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Efficacy of graphene nanocomposites for air disinfection in dental clinics: A randomized controlled study

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World Journal of Clinical Cases 2024年第28期12卷 6173-6179页

作者： Ya-Qiong Ju Xiang-Hua Yu Jing Wu Ying-Hui Hu Xiang-yong Han Dan fang Department of Nursing Minhang District Dental ClinicShanghai 201107China Department of Medical Sciences Minhang District Dental ClinicShanghai 201107China Department of Orthopedics Center for Spinal Minimally Invasive ResearchShanghai Jiao Tong UniversityShanghai 201107China

BACKGROUND Aerosols containing disease-causing microorganisms are produced during oral diagnosis and treatment can cause secondary *** To investigate the use of graphene material for air disinfection in dental clinics by leveraging its adsorption and antibacterial *** Patients who received ultrasonic cleaning at our hospital from April 2023 to April *** were randomly assigned to three groups(n=20 each):Graphene nanocomposite material suction group(Group A),ordinary filter suction group(Group B),and no air suction device group(Group C).The air quality and air colony count in the clinic rooms were assessed before,during,and after the ***,bacterial colony counts were obtained from the air outlets of the suction devices and the filter screens in Groups A and *** Before ultrasonic cleaning,no significant differences in air quality PM2.5 and colony counts were observed among the three ***,significant differences in air quality PM2.5 and colony counts were noted among the three groups during ultrasonic cleaning and after ultrasonic ***,the number of colonies on the exhaust port of the suction device and the surface of the filter were significantly lower in Group A than in Group B(P=0.000 and P=0.000,respectively).CONCLUSION Graphene nanocomposites can effectively sterilize the air in dental clinics by exerting their antimicrobial effects and may be used to reduce secondary pollution.

关键词： Graphene Nanocomposites Oral clinic Air disinfection Secondary contamination

Ferroptosis regulating lipid peroxidation metabolism in the occurrence and development of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2781-2792页

作者： Lan-Mei Wang Wei-Wei Zhang Ying-Yang Qiu fang Wang Department of Clinical Laboratory Anqiu People's HospitalWeifang 262123Shandong ProvinceChina Department of Gastroenterology Feicheng People's HospitalTai’an 271600Shandong ProvinceChina yong Loo Lin School of Medicine National University of Singapore119077Singapore Department of Gastroenterology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Gastric cancer is one of the most common malignant tumors in the world,and its occurrence and development involve complex biological *** death,as a new cell death mode,has attracted wide attention in recent ***,the regulatory mechanism of iron death in gastric cancer and its effect on lipid peroxidation metabolism remain *** To explore the role of iron death in the development of gastric cancer,reveal its relationship with lipid peroxidation,and provide a new theoretical basis for revealing the molecular mechanism of the occurrence and development of gastric *** The process of iron death in gastric cancer cells was simulated by cell culture model,and the occurrence of iron death was detected by fluorescence microscopy and flow *** changes of gene expression related to iron death and lipid peroxidation metabolism were analyzed by high-throughput sequencing *** addition,a mouse model of gastric cancer was established,and the role of iron death in vivo was studied by histology and immunohistochemistry,and the level of lipid peroxidation was *** methods comprehensively and deeply reveal the regulatory mechanism of iron death on lipid peroxidation metabolism in the occurrence and development of gastric *** Iron death was significantly activated in gastric cancer cells,and at the same time,associated lipid peroxidation levels increased *** high-throughput sequencing analysis,it was found that iron death regulated the expression of several genes related to lipid *** vivo experiments demonstrated that increased iron death in gastric cancer mice was accompanied by a significant increase in lipid *** This study confirmed the important role of iron death in regulating lipid peroxidation metabolism in the occurrence and development of gastric *** activation of iron death significantly increased lipid peroxidation levels,revealing it

关键词： Ferroptosis Lipid peroxidation Gastric cancer Lipid metabolism Systematic review

Exploring the mechanism of active ingredients of Smilacis Glabrae Rhizoma in treating migraine headache through network pharmacology and animal experiments

