at the sun Yat-sen University Cancer Center from 2017 to *** median follow-up time for the ESD group,the surgery group,and the d-CRT group was 42.0 mo(95%CI:35.0-60.2),45.0 mo(95%CI:34.0-61.75)and 32.5 mo(95%CI:28.3-40.0),*** adjusting for background factors using IPTW,the highest 3-year overall survival(OS)rate and 3-year recurrence-free survival(RFS)rate were observed in the ESD group(3-year OS:99.7% and 94.7% and 79.1%;and 3-year RFS:98.3%,87.4% and 79.1%,in the ESD,surgical,and d-CRT groups,respectively).There was no difference of severe complications occurring between the three groups(P≥0.05).Multivariate analysis showed that treatment method,histology and depth of infiltration were independently associated with OS and *** For cT1N0M0 EC,ESD had better long-term survival and lower hospitalization costs than those who underwent d-CRT and surgery,with a similar rate of severe complications occurring.

关键词： Retrospective study cT1N0M0 Esophageal squamous cell carcinoma Endoscopic submucosal dissection Surgery Definitive chemoradiotherapy

子宫内膜异位症患者血清VEGFR-1和MIP-3α水平表达对术后复发的预测价值研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

现代检验医学杂志 2024年第4期39卷 170-174页

作者：孙晓华宋雨霖李红秦皇岛市妇幼保健院河北秦皇岛066000

目的探究血清血管内皮生长因子受体1(vascular endothelial growth factor receptor-1,VEGFR-1)和巨噬细胞炎性蛋白-3α(macrophage inflammatory protein-3α,MIP-3α)在子宫内膜异位症(endometriosis,EMs)患者中的表达以及两者联合检测对EMs患者术后复发的预测价值。方法选取2019年4月~2021年6月秦皇岛市妇幼保健院行腹腔镜手术治疗的114例EMs患者作为观察组,同期选择在该院体检的孕龄期女性114例健康体检者作为对照组。采用酶联免疫吸附法(ELISA)测定患者血清中VEGFR-1和MIP-3α水平;根据术后二年复发情况,将其分为复发组(n=78)和未复发组(n=36)。采用多因素Logistic回归分析EMs患者术后复发的影响因素;采用受试者工作特征(receiver operating characteristic,ROC)曲线分析血清VEGFR-1与MIP-3α联合检测对EMs患者术后复发的预测价值。结果与对照组相比,观察组VEGFR-1(116.25±48.57pg/ml vs 92.43±25.37pg/ml)及MIP-3α(19.25±5.24pg/ml vs 13.67±4.28pg/ml)水平升高,差异具有统计学意义(t=4.641,8.806,均P<0.05)。轻度、中度、重度EMs患者VEGFR-1水平(104.22±5.78pg/ml,118.60±6.56pg/ml,138.55±7.85pg/ml)和MIP-3α水平(15.37±1.15pg/ml,19.28±2.12pg/ml,25.42±2.56pg/ml)依次升高,差异具有统计学意义(F=147.757,133.654,均P<0.001)。复发组中后穹隆存在触痛结节及r-AFS分期(Ⅲ~Ⅳ期)占比显著大于未复发组(χ^(2)=15.139,10.310,均P<0.05);复发组术后用药6个月及以上占比显著低于未复发组(χ^(2)=15.016,P<0.001),差异具有统计学意义。多因素Logistic回归分析显示,血清VEGFR-1,MIP-3α,后穹隆存在触痛结节及r-AFS分期为EMs术后复发的危险因素(均P<0.05),术后用药6个月及以上为保护因素(P<0.05)。ROC曲线显示,血清VEGFR-1与MIP-3α联合预测EMs术后复发的曲线下面积(area under the curve,AUC)最大(0.929),其敏感度和特异度分别为85.90%和86.11%。结论VEGFR-1及MIP-3α在EMs患者血清中表达升高,且二者联合检测在预测EMs术后复发的效能更佳。