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Integrative Medicine Discovery 2024年第18期8卷 1-10页

作者： Dao-Xian Shu Yan-Yan Chen Jiao-Rong Wang Ying Wang yong-fang Gu Yan-Xin Wang Department of Brain DiseaseⅡ The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230031China

Background:To explore the potential mechanism of action of the active ingredients of Smilacis Glabrae Rhizoma(SGR)in the treatment of migraine using network pharmacology and in vivo ***:Through the search of Traditional Chinese Medicines Systems Pharmacology Database and Analysis Platform,Genecards,Drugbank and other databases,we obtained active ingredients,targets of SGR and related disease targets of migraine,and took the intersection for protein-protein interactions *** constructing the network diagram,network topology analysis was performed to derive the core targets and key active ingredients,and Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were ***,molecular docking was performed and validated by in vivo *** vivo experiments,18 male BALB/c mice were selected,and the SGR group was fed with SGR drinking tablet concentrate,and nitroglycerin injection was used to construct a mouse model of ***-linked immunosorbent assay test was used to detect the levels of TNF-α,IL-1β,IL-6,and AKT1 in ***:The results showed that the core targets of SGR for the treatment of migraine were TNF-α,IL-1β,IL-6,and *** core targets and key active ingredients had better binding *** with the blank group,the number of head scratching in the model group *** with the model group,there was a significant reduction of the number of head scratching in the SGR *** comparison with the blank group,the protein level in the plasma in the model group was markedly *** with the model group,the protein level in the SGR group was significantly ***:SGR has the characteristics of improving migraine based on multi-targets,multi-components and multi-pathways,and the mechanism of action may be related to the inhibition of the release of inflammatory factors,neuron protection,and interference with apoptosis and other processes.

关键词： migraine Smilacis Glabrae Rhizoma network pharmacology molecular docking mechanism of effect

儿童急性T淋巴细胞白血病预后影响因素分析——CCCG-ALL-2015方案单中心临床研究

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中国当代儿科杂志 2024年第10期26卷 1078-1085页

作者：付文凤方拥军南京医科大学附属儿童医院血液肿瘤科江苏南京210008

目的探讨儿童急性T淋巴细胞白血病(acute T-lymphoblastic leukemia,T-ALL)患儿的临床特征,并分析其与预后的关系。方法回顾性分析2015年11月—2019年12月南京医科大学附属儿童医院血液肿瘤科采用CCCG-ALL-2015方案诊治的50例T-ALL患儿... 详细信息

目的探讨儿童急性T淋巴细胞白血病(acute T-lymphoblastic leukemia,T-ALL)患儿的临床特征,并分析其与预后的关系。方法回顾性分析2015年11月—2019年12月南京医科大学附属儿童医院血液肿瘤科采用CCCG-ALL-2015方案诊治的50例T-ALL患儿的临床资料及随访结果,运用Kaplan-Meier生存分析、Cox回归分析等方法分析患儿预后的影响因素。结果50例T-ALL患儿中,共复发7例。复发组和非复发组基本临床资料的比较差异无统计学意义(P>0.05)。复发组诱导缓解治疗后第4.天微小残留病(minimal residual disease,MRD)阳性率(≥0.01%)高于非复发组,差异有统计学意义(P=0.037)。50例患儿5年总体生存率为(87±5)%,5年无事件生存率为(86±5)%。多因素Cox回归分析显示诱导缓解治疗后第4.天MRD水平是预后的独立影响因素(HR=0.104.95%CI:0.015~0.74.,P=0.024.。结论MRD对T-ALL患儿的预后有重要意义,临床上需根据MRD水平提供个性化治疗,预防复发、改善预后。

关键词：急性T淋巴细胞白血病微小残留病临床特征预后危险因素儿童

“十四五”时期药品安全监管相关政策分析与比较

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中国新药杂志 2024年第7期33卷 644-650页

作者：唐湘燕曹永芳何辉国家药品监督管理局药品审评中心北京100061

人民健康是民族昌盛和国家强盛的重要标志。为保障人民健康、促进医药产业走高质量发展道路,我国先后发布了“十四五”时期的规划、纲要,针对国家药品安全、医药工业、中医药发展、市场监管等方面提出一系列重要政策和措施。本文围绕《... 详细信息