关键词：血管内皮生长因子受体1 巨噬细胞炎性蛋白-3α 子宫内膜异位症

在线全文

学校读者我要写书评

暂无评论

运动干预在炎症性肠病中的研究进展

世界华人消化杂志 2024年第5期32卷 339-346页

作者：孙少鹏陈佳佳郑明旭范一宏吕宾浙江中医药大学附属第一医院消化内科浙江省杭州市310003 浙江中医药大学附属第一医院护理部浙江省杭州市310003

炎症性肠病(inflammatory bowel disease,IBD)是一种肠道慢性疾病,需终身药物治疗.尽管生物制剂较传统药物而言,可增加临床获益,但药物应答率和用药风险仍是制约临床疗效的主要原因,因此,越来越多的研究致力于探索非药物干预措施对IBD... 详细信息

炎症性肠病(inflammatory bowel disease,IBD)是一种肠道慢性疾病,需终身药物治疗.尽管生物制剂较传统药物而言,可增加临床获益,但药物应答率和用药风险仍是制约临床疗效的主要原因,因此,越来越多的研究致力于探索非药物干预措施对IBD患者的潜在益处.在药物治疗的基础上,运动作为一种辅助治疗方式,可改善患者结局.本文从IBD患者的运动现状、不同运动类型对IBD患者的影响等方面进行综述,为IBD患者开展运动提供参考依据.

关键词：炎症性肠病体力活动运动锻炼克罗恩病溃疡性结肠炎

Two New Abietane Quinones from Isodon lophanthoides var. Micranthus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2003年第6期14卷 591-593页

作者： Ai Hua ZHAO Sheng hong LI yong Wei LI Quan Bin HUAN Qin Shi ZHAO Zhong Wen LIN Han Dong sun State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650204

The structures of two new abietane quinones, named micranthins A and B, were determined to be 7a-methoxy-14, 16-epoxy-8, 13-abietadiene-11, 12-dione (1) and 16-acetoxy-6, 7-dehydroroyleanone (2) respectively, which we... 详细信息

关键词： Isodon lophanthoides var. micranthus Labiatae abietane quinones micranthin A miranthin B.

Laparoscopic spleen-preserving total pancreatectomy for the treatment of low-grade malignant pancreatic tumors:Two case reports and review of literature

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第17期12卷 3206-3213页

作者： Meng-Qing sun Xiao-Man Kang Xiao-Dong He Xian-Lin Han Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China

BACKGROUND Function-preserving pancreatectomy can improve the long-term quality of life of patients with benign or low-grade malignant tumors,such as intraductal papillary mucinous neoplasms(IPMNs)and mucinous cystic ***,there is limited literature on laparoscopic spleen-preserving total pancreatectomy(LSpTP)due to technical *** SUMMARY Patient 1 was a 51-year-old male diagnosed with IPMN based on preoperative imaging,showing solid nodules in the pancreatic head and diffuse dilation of the main pancreatic duct with atrophy of the distal *** performed L-SpTP with preservation of the splenic vessels,and the postoperative pathology report revealed IPMN with invasive *** 2 was a 60-year-old male with multiple cystic lesions in the pancreatic head and body.L-SpTP was performed,and intraoperatively,the splenic vein was injured and required *** pathology revealed a mucinous cystic tumor of the pancreas with low-grade *** patients were discharged on postoperative day 7,and there were no major complications during the perioperative *** We believe that L-SpTP is a safe and feasible treatment for low-grade malignant pancreatic tumors,but more case studies are needed to evaluate its safety,efficacy,and long-term outcomes.