人民健康是民族昌盛和国家强盛的重要标志。为保障人民健康、促进医药产业走高质量发展道路,我国先后发布了“十四五”时期的规划、纲要,针对国家药品安全、医药工业、中医药发展、市场监管等方面提出一系列重要政策和措施。本文围绕《“十四五”国家药品安全及促进高质量发展规划》,系统梳理相关国家部委针对“十四五”所发布有关药品安全监管的相关内容,并对其进行分析和比较,以期更好地理解国家层面对药品安全监管政策的整体规划和制定脉络。

关键词：药品安全 “十四五”规划高质量发展监管现代化

基于处置效应及动量效应的加密货币市场投资策略

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管理评论 2024年第6期36卷 94-106页

作者：刘帅房勇汪寿阳中国科学院数学与系统科学研究院北京100190 中国科学院大学经济与管理学院北京100190

针对加密货币市场,本文选取资本利得量作为处置效应的代理变量,基于公开数据并采用计量方法实证检验了加密货币市场中存在处置效应和动量效应;然后依据处置效应和动量效应,针对仅含加密货币这一类资产而不含其他传统资产的投资池设计了... 详细信息

针对加密货币市场,本文选取资本利得量作为处置效应的代理变量,基于公开数据并采用计量方法实证检验了加密货币市场中存在处置效应和动量效应;然后依据处置效应和动量效应,针对仅含加密货币这一类资产而不含其他传统资产的投资池设计了三类投资策略。本文的投资标的不仅含有市值较大的比特币和以太坊等某几种加密货币,还选取了更多种类的货币,这些货币总市值占全部加密货币的95%以上,种类更丰富。在各种参数设置下,结合了两种效应的投资策略均表现优于单独基于某一效应指导设计的策略,并且基于投资者行为效应的三类投资策略均优于等权重模型,具有稳健性和普适性。特别地,本文还对加密货币市场中动量效应和处置效应的持续时长、资本利得量的参数选择和动量策略的排序期参数设置进行了讨论,发现:加密货币市场较股市的变换更快,迭代周期缩短很多,仅存在两周的动量效应,处置效应对收益率的影响不超过一个月;须选用日数据或更高频数据计算资本利得量并进行处置效应存在性检验的回测才有效,选用低频的周数据无效;动量策略的排序期超过动量效应持续时间的一半时,动量策略受排序期参数的影响不大。

关键词：加密货币处置效应行为金融资本利得量投资策略

基于MGWR的长江流域植被演化及其影响因素

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中国环境科学 2024年第1期44卷 352-362页

作者：李泳君陈青长方贺李建上海应用技术大学城市建设与安全工程学院上海201418 浙江省气候中心浙江杭州310057

以2000~2022年长江流域植被覆盖度为因变量,以地形、气象、社会经济因素为自变量,借助能很好处理尺度差异的多尺度地理加权回归(MGWR)探讨植被时空变化及其影响因素.结果表明:2000~2022年长江流域植被覆盖度呈现波动变化,以改善为主,增... 详细信息

以2000~2022年长江流域植被覆盖度为因变量,以地形、气象、社会经济因素为自变量,借助能很好处理尺度差异的多尺度地理加权回归(MGWR)探讨植被时空变化及其影响因素.结果表明:2000~2022年长江流域植被覆盖度呈现波动变化,以改善为主,增长速度为0.24.%/a;流域植被空间分布模式为东西低,中部高的空间分异;未来流域大部分地区有退化风险.不同影响因子对于长江植被的作用出现明显的空间差异,其中坡度、高程、气温及相对湿度是长江流域植被变化的主要驱动因素;值得注意的是人为因子对于植被的影响力相对较小.植被与各个影响因子的响应尺度具有显著差异,其中地形和气候因子等自然因素对于植被的作用尺度较小,仅为4.,而社会因素的作用尺度较大(>870).