关键词： Complete laparoscopic surgery Spleen-preserving total pancreatectomy Lowgrade malignant pancreatic tumors Function-preserving pancreatectomy Case report

腹腔镜子宫切除联合骶韧带悬吊与经阴子宫切除对中重度子宫脱垂治疗效果和预后的比较研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国卫生标准管理 2024年第14期15卷 32-35页

作者：孙心红林莉遇红乳山市人民医院妇科山东乳山264500 联勤保障部队第九七〇医院威海院区妇科山东威海264200

目的比较腹腔镜下全子宫切除联合宫骶韧带高位悬吊与经阴道全子宫切除术治疗中重度子宫脱垂(uterine prolapse,UP)的效果和预后。方法选取2018年1月—2022年3月因中重度UP在乳山市人民医院接受治疗的63例患者。并按照所选择术式不同,将... 详细信息

目的比较腹腔镜下全子宫切除联合宫骶韧带高位悬吊与经阴道全子宫切除术治疗中重度子宫脱垂(uterine prolapse,UP)的效果和预后。方法选取2018年1月—2022年3月因中重度UP在乳山市人民医院接受治疗的63例患者。并按照所选择术式不同,将患者分为观察组(n=31)和对照组(n=32)。观察组采用腹腔镜下全子宫切除联合高位宫骶韧带悬吊术,对照组采用经阴道全子宫切除术,对2组患者的治疗效果进行比较。结果观察组术中出血量为(33.1±5.6)mL,低于对照组的(73.6±4.4)mL(P<0.05);术后留置导尿管时间为(3.2±1.2)d,手术操作时间为(58.2±6.5)min,住院时间为(6.9±1.5)d,短于对照组的(6.1±1.3)d、(70.4±10.3)min、(8.6±2.3)d(P<0.05);观察组术后6个月PFIQ-7评分为(21.0±4.4)分,低于对照组的(28.6±5.1)分(P<0.05);观察组治疗总有效率为100%,高于对照组的81.3%,差异有统计学意义(P<0.05)。结论与经阴道全子宫切除术相比较,腹腔镜全子宫切除联合宫骶韧带高位悬吊术对中重度UP的治疗效果更显著,应加强其在临床实践中的应用。

关键词：中重度子宫脱垂腹腔镜子宫切除骶韧带高位悬吊阴式子宫切除治疗效果预后

Two-view attention-guided convolutional neural network for mammographic image classification

在线全文

学校读者我要写书评

暂无评论

CAAI Transactions on Intelligence Technology 2023年第2期8卷 453-467页

作者： Lilei sun Jie Wen Junqian Wang yong Zhao Bob Zhang Jian Wu yong Xu College of Computer Science and Technology Guizhou UniversityGuiyangChina Shenzhen Key Laboratory of Visual Object Detection and Recognition Harbin Institute of TechnologyShenzhenChina Harbin Institute of Technology ShenzhenChina School of Electronic and Computer Engineering Shenzhen Graduate School of Peking UniversityShenzhenChina Department of Computer and Information Science University of MacaoTaipaChina Science for Life Laboratory KTH Royal Institute of TechnologyStockholmSweden

Deep learning has been widely used in the field of mammographic image classification owing to its superiority in automatic feature ***,general deep learning models cannot achieve very satisfactory classification results on mammographic images because these models are not specifically designed for mammographic images and do not take the specific traits of these images into *** exploit the essential discriminant information of mammographic images,we propose a novel classification method based on a convolutional neural ***,the proposed method designs two branches to extract the discriminative features from mammographic images from the mediolateral oblique and craniocaudal(CC)mammographic *** features extracted from the two-view mammographic images contain complementary information that enables breast cancer to be more easily ***,the attention block is introduced to capture the channel-wise information by adjusting the weight of each feature map,which is beneficial to emphasising the important features of mammographic ***,we add a penalty term based on the fuzzy cluster algorithm to the cross-entropy function,which improves the generalisation ability of the classification model by maximising the interclass distance and minimising the intraclass distance of the *** experimental results on The Digital database for Screening Mammography INbreast and MIAS mammography databases illustrate that the proposed method achieves the best classification performance and is more robust than the compared state-ofthe-art classification methods.

关键词： convolutional neural network deep learning medical image processing mammographic image