关键词：长江流域植被覆盖度时空变化影响因素多尺度地理加权回归尺度效应

肿瘤患者中替雷利珠单抗血药浓度与免疫相关不良事件的相关性研究

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中国临床药理学杂志 2024年第8期40卷 1217-1221页

作者：诸慧原永芳徐影上海交通大学医学院附属第九人民医院药剂科上海200011 上海交通大学医学院附属第九人民医院呼吸与危重症医学科上海200011

目的研究恶性肿瘤患者应用替雷利珠单抗的血药浓度与发生免疫相关不良事件(irAEs)的相关性,并分析影响血药浓度的因素。方法选择用替雷利珠单抗治疗的恶性肿瘤患者为研究对象,用液相色谱-串联质谱法检测其血药浓度。观察患者治疗期间i... 详细信息

目的研究恶性肿瘤患者应用替雷利珠单抗的血药浓度与发生免疫相关不良事件(irAEs)的相关性,并分析影响血药浓度的因素。方法选择用替雷利珠单抗治疗的恶性肿瘤患者为研究对象,用液相色谱-串联质谱法检测其血药浓度。观察患者治疗期间irAEs的发生情况,并分析血药浓度与irAEs之间的相关性。同时,收集患者的诊疗资料,分析其对血药浓度的影响。结果纳入分析的50例接受替雷利珠单抗治疗的恶性肿瘤患者中,共有34.发生了irAEs,发生率为68%,包括甲状腺功能减退、皮疹、肝功能功损害等。发生irAEs组患者的平均血药浓度为16.69μg·mL^(-1)显著高于未发生irAEs组的8.4.μg·mL^(-1),在统计学上差异有统计学意义(P4.g·mL^(-1),发生肝功能损伤患者的平均血药浓度为23.4.μg·mL^(-1)显著高于未发生组的12.06μg·mL^(-1),在统计学上差异均有统计学意义(均P4.61和13.19μg·mL^(-1)。同时通过分析患者临床特征,结果显示,联合化疗组患者的平均血药浓度为9.67μg·mL^(-1)显著低于未联合组的19.03μg·mL^(-1),非小细胞肺癌组患者的血药浓度为12.74.g·mL^(-1)显著低于其他组的20.31μg·mL^(-1),在统计学上差异均有统计学意义(均P<0.05)。结论较高的替雷利珠单抗血药浓度会增加患者发生甲状腺功能减退和肝功能损伤的风险。

关键词：替雷利珠单抗免疫相关不良事件治疗药物浓度监测影响因素

Direct observation of shock-induced phase transformation in polycrystalline iron via in situ x-ray diffraction

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Chinese Physics B 2024年第10期33卷 337-342页

作者： Fan Zhang Jia-Qin Dong Zhi-yong Xie Zhi-Yu He Hua Shu Rui-Rong Wang Jun Xiong Guo Jia Zhi-Heng fang Wei Wang Da-Wu Xiao An-Le Lei Jie Chen Xiu-Guang Huang Collaborative Innovation Center of IFSA(CICIFSA) School of Physics and AstronomyCenter for Ultrafast Science and TechnologyKey Laboratory for Laser Plasmas(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Institute of Laser Plasma China Academy of Engineering PhysicsShanghai 201800China Institute of Materials China Academy of Engineering PhysicsMianyang 621700China

Phase transition of polycrystalline iron compressed along the Hugoniot is studied by combining laser-driven shock with in situ x-ray diffraction *** is suggested that polycrystalline iron changes from an initial body-centered cubic structure to a hexagonal close-packed structure with increasing pressure(i.e.,a phase transition fromαtoε).The relationship between density and pressure for polycrystalline iron obtained from the present experiments is found to be in good agreement with the gas-gun Hugoniot *** results show that experiments with samples at lower temperatures under static loading,such as in a diamond anvil cell,lead to higher densities measured than those found under dynamic *** means that extrapolating results of static experiments may not predict the dynamic responses of materials *** addition,neither the face-centered cubic structure seen in previous molecular-dynamics simulations or twophase coexistence are found within our experimental pressure range.

关键词： in situ x-ray diffraction phase transition polycrystalline iron